HLA-DMA Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description major histocompatibility complex, class II, DM alpha|HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3108)
External Link http://www.ncbi.nlm.nih.gov/gene/3108
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Genes

11 interacting proteins for HLA-DMA from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
B3GAT1 beta-1,3-glucuronyltransferase 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
MBP myelin basic protein
RUNX1 runt-related transcription factor 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBC ubiquitin C