HLA-DOA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description major histocompatibility complex, class II, DO alpha|HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3111)
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Genes

288 genes differentially expressed following the HLA-DOA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TUBA3D tubulin, alpha 3d 2.84828
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.84828
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.84828
BTC betacellulin 2.84828
TRIM10 tripartite motif containing 10 2.84828
ZEB2 zinc finger E-box binding homeobox 2 2.84828
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.84828
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.84828
MBLAC1 metallo-beta-lactamase domain containing 1 2.84828
NAPSA napsin A aspartic peptidase 2.84828
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.84828
PRB4 proline-rich protein BstNI subfamily 4 2.84828
PCDHA7 protocadherin alpha 7 2.84828
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.84828
PVRIG poliovirus receptor related immunoglobulin domain containing 2.84828
FRMD7 FERM domain containing 7 2.84828
ZNF98 zinc finger protein 98 2.84828
GJA3 gap junction protein, alpha 3, 46kDa 2.84828
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.84828
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.84828
BLK BLK proto-oncogene, Src family tyrosine kinase 2.84828
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.84828
SMIM5 small integral membrane protein 5 2.84828
CPB2 carboxypeptidase B2 (plasma) 2.84828
SOWAHB sosondowah ankyrin repeat domain family member B 2.84828
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.84828
ADAT3 adenosine deaminase, tRNA-specific 3 2.84828
S100A3 S100 calcium binding protein A3 2.84828
S100A5 S100 calcium binding protein A5 2.84828
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.84828
ZSCAN21 zinc finger and SCAN domain containing 21 2.84828
USP50 ubiquitin specific peptidase 50 2.84828
ARHGAP36 Rho GTPase activating protein 36 2.84828
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.84828
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.84828
GPR26 G protein-coupled receptor 26 2.84828
CXCL2 chemokine (C-X-C motif) ligand 2 2.84828
SFTPB surfactant protein B 2.84828
NCKAP1L NCK-associated protein 1-like 2.84828
ZNF556 zinc finger protein 556 2.84828
LOC105378220 macrophage receptor MARCO-like 2.84828
LOC107986837 uncharacterized LOC107986837 2.84828
MEIOSIN meiosis initiator 2.84828
NFILZ NFIL3 like basic leucine zipper 2.84828
PLAAT4 phospholipase A and acyltransferase 4 2.84828
H3-5 H3.5 histone 2.84828
CLDN16 claudin 16 2.84828
PNLIPRP1 pancreatic lipase-related protein 1 2.84828
ACER1 alkaline ceramidase 1 2.84828
FRG2C FSHD region gene 2 family, member C 2.84828
DNAAF6 dynein axonemal assembly factor 6 2.84828
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.84828
SPMIP11 sperm microtubule inner protein 11 2.84828
CIMIP4 ciliary microtubule inner protein 4 2.84828
LITAFD LITAF domain containing 2.84828
SPMIP3 sperm microtubule inner protein 3 2.84828
H2BK1 H2B.K variant histone 1 2.84828
H2BC12L H2B clustered histone 12 like 2.84828
SMIM43 small integral membrane protein 43 2.84828
SMIM31 small integral membrane protein 31 2.84828
TBC1D3B TBC1 domain family, member 3B 2.84828
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.84828
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.84828
INSRR insulin receptor-related receptor 2.84828
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 2.84828
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.84828
TFEC transcription factor EC 2.84828
C1ORF162 chromosome 1 open reading frame 162 2.84828
MSX1 msh homeobox 1 2.84828
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 2.84828
GAST gastrin 2.84828
CCR3 chemokine (C-C motif) receptor 3 2.84828
CLDN22 claudin 22 2.84828
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.84828
GC group-specific component (vitamin D binding protein) 2.84828
SRP72 signal recognition particle 72kDa 2.84828
DYNLRB2 dynein, light chain, roadblock-type 2 2.84828
GATA3 GATA binding protein 3 2.84828
SYT15 synaptotagmin XV 2.84828
DYNAP dynactin associated protein 2.84828
IL16 interleukin 16 2.84828
DAO D-amino-acid oxidase 2.84828
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.84828
PHACTR3 phosphatase and actin regulator 3 2.84828
C16ORF78 chromosome 16 open reading frame 78 2.84828
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.84828
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.84828
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.84828
OR9A4 olfactory receptor, family 9, subfamily A, member 4 2.84828
CST4 cystatin S 2.84828
LCT lactase 2.84828
