| Dataset | Pathway Commons Protein-Protein Interactions |
| Category | physical interactions |
| Type | interacting protein |
| Description | major histocompatibility complex, class II, DO beta|HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3112) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/3112 |
| Similar Terms | |
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4 interacting proteins for HLA-DOB from the Pathway Commons Protein-Protein Interactions dataset.
