HLA-B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description major histocompatibility complex, class I, B|HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3106)
Similar Terms
Downloads & Tools

Genes

339 genes differentially expressed following the HLA-B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ALAS2 5'-aminolevulinate synthase 2 2.65045
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.65045
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.65045
GPR20 G protein-coupled receptor 20 2.65045
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.65045
PAX5 paired box 5 2.65045
FAM107A family with sequence similarity 107, member A 2.65045
GCKR glucokinase (hexokinase 4) regulator 2.65045
PLIN4 perilipin 4 2.65045
LIPH lipase, member H 2.65045
TICAM1 toll-like receptor adaptor molecule 1 2.65045
UCN urocortin 2.65045
ANO3 anoctamin 3 2.65045
CXCR5 chemokine (C-X-C motif) receptor 5 2.65045
CLDN2 claudin 2 2.65045
CLDN16 claudin 16 2.65045
SMIM47 small integral membrane protein 47 2.65045
TMC8 transmembrane channel-like 8 2.65045
NYX nyctalopin 2.65045
GMNC geminin coiled-coil domain containing 2.65045
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.65045
LINC02798 long intergenic non-protein coding RNA 2798 2.65045
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.65045
KLK4 kallikrein-related peptidase 4 2.65045
TPH1 tryptophan hydroxylase 1 2.65045
TMPRSS11F transmembrane protease, serine 11F 2.5514
NKAPL NFKB activating protein-like 2.5514
SRL sarcalumenin 2.5514
LRRC66 leucine rich repeat containing 66 2.5514
PDILT protein disulfide isomerase-like, testis expressed 2.5514
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.5514
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 2.5514
DPF3 D4, zinc and double PHD fingers, family 3 2.5514
TREML4 triggering receptor expressed on myeloid cells-like 4 2.5514
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.5514
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.5514
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.5514
SHE Src homology 2 domain containing E 2.5514
ZNF648 zinc finger protein 648 2.5514
SLC9C2 solute carrier family 9, member C2 (putative) 2.5514
KCNRG potassium channel regulator 2.5514
MID2 midline 2 2.5514
CD300A CD300a molecule 2.5514
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.5514
HCST hematopoietic cell signal transducer 2.5514
TMEM100 transmembrane protein 100 2.5514
PROB1 proline-rich basic protein 1 2.5514
TRIM42 tripartite motif containing 42 2.5514
TNNI1 troponin I type 1 (skeletal, slow) 2.5514
APLN apelin 2.5514
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.5514
LOC390937 Ets2 repressor factor-like 2.5514
LOC124900192 uncharacterized LOC124900192 2.5514
ZAR1 zygote arrest 1 2.5514
MYZAP myocardial zonula adherens protein 2.5514
PRRT4 proline-rich transmembrane protein 4 2.5514
PAPOLB poly(A) polymerase beta (testis specific) 2.5514
MIOX myo-inositol oxygenase 2.5514
WNT16 wingless-type MMTV integration site family, member 16 2.5514
TSPAN1 tetraspanin 1 2.5514
IMPG1 interphotoreceptor matrix proteoglycan 1 2.5514
GOLGA6L7 golgin A6 family like 7 2.5514
TLE7 TLE family member 7 2.5514
SPMAP2L sperm microtubule associated protein 2 like 2.5514
SPMIP10 sperm microtubule inner protein 10 2.5514
EPCIP exosomal polycystin 1 interacting protein 2.5514
ZNF593OS ZNF593 opposite strand 2.5514
SMIM35 small integral membrane protein 35 2.5514
CFAP299 cilia and flagella associated protein 299 2.5514
ITPRID1 ITPR interacting domain containing 1 2.5514
DIPK2B divergent protein kinase domain 2B 2.5514
SYT15 synaptotagmin XV 2.5514
LTB lymphotoxin beta (TNF superfamily, member 3) 2.5514
PMP22 peripheral myelin protein 22 2.5514
CFAP45 cilia and flagella associated protein 45 2.5514
IL6 interleukin 6 2.5514
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.5514
ANXA13 annexin A13 2.5514
MAG myelin associated glycoprotein 2.5514
PCDHB10 protocadherin beta 10 2.5514
DMP1 dentin matrix acidic phosphoprotein 1 2.5514
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.5514
CREB3L3 cAMP responsive element binding protein 3-like 3 2.5514
LECT2 leukocyte cell-derived chemotaxin 2 2.5514
HAL histidine ammonia-lyase 2.5514
FGFBP2 fibroblast growth factor binding protein 2 2.5514
IL7R interleukin 7 receptor 2.5514
CLEC17A C-type lectin domain family 17, member A 2.5514
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.5514
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.5514
RASAL3 RAS protein activator like 3 2.5514
EAPP E2F-associated phosphoprotein 2.5514
FOXD1 forkhead box D1 2.5514
BHMT2 betaine--homocysteine S-methyltransferase 2 2.5514
SIRPG signal-regulatory protein gamma 2.5514
GOLGA8R golgin A8 family, member R 2.5514
CERS3 ceramide synthase 3 2.5514
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.5514
TIPRL TOR signaling pathway regulator 2.5514
ERICH4 glutamate-rich 4 2.5514
CCL27 chemokine (C-C motif) ligand 27 2.5514
ZC3H12D zinc finger CCCH-type containing 12D 2.5514
SMIM22 small integral membrane protein 22 2.5514
CD177 CD177 molecule 2.5514
POU3F2 POU class 3 homeobox 2 2.5514
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.5514
LRCOL1 leucine rich colipase-like 1 2.5514
MT1M metallothionein 1M 2.5514
FGF18 fibroblast growth factor 18 2.5514
WFDC10A WAP four-disulfide core domain 10A 2.5514
SAP30BP SAP30 binding protein 2.5514
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.5514
GCOM1 GRINL1A complex locus 1 2.5514
ASTL astacin-like metallo-endopeptidase (M12 family) 2.5514
UPK1B uroplakin 1B 2.5514
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.5514
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.5514
PCDHGA3 protocadherin gamma subfamily A, 3 2.5514
DRD4 dopamine receptor D4 2.5514
MAB21L1 mab-21-like 1 (C. elegans) 2.5514
CLEC4C C-type lectin domain family 4, member C 2.5514
SVOP SV2 related protein homolog (rat) 2.5514
CD52 CD52 molecule 2.5514
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.5514
HKDC1 hexokinase domain containing 1 2.5514
OLFML1 olfactomedin-like 1 2.5514
HLA-DOB major histocompatibility complex, class II, DO beta 2.5514
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.5514
EPN3 epsin 3 2.5514
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.5514
TAS2R19 taste receptor, type 2, member 19 2.5514
VPREB3 pre-B lymphocyte 3 2.5514
ZPLD1 zona pellucida-like domain containing 1 2.5514
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.5514
RAB6C RAB6C, member RAS oncogene family 2.5514
IL17B interleukin 17B 2.5514
MMP12 matrix metallopeptidase 12 2.5514
KIF19 kinesin family member 19 2.5514
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 2.5514
WNK4 WNK lysine deficient protein kinase 4 2.5514
ADCY4 adenylate cyclase 4 2.5514
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.5514
SP6 Sp6 transcription factor 2.5514
LOC105378220 macrophage receptor MARCO-like 2.5514
STEAP4 STEAP family member 4 2.5514
GOLGA8J golgin A8 family, member J 2.5514
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.5514
PCDH20 protocadherin 20 2.5514
RAMP3 receptor (G protein-coupled) activity modifying protein 3 2.5514
NMBR neuromedin B receptor 2.5514
PRH2 proline-rich protein HaeIII subfamily 2 2.5514
QRFP pyroglutamylated RFamide peptide 2.5514
UBXN10 UBX domain protein 10 2.5514
GOLGA8K golgin A8 family, member K 2.5514
CA5A carbonic anhydrase VA, mitochondrial 2.5514
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.5514
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.5514
ADAM29 ADAM metallopeptidase domain 29 2.5514
PF4V1 platelet factor 4 variant 1 2.5514
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 2.50359
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.49179
ELF4 E74-like factor 4 (ets domain transcription factor) 2.49179
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) 2.47999
CCDC57 coiled-coil domain containing 57 2.47698
F8A1 coagulation factor VIII-associated 1 2.42259
DPP8 dipeptidyl-peptidase 8 2.41528
RSAD1 radical S-adenosyl methionine domain containing 1 2.41528
RPL38 ribosomal protein L38 2.30515
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.30515
RCC1L RCC1 like 2.2903
NAF1 nuclear assembly factor 1 ribonucleoprotein 2.2903
MORC4 MORC family CW-type zinc finger 4 2.2903
MPND MPN domain containing 2.2903
C21ORF58 chromosome 21 open reading frame 58 2.2903
ARL6 ADP-ribosylation factor-like 6 2.2903
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2.2903
SAE1 SUMO1 activating enzyme subunit 1 2.2903
TMEM47 transmembrane protein 47 2.27423
MTREX Mtr4 exosome RNA helicase 2.23879
SPAG1 sperm associated antigen 1 2.21601
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.18758
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 2.18679
ERVK3-1 endogenous retrovirus group K3, member 1 2.18357
GTF2I general transcription factor IIi 2.17979
NXF1 nuclear RNA export factor 1 2.17073
ZNF180 zinc finger protein 180 2.15344
CDK6 cyclin-dependent kinase 6 2.13007
MAP2K5-DT MAP2K5 divergent transcript 2.12555
ESYT2 extended synaptotagmin-like protein 2 2.12554
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.12554
RHOQ ras homolog family member Q 2.12554
NKAPD1 NKAP domain containing 1 2.11256
RARG retinoic acid receptor, gamma 2.11062
ZNF620 zinc finger protein 620 2.10255
CXCL3 chemokine (C-X-C motif) ligand 3 2.09891
CADM3 cell adhesion molecule 3 2.09664
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.09664
TMEM266 transmembrane protein 266 2.09664
C6ORF89 chromosome 6 open reading frame 89 2.08807
HPDL 4-hydroxyphenylpyruvate dioxygenase-like 2.07595
LRRC1 leucine rich repeat containing 1 2.05403
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.05364
DRAM2 DNA-damage regulated autophagy modulator 2 2.04467
MBOAT7 membrane bound O-acyltransferase domain containing 7 2.04397
PROCA1 protein interacting with cyclin A1 2.03392
ASCC2 activating signal cointegrator 1 complex subunit 2 2.03392
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.03005
SNTG2 syntrophin, gamma 2 2.02765
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.00938

decreased expression

Symbol Name Standardized Value
HFE hemochromatosis -2.65045
BTN3A2 butyrophilin, subfamily 3, member A2 -2.65045
ARHGAP27 Rho GTPase activating protein 27 -2.65045
C3ORF70 chromosome 3 open reading frame 70 -2.65045
SGCZ sarcoglycan, zeta -2.65045
CD36 CD36 molecule (thrombospondin receptor) -2.5514
AKAP5 A kinase (PRKA) anchor protein 5 -2.5514
SERTAD2 SERTA domain containing 2 -2.5514
TECTA tectorin alpha -2.5514
STAU1 staufen double-stranded RNA binding protein 1 -2.5514
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -2.5514
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.5514
TULP2 tubby like protein 2 -2.5514
CCDC80 coiled-coil domain containing 80 -2.5514
SNX3 sorting nexin 3 -2.5514
MYD88 myeloid differentiation primary response 88 -2.5514
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.5514
PRELID1 PRELI domain containing 1 -2.5514
WNT5B wingless-type MMTV integration site family, member 5B -2.5514
TUBB1 tubulin, beta 1 class VI -2.5514
MARCHF10 membrane associated ring-CH-type finger 10 -2.5514
BORCS5 BLOC-1 related complex subunit 5 -2.5514
TMSB15C thymosin beta 15C -2.5514
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.5514
IFT70B intraflagellar transport 70B -2.5514
LIME1 Lck interacting transmembrane adaptor 1 -2.5514
MAP6D1 MAP6 domain containing 1 -2.5514
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.52199
EIF6 eukaryotic translation initiation factor 6 -2.48918
ADCY1 adenylate cyclase 1 (brain) -2.48799
BAZ2A bromodomain adjacent to zinc finger domain, 2A -2.47913
MRPS18A mitochondrial ribosomal protein S18A -2.47288
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha -2.45638
CUL4B cullin 4B -2.40499
RPL10 ribosomal protein L10 -2.39008
LYN LYN proto-oncogene, Src family tyrosine kinase -2.37599
TTLL2 tubulin tyrosine ligase-like family member 2 -2.2903
PRH1-TAS2R14 PRH1-TAS2R14 readthrough -2.2903
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.2903
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.2903
TMEM272 transmembrane protein 272 -2.2903
GSG1 germ cell associated 1 -2.2903
IFT70A intraflagellar transport 70A -2.2903
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.2903
CA7 carbonic anhydrase VII -2.2903
FOXN4 forkhead box N4 -2.2903
