HIF1A Gene Set

Dataset ChEA Transcription Factor Targets
Category genomics
Type transcription factor
Description hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)|This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 3091)
External Link http://www.ncbi.nlm.nih.gov/gene/3091
Similar Terms
Downloads & Tools

Genes

314 target genes of the HIF1A transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

Symbol Name
ACOT6 acyl-CoA thioesterase 6
ADM adrenomedullin
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHNAK AHNAK nucleoprotein
AKAP10 A kinase (PRKA) anchor protein 10
AKAP12 A kinase (PRKA) anchor protein 12
AKR1E2 aldo-keto reductase family 1, member E2
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ALKBH5 AlkB family member 5, RNA demethylase
ALOXE3 arachidonate lipoxygenase 3
ANGPTL4 angiopoietin-like 4
ANKRD37 ankyrin repeat domain 37
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANO6 anoctamin 6
ARID1B AT rich interactive domain 1B (SWI1-like)
ARRDC3 arrestin domain containing 3
ATP9A ATPase, class II, type 9A
BACE2 beta-site APP-cleaving enzyme 2
BCAS4 breast carcinoma amplified sequence 4
BCCIP BRCA2 and CDKN1A interacting protein
BCL2L2 BCL2-like 2
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BLCAP bladder cancer associated protein
BMP4 bone morphogenetic protein 4
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
BZW1 basic leucine zipper and W2 domains 1
C11ORF30 chromosome 11 open reading frame 30
C11ORF49 chromosome 11 open reading frame 49
C1D C1D nuclear receptor corepressor
C1ORF116 chromosome 1 open reading frame 116
C1ORF27 chromosome 1 open reading frame 27
C2ORF42 chromosome 2 open reading frame 42
C3ORF14 chromosome 3 open reading frame 14
C8ORF58 chromosome 8 open reading frame 58
CA9 carbonic anhydrase IX
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CCNL1 cyclin L1
CDC73 cell division cycle 73
CECR5 cat eye syndrome chromosome region, candidate 5
CGA glycoprotein hormones, alpha polypeptide
CHD2 chromodomain helicase DNA binding protein 2
CIART circadian associated repressor of transcription
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN14 claudin 14
CLIC6 chloride intracellular channel 6
CLK3 CDC-like kinase 3
CLN5 ceroid-lipofuscinosis, neuronal 5
COX20 COX20 cytochrome c oxidase assembly factor
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CUX1 cut-like homeobox 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAAM1 dishevelled associated activator of morphogenesis 1
DAB2IP DAB2 interacting protein
DAPK2 death-associated protein kinase 2
DARS aspartyl-tRNA synthetase
DAZL deleted in azoospermia-like
DDIT4 DNA-damage-inducible transcript 4
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DENND1A DENN/MADD domain containing 1A
DHCR7 7-dehydrocholesterol reductase
DHRS13 dehydrogenase/reductase (SDR family) member 13
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNASE1 deoxyribonuclease I
DNM2 dynamin 2
DPT dermatopontin
DSP desmoplakin
DYNLL1 dynein, light chain, LC8-type 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EGFR epidermal growth factor receptor
EGLN3 egl-9 family hypoxia-inducible factor 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELL2 elongation factor, RNA polymerase II, 2
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
ERRFI1 ERBB receptor feedback inhibitor 1
EVL Enah/Vasp-like
EVX1 even-skipped homeobox 1
FAM110C family with sequence similarity 110, member C
FAM129B family with sequence similarity 129, member B
FAM13A family with sequence similarity 13, member A
FAM162A family with sequence similarity 162, member A
FAM65C family with sequence similarity 65, member C
FBL fibrillarin
FBXO42 F-box protein 42
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FEM1C fem-1 homolog c (C. elegans)
FNTB farnesyltransferase, CAAX box, beta
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
GADD45B growth arrest and DNA-damage-inducible, beta
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GBE1 glucan (1,4-alpha-), branching enzyme 1
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA1 golgin A1
GPI glucose-6-phosphate isomerase
GPR135 G protein-coupled receptor 135
GPR37L1 G protein-coupled receptor 37 like 1
GRB10 growth factor receptor-bound protein 10
GSE1 Gse1 coiled-coil protein
GTF2IRD2B GTF2I repeat domain containing 2B
GUK1 guanylate kinase 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IGFBP3 insulin-like growth factor binding protein 3
ILVBL ilvB (bacterial acetolactate synthase)-like
INHA inhibin, alpha
INHBA inhibin, beta A
INSIG2 insulin induced gene 2
IRX1 iroquois homeobox 1
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JMJD6 jumonji domain containing 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD15 potassium channel tetramerization domain containing 15
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KDM4C lysine (K)-specific demethylase 4C
KDM5B lysine (K)-specific demethylase 5B
KIAA0195 KIAA0195
KLF10 Kruppel-like factor 10
KLHDC4 kelch domain containing 4
KLRF1 killer cell lectin-like receptor subfamily F, member 1
KMT2E lysine (K)-specific methyltransferase 2E
KRT19 keratin 19, type I
KRT80 keratin 80, type II
KXD1 KxDL motif containing 1
LDHA lactate dehydrogenase A
LINC00242 long intergenic non-protein coding RNA 242
LINC00574 long intergenic non-protein coding RNA 574
LINC01011 long intergenic non-protein coding RNA 1011
LONP1 lon peptidase 1, mitochondrial
LOXL2 lysyl oxidase-like 2
LPIN3 lipin 3
LRP1 low density lipoprotein receptor-related protein 1
MAB21L3 mab-21-like 3 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAML1 mastermind-like 1 (Drosophila)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK6 mitogen-activated protein kinase 6
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
MAX MYC associated factor X
MBTPS1 membrane-bound transcription factor peptidase, site 1
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MICALL2 MICAL-like 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MPI mannose phosphate isomerase
MRPL14 mitochondrial ribosomal protein L14
MRPS18A mitochondrial ribosomal protein S18A
MSANTD3 Myb/SANT-like DNA-binding domain containing 3
MTCH2 mitochondrial carrier 2
MTFP1 mitochondrial fission process 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP3 NEDD4 binding protein 3
NAMPT nicotinamide phosphoribosyltransferase
NARF nuclear prelamin A recognition factor
NAV1 neuron navigator 1
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NCOR2 nuclear receptor corepressor 2
NDRG1 N-myc downstream regulated 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5DC1 5'-nucleotidase domain containing 1
NTHL1 nth endonuclease III-like 1 (E. coli)
NUP210 nucleoporin 210kDa
NUPL1 nucleoporin like 1
OTUD7B OTU deubiquitinase 7B
OXSM 3-oxoacyl-ACP synthase, mitochondrial
OXSR1 oxidative stress responsive 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PARD6B par-6 family cell polarity regulator beta
PARN poly(A)-specific ribonuclease
PC pyruvate carboxylase
PDGFB platelet-derived growth factor beta polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFDN4 prefoldin subunit 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PFKL phosphofructokinase, liver
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PKM pyruvate kinase, muscle
PKP2 plakophilin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PNPO pyridoxamine 5'-phosphate oxidase
PNRC1 proline-rich nuclear receptor coactivator 1
POU2F1 POU class 2 homeobox 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PPP1R21 protein phosphatase 1, regulatory subunit 21
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM1 PR domain containing 1, with ZNF domain
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRM protein tyrosine phosphatase, receptor type, M
PTPRN protein tyrosine phosphatase, receptor type, N
PVRL4 poliovirus receptor-related 4
PXDN peroxidasin
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB6A RAB6A, member RAS oncogene family
RAD51B RAD51 paralog B
RAI14 retinoic acid induced 14
RAN RAN, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASEF RAS and EF-hand domain containing
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RIT1 Ras-like without CAAX 1
RNF126 ring finger protein 126
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RSBN1 round spermatid basic protein 1
RUNX1 runt-related transcription factor 1
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL1 SCY1-like 1 (S. cerevisiae)
SEC61G Sec61 gamma subunit
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
SERTAD2 SERTA domain containing 2
SIAH2 siah E3 ubiquitin protein ligase 2
SLA Src-like-adaptor
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC35E1 solute carrier family 35, member E1
SLC37A3 solute carrier family 37, member 3
SLC38A2 solute carrier family 38, member 2
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
SMC2 structural maintenance of chromosomes 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa
SOS1 son of sevenless homolog 1 (Drosophila)
SPAG4 sperm associated antigen 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF3 serine/arginine-rich splicing factor 3
SSUH2 ssu-2 homolog (C. elegans)
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
STC2 stanniocalcin 2
SUMF1 sulfatase modifying factor 1
TFF1 trefoil factor 1
TFRC transferrin receptor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM2D3 TM2 domain containing 3
TMEM18 transmembrane protein 18
TMEM183A transmembrane protein 183A
TMEM189 transmembrane protein 189
TMEM45A transmembrane protein 45A
TMEM45B transmembrane protein 45B
TMEM75 transmembrane protein 75
TMEM88 transmembrane protein 88
TNS1 tensin 1
TPCN2 two pore segment channel 2
TPD52 tumor protein D52
TRAM2 translocation associated membrane protein 2
TRIM33 tripartite motif containing 33
TRIM37 tripartite motif containing 37
TRIOBP TRIO and F-actin binding protein
TSC22D2 TSC22 domain family, member 2
UBA6 ubiquitin-like modifier activating enzyme 6
UBC ubiquitin C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UNKL unkempt family zinc finger-like
UPK1B uroplakin 1B
UTRN utrophin
VDAC1 voltage-dependent anion channel 1
VGLL4 vestigial-like family member 4
VKORC1 vitamin K epoxide reductase complex, subunit 1
VRK1 vaccinia related kinase 1
WBSCR22 Williams Beuren syndrome chromosome region 22
WDR54 WD repeat domain 54
WDR5B WD repeat domain 5B
WDR60 WD repeat domain 60
WDR89 WD repeat domain 89
WISP1 WNT1 inducible signaling pathway protein 1
WISP3 WNT1 inducible signaling pathway protein 3
WSB1 WD repeat and SOCS box containing 1
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like
ZFAT zinc finger and AT hook domain containing
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF19 zinc finger protein 19
ZNF331 zinc finger protein 331
ZNF395 zinc finger protein 395
ZNF407 zinc finger protein 407
ZNF572 zinc finger protein 572
ZSWIM4 zinc finger, SWIM-type containing 4