HIF1A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)|This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 3091)
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Genes

340 genes differentially expressed following the HIF1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM3D family with sequence similarity 3, member D 3.74489
SSTR1 somatostatin receptor 1 3.74489
HORMAD2 HORMA domain containing 2 3.74489
PGBDF plakoglobin binding and degradation factor 3.74489
NCF4 neutrophil cytosolic factor 4, 40kDa 3.74489
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.74489
GSTM5 glutathione S-transferase mu 5 3.74489
GJB3 gap junction protein, beta 3, 31kDa 3.74489
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.74489
FOXR1 forkhead box R1 3.74489
SLC30A4 solute carrier family 30 (zinc transporter), member 4 3.74489
HES4 hes family bHLH transcription factor 4 3.74489
IZUMO3 IZUMO family member 3 3.74489
RAET1E retinoic acid early transcript 1E 3.74489
NRN1 neuritin 1 3.74489
SRL sarcalumenin 3.74489
RNF17 ring finger protein 17 3.74489
MYBPHL myosin binding protein H-like 3.74489
CARD18 caspase recruitment domain family, member 18 3.74489
MAP3K7CL MAP3K7 C-terminal like 3.74489
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.74489
FAM180B family with sequence similarity 180, member B 3.74489
ZNF492 zinc finger protein 492 3.74489
MUSK muscle, skeletal, receptor tyrosine kinase 3.74489
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.74489
ASPA aspartoacylase 3.74489
SYCE3 synaptonemal complex central element protein 3 3.74489
OC90 otoconin 90 3.74489
MUC22 mucin 22 3.74489
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.74489
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 3.74489
MRC1 mannose receptor, C type 1 3.74489
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.74489
CRYAA crystallin, alpha A 3.74489
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.74489
CLCF1 cardiotrophin-like cytokine factor 1 3.74489
DPPA3 developmental pluripotency associated 3 3.74489
RLN1 relaxin 1 3.74489
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.74489
ADAD2 adenosine deaminase domain containing 2 3.74489
CA1 carbonic anhydrase I 3.74489
FHL5 four and a half LIM domains 5 3.74489
GFI1 growth factor independent 1 transcription repressor 3.74489
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 3.74489
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.74489
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.74489
CD68 CD68 molecule 3.74489
CRH corticotropin releasing hormone 3.74489
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 3.74489
FPR2 formyl peptide receptor 2 3.74489
FAM90A12 family with sequence similarity 90 member A12 3.74489
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 3.74489
RTL9 retrotransposon Gag like 9 3.74489
MARCHF10 membrane associated ring-CH-type finger 10 3.74489
PHF24 PHD finger protein 24 3.74489
ZNF726 zinc finger protein 726 3.74489
PNLIPRP1 pancreatic lipase-related protein 1 3.74489
ADGRG3 adhesion G protein-coupled receptor G3 3.74489
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.74489
MLN motilin 3.74489
FOXN4 forkhead box N4 3.74489
BNIP5 BCL2 interacting protein 5 3.74489
CATSPERZ catsper channel auxiliary subunit zeta 3.74489
DRC11L dynein regulatory complex subunit 11 like 3.74489
DRC5 dynein regulatory complex subunit 5 3.74489
SMIM32 small integral membrane protein 32 3.74489
PPIAP39 peptidylprolyl isomerase A pseudogene 39 3.74489
PRRT1B proline rich transmembrane protein 1B 3.74489
MYMK myomaker, myoblast fusion factor 3.74489
PEAK3 PEAK family member 3 3.74489
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.74489
SEPTIN12 septin 12 3.74489
TMEM225B transmembrane protein 225B 3.74489
TMPRSS7 transmembrane protease, serine 7 3.74489
ACSL5 acyl-CoA synthetase long-chain family member 5 3.74489
ASB4 ankyrin repeat and SOCS box containing 4 3.74489
EXOC3L1 exocyst complex component 3-like 1 3.74489
CREB3L3 cAMP responsive element binding protein 3-like 3 3.74489
TBX3 T-box 3 3.74489
DNASE2B deoxyribonuclease II beta 3.74489
SCN10A sodium channel, voltage gated, type X alpha subunit 3.74489
CD48 CD48 molecule 3.74489
ARL5C ADP-ribosylation factor-like 5C 3.74489
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.74489
PTPRH protein tyrosine phosphatase, receptor type, H 3.74489
PRB4 proline-rich protein BstNI subfamily 4 3.74489
CCR9 chemokine (C-C motif) receptor 9 3.74489
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.74489
BDKRB1 bradykinin receptor B1 3.74489
TTR transthyretin 3.74489
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.74489
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.74489
PRG3 proteoglycan 3 3.74489
GPR85 G protein-coupled receptor 85 3.74489
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.74489
TAS1R1 taste receptor, type 1, member 1 3.74489
FGFBP2 fibroblast growth factor binding protein 2 3.74489
PGA5 pepsinogen 5, group I (pepsinogen A) 3.74489
PTTG2 pituitary tumor-transforming 2 3.74489
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.74489
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.74489
KLF1 Kruppel-like factor 1 (erythroid) 3.74489
PRM1 protamine 1 3.74489
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.74489
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.74489
APOC2 apolipoprotein C-II 3.74489
CBX8 chromobox homolog 8 3.74489
RANBP3L RAN binding protein 3-like 3.74489
FAM209B family with sequence similarity 209, member B 3.74489
DRD2 dopamine receptor D2 3.74489
BAHCC1 BAH domain and coiled-coil containing 1 3.74489
NTN5 netrin 5 3.74489
CPSF4L cleavage and polyadenylation specific factor 4-like 3.74489
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.74489
APOF apolipoprotein F 3.74489
FNDC1 fibronectin type III domain containing 1 3.74489
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.74489
BRDT bromodomain, testis-specific 3.74489
CTLA4 cytotoxic T-lymphocyte-associated protein 4 3.74489
LYG2 lysozyme G-like 2 3.74489
THTPA thiamine triphosphatase 3.74489
SPANXN4 SPANX family, member N4 3.74489
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 3.74489
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.74489
ISL1 ISL LIM homeobox 1 3.74489
TEKT2 tektin 2 (testicular) 3.74489
SLC38A3 solute carrier family 38, member 3 3.74489
CTRB1 chymotrypsinogen B1 3.74489
RGS4 regulator of G-protein signaling 4 3.74489
LGALS12 lectin, galactoside-binding, soluble, 12 3.74489
FOXF1 forkhead box F1 3.74489
TSPAN19 tetraspanin 19 3.74489
GPR150 G protein-coupled receptor 150 3.74489
RIN1 Ras and Rab interactor 1 3.74489
TTC24 tetratricopeptide repeat domain 24 3.74489
LRRC24 leucine rich repeat containing 24 3.74489
IDI2 isopentenyl-diphosphate delta isomerase 2 3.74489
PRH2 proline-rich protein HaeIII subfamily 2 3.74489
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.74489
KLK15 kallikrein-related peptidase 15 3.74489
KLK14 kallikrein-related peptidase 14 3.74489
UTS2B urotensin 2B 3.74489
ARL13A ADP-ribosylation factor-like 13A 3.74489
TF transferrin 3.74489
TPPP3 tubulin polymerization-promoting protein family member 3 3.74489
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.74489
ACSBG2 acyl-CoA synthetase bubblegum family member 2 3.74489
PRSS38 protease, serine, 38 3.74489
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.74489
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.74489
DMTN dematin actin binding protein 3.74489
NEUROD1 neuronal differentiation 1 3.74489
NLRP3 NLR family, pyrin domain containing 3 3.74489
TECRL trans-2,3-enoyl-CoA reductase-like 3.74489
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.74489
SHISA3 shisa family member 3 3.74489
TMEM86B transmembrane protein 86B 3.74489
NPR3 natriuretic peptide receptor 3 3.74489
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 3.74489
ADAM21 ADAM metallopeptidase domain 21 3.74489
FOXP3 forkhead box P3 3.74489
ST18 suppression of tumorigenicity 18, zinc finger 3.74489
A1CF APOBEC1 complementation factor 3.74489
PRSS50 protease, serine, 50 3.74489
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.74489
POTEI POTE ankyrin domain family, member I 3.74489
DSPP dentin sialophosphoprotein 3.74489
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 3.74489
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 3.74489
HCAR1 hydroxycarboxylic acid receptor 1 3.74489
RBP3 retinol binding protein 3, interstitial 3.74489
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.74489
CD3G CD3g molecule, gamma (CD3-TCR complex) 3.74489
ZNF474 zinc finger protein 474 3.74489
PASD1 PAS domain containing 1 3.74489
R3HDML R3H domain containing-like 3.74489
CMKLR1 chemerin chemokine-like receptor 1 3.69491
MARCHF9 membrane associated ring-CH-type finger 9 3.69491
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) 3.69491
TDRD12 tudor domain containing 12 3.06373
MYOZ1 myozenin 1 3.06373
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 3.05816
APOLTP apolipoprotein lipid transfer particle homolog 3.00128
SON SON DNA binding protein 2.96047
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.86598
ZNF281 zinc finger protein 281 2.78987
ZFAND1 zinc finger, AN1-type domain 1 2.65338
PMP22 peripheral myelin protein 22 2.64373
FMO1 flavin containing monooxygenase 1 2.64373
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.64373
LDHAL6A lactate dehydrogenase A-like 6A 2.64373
KCNK2 potassium channel, two pore domain subfamily K, member 2 2.64373
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.64373
FBXW4 F-box and WD repeat domain containing 4 2.61714
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 2.61107
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.52385
DIPK1B divergent protein kinase domain 1B 2.50102
CIPC CLOCK-interacting pacemaker 2.48369
ELF1 E74-like factor 1 (ets domain transcription factor) 2.47243
DYNLL2 dynein, light chain, LC8-type 2 2.4716
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.42897
OVOL2 ovo-like zinc finger 2 2.42557
TMEM215 transmembrane protein 215 2.39841
TJP1 tight junction protein 1 2.39829
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.37961
SMIM45 small integral membrane protein 45 2.37961
ZNF684 zinc finger protein 684 2.37743
APP amyloid beta (A4) precursor protein 2.34701
RUSF1 RUS family member 1 2.31228
ZNF681 zinc finger protein 681 2.30017
USP22 ubiquitin specific peptidase 22 2.29149
HAUS2 HAUS augmin-like complex, subunit 2 2.28729
SERINC1 serine incorporator 1 2.28729
CCNG1 cyclin G1 2.262
MATN1 matrilin 1, cartilage matrix protein 2.26158
ASS1 argininosuccinate synthase 1 2.26158
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.24753
CD83 CD83 molecule 2.23028
CDK5 cyclin-dependent kinase 5 2.22254
TRIM35 tripartite motif containing 35 2.21953
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 2.19082
TKFC triokinase/FMN cyclase 2.18816
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 2.18213
VPS35L VPS35 endosomal protein sorting factor like 2.17154
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.16551
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 2.15584
PUS7 pseudouridylate synthase 7 (putative) 2.15584
LIN37 lin-37 DREAM MuvB core complex component 2.15547
ZNF540 zinc finger protein 540 2.15547
DPY19L1 dpy-19-like 1 (C. elegans) 2.14354
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.10208
CFAP46 cilia and flagella associated protein 46 2.10208
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.07497
ADNP2 ADNP homeobox 2 2.07312
PTK7 protein tyrosine kinase 7 (inactive) 2.07312
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 2.06315
ZNF345 zinc finger protein 345 2.06315
ATF5 activating transcription factor 5 2.04869

decreased expression

Symbol Name Standardized Value
C1ORF202 chromosome 1 open reading frame 202 -3.74489
RASA4B RAS p21 protein activator 4B -3.74489
TBX15 T-box 15 -3.74489
OLIG1 oligodendrocyte transcription factor 1 -3.74489
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -3.74489
THRSP thyroid hormone responsive -3.74489
EIF1 eukaryotic translation initiation factor 1 -3.74489
MYL5 myosin, light chain 5, regulatory -3.74489
VENTX VENT homeobox -3.74489
PRSS21 protease, serine, 21 (testisin) -3.74489
MMRN2 multimerin 2 -3.74489
NLRP1 NLR family, pyrin domain containing 1 -3.74489
TNMD tenomodulin -3.74489
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -3.74489
CYB561D1 cytochrome b561 family, member D1 -3.74489
ZEB2 zinc finger E-box binding homeobox 2 -3.74489
SPACA9 sperm acrosome associated 9 -3.74489
HPSE heparanase -3.74489
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) -3.74489
SMTNL1 smoothelin-like 1 -3.74489
F5 coagulation factor V (proaccelerin, labile factor) -3.74489
CFAP52 cilia and flagella associated protein 52 -3.74489
NPIPB7 nuclear pore complex interacting protein family, member B7 -3.74489
FIZ1 FLT3-interacting zinc finger 1 -3.74489
GJD2 gap junction protein, delta 2, 36kDa -3.74489
HAPLN2 hyaluronan and proteoglycan link protein 2 -3.74489
SCN4A sodium channel, voltage gated, type IV alpha subunit -3.74489
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -3.74489
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -3.74489
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 -3.74489
SLCO2B1 solute carrier organic anion transporter family, member 2B1 -3.74489
JSRP1 junctional sarcoplasmic reticulum protein 1 -3.74489
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -3.74489
C11ORF96 chromosome 11 open reading frame 96 -3.74489
ZC3H11D zinc finger CCCH-type containing 11D -3.74489
C2CD4D C2 calcium-dependent domain containing 4D -3.74489
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -3.74489
TEX11 testis expressed 11 -3.74489
FOXO3B forkhead box O3B pseudogene -3.7279
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -3.7208
BTBD17 BTB (POZ) domain containing 17 -3.57618
SZRD1 SUZ RNA binding domain containing 1 -3.44444
MRPS27 mitochondrial ribosomal protein S27 -3.35101
HELZ2 helicase with zinc finger 2, transcriptional coactivator -3.33934
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.1841
ARL9 ADP-ribosylation factor-like 9 -3.05982
NRBP1 nuclear receptor binding protein 1 -2.95073
EIF3A eukaryotic translation initiation factor 3, subunit A -2.86598
CBARP CACN subunit beta associated regulatory protein -2.7977
ZNF341 zinc finger protein 341 -2.72822
CEP63 centrosomal protein 63kDa -2.59102
PABPC5 poly(A) binding protein, cytoplasmic 5 -2.57012
CLIC2 chloride intracellular channel 2 -2.55389
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -2.55389
CBY3 chibby homolog 3 (Drosophila) -2.55389
SLITRK4 SLIT and NTRK-like family, member 4 -2.55389
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.54769
STX12 syntaxin 12 -2.52485
MRPL41 mitochondrial ribosomal protein L41 -2.50102
ZNF217 zinc finger protein 217 -2.49987
TUBB3 tubulin, beta 3 class III -2.48166
CLK2 CDC-like kinase 2 -2.44901
MATN2 matrilin 2 -2.43123
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.41411
RNF167 ring finger protein 167 -2.41397
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -2.40857
ZNF723 zinc finger protein 723 -2.39841
BRME1 break repair meiotic recombinase recruitment factor 1 -2.39841
CALHM6 calcium homeostasis modulator family member 6 -2.39841
COL12A1 collagen, type XII, alpha 1 -2.39841
FNDC5 fibronectin type III domain containing 5 -2.39841
BATF3 basic leucine zipper transcription factor, ATF-like 3 -2.39841
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.39841
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.39362
SYNM synemin, intermediate filament protein -2.39362
LIMCH1 LIM and calponin homology domains 1 -2.37743
ATF4 activating transcription factor 4 -2.36761
NRG2 neuregulin 2 -2.34568
C5ORF47 chromosome 5 open reading frame 47 -2.34568
SIAE sialic acid acetylesterase -2.33836
TTC6 tetratricopeptide repeat domain 6 -2.29792
APCDD1L adenomatosis polyposis coli down-regulated 1-like -2.29792
ARMC2 armadillo repeat containing 2 -2.26768
COL11A1 collagen, type XI, alpha 1 -2.26158
NAP1L4 nucleosome assembly protein 1-like 4 -2.22401
A2M alpha-2-macroglobulin -2.21839
ING2 inhibitor of growth family, member 2 -2.2066
RAB33A RAB33A, member RAS oncogene family -2.20628
LAMA2 laminin, alpha 2 -2.20628
JMJD7 jumonji domain containing 7 -2.19967
ZFR zinc finger RNA binding protein -2.18685
MANBAL mannosidase, beta A, lysosomal-like -2.16284
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -2.15547
RANBP3 RAN binding protein 3 -2.14557
RECQL4 RecQ protein-like 4 -2.14354
RNF10 ring finger protein 10 -2.12138
SH3RF1 SH3 domain containing ring finger 1 -2.08861
ILF2 interleukin enhancer binding factor 2 -2.03477
HARS2 histidyl-tRNA synthetase 2, mitochondrial -2.03477
RELT RELT tumor necrosis factor receptor -2.0251
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.01785
CCDC171 coiled-coil domain containing 171 -2.00993