CCL27 chemokine (C-C motif) ligand 27 2.84828
PALMD palmdelphin 2.84828
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.84828
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.84828
HSF4 heat shock transcription factor 4 2.84828
GPR50 G protein-coupled receptor 50 2.84828
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.84828
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.84828
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.84828
TRIM50 tripartite motif containing 50 2.84828
EMP1 epithelial membrane protein 1 2.84828
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.84828
GAS2L2 growth arrest-specific 2 like 2 2.84828
POU4F3 POU class 4 homeobox 3 2.84828
RASA4 RAS p21 protein activator 4 2.84828
NYX nyctalopin 2.84828
RGS4 regulator of G-protein signaling 4 2.84828
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.84828
SMIM17 small integral membrane protein 17 2.84828
PIP prolactin-induced protein 2.84828
IGF2 insulin-like growth factor 2 2.84828
HRCT1 histidine rich carboxyl terminus 1 2.84828
IL19 interleukin 19 2.84828
C17ORF99 chromosome 17 open reading frame 99 2.84828
VWA3B von Willebrand factor A domain containing 3B 2.84828
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.84828
FOXE3 forkhead box E3 2.84828
LRRC74A leucine rich repeat containing 74A 2.84828
KIF12 kinesin family member 12 2.84828
TPH1 tryptophan hydroxylase 1 2.84828
CCNO cyclin O 2.84828
CARD16 caspase recruitment domain family, member 16 2.84828
IL37 interleukin 37 2.84828
TMPRSS15 transmembrane protease, serine 15 2.84828
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.84828
ANXA9 annexin A9 2.84828
IRX5 iroquois homeobox 5 2.84828
SSX3 synovial sarcoma, X breakpoint 3 2.84828
TAS2R46 taste receptor, type 2, member 46 2.84828
LOXL4 lysyl oxidase-like 4 2.84828
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.84828
GPR179 G protein-coupled receptor 179 2.84828
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 2.84828
APOL3 apolipoprotein L, 3 2.84828
CLCNKB chloride channel, voltage-sensitive Kb 2.84828
BIN2 bridging integrator 2 2.84828
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.84828
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.84828
C5ORF58 chromosome 5 open reading frame 58 2.84766
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.76162
SPINK1 serine peptidase inhibitor, Kazal type 1 2.72017
DCDC2 doublecortin domain containing 2 2.67611
INAFM2 InaF-motif containing 2 2.62609
MTRF1L mitochondrial translational release factor 1-like 2.55488
HYDIN HYDIN, axonemal central pair apparatus protein 2.55149
HHAT hedgehog acyltransferase 2.52335
TTF2 transcription termination factor, RNA polymerase II 2.44662
PPP1R37 protein phosphatase 1, regulatory subunit 37 2.43296
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.38909
ARL9 ADP-ribosylation factor-like 9 2.38396
GLB1L2 galactosidase, beta 1-like 2 2.38396
ARRB2 arrestin, beta 2 2.35681
TMSB15C thymosin beta 15C 2.34611
SPC24 SPC24, NDC80 kinetochore complex component 2.34454
BTN1A1 butyrophilin, subfamily 1, member A1 2.32735
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.30917
SLC30A7 solute carrier family 30 (zinc transporter), member 7 2.28677
RDM1 RAD52 motif containing 1 2.28321
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 2.27349
FLT1 fms-related tyrosine kinase 1 2.27349
DNAH14 dynein, axonemal, heavy chain 14 2.27349
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 2.26509
MECR mitochondrial trans-2-enoyl-CoA reductase 2.26503
MSANTD7 Myb/SANT DNA binding domain containing 7 2.24422
RPS28 ribosomal protein S28 2.2395
TMEM258 transmembrane protein 258 2.22391
LYRM1 LYR motif containing 1 2.20122
FSIP2 fibrous sheath interacting protein 2 2.19474
OSBPL10 oxysterol binding protein-like 10 2.17569
ATRN attractin 2.16939
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.15777
ANK1 ankyrin 1, erythrocytic 2.15777
EFNB3 ephrin-B3 2.15385
NLGN2 neuroligin 2 2.14977
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) 2.14541
ZNF544 zinc finger protein 544 2.11818
SP8 Sp8 transcription factor 2.11267
CDC34 cell division cycle 34 2.0926
COL4A1 collagen, type IV, alpha 1 2.09038
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 2.06753
FAM216A family with sequence similarity 216, member A 2.04665
BICRAL BICRA like chromatin remodeling complex associated protein 2.04571
HIP1 huntingtin interacting protein 1 2.03292
IQCK IQ motif containing K 2.03292
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.02743
SMC5 structural maintenance of chromosomes 5 2.02743
CFAP74 cilia and flagella associated protein 74 2.02341
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.02341
RBBP6 retinoblastoma binding protein 6 2.02341
CDPF1 cysteine-rich, DPF motif domain containing 1 2.02341
ERBIN erbb2 interacting protein 2.02341
DOCK5 dedicator of cytokinesis 5 2.01924
FANK1 fibronectin type III and ankyrin repeat domains 1 2.01582
SCARF1 scavenger receptor class F, member 1 2.01582
ZFP64 ZFP64 zinc finger protein 2.01582
FYTTD1 forty-two-three domain containing 1 2.01354
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 2.00966

decreased expression

Symbol Name Standardized Value
IRF8 interferon regulatory factor 8 -2.84828
NRROS negative regulator of reactive oxygen species -2.84828
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 -2.84828
COX15 cytochrome c oxidase assembly homolog 15 (yeast) -2.84828
RGPD3 RANBP2-like and GRIP domain containing 3 -2.84828
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -2.84828
GTSF1 gametocyte specific factor 1 -2.84828
NUCB1 nucleobindin 1 -2.84828
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.84828
PRDM7 PR domain containing 7 -2.84828
NLRP6 NLR family, pyrin domain containing 6 -2.84828
LPA lipoprotein, Lp(a) -2.84828
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -2.84828
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.84828
TMEM100 transmembrane protein 100 -2.84828
ITK IL2-inducible T-cell kinase -2.84828
MLH1 mutL homolog 1 -2.84828
C7ORF25 chromosome 7 open reading frame 25 -2.84828
FAM240C family with sequence similarity 240 member C -2.84828
SIK1 salt-inducible kinase 1 -2.84828
DUXB double homeobox B -2.84828
IDO2 indoleamine 2,3-dioxygenase 2 -2.84828
NANOS3 nanos homolog 3 (Drosophila) -2.84828
MUC1 mucin 1, cell surface associated -2.84828
PKD1L1 polycystic kidney disease 1 like 1 -2.84828
CCDC69 coiled-coil domain containing 69 -2.84828
CLCNKA chloride channel, voltage-sensitive Ka -2.84828
GRAPL GRB2-related adaptor protein-like -2.84828
GOLGA8T golgin A8 family, member T -2.84828
MATN4 matrilin 4 -2.84828
CCDC187 coiled-coil domain containing 187 -2.84828
SEMG1 semenogelin I -2.84828
FYB2 FYN binding protein 2 -2.84828
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -2.84828
EMILIN3 elastin microfibril interfacer 3 -2.84828
LRRC19 leucine rich repeat containing 19 -2.84828
SAMD5 sterile alpha motif domain containing 5 -2.84828
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.84828
CSP2 CS pseudogene 2 -2.84828
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -2.84828
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.84828
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -2.84828
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.79801
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -2.74088
PERP PERP, TP53 apoptosis effector -2.71969
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.67611
ARMH1 armadillo like helical domain containing 1 -2.59378
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.51946
PRPF31 pre-mRNA processing factor 31 -2.47332
CCDC121 coiled-coil domain containing 121 -2.46762
CTRL chymotrypsin-like -2.46762
TUBB1 tubulin, beta 1 class VI -2.46644
H4C1 H4 clustered histone 1 -2.46644
C6ORF47 chromosome 6 open reading frame 47 -2.45504
LENG9 leukocyte receptor cluster (LRC) member 9 -2.45504
AGA aspartylglucosaminidase -2.44659
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.41046
ZNF536 zinc finger protein 536 -2.39469
WDR35 WD repeat domain 35 -2.35947
L2HGDH L-2-hydroxyglutarate dehydrogenase -2.3353
ZNF564 zinc finger protein 564 -2.31785
STPG4 sperm-tail PG-rich repeat containing 4 -2.28677
UBC ubiquitin C -2.2403
PNO1 partner of NOB1 homolog (S. cerevisiae) -2.22037
GYS1 glycogen synthase 1 (muscle) -2.20122
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.18169
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.17724
SNX15 sorting nexin 15 -2.17569
BUB1B-PAK6 BUB1B-PAK6 readthrough -2.15777
TBRG1 transforming growth factor beta regulator 1 -2.15253
COA8 cytochrome c oxidase assembly factor 8 -2.15004
KANK2 KN motif and ankyrin repeat domains 2 -2.14541
E4F1 E4F transcription factor 1 -2.14541
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.11818
IKZF2 IKAROS family zinc finger 2 (Helios) -2.11818
PAQR8 progestin and adipoQ receptor family member VIII -2.11818
DONSON downstream neighbor of SON -2.11078
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -2.10632
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) -2.0944
RAB3B RAB3B, member RAS oncogene family -2.09038
RPP25 ribonuclease P/MRP 25kDa subunit -2.07818
COPZ1 coatomer protein complex, subunit zeta 1 -2.06433
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -2.05483
ZFP42 ZFP42 zinc finger protein -2.05179
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.04939
SULF1 sulfatase 1 -2.04619
PNP purine nucleoside phosphorylase -2.02341
STK33 serine/threonine kinase 33 -2.02341
CDH13 cadherin 13 -2.01582
RHOXF1 Rhox homeobox family, member 1 -2.00966