HLA-DRB1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description major histocompatibility complex, class II, DR beta 1|HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3123)
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Genes

350 genes differentially expressed following the HLA-DRB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CEMP1 cementum protein 1 3.62541
PON1 paraoxonase 1 3.62541
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.62541
RASA4B RAS p21 protein activator 4B 3.62541
RRAD Ras-related associated with diabetes 3.62541
IL5RA interleukin 5 receptor, alpha 3.62541
UMOD uromodulin 3.62541
SLC25A45 solute carrier family 25, member 45 3.62541
ZNF560 zinc finger protein 560 3.62541
ARHGAP36 Rho GTPase activating protein 36 3.62541
EPHX4 epoxide hydrolase 4 3.62541
CRB2 crumbs family member 2 3.62541
TRIM15 tripartite motif containing 15 3.62541
CARD16 caspase recruitment domain family, member 16 3.62541
FAM167A family with sequence similarity 167, member A 3.62541
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.62541
COLEC10 collectin sub-family member 10 (C-type lectin) 3.62541
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.62541
PI16 peptidase inhibitor 16 3.62541
ACTG2 actin, gamma 2, smooth muscle, enteric 3.62541
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.62541
TMEM176B transmembrane protein 176B 3.62541
PRELP proline/arginine-rich end leucine-rich repeat protein 3.62541
DMRTC1B DMRT-like family C1B 3.62541
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.62541
RIMBP3C RIMS binding protein 3C 3.62541
S100A1 S100 calcium binding protein A1 3.62541
BRICD5 BRICHOS domain containing 5 3.62541
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.62541
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 3.62541
CPLX4 complexin 4 3.62541
SP2 Sp2 transcription factor 3.62541
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 3.62541
PRR22 proline rich 22 3.62541
KIAA1755 KIAA1755 3.62541
KIF2B kinesin family member 2B 3.62541
YY2 YY2 transcription factor 3.62541
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 3.62541
RFPL3 ret finger protein-like 3 3.62541
ANKRD34A ankyrin repeat domain 34A 3.62541
FAM221B family with sequence similarity 221, member B 3.62541
PTGFR prostaglandin F receptor (FP) 3.62541
ADAMTSL5 ADAMTS-like 5 3.62541
F7 coagulation factor VII (serum prothrombin conversion accelerator) 3.62541
TDRD9 tudor domain containing 9 3.62541
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.62541
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.62541
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.62541
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 3.62541
LOC107986837 uncharacterized LOC107986837 3.62541
YIPF7 Yip1 domain family, member 7 3.62541
AVPR1B arginine vasopressin receptor 1B 3.62541
SPEM1 spermatid maturation 1 3.62541
SPRR2F small proline-rich protein 2F 3.62541
FIMP1 fertilization-influencing membrane protein 1 3.62541
C9ORF43 chromosome 9 open reading frame 43 3.62541
PLCZ1 phospholipase C, zeta 1 3.62541
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.62541
TMEM40 transmembrane protein 40 3.62541
LY6H lymphocyte antigen 6 complex, locus H 3.62541
TMOD4 tropomodulin 4 (muscle) 3.62541
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 3.62541
TEKTL1 tektin like 1 3.62541
CPNE8-AS1 CPNE8 antisense RNA 1 3.62541
C17ORF113 chromosome 17 open reading frame 113 3.62541
ACP7 acid phosphatase 7, tartrate resistant (putative) 3.62541
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.62541
CBY2 chibby family member 2 3.62541
CFAP206 cilia and flagella associated protein 206 3.62541
DUSP29 dual specificity phosphatase 29 3.62541
HJV hemojuvelin BMP co-receptor 3.62541
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.62541
F5 coagulation factor V (proaccelerin, labile factor) 3.62541
DYNAP dynactin associated protein 3.62541
CALCR calcitonin receptor 3.62541
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.62541
CCDC13 coiled-coil domain containing 13 3.62541
PCDHA3 protocadherin alpha 3 3.62541
IZUMO4 IZUMO family member 4 3.62541
FAM3D family with sequence similarity 3, member D 3.62541
FFAR2 free fatty acid receptor 2 3.62541
KLHL35 kelch-like family member 35 3.62541
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.62541
SRL sarcalumenin 3.62541
CALCA calcitonin-related polypeptide alpha 3.62541
CATSPERD catsper channel auxiliary subunit delta 3.62541
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.62541
GDF9 growth differentiation factor 9 3.62541
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 3.62541
C7 complement component 7 3.62541
CNTFR ciliary neurotrophic factor receptor 3.62541
HSPB6 heat shock protein, alpha-crystallin-related, B6 3.62541
BHLHA9 basic helix-loop-helix family, member a9 3.62541
DMBX1 diencephalon/mesencephalon homeobox 1 3.62541
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.62541
UROC1 urocanate hydratase 1 3.62541
TMPRSS11D transmembrane protease, serine 11D 3.62541
TLDC2 TBC/LysM-associated domain containing 2 3.62541
ESAM endothelial cell adhesion molecule 3.62541
TPSB2 tryptase beta 2 (gene/pseudogene) 3.62541
SPINK9 serine peptidase inhibitor, Kazal type 9 3.62541
ZFPM2 zinc finger protein, FOG family member 2 3.62541
IL36R interleukin 36 receptor 3.62541
BAHCC1 BAH domain and coiled-coil containing 1 3.62541
PCDH17 protocadherin 17 3.62541
SLC22A24 solute carrier family 22, member 24 3.62541
KLK14 kallikrein-related peptidase 14 3.62541
C10ORF71 chromosome 10 open reading frame 71 3.62541
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.62541
NOX1 NADPH oxidase 1 3.62541
HHAT hedgehog acyltransferase 3.62541
APLNR apelin receptor 3.62541
SMKR1 small lysine-rich protein 1 3.62541
HDAC10 histone deacetylase 10 3.62541
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.62541
RAD51AP2 RAD51 associated protein 2 3.62541
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 3.62541
PDE2A phosphodiesterase 2A, cGMP-stimulated 3.62541
FAM107A family with sequence similarity 107, member A 3.62541
CATIP ciliogenesis associated TTC17 interacting protein 3.62541
GFY golgi-associated, olfactory signaling regulator 3.62541
TMEM253 transmembrane protein 253 3.62541
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.62541
LAMB4 laminin, beta 4 3.62541
CXORF58 chromosome X open reading frame 58 3.62541
C1ORF185 chromosome 1 open reading frame 185 3.62541
DRC1 dynein regulatory complex subunit 1 3.62541
ZNF831 zinc finger protein 831 3.62541
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.62541
CD28 CD28 molecule 3.62541
CTRB1 chymotrypsinogen B1 3.62541
PHOX2A paired-like homeobox 2a 3.62541
CFAP47 cilia and flagella associated protein 47 3.62541
CEL carboxyl ester lipase 3.62541
CFAP61 cilia and flagella associated protein 61 3.62541
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.62541
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.62541
GPR62 G protein-coupled receptor 62 3.62541
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 3.62541
BTG4 B-cell translocation gene 4 3.62541
KRTAP13-4 keratin associated protein 13-4 3.62541
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.62541
SNTN sentan, cilia apical structure protein 3.62541
PPP1R3E protein phosphatase 1, regulatory subunit 3E 3.62541
TMEM215 transmembrane protein 215 3.62541
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.62541
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.62541
BCAS1 breast carcinoma amplified sequence 1 3.62541
GCM2 glial cells missing homolog 2 (Drosophila) 3.62541
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.62541
EYA4 EYA transcriptional coactivator and phosphatase 4 3.62541
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 3.62541
APOL1 apolipoprotein L, 1 3.62541
KCNK13 potassium channel, two pore domain subfamily K, member 13 3.62541
ALOX15B arachidonate 15-lipoxygenase, type B 3.62541
LOXHD1 lipoxygenase homology domains 1 3.62541
TTC36 tetratricopeptide repeat domain 36 3.62541
TEX38 testis expressed 38 3.62541
TAS2R42 taste receptor, type 2, member 42 3.62541
PRND prion protein 2 (dublet) 3.62541
EBI3 Epstein-Barr virus induced 3 3.62541
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.62541
WFDC12 WAP four-disulfide core domain 12 3.62541
PRSS53 protease, serine, 53 3.62541
AK8 adenylate kinase 8 3.62541
TAS2R46 taste receptor, type 2, member 46 3.62541
NPAS4 neuronal PAS domain protein 4 3.62541
STK31 serine/threonine kinase 31 3.50796
SPPL2A signal peptide peptidase like 2A 3.43157
BID BH3 interacting domain death agonist 3.42791
MAGEH1 melanoma antigen family H1 3.42029
TM9SF3 transmembrane 9 superfamily member 3 3.31481
ING1 inhibitor of growth family, member 1 3.10888
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 3.0479
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 3.03623
MTFR2 mitochondrial fission regulator 2 2.94941
LYRM7 LYR motif containing 7 2.93186
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 2.87616
FOXP4 forkhead box P4 2.82553
ZSWIM3 zinc finger, SWIM-type containing 3 2.82553
RPL29 ribosomal protein L29 2.73446
CTBP1 C-terminal binding protein 1 2.71049
ATP5MC3 ATP synthase membrane subunit c locus 3 2.69994
MERTK MER proto-oncogene, tyrosine kinase 2.68214
RAB39A RAB39A, member RAS oncogene family 2.66958
IL4I1 interleukin 4 induced 1 2.6494
GGACT gamma-glutamylamine cyclotransferase 2.6494
IFI16 interferon, gamma-inducible protein 16 2.6494
CD63 CD63 molecule 2.62667
NPR1 natriuretic peptide receptor 1 2.61974
SERTAD4 SERTA domain containing 4 2.61974
ALK anaplastic lymphoma receptor tyrosine kinase 2.61974
CEP19 centrosomal protein 19kDa 2.61974
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.61974
NUTM2E NUT family member 2E 2.61974
ACACA acetyl-CoA carboxylase alpha 2.61172
ACAA2 acetyl-CoA acyltransferase 2 2.60104
GSPT1 G1 to S phase transition 1 2.54724
LZTFL1 leucine zipper transcription factor-like 1 2.52352
CCNI cyclin I 2.49056
ADTRP androgen-dependent TFPI-regulating protein 2.46258
ADH6 alcohol dehydrogenase 6 (class V) 2.4624
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.4624
NRCAM neuronal cell adhesion molecule 2.45947
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 2.4118
CDC25A cell division cycle 25A 2.40318
CAPS2 calcyphosine 2 2.39317
ZCCHC3 zinc finger, CCHC domain containing 3 2.35965
MXD4 MAX dimerization protein 4 2.34045
TDRD3 tudor domain containing 3 2.31632
BANF1 barrier to autointegration factor 1 2.30558
ZNF438 zinc finger protein 438 2.28805
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 2.28672
ZNF599 zinc finger protein 599 2.28323
CBX5 chromobox homolog 5 2.26035
UHMK1 U2AF homology motif (UHM) kinase 1 2.25616
PLAGL2 pleiomorphic adenoma gene-like 2 2.25236
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.23008
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.18465
ZNF723 zinc finger protein 723 2.18043
PFAS phosphoribosylformylglycinamidine synthase 2.18043
C16ORF89 chromosome 16 open reading frame 89 2.1605
SLC16A13 solute carrier family 16, member 13 2.1605
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 2.15555
CD4 CD4 molecule 2.15307
ZNF789 zinc finger protein 789 2.15307
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.15307
MAP3K21 mitogen-activated protein kinase kinase kinase 21 2.15307
ZDBF2 zinc finger, DBF-type containing 2 2.15307
MIER1 mesoderm induction early response 1, transcriptional regulator 2.15307
MPPED2 metallophosphoesterase domain containing 2 2.15307
ZMPSTE24 zinc metallopeptidase STE24 2.13677
WDR20 WD repeat domain 20 2.08573
BTD biotinidase 2.07393
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.04472
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 2.03768
TC2N tandem C2 domains, nuclear 2.03529
KIAA1217 KIAA1217 2.00144
INAFM2 InaF-motif containing 2 2.00144

decreased expression

Symbol Name Standardized Value
ACSL3 acyl-CoA synthetase long-chain family member 3 -3.62541
ZNF667 zinc finger protein 667 -3.62541
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) -3.62541
CRYBB1 crystallin, beta B1 -3.62541
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 -3.62541
TBKBP1 TBK1 binding protein 1 -3.62541
CPN1 carboxypeptidase N, polypeptide 1 -3.62541
ODAD4 outer dynein arm docking complex subunit 4 -3.62541
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -3.44384
CPED1 cadherin-like and PC-esterase domain containing 1 -3.44384
SCRT2 scratch family zinc finger 2 -3.44384
TFEB transcription factor EB -3.44384
RHBG Rh family, B glycoprotein (gene/pseudogene) -3.44384
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -3.44384
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -3.44384
HIGD1B HIG1 hypoxia inducible domain family, member 1B -3.44384
LIN37 lin-37 DREAM MuvB core complex component -3.44384
VSTM2A V-set and transmembrane domain containing 2A -3.44384
FRMD1 FERM domain containing 1 -3.44384
PKP3 plakophilin 3 -3.44384
