HLA-DRA Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description major histocompatibility complex, class II, DR alpha|HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3122)
External Link http://www.ncbi.nlm.nih.gov/gene/3122
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131 interacting proteins for HLA-DRA from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ANXA11 annexin A11
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD1D CD1d molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD38 CD38 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD63 CD63 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD80 CD80 molecule
CD82 CD82 molecule
CD86 CD86 molecule
CENPE centromere protein E, 312kDa
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CTSA cathepsin A
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSE cathepsin E
CTSF cathepsin F
CTSH cathepsin H
CTSK cathepsin K
CTSO cathepsin O
CTSS cathepsin S
DBNL drebrin-like
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
FKBP1A FK506 binding protein 1A, 12kDa
FYB FYN binding protein
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRAP2 GRB2-related adaptor protein 2
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA8 heat shock 70kDa protein 8
ITK IL2-inducible T-cell kinase
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF26A kinesin family member 26A
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KIF3A kinesin family member 3A
KIF3B kinesin family member 3B
KIF3C kinesin family member 3C
KIF4A kinesin family member 4A
KIF4B kinesin family member 4B
KIF5A kinesin family member 5A
KIF5B kinesin family member 5B
KIFAP3 kinesin-associated protein 3
KLC1 kinesin light chain 1
KLC2 kinesin light chain 2
KLC3 kinesin light chain 3
KLC4 kinesin light chain 4
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGMN legumain
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MBP myelin basic protein
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOS3 nitric oxide synthase 3 (endothelial cell)
OSBPL1A oxysterol binding protein-like 1A
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDIA4 protein disulfide isomerase family A, member 4
PKM pyruvate kinase, muscle
PLCG1 phospholipase C, gamma 1
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCG protein kinase C, gamma
PRKCQ protein kinase C, theta
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RAB7A RAB7A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RILP Rab interacting lysosomal protein
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPHK1 sphingosine kinase 1
SPTBN2 spectrin, beta, non-erythrocytic 2
UBC ubiquitin C
VAV1 vav 1 guanine nucleotide exchange factor
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa