HLA-C Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description major histocompatibility complex, class I, C|HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3107)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_HLA-C
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Genes

47 co-expressed genes for HLA-C from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ARF6 ADP-ribosylation factor 6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B2M beta-2-microglobulin
C17ORF62 chromosome 17 open reading frame 62
CD48 CD48 molecule
CD53 CD53 molecule
CORO1A coronin, actin binding protein, 1A
CORO7 coronin 7
CYBA cytochrome b-245, alpha polypeptide
CYTIP cytohesin 1 interacting protein
ELF4 E74-like factor 4 (ets domain transcription factor)
FXYD5 FXYD domain containing ion transport regulator 5
GPSM3 G-protein signaling modulator 3
GRK6 G protein-coupled receptor kinase 6
HCLS1 hematopoietic cell-specific Lyn substrate 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMHA1 histocompatibility (minor) HA-1
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF1 interferon regulatory factor 1
LAPTM5 lysosomal protein transmembrane 5
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAX MYC associated factor X
PHF11 PHD finger protein 11
PNRC1 proline-rich nuclear receptor coactivator 1
PRR13 proline rich 13
PSD4 pleckstrin and Sec7 domain containing 4
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RIN3 Ras and Rab interactor 3
SASH3 SAM and SH3 domain containing 3
SERP1 stress-associated endoplasmic reticulum protein 1
SIPA1 signal-induced proliferation-associated 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUSD6 sushi domain containing 6
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome