HIF1A Gene Set

Dataset JASPAR Predicted Human Transcription Factor Targets 2025
Category genomics
Type transcription factor
Description hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)|This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 3091)
External Link https://ncbi.nlm.nih.gov/gene/3091
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Genes

310 target genes of the HIF1A transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

Symbol Name Standardized Value
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 45.2316
TRIM50 tripartite motif containing 50 42.1102
FKBP6 FK506 binding protein 6, 36kDa 42.1102
TFDP3 transcription factor Dp family, member 3 39.6357
ANKRD37 ankyrin repeat domain 37 36.3622
ZNF565 zinc finger protein 565 34.7796
TEX28 testis expressed 28 33.9735
GTPBP6 GTP binding protein 6 (putative) 33.9735
TKTL1 transketolase-like 1 33.9735
ENO1 enolase 1, (alpha) 32.3796
TRIM74 tripartite motif containing 74 31.5612
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 30.7857
EOLA2 endothelium and lymphocyte associated ASCH domain 2 29.2776
DVL2 dishevelled segment polarity protein 2 29.2684
MPC1L mitochondrial pyruvate carrier 1-like 28.3112
POTEH POTE ankyrin domain family, member H 27.4929
H4C15 H4 clustered histone 15 26.7714
CIART circadian associated repressor of transcription 26.6745
LAMP1 lysosomal-associated membrane protein 1 25.9643
ATG3 autophagy related 3 25.2429
ILF3 interleukin enhancer binding factor 3, 90kDa 25.1888
CENPP centromere protein P 25.1459
USP48 ubiquitin specific peptidase 48 25.1347
PPID peptidylprolyl isomerase D 25.0378
SLC39A13-AS1 SLC39A13 antisense RNA 1 24.4898
RGS9BP regulator of G protein signaling 9 binding protein 24.3816
FAM83F family with sequence similarity 83, member F 21.8847
EIF4A3 eukaryotic translation initiation factor 4A3 21.8847
RPL22 ribosomal protein L22 21.8735
POTEM POTE ankyrin domain family, member M 21.8306
TBC1D3G TBC1 domain family member 3G 21.8306
TEC tec protein tyrosine kinase 21.1204
HPS5 Hermansky-Pudlak syndrome 5 21.1204
SSBP4 single stranded DNA binding protein 4 21.1092
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 21.0663
PGRMC2 progesterone receptor membrane component 2 21.0663
CMC4 C-x(9)-C motif containing 4 21.0663
PCGF2 polycomb group ring finger 2 21.0663
AMPD3 adenosine monophosphate deaminase 3 21.0663
MAMDC4 MAM domain containing 4 21.0122
RNASEK ribonuclease, RNase K 20.3561
CUTA cutA divalent cation tolerance homolog (E. coli) 20.3561
CHIC2 cysteine-rich hydrophobic domain 2 20.3337
STK31 serine/threonine kinase 31 20.302
PPIH peptidylprolyl isomerase H (cyclophilin H) 20.302
CLTRN collectrin, amino acid transport regulator 20.302
RNASEH1 ribonuclease H1 20.248
DRAM2 DNA-damage regulated autophagy modulator 2 20.248
NR4A3 nuclear receptor subfamily 4, group A, member 3 20.1939
CD300A CD300a molecule 20.1939
GCC2 GRIP and coiled-coil domain containing 2 20.1939
ZMYND12 zinc finger, MYND-type containing 12 19.5918
ATP7A ATPase, Cu++ transporting, alpha polypeptide 19.5918
BAX BCL2-associated X protein 19.5918
PGK1 phosphoglycerate kinase 1 19.5918
PPP1R3B protein phosphatase 1, regulatory subunit 3B 19.5806
NRN1 neuritin 1 19.5582
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 19.5378
WDR62 WD repeat domain 62 19.5265
THAP8 THAP domain containing 8 19.5265
H2AC11 H2A clustered histone 11 19.5153
ZRANB3 zinc finger, RAN-binding domain containing 3 19.5153
H2BC12 H2B clustered histone 12 19.5153
R3HDM1 R3H domain containing 1 19.5153
GZF1 GDNF-inducible zinc finger protein 1 19.4837
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 19.4837
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 19.4837
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 19.4724
CCDC27 coiled-coil domain containing 27 19.4612
H2BC4 H2B clustered histone 4 19.4612
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 19.4296
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 19.4184
TMEM204 transmembrane protein 204 19.4184
MAP7D2 MAP7 domain containing 2 16.9867
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 16.9867
RHOD ras homolog family member D 16.9867
BNC2 basonuclin 2 16.9867
ATOH7 atonal homolog 7 (Drosophila) 16.9867
RIPK4 receptor-interacting serine-threonine kinase 4 16.9867
LY75-CD302 LY75-CD302 readthrough 16.9867
TSPY10 testis specific protein, Y-linked 10 16.9867
HRAS Harvey rat sarcoma viral oncogene homolog 16.9867
RAB3A RAB3A, member RAS oncogene family 16.9867
AATF apoptosis antagonizing transcription factor 16.9867
TFDP1 transcription factor Dp-1 16.9867
FAM184B family with sequence similarity 184, member B 16.9867
GNPDA1 glucosamine-6-phosphate deaminase 1 16.9867
HSFX1 heat shock transcription factor family, X linked 1 16.9867
FAM178B family with sequence similarity 178, member B 16.9867
DUT-AS1 DUT antisense RNA 1 16.9867
CRAMP1 cramped chromatin regulator homolog 1 16.9867
ZNF341 zinc finger protein 341 16.2224
LHFPL7 LHFPL tetraspan subfamily member 7 16.2224
RMDN3 regulator of microtubule dynamics 3 16.2224
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough 16.2224
CD320 CD320 molecule 16.2224
ZNF511-PRAP1 ZNF511-PRAP1 readthrough 16.2224
CLEC18C C-type lectin domain family 18, member C 16.2224
TLE6 transducin-like enhancer of split 6 16.2224
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 16.2224
TMED4 transmembrane emp24 protein transport domain containing 4 16.2224
SOWAHA sosondowah ankyrin repeat domain family member A 16.2224
PDE8A phosphodiesterase 8A 16.2224
MTUS1 microtubule associated tumor suppressor 1 16.2224
FAM210A family with sequence similarity 210, member A 16.2224
GJA3 gap junction protein, alpha 3, 46kDa 16.2224
RNMT RNA (guanine-7-) methyltransferase 16.2224
TMEM232 transmembrane protein 232 16.2224
PDK3 pyruvate dehydrogenase kinase, isozyme 3 16.2224
CLEC18A C-type lectin domain family 18, member A 16.2224
ENTHD1 ENTH domain containing 1 16.2224
PNMA6E PNMA family member 6E 16.2224
UBXN6 UBX domain protein 6 16.2224
LMBR1 limb development membrane protein 1 16.2224
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 16.2224
LOC102724560 cystathionine beta-synthase 16.2224
NAT10 N-acetyltransferase 10 (GCN5-related) 16.2224
AURKA aurora kinase A 16.2224
KCTD11 potassium channel tetramerization domain containing 11 16.2224
STMN1 stathmin 1 16.2224
MACROD1 MACRO domain containing 1 16.2224
CA12 carbonic anhydrase XII 16.2112
FAM156B family with sequence similarity 156, member B 16.2112
YY2 YY2 transcription factor 16.2112
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 16.2112
EBPL emopamil binding protein-like 16.2112
NADK2 NAD kinase 2, mitochondrial 16.2112
PBX4 pre-B-cell leukemia homeobox 4 16.2112
ICAM2 intercellular adhesion molecule 2 16.2112
NSMCE3 NSE3 homolog, SMC5-SMC6 complex component 16.2112
MRPL39 mitochondrial ribosomal protein L39 16.2112
WDR4 WD repeat domain 4 16.2112
WDR45B WD repeat domain 45B 16.2112
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 16.2112
MZB1 marginal zone B and B1 cell-specific protein 16.1684
ERGIC2 ERGIC and golgi 2 16.1684
DDN dendrin 16.1684
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 16.1684
CABP7 calcium binding protein 7 16.1684
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 16.1684
EIF3H eukaryotic translation initiation factor 3, subunit H 16.1684
BEND4 BEN domain containing 4 16.1684
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 15.4582
FAM47E-STBD1 FAM47E-STBD1 readthrough 15.4582
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 15.4582
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 15.4582
CCL20 chemokine (C-C motif) ligand 20 15.4582
MTDH metadherin 15.4582
HEXA hexosaminidase A (alpha polypeptide) 15.4582
CDK5RAP3 CDK5 regulatory subunit associated protein 3 15.4582
CYCS cytochrome c, somatic 15.4582
