HLA-C Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description major histocompatibility complex, class I, C|HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3107)
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Genes

335 genes differentially expressed following the HLA-C gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FGF21 fibroblast growth factor 21 2.9883
CHRM1 cholinergic receptor, muscarinic 1 2.9883
FGF23 fibroblast growth factor 23 2.9883
CNTN6 contactin 6 2.9883
ANKRD22 ankyrin repeat domain 22 2.9883
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.9883
SLC46A3 solute carrier family 46, member 3 2.9883
FSHR follicle stimulating hormone receptor 2.9883
KLK6 kallikrein-related peptidase 6 2.9883
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.9883
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.9883
CTRC chymotrypsin C (caldecrin) 2.9883
PTPRC protein tyrosine phosphatase, receptor type, C 2.9883
NMBR neuromedin B receptor 2.9883
MAGED4 melanoma antigen family D4 2.9883
ICAM2 intercellular adhesion molecule 2 2.9883
C11ORF16 chromosome 11 open reading frame 16 2.9883
LRRN4 leucine rich repeat neuronal 4 2.9883
LY6S lymphocyte antigen 6 family member S 2.9883
PSCA prostate stem cell antigen 2.97213
TAS2R13 taste receptor, type 2, member 13 2.97213
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.97213
BFSP2 beaded filament structural protein 2, phakinin 2.97213
LBX2 ladybird homeobox 2 2.97213
PI16 peptidase inhibitor 16 2.97213
TECTB tectorin beta 2.97213
COLEC10 collectin sub-family member 10 (C-type lectin) 2.97213
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.97213
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.97213
WT1 Wilms tumor 1 2.97213
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.97213
CEMP1 cementum protein 1 2.97213
CLEC12A C-type lectin domain family 12, member A 2.97213
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.97213
HBZ hemoglobin, zeta 2.97213
PLIN4 perilipin 4 2.97213
ASB17 ankyrin repeat and SOCS box containing 17 2.97213
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.97213
TBATA thymus, brain and testes associated 2.97213
SLC39A5 solute carrier family 39 (zinc transporter), member 5 2.97213
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.97213
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.97213
SPP2 secreted phosphoprotein 2, 24kDa 2.97213
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.97213
SIGLEC9 sialic acid binding Ig-like lectin 9 2.97213
DSG3 desmoglein 3 2.97213
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.97213
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.97213
TMEM151A transmembrane protein 151A 2.97213
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.97213
HORMAD1 HORMA domain containing 1 2.97213
PEAR1 platelet endothelial aggregation receptor 1 2.97213
PNOC prepronociceptin 2.97213
GJB4 gap junction protein, beta 4, 30.3kDa 2.97213
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.97213
SLC22A10 solute carrier family 22, member 10 2.97213
SPMAP1 sperm microtubule associated protein 1 2.97213
SMIM40 small integral membrane protein 40 2.97213
PHF24 PHD finger protein 24 2.97213
ALDOB aldolase B, fructose-bisphosphate 2.97213
ROPN1L rhophilin associated tail protein 1-like 2.97213
AANAT aralkylamine N-acetyltransferase 2.97213
ELOVL3 ELOVL fatty acid elongase 3 2.97213
FOXC2 forkhead box C2 2.97213
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.97213
FAM228A family with sequence similarity 228, member A 2.97213
ELOA2 elongin A2 2.97213
GSTT4 glutathione S-transferase theta 4 2.97213
TEKTL1 tektin like 1 2.97213
CIMIP4 ciliary microtubule inner protein 4 2.97213
LITAFD LITAF domain containing 2.97213
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.97213
GSG1L2 GSG1 like 2 2.97213
HOATZ HOATZ cilia and flagella associated protein 2.97213
CFAP276 cilia and flagella associated protein 276 2.97213
H2BW2 H2B.W histone 2 2.97213
TEX13C TEX13 family member C 2.97213
F5 coagulation factor V (proaccelerin, labile factor) 2.97213
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.97213
