HIF1A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)|This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 3091)
External Link http://www.ncbi.nlm.nih.gov/gene/3091
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164 interacting proteins for HIF1A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTB actin, beta
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOD apolipoprotein D
AR androgen receptor
ARG1 arginase 1
ARNT aryl hydrocarbon receptor nuclear translocator
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB1 arrestin, beta 1
ATM ATM serine/threonine kinase
BANP BTG3 associated nuclear protein
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BHLHE41 basic helix-loop-helix family, member e41
BRCA1 breast cancer 1, early onset
BUD13 BUD13 homolog (S. cerevisiae)
CAPN1 calpain 1, (mu/I) large subunit
CBX4 chromobox homolog 4
CDC34 cell division cycle 34
CDK1 cyclin-dependent kinase 1
CDK8 cyclin-dependent kinase 8
CDKN2A cyclin-dependent kinase inhibitor 2A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLTCL1 clathrin, heavy chain-like 1
COMMD1 copper metabolism (Murr1) domain containing 1
COPS5 COP9 signalosome subunit 5
CREBBP CREB binding protein
CSNK1D casein kinase 1, delta
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL2 cullin 2
DAP3 death associated protein 3
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSG1 desmoglein 1
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
F12 coagulation factor XII (Hageman factor)
FAF1 Fas (TNFRSF6) associated factor 1
FAF2 Fas associated factor family member 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXO3 forkhead box O3
GATA2 GATA binding protein 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC6 histone deacetylase 6
HDAC7 histone deacetylase 7
HEXIM1 hexamethylene bis-acetamide inducible 1
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIF3A hypoxia inducible factor 3, alpha subunit
HNF4A hepatocyte nuclear factor 4, alpha
HPCAL1 hippocalcin-like 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KDM3A lysine (K)-specific demethylase 3A
LAMP2 lysosomal-associated membrane protein 2
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
MAML1 mastermind-like 1 (Drosophila)
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAX MYC associated factor X
MCM3 minichromosome maintenance complex component 3
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED12 mediator complex subunit 12
MED13 mediator complex subunit 13
MED13L mediator complex subunit 13-like
MED14 mediator complex subunit 14
MED15 mediator complex subunit 15
MED23 mediator complex subunit 23
MTA1 metastasis associated 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK2 myosin light chain kinase 2
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NDN necdin, melanoma antigen (MAGE) family member
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NOTCH1 notch 1
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSFL1C NSFL1 (p97) cofactor (p47)
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PARP1 poly (ADP-ribose) polymerase 1
PCGF2 polycomb group ring finger 2
PER1 period circadian clock 1
PGK1 phosphoglycerate kinase 1
PIAS4 protein inhibitor of activated STAT, 4
PKM pyruvate kinase, muscle
PLK3 polo-like kinase 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTGES3 prostaglandin E synthase 3 (cytosolic)
RAD23B RAD23 homolog B (S. cerevisiae)
RB1 retinoblastoma 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPTOR regulatory associated protein of MTOR, complex 1
RUNX2 runt-related transcription factor 2
RUVBL2 RuvB-like AAA ATPase 2
RWDD3 RWD domain containing 3
SART3 squamous cell carcinoma antigen recognized by T cells 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SAT2 spermidine/spermine N1-acetyltransferase family member 2
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SEPT9 septin 9
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIN3A SIN3 transcription regulator family member A
SMAD3 SMAD family member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SP1 Sp1 transcription factor
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSX4B synovial sarcoma, X breakpoint 4B
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM28 tripartite motif containing 28
TSGA10 testis specific, 10
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBXN1 UBX domain protein 1
UBXN7 UBX domain protein 7
UFD1L ubiquitin fusion degradation 1 like (yeast)
USP19 ubiquitin specific peptidase 19
USP20 ubiquitin specific peptidase 20
USP8 ubiquitin specific peptidase 8
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VHLL von Hippel-Lindau tumor suppressor-like
XBP1 X-box binding protein 1
ZNF197 zinc finger protein 197