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -3.44384
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -3.44384
GIP gastric inhibitory polypeptide -3.44384
UPP2 uridine phosphorylase 2 -3.44384
HCST hematopoietic cell signal transducer -3.44384
MYOCOS myocilin opposite strand -3.44384
C1QTNF12 C1q and TNF related 12 -3.44384
ARC activity-regulated cytoskeleton-associated protein -3.44384
FBP2 fructose-1,6-bisphosphatase 2 -3.44384
CCN6 cellular communication network factor 6 -3.44384
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -3.44384
TMED6 transmembrane emp24 protein transport domain containing 6 -3.44384
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -3.44384
PCDHA11 protocadherin alpha 11 -3.44384
CALHM2 calcium homeostasis modulator 2 -3.44384
LSMEM1 leucine-rich single-pass membrane protein 1 -3.44384
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -3.44384
MEOX2 mesenchyme homeobox 2 -3.44384
GBA1 glucosylceramidase beta 1 -3.44384
EFCAB8 EF-hand calcium binding domain 8 -3.44384
MGAM maltase-glucoamylase -3.44384
FGFBP3 fibroblast growth factor binding protein 3 -2.9529
GLB1L3 galactosidase, beta 1-like 3 -2.92806
ARHGAP11B Rho GTPase activating protein 11B -2.82855
ACER3 alkaline ceramidase 3 -2.81957
PRC1 protein regulator of cytokinesis 1 -2.81528
STX1B syntaxin 1B -2.79543
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -2.76152
MDFIC MyoD family inhibitor domain containing -2.74023
H3C6 H3 clustered histone 6 -2.73462
REV1 REV1, polymerase (DNA directed) -2.6494
FOXK1 forkhead box K1 -2.64127
LAYN layilin -2.61974
GRIP1 glutamate receptor interacting protein 1 -2.61503
SRBD1 S1 RNA binding domain 1 -2.52989
SYNPO2L synaptopodin 2-like -2.52691
ZNF782 zinc finger protein 782 -2.52284
CRIPTO3 cripto, EGF-CFC family member 3 -2.46154
ARRDC4 arrestin domain containing 4 -2.46154
AKR1E2 aldo-keto reductase family 1, member E2 -2.46154
OAZ2 ornithine decarboxylase antizyme 2 -2.45175
HAS2 hyaluronan synthase 2 -2.42841
INTS2 integrator complex subunit 2 -2.41251
ACOT7 acyl-CoA thioesterase 7 -2.40318
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -2.40213
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -2.3893
FAM13A family with sequence similarity 13, member A -2.36796
SESTD1 SEC14 and spectrin domains 1 -2.35937
CDK3 cyclin-dependent kinase 3 -2.34045
TRIP6 thyroid hormone receptor interactor 6 -2.31632
BEST4 bestrophin 4 -2.28895
TMEM44 transmembrane protein 44 -2.28336
MARVELD2 MARVEL domain containing 2 -2.25769
CDC42SE1 CDC42 small effector 1 -2.25141
NRBP2 nuclear receptor binding protein 2 -2.2326
CCDC61 coiled-coil domain containing 61 -2.2326
STX19 syntaxin 19 -2.2326
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.2326
RMP64 ribonuclease MRP subunit p64 -2.22989
POU2F1 POU class 2 homeobox 1 -2.2277
GREB1 growth regulation by estrogen in breast cancer 1 -2.2277
BAG1 BCL2-associated athanogene -2.21011
PKN2 protein kinase N2 -2.1965
PHF6 PHD finger protein 6 -2.18043
LBP lipopolysaccharide binding protein -2.17571
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.17571
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -2.17571
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.17571
FOXL2NB FOXL2 neighbor -2.17571
FAAP24 FA core complex associated protein 24 -2.17571
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -2.15939
CTSV cathepsin V -2.15307
LSR lipolysis stimulated lipoprotein receptor -2.15307
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -2.15307
LTBP4 latent transforming growth factor beta binding protein 4 -2.15307
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -2.15307
MLH3 mutL homolog 3 -2.13395
TMEM245 transmembrane protein 245 -2.12833
FKBP4 FK506 binding protein 4, 59kDa -2.11827
KLF6 Kruppel-like factor 6 -2.11575
CDO1 cysteine dioxygenase type 1 -2.10852
KANK1 KN motif and ankyrin repeat domains 1 -2.10852
RESF1 retroelement silencing factor 1 -2.10448
EIF6 eukaryotic translation initiation factor 6 -2.08487
CNST consortin, connexin sorting protein -2.07911
HRH2 histamine receptor H2 -2.06078
ACSL4 acyl-CoA synthetase long-chain family member 4 -2.05668
TEX14 testis expressed 14 -2.03659
PRSS3 protease, serine, 3 -2.03529
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -2.0347
RAMAC RNA guanine-7 methyltransferase activating subunit -2.0234