HIPK2 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description homeodomain interacting protein kinase 2|This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (NCBI Entrez Gene Database, 28996)
External Link https://ncbi.nlm.nih.gov/gene/28996
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Genes

499 genes differentially expressed following the HIPK2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I 0.0141724
CCN2 cellular communication network factor 2 0.0132482
KRT15 keratin 15, type I 0.0127567
POU2AF1 POU class 2 associating factor 1 0.0106801
CXCL14 chemokine (C-X-C motif) ligand 14 0.010636
KRT5 keratin 5, type II 0.0105896
MT1X metallothionein 1X 0.0104288
MMP12 matrix metallopeptidase 12 0.0103893
COL2A1 collagen, type II, alpha 1 0.0103536
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 0.0101565
BGN biglycan 0.0101002
ADM adrenomedullin 0.0100747
HSPA1A heat shock 70kDa protein 1A 0.00993723
HIST1H2BK histone cluster 1, H2bk 0.00966727
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.0096122
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.00956902
MZB1 marginal zone B and B1 cell-specific protein 0.00953418
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.00947662
HIST1H2AC histone cluster 1, H2ac 0.00931742
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.00898087
TXNDC9 thioredoxin domain containing 9 0.00895159
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.00890244
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.00886547
MT1H metallothionein 1H 0.00877504
MT1G metallothionein 1G 0.00865454
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.00863596
CD52 CD52 molecule 0.00862592
CRABP1 cellular retinoic acid binding protein 1 0.00857267
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.00846554
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0084495
INHBA inhibin, beta A 0.00842943
MT1HL1 metallothionein 1H-like 1 0.00842526
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 0.00833839
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.00832965
CXADR coxsackie virus and adenovirus receptor 0.00832289
EPCAM epithelial cell adhesion molecule 0.00830514
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.00825261
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.00825127
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.00823943
SORBS2 sorbin and SH3 domain containing 2 0.0082309
HIST1H2BD histone cluster 1, H2bd 0.00822386
CD9 CD9 molecule 0.00822363
EPS8L2 EPS8-like 2 0.00821109
ISG20 interferon stimulated exonuclease gene 20kDa 0.00819006
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.00818635
CD3D CD3d molecule, delta (CD3-TCR complex) 0.00810175
CD200 CD200 molecule 0.00809505
CXCL13 chemokine (C-X-C motif) ligand 13 0.00807379
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 0.00799374
SMCO4 single-pass membrane protein with coiled-coil domains 4 0.00795779
THBS2 thrombospondin 2 0.0078663
FERMT1 fermitin family member 1 0.00774281
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.00770381
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 0.00767604
SOX10 SRY (sex determining region Y)-box 10 0.00765698
CD27 CD27 molecule 0.00764745
CXCL9 chemokine (C-X-C motif) ligand 9 0.00761131
PERP PERP, TP53 apoptosis effector 0.00756658
CHPT1 choline phosphotransferase 1 0.00755957
KLF4 Kruppel-like factor 4 (gut) 0.00755823
KRT16 keratin 16, type I 0.00751824
DSP desmoplakin 0.00748432
CCL19 chemokine (C-C motif) ligand 19 0.00747319
ASS1 argininosuccinate synthase 1 0.00746807
PROM1 prominin 1 0.00743058
ACTA2 actin, alpha 2, smooth muscle, aorta 0.00733586
EFNA1 ephrin-A1 0.00731192
WFDC1 WAP four-disulfide core domain 1 0.0072752
AKR1C2 aldo-keto reductase family 1, member C2 0.00725281
CRYAB crystallin, alpha B 0.00724997
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.00724542
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00723606
IFITM1 interferon induced transmembrane protein 1 0.00719334
AMH anti-Mullerian hormone 0.00717109
AQP3 aquaporin 3 (Gill blood group) 0.00709096
COCH cochlin 0.0070462
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.00695209
RGS10 regulator of G-protein signaling 10 0.0069457
DYNLL1 dynein, light chain, LC8-type 1 0.00693051
FABP1 fatty acid binding protein 1, liver 0.00691951
TPD52L1 tumor protein D52-like 1 0.00685236
PLAAT3 phospholipase A and acyltransferase 3 0.00681072
TAGLN transgelin 0.00680461
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.00674286
PRELP proline/arginine-rich end leucine-rich repeat protein 0.00673983
KRT17 keratin 17, type I 0.00671458
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.00670378
AKR1C1 aldo-keto reductase family 1, member C1 0.00669234
CAVIN3 caveolae associated protein 3 0.00667401
FRZB frizzled-related protein 0.00660822
F3 coagulation factor III (thromboplastin, tissue factor) 0.00658452
MFGE8 milk fat globule-EGF factor 8 protein 0.00656815
EFHD1 EF-hand domain family, member D1 0.00647679
GPNMB glycoprotein (transmembrane) nmb 0.00647495
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.00646008
ARMCX6 armadillo repeat containing, X-linked 6 0.00644282
TSPAN1 tetraspanin 1 0.00642436
NDRG1 N-myc downstream regulated 1 0.00640668
A2M alpha-2-macroglobulin 0.00640287
ITGA6 integrin, alpha 6 0.00638113
DMAC2L distal membrane arm assembly component 2 like 0.00638086
CHKB choline kinase beta 0.00637775
COMP cartilage oligomeric matrix protein 0.00636574
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.00635144
GSTZ1 glutathione S-transferase zeta 1 0.00634805
KLF6 Kruppel-like factor 6 0.00633293
CKS2 CDC28 protein kinase regulatory subunit 2 0.00632716
MGP matrix Gla protein 0.00632383
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.00630673
GRB14 growth factor receptor-bound protein 14 0.00629958
XPO7 exportin 7 0.00625238
MYH11 myosin, heavy chain 11, smooth muscle 0.00623931
MAP7 microtubule-associated protein 7 0.00623276
SS18 synovial sarcoma translocation, chromosome 18 0.00618986
MEF2C myocyte enhancer factor 2C 0.00618918
QPCT glutaminyl-peptide cyclotransferase 0.00611478
AEBP1 AE binding protein 1 0.0061056
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00601912
MRPL18 mitochondrial ribosomal protein L18 0.00600207
SIRT3 sirtuin 3 0.00596882
SLC31A2 solute carrier family 31 (copper transporter), member 2 0.00596317
ELF5 E74-like factor 5 (ets domain transcription factor) 0.00595137
MCAM melanoma cell adhesion molecule 0.00594973
AKR1C3 aldo-keto reductase family 1, member C3 0.00594557
CA12 carbonic anhydrase XII 0.00591368
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.00590806
PRDX1 peroxiredoxin 1 0.00588849
SAT1 spermidine/spermine N1-acetyltransferase 1 0.00588625
CXCL12 chemokine (C-X-C motif) ligand 12 0.00588309
H1-2 H1.2 linker histone, cluster member 0.00587754
BTG1 B-cell translocation gene 1, anti-proliferative 0.00587728
HIST1H2BH histone cluster 1, H2bh 0.00586837
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.00586656
IRF6 interferon regulatory factor 6 0.00586346
ARMCX2 armadillo repeat containing, X-linked 2 0.00586142
CRIP1 cysteine-rich protein 1 (intestinal) 0.00585181
AKIRIN1 akirin 1 0.00584911
MED6 mediator complex subunit 6 0.00584748
LEFTY1 left-right determination factor 1 0.00581591
LAMC2 laminin, gamma 2 0.00581126
NRIP3 nuclear receptor interacting protein 3 0.00577908
CYB5R2 cytochrome b5 reductase 2 0.00573074
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.00572437
MT2A metallothionein 2A 0.00571823
MAL mal, T-cell differentiation protein 0.00571017
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.00570002
PSAP prosaposin 0.00569714
LCK LCK proto-oncogene, Src family tyrosine kinase 0.00569112
DENND1B DENN/MADD domain containing 1B 0.0056884
DNASE1L3 deoxyribonuclease I-like 3 0.00568167
SFRP4 secreted frizzled-related protein 4 0.00567567
HOOK2 hook microtubule-tethering protein 2 0.00559282
CTSD cathepsin D 0.00557551
GLYAT glycine-N-acyltransferase 0.00556129
FN1 fibronectin 1 0.00556008
TFF3 trefoil factor 3 (intestinal) 0.00555534
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.00555255
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.00553893
SOSTDC1 sclerostin domain containing 1 0.00552478
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.00551205
VIM vimentin 0.00549681
MT1F metallothionein 1F 0.00548766
DDB2 damage-specific DNA binding protein 2, 48kDa 0.00546539
ABHD17B abhydrolase domain containing 17B 0.00546252
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.00544652
APOD apolipoprotein D 0.00542174
NANS N-acetylneuraminic acid synthase 0.00541596
SGK1 serum/glucocorticoid regulated kinase 1 0.00541065
BAMBI BMP and activin membrane-bound inhibitor 0.00540711
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.00540425
COL9A3 collagen, type IX, alpha 3 0.00539331
DNTT DNA nucleotidylexotransferase 0.0053442
FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.00532406
HOXD1 homeobox D1 0.0053205
CFAP20 cilia and flagella associated protein 20 0.00530253
SGPP1 sphingosine-1-phosphate phosphatase 1 0.00529244
RAB21 RAB21, member RAS oncogene family 0.00526448
FGFR1 fibroblast growth factor receptor 1 0.00526307
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.00525747
MRPS18B mitochondrial ribosomal protein S18B 0.00525073
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.00523798
GLRX3 glutaredoxin 3 0.00523287
RPP38 ribonuclease P/MRP 38kDa subunit 0.00522898
KRT20 keratin 20, type I 0.00522271
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.00521914
DLK1 delta-like 1 homolog (Drosophila) 0.00521154
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.005202
LUM lumican 0.00517903
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.00517719
MYB v-myb avian myeloblastosis viral oncogene homolog 0.00517571
NPC2 Niemann-Pick disease, type C2 0.00517198
MYO1D myosin ID 0.00516598
ACP5 acid phosphatase 5, tartrate resistant 0.00514896
NKX3-1 NK3 homeobox 1 0.00512204
LY96 lymphocyte antigen 96 0.0051165
TMEM140 transmembrane protein 140 0.00509983
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.00509752
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.00509611
MICB MHC class I polypeptide-related sequence B 0.00507742
CSTB cystatin B (stefin B) 0.00507554
SDF2 stromal cell-derived factor 2 0.00507105
TOB1 transducer of ERBB2, 1 0.00506732
NOX1 NADPH oxidase 1 0.00506631
ACAA2 acetyl-CoA acyltransferase 2 0.00506522
DDT D-dopachrome tautomerase 0.00506089
LBH limb bud and heart development 0.00505007
TUBB2A tubulin, beta 2A class IIa 0.00504605
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.00504574
TXN thioredoxin 0.0050391
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.00503538
GMFG glia maturation factor, gamma 0.00503461
MLH1 mutL homolog 1 0.00502969
OCA2 oculocutaneous albinism II 0.00500901
JCHAIN joining chain of multimeric IgA and IgM 0.00500714
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.00500406
TALDO1 transaldolase 1 0.00500112
PKP3 plakophilin 3 0.00498592
CGA glycoprotein hormones, alpha polypeptide 0.00497266
COL15A1 collagen, type XV, alpha 1 0.00497154
SIX1 SIX homeobox 1 0.00497063
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.00497041
CLEC2B C-type lectin domain family 2, member B 0.00496586
SNRPF small nuclear ribonucleoprotein polypeptide F 0.00496408
CRLF1 cytokine receptor-like factor 1 0.00496269
IRF4 interferon regulatory factor 4 0.00495177
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.00494764
SMAD7 SMAD family member 7 0.00494486
CALML3 calmodulin-like 3 0.00494385
ATG4A autophagy related 4A, cysteine peptidase 0.00494163
ZG16 zymogen granule protein 16 0.00493662
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0049348
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.00493345
CIAO3 cytosolic iron-sulfur assembly component 3 0.00492855
TMEM243 transmembrane protein 243, mitochondrial 0.00492591
C8ORF4 chromosome 8 open reading frame 4 0.00492533
CDKN2A cyclin-dependent kinase inhibitor 2A 0.00491069
CALML4 calmodulin-like 4 0.00490899
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0049007
SUGCT succinyl-CoA:glutarate-CoA transferase 0.00489176
C11ORF58 chromosome 11 open reading frame 58 0.00489173
CD2 CD2 molecule 0.00488988
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.00487846
TFF1 trefoil factor 1 0.00487741
RPS27L ribosomal protein S27-like 0.00486977
ASPN asporin 0.00485955
SERINC5 serine incorporator 5 0.0048573
HOXC6 homeobox C6 0.00484152
CD8A CD8a molecule 0.00484004
SLC44A4 solute carrier family 44, member 4 0.00483889

decreased expression

Symbol Name Standardized Value
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -0.0114916
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -0.011285
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0111276
MEIS1 Meis homeobox 1 -0.010755
PBX1 pre-B-cell leukemia homeobox 1 -0.0104743
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0103091
MEIS2 Meis homeobox 2 -0.00996768
RTN2 reticulon 2 -0.00980629
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -0.00971867
SHOX2 short stature homeobox 2 -0.0094036
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -0.00938938
CX3CR1 chemokine (C-X3-C motif) receptor 1 -0.00933757
LYPD1 LY6/PLAUR domain containing 1 -0.00929421
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.00915409
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0091063
MFSD10 major facilitator superfamily domain containing 10 -0.00906348
HOXB6 homeobox B6 -0.0090631
TRIB3 tribbles pseudokinase 3 -0.0090566
EREG epiregulin -0.0089967
SMAD3 SMAD family member 3 -0.00889768
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.00872288
AUTS2 autism susceptibility candidate 2 -0.00842282
GRIA2 glutamate receptor, ionotropic, AMPA 2 -0.00835968
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00831168
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.00830791
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00821135
DCK deoxycytidine kinase -0.00818381
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.0081242
MTCL1 microtubule crosslinking factor 1 -0.00811593
PNMA2 paraneoplastic Ma antigen 2 -0.00805809
COPS7A COP9 signalosome subunit 7A -0.00786066
MMD monocyte to macrophage differentiation-associated -0.00783369
GPM6A glycoprotein M6A -0.00771339
PDZD2 PDZ domain containing 2 -0.00765647
MYRF myelin regulatory factor -0.00763813
GSDME gasdermin E -0.00757028
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.00755719
PITX3 paired-like homeodomain 3 -0.00747764
PARP2 poly (ADP-ribose) polymerase 2 -0.00747059
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.00739354
GRB7 growth factor receptor-bound protein 7 -0.00732535
ENOPH1 enolase-phosphatase 1 -0.0072496
CTBP1 C-terminal binding protein 1 -0.00723879
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -0.007225
SPON2 spondin 2, extracellular matrix protein -0.00721191
IL1R1 interleukin 1 receptor, type I -0.00719273
HNMT histamine N-methyltransferase -0.00717798
COLEC12 collectin sub-family member 12 -0.00713544
SOX11 SRY (sex determining region Y)-box 11 -0.00710028
OPN3 opsin 3 -0.00708618
PON2 paraoxonase 2 -0.00704514
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00702707
STC2 stanniocalcin 2 -0.00698154
MNDA myeloid cell nuclear differentiation antigen -0.0069505
BEX1 brain expressed, X-linked 1 -0.00690201
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.00688196
CLC Charcot-Leyden crystal galectin -0.00688146
HOXB2 homeobox B2 -0.00685677
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) -0.00683181
FOXF1 forkhead box F1 -0.00682211
KIF20A kinesin family member 20A -0.00681021
TRIB2 tribbles pseudokinase 2 -0.00680604
PGC progastricsin (pepsinogen C) -0.00679111
LRRC17 leucine rich repeat containing 17 -0.00675665
ANXA3 annexin A3 -0.00674745
CNTN1 contactin 1 -0.00670724
APMAP adipocyte plasma membrane associated protein -0.00669578
ZNF395 zinc finger protein 395 -0.00662064
DEFA4 defensin, alpha 4, corticostatin -0.00661759
PLAT plasminogen activator, tissue -0.0066116
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.00658418
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0065735
MANSC1 MANSC domain containing 1 -0.00650159
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -0.00647985
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.00645464
MLF2 myeloid leukemia factor 2 -0.00643262
DMXL2 Dmx-like 2 -0.00642817
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.00638737
FGR FGR proto-oncogene, Src family tyrosine kinase -0.00638568
COL4A5 collagen, type IV, alpha 5 -0.0063747
NLGN4X neuroligin 4, X-linked -0.00637382
CAMTA1 calmodulin binding transcription activator 1 -0.00635664
BCAT2 branched chain amino-acid transaminase 2, mitochondrial -0.0063344
PEA15 phosphoprotein enriched in astrocytes 15 -0.00632871
WT1 Wilms tumor 1 -0.00632122
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.00630273
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -0.00629604
BTBD3 BTB (POZ) domain containing 3 -0.00629595
TPBG trophoblast glycoprotein -0.00627528
CTSG cathepsin G -0.0062648
TNIK TRAF2 and NCK interacting kinase -0.00626238
PAX6 paired box 6 -0.00615649
REEP1 receptor accessory protein 1 -0.00613419
PDGFC platelet derived growth factor C -0.00612827
ANKRD10 ankyrin repeat domain 10 -0.00612295
CADPS2 Ca++-dependent secretion activator 2 -0.00607673
S100A9 S100 calcium binding protein A9 -0.00607508
CNR1 cannabinoid receptor 1 (brain) -0.0060635
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.00605834
CLGN calmegin -0.00604383
TRIM9 tripartite motif containing 9 -0.00600403
TPM4 tropomyosin 4 -0.00600301
GAP43 growth associated protein 43 -0.00599818
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 -0.00599772
ACADVL acyl-CoA dehydrogenase, very long chain -0.0059847
C2CD5 C2 calcium-dependent domain containing 5 -0.0059737
SNAP25 synaptosomal-associated protein, 25kDa -0.00596926
IRS2 insulin receptor substrate 2 -0.00593306
STON1 stonin 1 -0.00593096
SACS sacsin molecular chaperone -0.00587535
TGFB1 transforming growth factor, beta 1 -0.00585944
IL18RAP interleukin 18 receptor accessory protein -0.00585174
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.00585027
DYNLT1 dynein, light chain, Tctex-type 1 -0.00582605
TRIO trio Rho guanine nucleotide exchange factor -0.00582159
TARP TCR gamma alternate reading frame protein -0.00581461
TWIST1 twist family bHLH transcription factor 1 -0.00579133
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) -0.00577839
TMOD1 tropomodulin 1 -0.00575965
QKI QKI, KH domain containing, RNA binding -0.00574653
KLHL9 kelch-like family member 9 -0.00572547
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0057138
ALOX15B arachidonate 15-lipoxygenase, type B -0.00570263
LOC105375355 uroplakin-3b -0.00568409
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.00567759
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.00566563
SLC16A4 solute carrier family 16, member 4 -0.00566378
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.00566009
S100P S100 calcium binding protein P -0.00565946
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.00564772
RHOBTB1 Rho-related BTB domain containing 1 -0.00563974
RNF4 ring finger protein 4 -0.00560963
SYT11 synaptotagmin XI -0.00559586
WASF1 WAS protein family, member 1 -0.00559077
SEPP1 selenoprotein P, plasma, 1 -0.0055795
SH3GL2 SH3-domain GRB2-like 2 -0.00557574
MSX1 msh homeobox 1 -0.00556934
ELOVL5 ELOVL fatty acid elongase 5 -0.00556123
BACE1 beta-site APP-cleaving enzyme 1 -0.00554697
SUB1 SUB1 homolog (S. cerevisiae) -0.00552379
PDGFD platelet derived growth factor D -0.00552198
SPARCL1 SPARC-like 1 (hevin) -0.0055124
PEG3 paternally expressed 3 -0.00550381
ZFPM2 zinc finger protein, FOG family member 2 -0.00546531
POGLUT2 protein O-glucosyltransferase 2 -0.00545715
MUC16 mucin 16, cell surface associated -0.00544526
PHC2 polyhomeotic homolog 2 (Drosophila) -0.00544273
ADAM10 ADAM metallopeptidase domain 10 -0.0054412
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 -0.00543055
ANXA10 annexin A10 -0.00542295
GBAP1 glucosidase, beta, acid pseudogene 1 -0.00542055
PLEK pleckstrin -0.00540838
AADAC arylacetamide deacetylase -0.00540572
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -0.00540417
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.00538801
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -0.00538698
S100A12 S100 calcium binding protein A12 -0.00537478
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -0.0053722
RNASE3 ribonuclease, RNase A family, 3 -0.0053704
ADAR adenosine deaminase, RNA-specific -0.0053634
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.00535962
WLS wntless Wnt ligand secretion mediator -0.00530824
CTNND2 catenin (cadherin-associated protein), delta 2 -0.00530183
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase -0.00529009
RPIA ribose 5-phosphate isomerase A -0.00528855
IRAK1 interleukin-1 receptor-associated kinase 1 -0.00527788
CLU clusterin -0.00525969
PAQR3 progestin and adipoQ receptor family member III -0.00525609
NEUROD1 neuronal differentiation 1 -0.00521984
MSRA methionine sulfoxide reductase A -0.00521974
CFI complement factor I -0.00520906
GFAP glial fibrillary acidic protein -0.00520831
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.00520531
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene) -0.00519865
EFNB3 ephrin-B3 -0.00519119
HPSE heparanase -0.00519065
ERBIN erbb2 interacting protein -0.00519008
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.00518578
TNNT1 troponin T type 1 (skeletal, slow) -0.00516104
ANXA4 annexin A4 -0.00515823
NCKAP1 NCK-associated protein 1 -0.00515068
DPYD dihydropyrimidine dehydrogenase -0.00514924
APLP2 amyloid beta (A4) precursor-like protein 2 -0.00514098
PLAGL1 pleiomorphic adenoma gene-like 1 -0.00512756
ECT2 epithelial cell transforming 2 -0.00510849
MGAM maltase-glucoamylase -0.00510774
ARID5B AT rich interactive domain 5B (MRF1-like) -0.00509033
ALOX5 arachidonate 5-lipoxygenase -0.00508918
ATP13A2 ATPase type 13A2 -0.00507886
CORO2B coronin, actin binding protein, 2B -0.00507684
PCDH17 protocadherin 17 -0.00505801
NIPSNAP2 nipsnap homolog 2 -0.00505293
HMGN1 high mobility group nucleosome binding domain 1 -0.00504709
PTN pleiotrophin -0.00504267
MPPED2 metallophosphoesterase domain containing 2 -0.00503353
CDK16 cyclin-dependent kinase 16 -0.00502987
FABP7 fatty acid binding protein 7, brain -0.00502984
LY6G6C lymphocyte antigen 6 complex, locus G6C -0.00501002
TACC3 transforming, acidic coiled-coil containing protein 3 -0.0050034
RNPS1 RNA binding protein S1, serine-rich domain -0.00500166
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.00499194
EMX2 empty spiracles homeobox 2 -0.00498558
EFHD2 EF-hand domain family, member D2 -0.0049817
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -0.00496861
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -0.0049646
ADGRB3 adhesion G protein-coupled receptor B3 -0.00496414
RGL1 ral guanine nucleotide dissociation stimulator-like 1 -0.00495765
SNX10 sorting nexin 10 -0.00495259
PBK PDZ binding kinase -0.00495172
TMED5 transmembrane emp24 protein transport domain containing 5 -0.00495094
CRABP2 cellular retinoic acid binding protein 2 -0.00495012
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.00494988
F13A1 coagulation factor XIII, A1 polypeptide -0.00494702
HCRT hypocretin (orexin) neuropeptide precursor -0.00492482
BCHE butyrylcholinesterase -0.00492308
PFKM phosphofructokinase, muscle -0.00491577
RIN2 Ras and Rab interactor 2 -0.0049085
ZEB1 zinc finger E-box binding homeobox 1 -0.00490235
CDR2L cerebellar degeneration-related protein 2-like -0.00490038
LAMP5 lysosomal-associated membrane protein family, member 5 -0.00489472
TMED7 transmembrane emp24 protein transport domain containing 7 -0.00489384
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.00488128
GAS7 growth arrest-specific 7 -0.00487598
MDK midkine (neurite growth-promoting factor 2) -0.00487582
G6PD glucose-6-phosphate dehydrogenase -0.00486519
ADGRL3 adhesion G protein-coupled receptor L3 -0.0048592
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.00485525
TSPAN5 tetraspanin 5 -0.00485428
FRY furry homolog (Drosophila) -0.00484843
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0048415
ZSCAN31 zinc finger and SCAN domain containing 31 -0.00483475
HOXB7 homeobox B7 -0.00482441
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.00480326
COMT catechol-O-methyltransferase -0.00479
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.00478968
PLXNB2 plexin B2 -0.0047792
SLC35E2B solute carrier family 35, member E2B -0.00477629
SEPHS2 selenophosphate synthetase 2 -0.0047707
DENND5A DENN/MADD domain containing 5A -0.00476646
ANPEP alanyl (membrane) aminopeptidase -0.00476218
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -0.00475126
TSPAN15 tetraspanin 15 -0.00474363
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.0047326
KANK2 KN motif and ankyrin repeat domains 2 -0.00472948
CDK19 cyclin-dependent kinase 19 -0.00470999
MT3 metallothionein 3 -0.00470928
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -0.00470663
LAPTM4B lysosomal protein transmembrane 4 beta -0.00469734
CLIP2 CAP-GLY domain containing linker protein 2 -0.00468078
SYT1 synaptotagmin I -0.00467315