H2AC19 H2A clustered histone 19 15.4582
FOXRED2 FAD-dependent oxidoreductase domain containing 2 15.4582
PCDHB16 protocadherin beta 16 15.4582
WASHC2A WASH complex subunit 2A 15.4582
WASHC2C WASH complex subunit 2C 15.4582
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 15.4582
PPP1R3C protein phosphatase 1, regulatory subunit 3C 15.4582
YTHDC1 YTH domain containing 1 15.4582
FAM216A family with sequence similarity 216, member A 15.4582
CLCN7 chloride channel, voltage-sensitive 7 15.4582
KIF22 kinesin family member 22 15.4582
NPIPA2 nuclear pore complex interacting protein family, member A2 15.4582
CD164 CD164 molecule, sialomucin 15.4469
PHRF1 PHD and ring finger domains 1 15.4469
PNPLA8 patatin-like phospholipase domain containing 8 15.4469
THAP5 THAP domain containing 5 15.4469
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 15.4469
WDR89 WD repeat domain 89 15.4469
NEU4 sialidase 4 15.4469
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 15.4469
OR9G4 olfactory receptor, family 9, subfamily G, member 4 15.4469
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 15.4469
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 15.4469
GTF2IRD2B GTF2I repeat domain containing 2B 15.4469
PRKCA protein kinase C, alpha 15.4469
TMEM67 transmembrane protein 67 15.4469
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 15.4357
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 15.4357
ZNF491 zinc finger protein 491 15.4357
CEP120 centrosomal protein 120kDa 15.4357
DCLK3 doublecortin-like kinase 3 15.4357
SEC61G Sec61 gamma subunit 15.4041
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 15.4041
TRAPPC5 trafficking protein particle complex 5 15.4041
PTEN phosphatase and tensin homolog 15.4041
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 15.4041
GIGYF2 GRB10 interacting GYF protein 2 15.4041
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 15.4041
CYTH4 cytohesin 4 15.4041
FAM174C family with sequence similarity 174 member C 15.4041
PAIP2 poly(A) binding protein interacting protein 2 15.4041
ADAM2 ADAM metallopeptidase domain 2 15.4041
KLHL42 kelch-like family member 42 15.4041
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 15.4041
TBCEL tubulin folding cofactor E-like 15.4041
LIMS3 LIM and senescent cell antigen-like domains 3 15.4041
TBC1D28 TBC1 domain family, member 28 15.4041
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough 15.4041
GPR19 G protein-coupled receptor 19 15.4041
BRDT bromodomain, testis-specific 15.4041
LPIN2 lipin 2 15.4041
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 15.4041
RNF227 ring finger protein 227 15.4041
SOS1 son of sevenless homolog 1 (Drosophila) 15.4041
ATXN3 ataxin 3 15.4041
LINC02854 long intergenic non-protein coding RNA 2854 15.4041
DEFB131A defensin beta 131A 15.4041
TEF thyrotrophic embryonic factor 15.4041
EFCAB9 EF-hand calcium binding domain 9 15.4041
NPIPA6 nuclear pore complex interacting protein family, member A6 15.4041
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 15.4041
PCDHGA8 protocadherin gamma subfamily A, 8 15.4041
ZNF613 zinc finger protein 613 15.4041
TBC1D22A TBC1 domain family, member 22A 15.4041
CFAP276 cilia and flagella associated protein 276 15.3929
RPL9 ribosomal protein L9 15.3929
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 15.3929
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 15.3929
HAL histidine ammonia-lyase 15.3929
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 15.3929
RASGEF1B RasGEF domain family, member 1B 15.35
FOXK2 forkhead box K2 15.35
PADI4 peptidyl arginine deiminase, type IV 15.35
INO80 INO80 complex subunit 15.35
SPMAP2 sperm microtubule associated protein 2 15.35
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 15.35
PGAM4 phosphoglycerate mutase family member 4 15.35
TBC1D3 TBC1 domain family, member 3 15.35
TBC1D3B TBC1 domain family, member 3B 15.35
BOD1 biorientation of chromosomes in cell division 1 15.35
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine 15.35
SCO2 SCO2 cytochrome c oxidase assembly protein 15.35
GABARAPL1 GABA(A) receptor-associated protein like 1 14.6939
PICALM phosphatidylinositol binding clathrin assembly protein 14.6939
ITGA7 integrin, alpha 7 14.6939
DCPH1 damage control phosphatase 1 14.6939
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 14.6939
KHSRP KH-type splicing regulatory protein 14.6939
SIRT1 sirtuin 1 14.6939
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 14.6939
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 14.6939
KAT5 K(lysine) acetyltransferase 5 14.6939
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 14.6939
RUVBL1 RuvB-like AAA ATPase 1 14.6939
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 14.6939
KRTAP13-2 keratin associated protein 13-2 14.6939
MCM7 minichromosome maintenance complex component 7 14.6939
RBM27 RNA binding motif protein 27 14.6939
GIGYF1 GRB10 interacting GYF protein 1 14.6939
RRAGB Ras-related GTP binding B 14.6939
UBAP2 ubiquitin associated protein 2 14.6939
IGF2R insulin-like growth factor 2 receptor 14.6939
TBC1D30 TBC1 domain family, member 30 14.6827
SYNRG synergin, gamma 14.6827
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 14.6827
PLD3 phospholipase D family, member 3 14.6827
NAPSA napsin A aspartic peptidase 14.6827
GOLGA6L7 golgin A6 family like 7 14.6827
H2BC13 H2B clustered histone 13 14.6714
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 14.6602
PPY pancreatic polypeptide 14.6398
DOP1B DOP1 leucine zipper like protein B 14.6398
IP6K1 inositol hexakisphosphate kinase 1 14.6398
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 14.6398
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 14.6398
CPA2 carboxypeptidase A2 (pancreatic) 14.6398
APAF1 apoptotic peptidase activating factor 1 14.6398
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 14.6398
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 14.6398
BEX2 brain expressed X-linked 2 14.6398
ZEB2 zinc finger E-box binding homeobox 2 14.6398
PRR32 proline rich 32 14.6286
PTGES2 prostaglandin E synthase 2 14.6286
H3-3B H3.3 histone B 14.6286
HSPE1-MOB4 HSPE1-MOB4 readthrough 14.6286
ZNF135 zinc finger protein 135 14.6286
MRPS24 mitochondrial ribosomal protein S24 14.6286
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 14.6286
SMYD3 SET and MYND domain containing 3 14.6286
OLFM2 olfactomedin 2 14.6286
GOLGA6L2 golgin A6 family-like 2 14.6286
HERPUD2 HERPUD family member 2 14.6286
HSPE1 heat shock 10kDa protein 1 14.6286
H2AC14 H2A clustered histone 14 14.6173
H3C7 H3 clustered histone 7 14.6173
H2BC14 H2B clustered histone 14 14.6173
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 14.5857
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 14.5857
SIDT2 SID1 transmembrane family, member 2 14.5857
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 14.5857
PHAF1 phagosome assembly factor 1 14.5857
MAP9 microtubule-associated protein 9 14.5857
ZBED6 zinc finger, BED-type containing 6 14.5857
ZC3H11A zinc finger CCCH-type containing 11A 14.5857
NOL8 nucleolar protein 8 14.5857
MRPS21 mitochondrial ribosomal protein S21 14.5857
UTP4 UTP4 small subunit processome component 14.5857
PAGE2B P antigen family, member 2B 14.5745
SDE2 SDE2 telomere maintenance homolog (S. pombe) 14.5745
HOOK3 hook microtubule-tethering protein 3 14.5745
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 14.5745
RPL17-C18ORF32 RPL17-C18orf32 readthrough 14.5745
PAGE2 P antigen family, member 2 (prostate associated) 14.5745
TXNL4A thioredoxin-like 4A 14.5745
ZNF438 zinc finger protein 438 14.5316
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 14.5316
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 14.5316
RGS14 regulator of G-protein signaling 14 14.5316
QTGAL queuosine-tRNA galactosyltransferase 14.5316