| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | major histocompatibility complex, class II, DO beta|HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3112) |
| External Link | https://ncbi.nlm.nih.gov/gene/3112 |
| Similar Terms | |
| Downloads & Tools |
497 genes differentially expressed following the HLA-DOB gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASS1 | argininosuccinate synthase 1 | 0.0162594 |
| S100P | S100 calcium binding protein P | 0.015764 |
| MME | membrane metallo-endopeptidase | 0.0148011 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0143727 |
| DAXX | death-domain associated protein | 0.0135528 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.0133812 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0131506 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.01246 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.0120672 |
| RGCC | regulator of cell cycle | 0.0119233 |
| S100A9 | S100 calcium binding protein A9 | 0.0116127 |
| CRYAB | crystallin, alpha B | 0.0115572 |
| TUBB2A | tubulin, beta 2A class IIa | 0.0113461 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.011332 |
| FBXO11 | F-box protein 11 | 0.0111179 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.0111152 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0111103 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.0110576 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.0110165 |
| DOK5 | docking protein 5 | 0.010868 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.010765 |
| CSRP2 | cysteine and glycine-rich protein 2 | 0.010716 |
| MYBPC1 | myosin binding protein C, slow type | 0.0106629 |
| CA2 | carbonic anhydrase II | 0.0105889 |
| LTF | lactotransferrin | 0.0104478 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0104104 |
| ADIRF | adipogenesis regulatory factor | 0.0103585 |
| MAGEA3 | melanoma antigen family A3 | 0.0103524 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.0102985 |
| GRB7 | growth factor receptor-bound protein 7 | 0.0101928 |
| XPO7 | exportin 7 | 0.0101258 |
| EMX2 | empty spiracles homeobox 2 | 0.0101094 |
| TRIM29 | tripartite motif containing 29 | 0.01006 |
| XK | X-linked Kx blood group | 0.0100043 |
| GPM6B | glycoprotein M6B | 0.00991977 |
| CLIC5 | chloride intracellular channel 5 | 0.00989522 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00978819 |
| OXTR | oxytocin receptor | 0.00976868 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00968923 |
| TFRC | transferrin receptor | 0.00963735 |
| ANXA1 | annexin A1 | 0.00953642 |
| GAS1 | growth arrest-specific 1 | 0.00947907 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.00943189 |
| STOM | stomatin | 0.00939199 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00931061 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00928286 |
| KRT15 | keratin 15, type I | 0.00920946 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 0.00917615 |
| MT1X | metallothionein 1X | 0.00909712 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00902651 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00902464 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00900417 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00897105 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0089265 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | 0.00891969 |
| S100A14 | S100 calcium binding protein A14 | 0.00890563 |
| DCN | decorin | 0.00887736 |
| CDC20 | cell division cycle 20 | 0.00884457 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00881568 |
| TAC1 | tachykinin, precursor 1 | 0.00863492 |
| CHN1 | chimerin 1 | 0.00860573 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00850479 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.0085016 |
| AHSP | alpha hemoglobin stabilizing protein | 0.00848555 |
| HBD | hemoglobin, delta | 0.00843874 |
| FKBP11 | FK506 binding protein 11, 19 kDa | 0.00842526 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00841953 |
| KRT14 | keratin 14, type I | 0.00826892 |
| AGTR1 | angiotensin II receptor, type 1 | 0.00824514 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00822917 |
| SRGN | serglycin | 0.00821378 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.0082083 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | 0.00820662 |
| NEBL | nebulette | 0.00819231 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | 0.00818057 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00816021 |
| COL21A1 | collagen, type XXI, alpha 1 | 0.00810637 |
| S100A8 | S100 calcium binding protein A8 | 0.00803567 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00802284 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00800952 |
| ALAS2 | 5'-aminolevulinate synthase 2 | 0.00784427 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00784189 |
| MLF1 | myeloid leukemia factor 1 | 0.00781471 |
| ADH1C | alcohol dehydrogenase 1C (class I), gamma polypeptide | 0.00778662 |
| EGR3 | early growth response 3 | 0.00777279 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00774962 |
| ATF3 | activating transcription factor 3 | 0.00771361 |
| S100A7 | S100 calcium binding protein A7 | 0.00770337 |
| COL3A1 | collagen, type III, alpha 1 | 0.00768553 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | 0.00768327 |
| MFAP5 | microfibrillar associated protein 5 | 0.00767062 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00763541 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.00761798 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.00761515 |
| CSTA | cystatin A (stefin A) | 0.00761222 |
| MEOX2 | mesenchyme homeobox 2 | 0.00759124 |
| MUC16 | mucin 16, cell surface associated | 0.00758851 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00754541 |
| C1ORF54 | chromosome 1 open reading frame 54 | 0.00754467 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00751539 |
| ETNK1 | ethanolamine kinase 1 | 0.00750188 |
| KRT23 | keratin 23, type I | 0.00747835 |
| KRT5 | keratin 5, type II | 0.00747275 |
| LDB2 | LIM domain binding 2 | 0.00741197 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00740622 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00740476 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00734962 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00720108 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00719138 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00714065 |
| DSP | desmoplakin | 0.00712907 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.00711848 |
| SELENBP1 | selenium binding protein 1 | 0.00709144 |
| GPR137B | G protein-coupled receptor 137B | 0.00709072 |
| XIC | X chromosome inactivation center | 0.0070881 |
| TPM2 | tropomyosin 2 (beta) | 0.00707975 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00706699 |
| MT1G | metallothionein 1G | 0.00703265 |
| CFAP20 | cilia and flagella associated protein 20 | 0.0070044 |
| MSLN | mesothelin | 0.00699827 |
| C14ORF132 | chromosome 14 open reading frame 132 | 0.00698503 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | 0.00698153 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0069547 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | 0.00690685 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.00686883 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.006848 |
| KLHL41 | kelch-like family member 41 | 0.00681518 |
| CP | ceruloplasmin (ferroxidase) | 0.00680008 |
| DEFB1 | defensin, beta 1 | 0.00674373 |
| CD52 | CD52 molecule | 0.00672476 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00671283 |
| IL15 | interleukin 15 | 0.00669252 |
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.00664307 |
| IQCG | IQ motif containing G | 0.00663887 |
| EPB42 | erythrocyte membrane protein band 4.2 | 0.00663345 |
| AQP9 | aquaporin 9 | 0.00662994 |
| MAB21L2 | mab-21-like 2 (C. elegans) | 0.0066239 |
| BPGM | 2,3-bisphosphoglycerate mutase | 0.00662322 |
| COG7 | component of oligomeric golgi complex 7 | 0.00661047 |
| ELOVL4 | ELOVL fatty acid elongase 4 | 0.00660586 |
| BCL2A1 | BCL2-related protein A1 | 0.006563 |
| PON2 | paraoxonase 2 | 0.0065608 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00655811 |
| MAGEA12 | melanoma antigen family A12 | 0.00655361 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00653947 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.0065229 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.00651438 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | 0.00651115 |
| CLDN8 | claudin 8 | 0.00648991 |
| OLFML3 | olfactomedin-like 3 | 0.00648804 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00648054 |
| SPP1 | secreted phosphoprotein 1 | 0.00645911 |
| CFH | complement factor H | 0.00642848 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.00641793 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.00640942 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.00639445 |
| FGF13 | fibroblast growth factor 13 | 0.00637079 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0063706 |
| HMGA1 | high mobility group AT-hook 1 | 0.00636293 |
| PLP1 | proteolipid protein 1 | 0.00632411 |
| EDN3 | endothelin 3 | 0.00632235 |
| CCDC176 | coiled-coil domain containing 176 | 0.0062698 |
| BTG3 | BTG family, member 3 | 0.00624156 |
| GBAP1 | glucosidase, beta, acid pseudogene 1 | 0.00622272 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00621577 |
| TPBG | trophoblast glycoprotein | 0.0062105 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00620522 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00618753 |
| TMEM100 | transmembrane protein 100 | 0.00617997 |
| CHMP2A | charged multivesicular body protein 2A | 0.00615417 |
| ARL3 | ADP-ribosylation factor-like 3 | 0.00614307 |
| PLCL1 | phospholipase C-like 1 | 0.00614012 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.00613832 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | 0.00612825 |
| C5AR1 | complement component 5a receptor 1 | 0.00612591 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | 0.00610845 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.00610228 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00610146 |
| UROS | uroporphyrinogen III synthase | 0.0060822 |
| KRT13 | keratin 13, type I | 0.00607189 |
| SLIRP | SRA stem-loop interacting RNA binding protein | 0.0060583 |
| FGFR4 | fibroblast growth factor receptor 4 | 0.00605287 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.00604946 |
| RRAD | Ras-related associated with diabetes | 0.00601715 |
| OGN | osteoglycin | 0.00600249 |
| PENK | proenkephalin | 0.00600115 |
| SMPX | small muscle protein, X-linked | 0.00599798 |
| LXN | latexin | 0.00599332 |
| CLDN10 | claudin 10 | 0.00598579 |
| MT1E | metallothionein 1E | 0.0059846 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.0059778 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.00596934 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | 0.00595324 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.00593918 |
| GYPC | glycophorin C (Gerbich blood group) | 0.00593406 |
| CLCA4 | chloride channel accessory 4 | 0.00589838 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.00589481 |
| PITX3 | paired-like homeodomain 3 | 0.00589268 |
| MAGEA1 | melanoma antigen family A1 | 0.00588744 |
| MYOT | myotilin | 0.00587998 |
| MSMB | microseminoprotein, beta- | 0.00587323 |
| EMC3 | ER membrane protein complex subunit 3 | 0.00586364 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.00585688 |
| MMP19 | matrix metallopeptidase 19 | 0.00585516 |
| LRRC2 | leucine rich repeat containing 2 | 0.00584784 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.00583278 |
| ANK2 | ankyrin 2, neuronal | 0.00582594 |
| BLVRB | biliverdin reductase B | 0.00582435 |
| PNMA8A | PNMA family member 8A | 0.0058217 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | 0.00581352 |
| TUBA1A | tubulin, alpha 1a | 0.00581146 |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | 0.00580838 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00578941 |
| ADM | adrenomedullin | 0.00578456 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.00578439 |
| C14ORF105 | chromosome 14 open reading frame 105 | 0.00576722 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.00575887 |
| MAB21L1 | mab-21-like 1 (C. elegans) | 0.00575083 |
| FOXG1 | forkhead box G1 | 0.00574816 |
| MRPL19 | mitochondrial ribosomal protein L19 | 0.0057477 |
| NDUFB3 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa | 0.00572226 |
| PRMT1 | protein arginine methyltransferase 1 | 0.00572042 |
| COX5B | cytochrome c oxidase subunit Vb | 0.00571412 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00570951 |
| RND3 | Rho family GTPase 3 | 0.00570886 |
| NES | nestin | 0.00568914 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00568847 |
| RABAC1 | Rab acceptor 1 (prenylated) | 0.00568568 |
| OLFML1 | olfactomedin-like 1 | 0.00567821 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.00567755 |
| ANXA2P2 | annexin A2 pseudogene 2 | 0.00565436 |
| SELE | selectin E | 0.00563967 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.00563819 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.00563706 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00563586 |
| DMD | dystrophin | 0.00563109 |
| CHRDL1 | chordin-like 1 | 0.00561299 |
| MT1F | metallothionein 1F | 0.0056044 |
| TMEM47 | transmembrane protein 47 | 0.00557838 |
| RAB9A | RAB9A, member RAS oncogene family | 0.00557047 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.00556883 |
| KRT6A | keratin 6A, type II | 0.00556649 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00556189 |
| PDHX | pyruvate dehydrogenase complex, component X | 0.00554973 |
| RRAGD | Ras-related GTP binding D | 0.00554073 |
| MREG | melanoregulin | 0.00553329 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | 0.00552342 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00550806 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0054982 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | -0.0166174 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0124852 |
| CTSZ | cathepsin Z | -0.0123491 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | -0.011754 |
| SNX7 | sorting nexin 7 | -0.0112678 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0109687 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.0108863 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0107338 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.0100319 |
| NDRG1 | N-myc downstream regulated 1 | -0.00963465 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00960742 |
| PTK2 | protein tyrosine kinase 2 | -0.00959999 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00924172 |
| NOTCH2 | notch 2 | -0.00916981 |
| CPE | carboxypeptidase E | -0.00889694 |
| HHEX | hematopoietically expressed homeobox | -0.00883348 |
| TPSAB1 | tryptase alpha/beta 1 | -0.0087474 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00870633 |
| ZBTB16 | zinc finger and BTB domain containing 16 | -0.00850476 |
| SPATA20 | spermatogenesis associated 20 | -0.00840377 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | -0.00829652 |
| CRTC3 | CREB regulated transcription coactivator 3 | -0.00824272 |
| CST3 | cystatin C | -0.00818991 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00812873 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.00810282 |
| COL9A2 | collagen, type IX, alpha 2 | -0.00808101 |
| PCP4 | Purkinje cell protein 4 | -0.00798816 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.00793266 |
| ELN | elastin | -0.00790112 |
| CYTH1 | cytohesin 1 | -0.00789762 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00781835 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0077091 |
| EPHB2 | EPH receptor B2 | -0.0076687 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00760562 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00756435 |
| RHOB | ras homolog family member B | -0.00755423 |
| COMP | cartilage oligomeric matrix protein | -0.00722236 |
| MMP2 | matrix metallopeptidase 2 | -0.00711492 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.00711271 |
| IPO13 | importin 13 | -0.00707966 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.00703822 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00698686 |
| IPO9 | importin 9 | -0.0069169 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00690655 |
| SPEN | spen family transcriptional repressor | -0.00687527 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00683785 |
| NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor | -0.00682592 |
| MED13 | mediator complex subunit 13 | -0.00678586 |
| TLN1 | talin 1 | -0.00678108 |
| SC5D | sterol-C5-desaturase | -0.00675645 |
| AEBP1 | AE binding protein 1 | -0.00673392 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | -0.00671675 |
| CREB1 | cAMP responsive element binding protein 1 | -0.0066882 |
| CTSH | cathepsin H | -0.00667221 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00664285 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | -0.00662831 |
| MLXIP | MLX interacting protein | -0.0066256 |
| ACD | adrenocortical dysplasia homolog (mouse) | -0.00661082 |
| GPX3 | glutathione peroxidase 3 | -0.00658202 |
| CCDC86 | coiled-coil domain containing 86 | -0.00657172 |
| GRK2 | G protein-coupled receptor kinase 2 | -0.00657167 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00656942 |
| DUOX2 | dual oxidase 2 | -0.00656203 |
| CDCP1 | CUB domain containing protein 1 | -0.0065159 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00651209 |
| TRIB3 | tribbles pseudokinase 3 | -0.00648894 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.00648245 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00647532 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.00646909 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.00646872 |
| TG | thyroglobulin | -0.00646207 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00639714 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00638684 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.00637172 |
| NBL1 | neuroblastoma 1, DAN family BMP antagonist | -0.00634289 |
| CADM1 | cell adhesion molecule 1 | -0.00628804 |
| EFHD2 | EF-hand domain family, member D2 | -0.00627003 |
| AHSG | alpha-2-HS-glycoprotein | -0.00620794 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.00618449 |
| APH1A | APH1A gamma secretase subunit | -0.00618226 |
| WWC3 | WWC family member 3 | -0.00616347 |
| CD2 | CD2 molecule | -0.00612586 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00612538 |
| SLC46A3 | solute carrier family 46, member 3 | -0.00612195 |
| INSR | insulin receptor | -0.00612019 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.00611949 |
| NOTCH2NL | notch 2 N-terminal like | -0.00611784 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00610401 |
| SORD | sorbitol dehydrogenase | -0.00608435 |
| BGN | biglycan | -0.00608238 |
| RAD21 | RAD21 homolog (S. pombe) | -0.00606421 |
| MAOA | monoamine oxidase A | -0.00606338 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00605967 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | -0.00605116 |
| C4BPB | complement component 4 binding protein, beta | -0.00603789 |
| SVIL | supervillin | -0.00603479 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.00602515 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00601554 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00601093 |
| ENG | endoglin | -0.00599417 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.00599366 |
| KCTD14 | potassium channel tetramerization domain containing 14 | -0.00597317 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -0.00595355 |
| TPM4 | tropomyosin 4 | -0.00592974 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | -0.00592426 |
| CCDC47 | coiled-coil domain containing 47 | -0.00592136 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00591871 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 | -0.00590582 |
| CCND2 | cyclin D2 | -0.00588394 |
| KIF1B | kinesin family member 1B | -0.00587701 |
| CALCA | calcitonin-related polypeptide alpha | -0.00586875 |
| IGSF1 | immunoglobulin superfamily, member 1 | -0.00585662 |
| AFP | alpha-fetoprotein | -0.00584979 |
| SHTN1 | shootin 1 | -0.0058135 |
| SERINC5 | serine incorporator 5 | -0.00580869 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.00580796 |
| WASHC4 | WASH complex subunit 4 | -0.00577341 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.0057594 |
| NFIC | nuclear factor I/C (CCAAT-binding transcription factor) | -0.00575631 |
| KIF5B | kinesin family member 5B | -0.00573329 |
| MXRA5 | matrix-remodelling associated 5 | -0.00572507 |
| NAV2 | neuron navigator 2 | -0.00572143 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.00570921 |
| HYOU1 | hypoxia up-regulated 1 | -0.00569619 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.00569461 |
| LIMA1 | LIM domain and actin binding 1 | -0.00568883 |
| NUMA1 | nuclear mitotic apparatus protein 1 | -0.0056715 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | -0.00565925 |
| SFTPB | surfactant protein B | -0.00565418 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00564537 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00562111 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | -0.00562 |
| MCCC2 | methylcrotonoyl-CoA carboxylase 2 (beta) | -0.00561312 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.00559661 |
| SCARB2 | scavenger receptor class B, member 2 | -0.00559304 |
| TARDBP | TAR DNA binding protein | -0.00559237 |
| THAP12 | THAP domain containing 12 | -0.00556455 |
| TLK2 | tousled-like kinase 2 | -0.00556207 |
| BMI1 | BMI1 proto-oncogene, polycomb ring finger | -0.0055543 |
| SYNJ2 | synaptojanin 2 | -0.00555341 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.00555148 |
| IRS1 | insulin receptor substrate 1 | -0.00552755 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00551836 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00550988 |
| PAX6 | paired box 6 | -0.00549597 |
| FLJ22184 | -0.00549576 | |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.00548275 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00545811 |
| CD4 | CD4 molecule | -0.00544394 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00542503 |
| PGC | progastricsin (pepsinogen C) | -0.00541664 |
| PLXNC1 | plexin C1 | -0.00540508 |
| CELP | carboxyl ester lipase pseudogene | -0.0054036 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | -0.00539145 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | -0.00538689 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.00538089 |
| LPAR2 | lysophosphatidic acid receptor 2 | -0.00536976 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0053647 |
| CERK | ceramide kinase | -0.00534787 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00534499 |
| STAT5B | signal transducer and activator of transcription 5B | -0.00533806 |
| LMNB2 | lamin B2 | -0.00532882 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.00532485 |
| COPS7A | COP9 signalosome subunit 7A | -0.00532448 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | -0.00531313 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.00531109 |
| MAT2A | methionine adenosyltransferase II, alpha | -0.00530193 |
| ARAP1 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 | -0.0052999 |
| HIRA | histone cell cycle regulator | -0.00529642 |
| LMNB1 | lamin B1 | -0.00528403 |
| HELZ | helicase with zinc finger | -0.00527448 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00526871 |
| IL6ST | interleukin 6 signal transducer | -0.00524427 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.00523967 |
| RNF43 | ring finger protein 43 | -0.00522341 |
| GGTLC1 | gamma-glutamyltransferase light chain 1 | -0.00522308 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.00521138 |
| TGFB1 | transforming growth factor, beta 1 | -0.0051988 |
| PRKCB | protein kinase C, beta | -0.00519371 |
| HOXB13 | homeobox B13 | -0.00517487 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -0.00517107 |
| ESYT1 | extended synaptotagmin-like protein 1 | -0.00516592 |
| RRAGA | Ras-related GTP binding A | -0.00516077 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.00515637 |
| AHCYL1 | adenosylhomocysteinase-like 1 | -0.00512821 |
| SLC25A24 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 | -0.00512269 |
| ZBTB18 | zinc finger and BTB domain containing 18 | -0.00511386 |
| BSPRY | B-box and SPRY domain containing | -0.00511345 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | -0.00511229 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00509871 |
| GTF3C1 | general transcription factor IIIC, polypeptide 1, alpha 220kDa | -0.00509696 |
| RNF167 | ring finger protein 167 | -0.0050892 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00508521 |
| KIAA0930 | KIAA0930 | -0.00506661 |
| SETD1B | SET domain containing 1B | -0.00505885 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.00505469 |
| SH3TC1 | SH3 domain and tetratricopeptide repeats 1 | -0.0050426 |
| TRIM44 | tripartite motif containing 44 | -0.00504177 |
| CDC7 | cell division cycle 7 | -0.00504037 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.00503735 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.00503391 |
| SRPRA | SRP receptor subunit alpha | -0.00503382 |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha | -0.0050277 |
| TMC6 | transmembrane channel-like 6 | -0.00502624 |
| ACO1 | aconitase 1, soluble | -0.00501643 |
| C5 | complement component 5 | -0.00501607 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) | -0.00499923 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.00499829 |
| STC1 | stanniocalcin 1 | -0.00499116 |
| TBL2 | transducin (beta)-like 2 | -0.00498836 |
| PRKCSH | protein kinase C substrate 80K-H | -0.00497968 |
| NKX2-1 | NK2 homeobox 1 | -0.0049752 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.00497444 |
| HPN | hepsin | -0.00496845 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.00496715 |
| STK38L | serine/threonine kinase 38 like | -0.0049659 |
| ISOC1 | isochorismatase domain containing 1 | -0.00496255 |
| MAPT | microtubule-associated protein tau | -0.00495611 |
| AGR2 | anterior gradient 2 | -0.00495136 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | -0.00494762 |
| SH3BP4 | SH3-domain binding protein 4 | -0.0049072 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00490699 |
| TYMP | thymidine phosphorylase | -0.00490621 |
| MPZL2 | myelin protein zero-like 2 | -0.00489527 |
| RXRA | retinoid X receptor, alpha | -0.00489445 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.00489329 |
| BCL7B | B-cell CLL/lymphoma 7B | -0.00489281 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | -0.00488883 |
| BCAT2 | branched chain amino-acid transaminase 2, mitochondrial | -0.00488815 |
| CD33 | CD33 molecule | -0.00488338 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.00488125 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.00487801 |
| DHDDS | dehydrodolichyl diphosphate synthase | -0.00486219 |
| SUN1 | Sad1 and UNC84 domain containing 1 | -0.00485741 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00485127 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.00484379 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.00483591 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00483346 |
| ZNF266 | zinc finger protein 266 | -0.00482517 |
| ANGPTL4 | angiopoietin-like 4 | -0.0048191 |
| GRAMD4 | GRAM domain containing 4 | -0.00481424 |
| CLDN1 | claudin 1 | -0.0048101 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.00479783 |
| EXOC7 | exocyst complex component 7 | -0.00478736 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.00478337 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.00478266 |
| FAAH | fatty acid amide hydrolase | -0.00477844 |
| NCAM1 | neural cell adhesion molecule 1 | -0.00477797 |