OR2A12 olfactory receptor, family 2, subfamily A, member 12 -2.2903
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.2903
TMEM98 transmembrane protein 98 -2.2903
RNASE4 ribonuclease, RNase A family, 4 -2.2903
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.2903
FAM186A family with sequence similarity 186, member A -2.2903
TSSK6 testis-specific serine kinase 6 -2.2903
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.2903
CX3CL1 chemokine (C-X3-C motif) ligand 1 -2.2903
C11ORF52 chromosome 11 open reading frame 52 -2.2903
ZNF780B zinc finger protein 780B -2.2903
RAB36 RAB36, member RAS oncogene family -2.2903
TNC tenascin C -2.2903
UPP2 uridine phosphorylase 2 -2.2903
STAB2 stabilin 2 -2.2903
IGSF6 immunoglobulin superfamily, member 6 -2.2903
EFCAB12 EF-hand calcium binding domain 12 -2.2903
NLRC4 NLR family, CARD domain containing 4 -2.2903
F5 coagulation factor V (proaccelerin, labile factor) -2.2903
SYNPO synaptopodin -2.2903
TRAPPC11 trafficking protein particle complex 11 -2.2903
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 -2.2903
ADGRA2 adhesion G protein-coupled receptor A2 -2.2903
AQP5 aquaporin 5 -2.2903
FAM222A family with sequence similarity 222, member A -2.2903
TIGD2 tigger transposable element derived 2 -2.2903
JSRP1 junctional sarcoplasmic reticulum protein 1 -2.2903
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.2903
CYS1 cystin 1 -2.2903
XPR1 xenotropic and polytropic retrovirus receptor 1 -2.2903
PCDHAC1 protocadherin alpha subfamily C, 1 -2.2903
GPNMB glycoprotein (transmembrane) nmb -2.2903
LMX1B LIM homeobox transcription factor 1, beta -2.2903
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -2.2903
WNT4 wingless-type MMTV integration site family, member 4 -2.2903
INTS3 integrator complex subunit 3 -2.27115
ZNF837 zinc finger protein 837 -2.24215
ZNF543 zinc finger protein 543 -2.24215
ABHD14A abhydrolase domain containing 14A -2.24215
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.24215
ZNF473 zinc finger protein 473 -2.24215
RBM45 RNA binding motif protein 45 -2.24215
PLXDC1 plexin domain containing 1 -2.24215
IL6ST-DT IL6ST divergent transcript -2.22845
DPY30 dpy-30 homolog (C. elegans) -2.22557
CREB3L4 cAMP responsive element binding protein 3-like 4 -2.22468
PABIR1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 -2.21188
NHSL3 NHS like 3 -2.20552
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) -2.20552
SLC38A9 solute carrier family 38, member 9 -2.18758
PCBP1 poly(rC) binding protein 1 -2.18758
PTRH1 peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) -2.18679
FIGNL1 fidgetin-like 1 -2.18474
CDCA7 cell division cycle associated 7 -2.17073
SPAG7 sperm associated antigen 7 -2.14872
SPPL2A signal peptide peptidase like 2A -2.14566
COMMD10 COMM domain containing 10 -2.14486
ZNF774 zinc finger protein 774 -2.10846
RBM22 RNA binding motif protein 22 -2.10461
CLIC4 chloride intracellular channel 4 -2.10087
H2AC4 H2A clustered histone 4 -2.09664
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -2.09664
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -2.08741
ZNF20 zinc finger protein 20 -2.08656
PYGO1 pygopus family PHD finger 1 -2.07595
EMP3 epithelial membrane protein 3 -2.07595
MEX3B mex-3 RNA binding family member B -2.07595
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa -2.05796
NOL10 nucleolar protein 10 -2.05612
C17ORF67 chromosome 17 open reading frame 67 -2.05403
IQCC IQ motif containing C -2.04467
CRAMP1 cramped chromatin regulator homolog 1 -2.03091
PHKB phosphorylase kinase, beta -2.03005
RCN2 reticulocalbin 2, EF-hand calcium binding domain -2.02349
CD79B CD79b molecule, immunoglobulin-associated beta -2.02349
TMEM45A transmembrane protein 45A -2.0154
HACD4 3-hydroxyacyl-CoA dehydratase 4 -2.0154
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -2.0154
RELT RELT tumor necrosis factor receptor -2.0154
GLIPR1L1 GLI pathogenesis-related 1 like 1 -2.0154
MRPL34 mitochondrial ribosomal protein L34 -2.00996
ZNF606 zinc finger protein 606 -2.0081
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) -2.00673
DLEC1 deleted in lung and esophageal cancer 1 -2.00673