TLR8 toll-like receptor 8 2.97213
TMEM235 transmembrane protein 235 2.97213
WNT11 wingless-type MMTV integration site family, member 11 2.97213
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.97213
TEX101 testis expressed 101 2.97213
LOC124905976 uncharacterized LOC124905976 2.97213
REG4 regenerating islet-derived family, member 4 2.97213
RS1 retinoschisin 1 2.97213
ISM2 isthmin 2 2.97213
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.97213
TCF23 transcription factor 23 2.97213
KL klotho 2.97213
PRDM7 PR domain containing 7 2.97213
TXNRD2 thioredoxin reductase 2 2.97213
LTA lymphotoxin alpha 2.97213
ASIC3 acid sensing (proton gated) ion channel 3 2.97213
CAPN8 calpain 8 2.97213
BARX2 BARX homeobox 2 2.97213
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.97213
S100B S100 calcium binding protein B 2.97213
TAS2R39 taste receptor, type 2, member 39 2.97213
CD5L CD5 molecule-like 2.97213
SMIM22 small integral membrane protein 22 2.97213
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.97213
OR8H1 olfactory receptor, family 8, subfamily H, member 1 2.97213
MAGEB17 melanoma antigen family B17 2.97213
PENK proenkephalin 2.97213
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.97213
PRSS55 protease, serine, 55 2.97213
PRSS57 protease, serine, 57 2.97213
PGR progesterone receptor 2.97213
NCR1 natural cytotoxicity triggering receptor 1 2.97213
CTRB1 chymotrypsinogen B1 2.97213
SPRN shadow of prion protein homolog (zebrafish) 2.97213
C5AR2 complement component 5a receptor 2 2.97213
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.97213
CLEC1A C-type lectin domain family 1, member A 2.97213
DLX2 distal-less homeobox 2 2.97213
SPATA25 spermatogenesis associated 25 2.97213
DMRT1 doublesex and mab-3 related transcription factor 1 2.97213
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.97213
OR52K1 olfactory receptor, family 52, subfamily K, member 1 2.97213
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.97213
IL21R interleukin 21 receptor 2.97213
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.97213
ADAMDEC1 ADAM-like, decysin 1 2.97213
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.97213
LRRK2 leucine-rich repeat kinase 2 2.97213
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.97213
GLOD5 glyoxalase domain containing 5 2.97213
CYSLTR1 cysteinyl leukotriene receptor 1 2.97213
RGSL1 regulator of G-protein signaling like 1 2.97213
LCT lactase 2.97213
LMOD2 leiomodin 2 (cardiac) 2.97213
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.97213
TECRL trans-2,3-enoyl-CoA reductase-like 2.97213
OR10G4 olfactory receptor, family 10, subfamily G, member 4 2.97213
FBXL14 F-box and leucine-rich repeat protein 14 2.97213
SYNGR4 synaptogyrin 4 2.97213
CFP complement factor properdin 2.97213
NLRP14 NLR family, pyrin domain containing 14 2.97213
ZNF648 zinc finger protein 648 2.97213
NLRP5 NLR family, pyrin domain containing 5 2.97213
MROH2A maestro heat-like repeat family member 2A 2.97213
C5ORF46 chromosome 5 open reading frame 46 2.97213
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2.97213
CLEC2A C-type lectin domain family 2, member A 2.97213
CRTAM cytotoxic and regulatory T cell molecule 2.97213
NPC1L1 NPC1-like 1 2.97213
ITGAD integrin, alpha D 2.97213
MMRN1 multimerin 1 2.97213
HRG histidine-rich glycoprotein 2.97213
SDSL serine dehydratase-like 2.97213
NKX6-1 NK6 homeobox 1 2.97213
MEIS1 Meis homeobox 1 2.97213
NPAS4 neuronal PAS domain protein 4 2.97213
VTCN1 V-set domain containing T cell activation inhibitor 1 2.97213
TMEM86A transmembrane protein 86A 2.97213
CLEC18B C-type lectin domain family 18, member B 2.97213
NUTM2B NUT family member 2B 2.97213
NUTM2D NUT family member 2D 2.97213
HMGB4 high mobility group box 4 2.97213
KLRG2 killer cell lectin-like receptor subfamily G, member 2 2.94502
PRODH proline dehydrogenase (oxidase) 1 2.92824
CES3 carboxylesterase 3 2.92824
PVALEF parvalbumin like EF-hand containing 2.92824
UTS2 urotensin 2 2.92824
RPL18A ribosomal protein L18a 2.92275
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 2.89217
PRDM11 PR domain containing 11 2.84507
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.70242
ITCH itchy E3 ubiquitin protein ligase 2.70181
MBIP MAP3K12 binding inhibitory protein 1 2.69773
GINM1 glycoprotein integral membrane 1 2.60533
LPIN1 lipin 1 2.59803
WDR82 WD repeat domain 82 2.55456
ACSS2 acyl-CoA synthetase short-chain family member 2 2.51834
NPSR1 neuropeptide S receptor 1 2.50579
MCM2 minichromosome maintenance complex component 2 2.50111
CCDC90B coiled-coil domain containing 90B 2.48535
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 2.46768
SCNN1A sodium channel, non voltage gated 1 alpha subunit 2.46415
NAV2 neuron navigator 2 2.46415
FA2H fatty acid 2-hydroxylase 2.46415
SRPRB signal recognition particle receptor, B subunit 2.4528
EFCAB11 EF-hand calcium binding domain 11 2.4206
MKRN1 makorin ring finger protein 1 2.4206
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 2.41759
MPG N-methylpurine-DNA glycosylase 2.41759
SPAG9 sperm associated antigen 9 2.40561
LRP4 low density lipoprotein receptor-related protein 4 2.40322
AURKB aurora kinase B 2.37767
SPESP1 sperm equatorial segment protein 1 2.37381
SLC75A1 solute carrier family 75 member 1 2.37381
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.35583
MYO19 myosin XIX 2.3504
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.3504
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.33396
CRLF2 cytokine receptor-like factor 2 2.31961
PRUNE1 prune exopolyphosphatase 1 2.30834
IRS1 insulin receptor substrate 1 2.30728
PDZK1 PDZ domain containing 1 2.29679
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.27709
MANEA mannosidase, endo-alpha 2.25149
BCDIN3D BCDIN3 domain containing 2.24964
GDF9 growth differentiation factor 9 2.24131
GTF2A1 general transcription factor IIA, 1, 19/37kDa 2.2338
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 2.20119
GPSM2 G-protein signaling modulator 2 2.19522
COMMD2 COMM domain containing 2 2.19339
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 2.19026
TMEM138 transmembrane protein 138 2.17037
EFCAB14 EF-hand calcium binding domain 14 2.16378
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.16067
NSUN6 NOP2/Sun domain family, member 6 2.14497
PDZD7 PDZ domain containing 7 2.13338
SERINC3 serine incorporator 3 2.12899
RRM2 ribonucleotide reductase M2 2.10577
CTSA cathepsin A 2.10414
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 2.10348
SBNO2 strawberry notch homolog 2 (Drosophila) 2.08888
LMBR1 limb development membrane protein 1 2.08393
RREB1 ras responsive element binding protein 1 2.07546
BTBD2 BTB (POZ) domain containing 2 2.06654
FGF22 fibroblast growth factor 22 2.06348
SNTN sentan, cilia apical structure protein 2.06348
RAD21L1 RAD21-like 1 (S. pombe) 2.06348
AADACL3 arylacetamide deacetylase-like 3 2.06348
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.06348
FOXB1 forkhead box B1 2.05863
GMFB glia maturation factor, beta 2.03019
TTC26 tetratricopeptide repeat domain 26 2.03019
CRIPTO3 cripto, EGF-CFC family member 3 2.02176
COPG1 coatomer protein complex, subunit gamma 1 2.01812
CYB5R3 cytochrome b5 reductase 3 2.01812
TDRD3 tudor domain containing 3 2.01812
RCCD1 RCC1 domain containing 1 2.01812
PLK4 polo-like kinase 4 2.01812
SRCIN1 SRC kinase signaling inhibitor 1 2.01637
ELP3 elongator acetyltransferase complex subunit 3 2.0046

decreased expression

Symbol Name Standardized Value
HLA-C major histocompatibility complex, class I, C -2.9883
H2BC8 H2B clustered histone 8 -2.9883
CRYAB crystallin, alpha B -2.9883
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.97213
TMC2 transmembrane channel-like 2 -2.97213
NRIP2 nuclear receptor interacting protein 2 -2.97213
CHUK conserved helix-loop-helix ubiquitous kinase -2.97213
ZNF32 zinc finger protein 32 -2.97213
NTSR1 neurotensin receptor 1 (high affinity) -2.97213
H2BC13 H2B clustered histone 13 -2.97213
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 -2.92824
MPL MPL proto-oncogene, thrombopoietin receptor -2.92824
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.92824
PRR22 proline rich 22 -2.92824
GPR83 G protein-coupled receptor 83 -2.92824
CCL27 chemokine (C-C motif) ligand 27 -2.92824
EMCN endomucin -2.92824
AXDND1 axonemal dynein light chain domain containing 1 -2.92824
CXCR5 chemokine (C-X-C motif) receptor 5 -2.92824
THSD8 thrombospondin type 1 domain containing 8 -2.92824
FAM240C family with sequence similarity 240 member C -2.92824
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 -2.92824
MPIG6B megakaryocyte and platelet inhibitory receptor G6b -2.92824
CFAP141 cilia and flagella associated protein 141 -2.92824
PCDHB6 protocadherin beta 6 -2.92824
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.92824
FETUB fetuin B -2.92824
HLF hepatic leukemia factor -2.92824
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -2.92824
ANKRD34A ankyrin repeat domain 34A -2.92824
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.92824
USH1G Usher syndrome 1G (autosomal recessive) -2.92824
P3H1 prolyl 3-hydroxylase 1 -2.91269
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.83814
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.81257
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 -2.7657
MED18 mediator complex subunit 18 -2.74473
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -2.64901
IQGAP1 IQ motif containing GTPase activating protein 1 -2.6361
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) -2.59236
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -2.58164
EIF2D eukaryotic translation initiation factor 2D -2.48861
SNX1 sorting nexin 1 -2.48535
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.47224
PLCD4 phospholipase C, delta 4 -2.46429
TRPC6 transient receptor potential cation channel, subfamily C, member 6 -2.46429
PGAM2 phosphoglycerate mutase 2 (muscle) -2.46415
SLFN5 schlafen family member 5 -2.45331
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) -2.4269
LIME1 Lck interacting transmembrane adaptor 1 -2.41446
CNGB3 cyclic nucleotide gated channel beta 3 -2.41446
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -2.41446
DCDC1 doublecortin domain containing 1 -2.40561
INTS11 integrator complex subunit 11 -2.38811
ZNF157 zinc finger protein 157 -2.38561
SCX scleraxis basic helix-loop-helix transcription factor -2.35983
POFUT3 protein O-fucosyltransferase 3 -2.35688
CISD1 CDGSH iron sulfur domain 1 -2.35505
LUC7L3 LUC7-like 3 (S. cerevisiae) -2.33112
MCUR1 mitochondrial calcium uniporter regulator 1 -2.28576
OPRK1 opioid receptor, kappa 1 -2.27849
BIRC6 baculoviral IAP repeat containing 6 -2.27124
POU6F2 POU class 6 homeobox 2 -2.24964
SRSF1 serine/arginine-rich splicing factor 1 -2.23676
TMSB15C thymosin beta 15C -2.22978
CCDC57 coiled-coil domain containing 57 -2.22405
PLAA phospholipase A2-activating protein -2.21625
RO60 Ro60, Y RNA binding protein -2.19147
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.19026
ATR ATR serine/threonine kinase -2.19026
CDC20B cell division cycle 20B -2.19026
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.19026
ISY1 ISY1 splicing factor homolog (S. cerevisiae) -2.18503
OAF OAF homolog (Drosophila) -2.16067
IER5L immediate early response 5-like -2.15186
PIH1D2 PIH1 domain containing 2 -2.15186
PCSK4 proprotein convertase subtilisin/kexin type 4 -2.13099
MPHOSPH9 M-phase phosphoprotein 9 -2.12828
BRCA2 breast cancer 2, early onset -2.12232
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.10414
FMO1 flavin containing monooxygenase 1 -2.10414
MAGEL2 melanoma antigen family L2 -2.10414
DHRSX dehydrogenase/reductase (SDR family) X-linked -2.09924
MED13L mediator complex subunit 13-like -2.09297
HYAL2 hyaluronoglucosaminidase 2 -2.09165
GPBP1 GC-rich promoter binding protein 1 -2.09002
ZNHIT2 zinc finger, HIT-type containing 2 -2.06348
MEX3B mex-3 RNA binding family member B -2.06347
HLA-B major histocompatibility complex, class I, B -2.05187
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -2.04843
PTPDC1 protein tyrosine phosphatase domain containing 1 -2.04209
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -2.04079
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -2.03482
CAPN15 calpain 15 -2.03019
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 -2.01812
TUG1 taurine up-regulated 1 (non-protein coding) -2.00626