HLA-DMB Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description major histocompatibility complex, class II, DM beta|HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3109)
External Link http://www.ncbi.nlm.nih.gov/gene/3109
Similar Terms
Downloads & Tools

Genes

13 interacting proteins for HLA-DMB from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
CD63 CD63 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
CUL3 cullin 3
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DOB major histocompatibility complex, class II, DO beta
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
MBP myelin basic protein
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)