| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | major histocompatibility complex, class II, DR beta 1|HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3123) |
| External Link | https://ncbi.nlm.nih.gov/gene/3123 |
| Similar Terms | |
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498 genes differentially expressed following the HLA-DRB1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ANXA1 | annexin A1 | 0.01544 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0151427 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0143959 |
| LTF | lactotransferrin | 0.0141248 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0138043 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.013165 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.0129485 |
| ADIRF | adipogenesis regulatory factor | 0.0129176 |
| S100P | S100 calcium binding protein P | 0.0124342 |
| WDR7 | WD repeat domain 7 | 0.0123291 |
| PROM1 | prominin 1 | 0.0120379 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.0119788 |
| FAR2 | fatty acyl CoA reductase 2 | 0.0118929 |
| KRT23 | keratin 23, type I | 0.0117196 |
| MX1 | MX dynamin-like GTPase 1 | 0.0115013 |
| DAXX | death-domain associated protein | 0.0114516 |
| CLIC5 | chloride intracellular channel 5 | 0.0113709 |
| SRGN | serglycin | 0.011328 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0112882 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.0112655 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.0112649 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.0112311 |
| MT1F | metallothionein 1F | 0.0110582 |
| POSTN | periostin, osteoblast specific factor | 0.0107529 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0107031 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.0106282 |
| THBS1 | thrombospondin 1 | 0.0106233 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0106002 |
| MT1X | metallothionein 1X | 0.0105681 |
| TEX10 | testis expressed 10 | 0.0105202 |
| MLF1 | myeloid leukemia factor 1 | 0.0103809 |
| LXN | latexin | 0.0103228 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0101154 |
| MYBPC1 | myosin binding protein C, slow type | 0.0100622 |
| CHRDL1 | chordin-like 1 | 0.00998604 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0099 |
| CCN2 | cellular communication network factor 2 | 0.00987609 |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | 0.00976463 |
| ATF3 | activating transcription factor 3 | 0.00975929 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00972653 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00967011 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.0096696 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00964108 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00963463 |
| MT1H | metallothionein 1H | 0.00957535 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00955609 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | 0.00934512 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00934102 |
| EGR3 | early growth response 3 | 0.00927512 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00924348 |
| LCN2 | lipocalin 2 | 0.009103 |
| RGCC | regulator of cell cycle | 0.00905662 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.00901543 |
| S100A8 | S100 calcium binding protein A8 | 0.00900773 |
| PADI2 | peptidyl arginine deiminase, type II | 0.0090019 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00893283 |
| MT1E | metallothionein 1E | 0.00890819 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00889336 |
| CSTA | cystatin A (stefin A) | 0.0088139 |
| CLDN10 | claudin 10 | 0.00874448 |
| EGR2 | early growth response 2 | 0.00867251 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.00866177 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.0086542 |
| DCN | decorin | 0.0086392 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00853853 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.00851359 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00844585 |
| DOK5 | docking protein 5 | 0.00837719 |
| PEG3 | paternally expressed 3 | 0.00833282 |
| TPBG | trophoblast glycoprotein | 0.0083265 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.0082675 |
| GPX7 | glutathione peroxidase 7 | 0.00822054 |
| MDFIC | MyoD family inhibitor domain containing | 0.00817301 |
| SFRP4 | secreted frizzled-related protein 4 | 0.00813004 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.0080941 |
| IFI44 | interferon-induced protein 44 | 0.00806346 |
| S100A9 | S100 calcium binding protein A9 | 0.00805648 |
| BTG3 | BTG family, member 3 | 0.00805438 |
| THBS2 | thrombospondin 2 | 0.00803263 |
| AZIN1 | antizyme inhibitor 1 | 0.00792315 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00788659 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00788218 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00781689 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | 0.00778953 |
| IL17RB | interleukin 17 receptor B | 0.0077424 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | 0.00771767 |
| SCAND1 | SCAN domain containing 1 | 0.0076915 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | 0.00765444 |
| MYO1C | myosin IC | 0.00761604 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00758849 |
| LY75 | lymphocyte antigen 75 | 0.00757166 |
| MUC16 | mucin 16, cell surface associated | 0.00752166 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00751395 |
| SP100 | SP100 nuclear antigen | 0.00750735 |
| ZNF423 | zinc finger protein 423 | 0.00750544 |
| HOMER1 | homer scaffolding protein 1 | 0.00750484 |
| TXNL1 | thioredoxin-like 1 | 0.00737857 |
| MMP9 | matrix metallopeptidase 9 | 0.00737719 |
| CFAP20 | cilia and flagella associated protein 20 | 0.00737204 |
| CLDN5 | claudin 5 | 0.0073668 |
| MT1G | metallothionein 1G | 0.00736588 |
| MT1M | metallothionein 1M | 0.00735584 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 0.00733183 |
| ZNF706 | zinc finger protein 706 | 0.00730007 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00729745 |
| EVI2A | ecotropic viral integration site 2A | 0.00728105 |
| SATB2 | SATB homeobox 2 | 0.00724624 |
| PITX3 | paired-like homeodomain 3 | 0.00723034 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | 0.00721128 |
| ICAM2 | intercellular adhesion molecule 2 | 0.00720611 |
| CD52 | CD52 molecule | 0.00716402 |
| ANXA2P2 | annexin A2 pseudogene 2 | 0.00715934 |
| NXT2 | nuclear transport factor 2-like export factor 2 | 0.00714561 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00714333 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00713664 |
| C1ORF54 | chromosome 1 open reading frame 54 | 0.00708723 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00707478 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00703116 |
| COL3A1 | collagen, type III, alpha 1 | 0.00699436 |
| TMEM100 | transmembrane protein 100 | 0.00698141 |
| KLK6 | kallikrein-related peptidase 6 | 0.00697767 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00690243 |
| KRT19 | keratin 19, type I | 0.00688961 |
| SLN | sarcolipin | 0.0068677 |
| MEF2C | myocyte enhancer factor 2C | 0.00686249 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.006861 |
| TSPAN1 | tetraspanin 1 | 0.00685853 |
| CA2 | carbonic anhydrase II | 0.00680829 |
| CLDN8 | claudin 8 | 0.00679769 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00679577 |
| GAS1 | growth arrest-specific 1 | 0.0067942 |
| MSLN | mesothelin | 0.00674004 |
| PHYH | phytanoyl-CoA 2-hydroxylase | 0.00673049 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0067262 |
| MB | myoglobin | 0.00672108 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00671324 |
| NME5 | NME/NM23 family member 5 | 0.00669547 |
| CAMP | cathelicidin antimicrobial peptide | 0.00669383 |
| LYZ | lysozyme | 0.00669309 |
| RRAGD | Ras-related GTP binding D | 0.00667345 |
| PYROXD1 | pyridine nucleotide-disulphide oxidoreductase domain 1 | 0.0066105 |
| TXN | thioredoxin | 0.00657236 |
| MRPL19 | mitochondrial ribosomal protein L19 | 0.00656032 |
| HAT1 | histone acetyltransferase 1 | 0.00655866 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.00655564 |
| GPM6B | glycoprotein M6B | 0.00653576 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.00652875 |
| RELN | reelin | 0.0065037 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00645515 |
| PALMD | palmdelphin | 0.00644139 |
| INHBA | inhibin, beta A | 0.00642879 |
| MAB21L2 | mab-21-like 2 (C. elegans) | 0.00642752 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.0064265 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.00640482 |
| LY96 | lymphocyte antigen 96 | 0.00638155 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.00638036 |
| COX5B | cytochrome c oxidase subunit Vb | 0.00635885 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00632454 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00632285 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00631205 |
| CHMP1B | charged multivesicular body protein 1B | 0.00630104 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | 0.00630012 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00628165 |
| TSPAN8 | tetraspanin 8 | 0.00627783 |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 | 0.0062483 |
| MX2 | MX dynamin-like GTPase 2 | 0.00623595 |
| MT2A | metallothionein 2A | 0.00623086 |
| RCAN1 | regulator of calcineurin 1 | 0.00622034 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.00621182 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.00620126 |
| TSPO | translocator protein (18kDa) | 0.00620082 |
| KLF10 | Kruppel-like factor 10 | 0.00619704 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00617693 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | 0.00616892 |
| FZD6 | frizzled class receptor 6 | 0.0061511 |
| HBEGF | heparin-binding EGF-like growth factor | 0.00613935 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00611233 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.00610682 |
| KLF6 | Kruppel-like factor 6 | 0.00610513 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00610482 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.00610404 |
| FRZB | frizzled-related protein | 0.00610184 |
| GRAMD1C | GRAM domain containing 1C | 0.00608482 |
| KLK8 | kallikrein-related peptidase 8 | 0.00605542 |
| NEBL | nebulette | 0.00604687 |
| OLFML3 | olfactomedin-like 3 | 0.00604566 |
| DCTPP1 | dCTP pyrophosphatase 1 | 0.00604016 |
| OPTN | optineurin | 0.00603913 |
| MSH2 | mutS homolog 2 | 0.00603027 |
| PKP2 | plakophilin 2 | 0.00602241 |
| SH3BGR | SH3 domain binding glutamate-rich protein | 0.00602165 |
| S100A7 | S100 calcium binding protein A7 | 0.00599854 |
| GOLT1B | golgi transport 1B | 0.00598054 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.00596477 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00594034 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00592748 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00592394 |
| MFAP5 | microfibrillar associated protein 5 | 0.00590678 |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A | 0.00590185 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.00589921 |
| OSBPL1A | oxysterol binding protein-like 1A | 0.00588492 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | 0.00587464 |
| S100A14 | S100 calcium binding protein A14 | 0.00584587 |
| PENK | proenkephalin | 0.00583486 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00583103 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00582562 |
| LZTFL1 | leucine zipper transcription factor-like 1 | 0.00582427 |
| ANO10 | anoctamin 10 | 0.00582343 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00580263 |
| RFK | riboflavin kinase | 0.00580012 |
| PIP | prolactin-induced protein | 0.00578891 |
| ZNF652 | zinc finger protein 652 | 0.00578782 |
| IER3IP1 | immediate early response 3 interacting protein 1 | 0.00577908 |
| NLGN4X | neuroligin 4, X-linked | 0.00577846 |
| MSMB | microseminoprotein, beta- | 0.00576542 |
| PUDP | pseudouridine 5'-phosphatase | 0.00576399 |
| CYRIA | CYFIP related Rac1 interactor A | 0.00576048 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00575946 |
| MPO | myeloperoxidase | 0.0057569 |
| TMC5 | transmembrane channel-like 5 | 0.00575583 |
| TEK | TEK tyrosine kinase, endothelial | 0.00575422 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00574989 |
| IFI44L | interferon-induced protein 44-like | 0.00573903 |
| CLDN7 | claudin 7 | 0.00573011 |
| ANK2 | ankyrin 2, neuronal | 0.00572452 |
| IQCK | IQ motif containing K | 0.00572416 |
| ESR1 | estrogen receptor 1 | 0.005716 |
| CLDN3 | claudin 3 | 0.00571288 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.00570912 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.005703 |
| SSPN | sarcospan | 0.00570159 |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 0.00569628 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 0.00569458 |
| CYB5R2 | cytochrome b5 reductase 2 | 0.00569217 |
| MME | membrane metallo-endopeptidase | 0.0056829 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00568026 |
| CA4 | carbonic anhydrase IV | 0.00567866 |
| ANXA2 | annexin A2 | 0.00567843 |
| MGP | matrix Gla protein | 0.00567524 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00567376 |
| SYBU | syntabulin (syntaxin-interacting) | 0.005655 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | 0.0056457 |
| SCRG1 | stimulator of chondrogenesis 1 | 0.00564066 |
| TBC1D15 | TBC1 domain family, member 15 | 0.00562674 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00562574 |
| IL1R1 | interleukin 1 receptor, type I | 0.00561021 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00560764 |
| MRPL13 | mitochondrial ribosomal protein L13 | 0.00559761 |
| CRYAB | crystallin, alpha B | 0.00559376 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.00558781 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0126939 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.0119509 |
| RRAGA | Ras-related GTP binding A | -0.0116999 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0116658 |
| AUTS2 | autism susceptibility candidate 2 | -0.0112532 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.0102711 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.00988915 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00962294 |
| RBPMS | RNA binding protein with multiple splicing | -0.00941034 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00872396 |
| MAP7 | microtubule-associated protein 7 | -0.00868981 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00858524 |
| GPX3 | glutathione peroxidase 3 | -0.00842733 |
| GNAS | GNAS complex locus | -0.00823027 |
| TXNIP | thioredoxin interacting protein | -0.00822587 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00817927 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.00817811 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00811078 |
| APOA2 | apolipoprotein A-II | -0.00800311 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00793922 |
| RXRA | retinoid X receptor, alpha | -0.00789095 |
| GANAB | glucosidase, alpha; neutral AB | -0.00786395 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00767669 |
| CCDC86 | coiled-coil domain containing 86 | -0.00758245 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | -0.00756322 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00755488 |
| CALD1 | caldesmon 1 | -0.00746638 |
| NUCB1 | nucleobindin 1 | -0.00744784 |
| TBL1X | transducin (beta)-like 1X-linked | -0.00744117 |
| ACP3 | acid phosphatase 3 | -0.0072217 |
| TLN1 | talin 1 | -0.00720879 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0072018 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.00717902 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.00714317 |
| NVL | nuclear VCP-like | -0.00713708 |
| TLK2 | tousled-like kinase 2 | -0.00713536 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00712582 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00710822 |
| ACTB | actin, beta | -0.00707594 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | -0.00702721 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00699774 |
| COL4A2 | collagen, type IV, alpha 2 | -0.00698176 |
| TPSAB1 | tryptase alpha/beta 1 | -0.00688664 |
| FBXO11 | F-box protein 11 | -0.00688001 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00685345 |
| GZMK | granzyme K (granzyme 3; tryptase II) | -0.0068144 |
| HPN | hepsin | -0.00681197 |
| AXL | AXL receptor tyrosine kinase | -0.00680834 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00669176 |
| BHMT2 | betaine--homocysteine S-methyltransferase 2 | -0.00667241 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0066591 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.00665787 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00660786 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | -0.00658525 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00658264 |
| WWC3 | WWC family member 3 | -0.00656545 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | -0.00655018 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | -0.00653065 |
| TSPAN4 | tetraspanin 4 | -0.00650703 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.00648444 |
| FGG | fibrinogen gamma chain | -0.00647124 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00641584 |
| APMAP | adipocyte plasma membrane associated protein | -0.00640178 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00639974 |
| DENND2B | DENN domain containing 2B | -0.00639503 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -0.00636903 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.00628209 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00627715 |
| DUOX2 | dual oxidase 2 | -0.00627071 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00623144 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00622513 |
| TNC | tenascin C | -0.00621626 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.00618607 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0061857 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00614703 |
| UTRN | utrophin | -0.00614314 |
| ADIPOR2 | adiponectin receptor 2 | -0.00611179 |
| PON3 | paraoxonase 3 | -0.00611002 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.00606221 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | -0.00605894 |
| NAV2 | neuron navigator 2 | -0.00605878 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | -0.0060342 |
| NKG7 | natural killer cell granule protein 7 | -0.00603229 |
| NOTCH2 | notch 2 | -0.00602176 |
| HYOU1 | hypoxia up-regulated 1 | -0.00601492 |
| ACO1 | aconitase 1, soluble | -0.00599081 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.00598831 |
| COL9A2 | collagen, type IX, alpha 2 | -0.00598691 |
| TGFB1 | transforming growth factor, beta 1 | -0.00597209 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.00595835 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.005935 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00593295 |
| HMG20B | high mobility group 20B | -0.00591274 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -0.00590199 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.00587592 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.00587402 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | -0.00586937 |
| RNF167 | ring finger protein 167 | -0.00586 |
| HP | haptoglobin | -0.00584602 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | -0.00583235 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00582287 |
| SUN1 | Sad1 and UNC84 domain containing 1 | -0.00581978 |
| CA9 | carbonic anhydrase IX | -0.00580224 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | -0.00577667 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00575001 |
| FGL2 | fibrinogen-like 2 | -0.005745 |
| APOC3 | apolipoprotein C-III | -0.00572323 |
| PRF1 | perforin 1 (pore forming protein) | -0.0056941 |
| RRBP1 | ribosome binding protein 1 | -0.00569199 |
| GPR18 | G protein-coupled receptor 18 | -0.00567505 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.00563848 |
| SPEN | spen family transcriptional repressor | -0.00560509 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0056011 |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | -0.00559859 |
| TRIB2 | tribbles pseudokinase 2 | -0.00558953 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | -0.0055895 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.00557591 |
| GDI1 | GDP dissociation inhibitor 1 | -0.00557557 |
| KIF1B | kinesin family member 1B | -0.0055607 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00554494 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0055219 |
| GNLY | granulysin | -0.00549669 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00549069 |
| TKTL1 | transketolase-like 1 | -0.00548338 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.00548022 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.00547336 |
| CST7 | cystatin F (leukocystatin) | -0.00546686 |
| TMEM176B | transmembrane protein 176B | -0.00545596 |
| PRKCSH | protein kinase C substrate 80K-H | -0.00544173 |
| DENND5A | DENN/MADD domain containing 5A | -0.00543686 |
| ACTN4 | actinin, alpha 4 | -0.00542613 |
| ALB | albumin | -0.00541867 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | -0.00541838 |
| CROCCP2 | ciliary rootlet coiled-coil, rootletin pseudogene 2 | -0.00541346 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00538004 |
| NOTCH2NL | notch 2 N-terminal like | -0.00535371 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.00534743 |
| CBS | cystathionine-beta-synthase | -0.00534517 |
| DCT | dopachrome tautomerase | -0.00533693 |
| RNF130 | ring finger protein 130 | -0.00533549 |
| AHSG | alpha-2-HS-glycoprotein | -0.00533064 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0053298 |
| DENND4B | DENN/MADD domain containing 4B | -0.00532544 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00531926 |
| TTTY15 | testis-specific transcript, Y-linked 15 (non-protein coding) | -0.00531114 |
| ISL1 | ISL LIM homeobox 1 | -0.00529748 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.00529727 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | -0.00529616 |
| RHOB | ras homolog family member B | -0.00528724 |
| SERPIND1 | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | -0.00528405 |
| STX16 | syntaxin 16 | -0.00528002 |
| CDA | cytidine deaminase | -0.005276 |
| MTMR1 | myotubularin related protein 1 | -0.00527404 |
| TNS3 | tensin 3 | -0.0052556 |
| DVL1 | dishevelled segment polarity protein 1 | -0.0052405 |
| CDK11A | cyclin-dependent kinase 11A | -0.00523493 |
| PMEL | premelanosome protein | -0.00523311 |
| PLXNB2 | plexin B2 | -0.00522559 |
| FASN | fatty acid synthase | -0.0052231 |
| SORD | sorbitol dehydrogenase | -0.0052177 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.00521243 |
| NUMA1 | nuclear mitotic apparatus protein 1 | -0.00519823 |
| GLS | glutaminase | -0.0051967 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00518682 |
| IPO9 | importin 9 | -0.00518509 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | -0.0051773 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00516781 |
| FCMR | Fc fragment of IgM receptor | -0.00514316 |
| KCNMB1 | potassium channel subfamily M regulatory beta subunit 1 | -0.00513488 |
| ZNF146 | zinc finger protein 146 | -0.00513114 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00511738 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.0051148 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.00509534 |
| CD1E | CD1e molecule | -0.00508413 |
| CD8A | CD8a molecule | -0.0050792 |
| SNX7 | sorting nexin 7 | -0.00507902 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | -0.00507719 |
| EXOC7 | exocyst complex component 7 | -0.00507398 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | -0.00506668 |
| CD2 | CD2 molecule | -0.0050655 |
| CCNL2 | cyclin L2 | -0.00505718 |
| PNPLA6 | patatin-like phospholipase domain containing 6 | -0.0050523 |
| GZMH | granzyme H (cathepsin G-like 2, protein h-CCPX) | -0.00505176 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00503951 |
| FOXE1 | forkhead box E1 | -0.00502751 |
| FOXM1 | forkhead box M1 | -0.00502517 |
| PFKL | phosphofructokinase, liver | -0.00502435 |
| NPIPA1 | nuclear pore complex interacting protein family, member A1 | -0.00499171 |
| MINK1 | misshapen-like kinase 1 | -0.00499148 |
| WDR6 | WD repeat domain 6 | -0.00497707 |
| MAOA | monoamine oxidase A | -0.00497671 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 | -0.00494697 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | -0.00494502 |
| PRKCA | protein kinase C, alpha | -0.0049449 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | -0.00493889 |
| APOA1 | apolipoprotein A-I | -0.00493083 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00492961 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.00492645 |
| NKX3-1 | NK3 homeobox 1 | -0.0049238 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00492277 |
| KIF20A | kinesin family member 20A | -0.0049221 |
| BCHE | butyrylcholinesterase | -0.00492059 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.00490471 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -0.00490289 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | -0.00489814 |
| APOB | apolipoprotein B | -0.00489764 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.00488462 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.00488422 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.00488267 |
| MEA1 | male-enhanced antigen 1 | -0.00487413 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | -0.0048614 |
| ANXA10 | annexin A10 | -0.00485622 |
| IPW | imprinted in Prader-Willi syndrome (non-protein coding) | -0.00485408 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.00485269 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00485064 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.00483791 |
| PFN1 | profilin 1 | -0.00482416 |
| L1CAM | L1 cell adhesion molecule | -0.00482255 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.00482064 |
| NR1H4 | nuclear receptor subfamily 1, group H, member 4 | -0.00481721 |
| COPS7A | COP9 signalosome subunit 7A | -0.00481554 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.00481414 |
| BEX1 | brain expressed, X-linked 1 | -0.00481235 |
| KIAA0125 | KIAA0125 | -0.00479908 |
| CBX6 | chromobox homolog 6 | -0.0047963 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | -0.00478317 |
| DHFR | dihydrofolate reductase | -0.00475379 |
| CST2 | cystatin SA | -0.00473803 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | -0.00473789 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | -0.00473694 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -0.00473577 |
| TUG1 | taurine up-regulated 1 (non-protein coding) | -0.00473234 |
| ASGR2 | asialoglycoprotein receptor 2 | -0.00471937 |
| SOCS1 | suppressor of cytokine signaling 1 | -0.00471703 |
| NPTN | neuroplastin | -0.00471502 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.00471418 |
| TRAF5 | TNF receptor-associated factor 5 | -0.0047127 |
| ECHDC2 | enoyl CoA hydratase domain containing 2 | -0.0047005 |
| CD1D | CD1d molecule | -0.00468177 |
| AHCYL1 | adenosylhomocysteinase-like 1 | -0.00466853 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | -0.00466067 |
| BHMT | betaine--homocysteine S-methyltransferase | -0.00465965 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.00464728 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00464423 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00463982 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00463815 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.00462332 |
| PXN | paxillin | -0.00462196 |
