HLA-DQA1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description major histocompatibility complex, class II, DQ alpha 1|HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3117)
External Link http://www.ncbi.nlm.nih.gov/gene/3117
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83 interacting proteins for HLA-DQA1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
APLP1 amyloid beta (A4) precursor-like protein 1
CD247 CD247 molecule
CD274 CD274 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK7 cyclin-dependent kinase 7
CENPE centromere protein E, 312kDa
CSK c-src tyrosine kinase
CTSA cathepsin A
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSE cathepsin E
CTSF cathepsin F
CTSH cathepsin H
CTSK cathepsin K
CTSO cathepsin O
CTSS cathepsin S
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
GRAP2 GRB2-related adaptor protein 2
HCRT hypocretin (orexin) neuropeptide precursor
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF26A kinesin family member 26A
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KIF3A kinesin family member 3A
KIF3B kinesin family member 3B
KIF3C kinesin family member 3C
KIF4A kinesin family member 4A
KIF4B kinesin family member 4B
KIF5A kinesin family member 5A
KIF5B kinesin family member 5B
KIFAP3 kinesin-associated protein 3
KLC1 kinesin light chain 1
KLC2 kinesin light chain 2
KLC3 kinesin light chain 3
KLC4 kinesin light chain 4
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGMN legumain
LRIF1 ligand dependent nuclear receptor interacting factor 1
OSBPL1A oxysterol binding protein-like 1A
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PLCG1 phospholipase C, gamma 1
PRKCQ protein kinase C, theta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RAB7A RAB7A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RIF1 replication timing regulatory factor 1
RILP Rab interacting lysosomal protein
SH3GL2 SH3-domain GRB2-like 2
SPTBN2 spectrin, beta, non-erythrocytic 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
UBC ubiquitin C
UNC119 unc-119 homolog (C. elegans)
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa