| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | major histocompatibility complex, class II, DR beta 5|HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3127) |
| External Link | https://ncbi.nlm.nih.gov/gene/3127 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the HLA-DRB5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| XPO7 | exportin 7 | 0.0151573 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.0145794 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.0135562 |
| SIRT3 | sirtuin 3 | 0.0132187 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0117467 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0114992 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0113279 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.0102498 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00989236 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00955414 |
| DEFB1 | defensin, beta 1 | 0.00945506 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.00942305 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00937026 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00933343 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.00930509 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00889651 |
| PRKCA | protein kinase C, alpha | 0.00881672 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00868607 |
| ARG2 | arginase 2 | 0.00864067 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.00860962 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 0.00857199 |
| NPY | neuropeptide Y | 0.00853023 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | 0.00848366 |
| MARCH8 | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase | 0.00846383 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00833766 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.00832109 |
| NAV2 | neuron navigator 2 | 0.00829198 |
| TGM2 | transglutaminase 2 | 0.00823926 |
| HMGB3 | high mobility group box 3 | 0.0079004 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | 0.00786829 |
| SALL1 | spalt-like transcription factor 1 | 0.00786379 |
| AOC1 | amine oxidase, copper containing 1 | 0.00784545 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | 0.00783214 |
| TADA2A | transcriptional adaptor 2A | 0.00780444 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | 0.00775148 |
| LTA4H | leukotriene A4 hydrolase | 0.00773715 |
| CES1 | carboxylesterase 1 | 0.00771137 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00769841 |
| MPP1 | membrane protein, palmitoylated 1, 55kDa | 0.0076929 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00768576 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.00766575 |
| PGD | phosphogluconate dehydrogenase | 0.00765919 |
| MAMLD1 | mastermind-like domain containing 1 | 0.00765787 |
| CETN2 | centrin, EF-hand protein, 2 | 0.0075077 |
| CAPG | capping protein (actin filament), gelsolin-like | 0.00750394 |
| KIAA0226L | KIAA0226-like | 0.00749455 |
| MMP12 | matrix metallopeptidase 12 | 0.00740017 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00738869 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.00738794 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00729073 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.00718926 |
| AUTS2 | autism susceptibility candidate 2 | 0.00712069 |
| SEPHS1 | selenophosphate synthetase 1 | 0.00708553 |
| GLOD4 | glyoxalase domain containing 4 | 0.00698724 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.00694482 |
| EPHB2 | EPH receptor B2 | 0.00692864 |
| CNN3 | calponin 3, acidic | 0.0069268 |
| AMACR | alpha-methylacyl-CoA racemase | 0.00692115 |
| MME | membrane metallo-endopeptidase | 0.00687305 |
| NEBL | nebulette | 0.00685695 |
| HMGB1 | high mobility group box 1 | 0.00684078 |
| ACP3 | acid phosphatase 3 | 0.00682759 |
| CD9 | CD9 molecule | 0.00680505 |
| FZD5 | frizzled class receptor 5 | 0.00679693 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00677849 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00676569 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00675251 |
| BPGM | 2,3-bisphosphoglycerate mutase | 0.00672575 |
| STK24 | serine/threonine kinase 24 | 0.00672152 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00671066 |
| C14ORF132 | chromosome 14 open reading frame 132 | 0.00668316 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00662696 |
| FABP1 | fatty acid binding protein 1, liver | 0.00661697 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00660015 |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) | 0.0065805 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00657866 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 0.00654821 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00651961 |
| SATB2 | SATB homeobox 2 | 0.00649907 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00647406 |
| CLC | Charcot-Leyden crystal galectin | 0.00644154 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 0.00642446 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00640792 |
| MMP8 | matrix metallopeptidase 8 | 0.00640511 |
| EFNB2 | ephrin-B2 | 0.00633229 |
| ZNF22 | zinc finger protein 22 | 0.00631698 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | 0.0062699 |
| TMPRSS2 | transmembrane protease, serine 2 | 0.00624954 |
| AGTR1 | angiotensin II receptor, type 1 | 0.00624716 |
| KLK3 | kallikrein-related peptidase 3 | 0.00623831 |
| GRAMD1C | GRAM domain containing 1C | 0.00617106 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00615414 |
| PFKP | phosphofructokinase, platelet | 0.00614712 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.00614316 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.00610392 |
| SGMS1 | sphingomyelin synthase 1 | 0.00601106 |
| CTSZ | cathepsin Z | 0.00596416 |
| UPB1 | ureidopropionase, beta | 0.00596355 |
| MGAM | maltase-glucoamylase | 0.00594922 |
| IL2RG | interleukin 2 receptor, gamma | 0.00592012 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.00591809 |
| KLK2 | kallikrein-related peptidase 2 | 0.0059105 |
| CHMP4A | charged multivesicular body protein 4A | 0.00590348 |
| AFF1 | AF4/FMR2 family, member 1 | 0.00588121 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 0.00588048 |
| SYBU | syntabulin (syntaxin-interacting) | 0.00587288 |
| DPEP1 | dipeptidase 1 (renal) | 0.00586279 |
| DMTN | dematin actin binding protein | 0.00583496 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00582064 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.00580634 |
| CS | citrate synthase | 0.00580181 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00579867 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | 0.00574653 |
| TMEM100 | transmembrane protein 100 | 0.00574614 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.00574592 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.00573662 |
| NME4 | NME/NM23 nucleoside diphosphate kinase 4 | 0.00573621 |
| CRYL1 | crystallin, lambda 1 | 0.00573007 |
| PAH | phenylalanine hydroxylase | 0.00572322 |
| NEO1 | neogenin 1 | 0.00572276 |
| ARG1 | arginase 1 | 0.00569302 |
| OLFM4 | olfactomedin 4 | 0.00567675 |
| PITRM1 | pitrilysin metallopeptidase 1 | 0.00566828 |
| PAAF1 | proteasomal ATPase-associated factor 1 | 0.00566417 |
| GRWD1 | glutamate-rich WD repeat containing 1 | 0.00565616 |
| RCAN1 | regulator of calcineurin 1 | 0.00564084 |
| PRUNE2 | prune homolog 2 (Drosophila) | 0.00563575 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00562967 |
| ACACA | acetyl-CoA carboxylase alpha | 0.00562503 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.00561507 |
| CORO1C | coronin, actin binding protein, 1C | 0.0056039 |
| ASRGL1 | asparaginase like 1 | 0.00559772 |
| C10ORF10 | chromosome 10 open reading frame 10 | 0.00559482 |
| PER2 | period circadian clock 2 | 0.00558104 |
| KL | klotho | 0.00558004 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00555395 |
| RANBP1 | RAN binding protein 1 | 0.00554882 |
| BCR | breakpoint cluster region | 0.00554542 |
| GLUD1 | glutamate dehydrogenase 1 | 0.00554131 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.00548772 |
| DLEU1 | deleted in lymphocytic leukemia 1 (non-protein coding) | 0.00545289 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.00544653 |
| ECI2 | enoyl-CoA delta isomerase 2 | 0.00544205 |
| TARP | TCR gamma alternate reading frame protein | 0.00543817 |
| ANKRD17 | ankyrin repeat domain 17 | 0.00542923 |
| PRKD1 | protein kinase D1 | 0.00541118 |
| AZU1 | azurocidin 1 | 0.00541082 |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 | 0.00539983 |
| ACOX1 | acyl-CoA oxidase 1, palmitoyl | 0.00539525 |
| USP12P1 | ubiquitin specific peptidase 12 pseudogene 1 | 0.00538937 |
| MSRB1 | methionine sulfoxide reductase B1 | 0.00537612 |
| TPX2 | TPX2, microtubule-associated | 0.00536944 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.00536349 |
| RUVBL2 | RuvB-like AAA ATPase 2 | 0.00535838 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.0053576 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.00534958 |
| REG3A | regenerating islet-derived 3 alpha | 0.00534029 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.00530458 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | 0.00530282 |
| ALB | albumin | 0.00528764 |
| MEPCE | methylphosphate capping enzyme | 0.00528647 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.00528549 |
| RIT1 | Ras-like without CAAX 1 | 0.00527597 |
| COA3 | cytochrome c oxidase assembly factor 3 | 0.00526063 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00525261 |
| GSPT2 | G1 to S phase transition 2 | 0.00525052 |
| RGCC | regulator of cell cycle | 0.00523416 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.00523319 |
| TALDO1 | transaldolase 1 | 0.00521905 |
| BANF1 | barrier to autointegration factor 1 | 0.00521752 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.00521722 |
| EXOC5 | exocyst complex component 5 | 0.00520196 |
| RNASE6 | ribonuclease, RNase A family, k6 | 0.0051914 |
| CCNA2 | cyclin A2 | 0.00517988 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.005175 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00516812 |
| ARL3 | ADP-ribosylation factor-like 3 | 0.00516419 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.00516129 |
| PKM | pyruvate kinase, muscle | 0.00514523 |
| TMC5 | transmembrane channel-like 5 | 0.0051439 |
| KLF1 | Kruppel-like factor 1 (erythroid) | 0.00513167 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.00513127 |
| FAXDC2 | fatty acid hydroxylase domain containing 2 | 0.00513119 |
| CDH16 | cadherin 16, KSP-cadherin | 0.00513019 |
| SLC16A4 | solute carrier family 16, member 4 | 0.00513001 |
| GLUD2 | glutamate dehydrogenase 2 | 0.00512962 |
| JADE2 | jade family PHD finger 2 | 0.00512954 |
| WFDC2 | WAP four-disulfide core domain 2 | 0.0051222 |
| SUCLA2 | succinate-CoA ligase, ADP-forming, beta subunit | 0.00512197 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 0.00511744 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.00510989 |
| CAPRIN1 | cell cycle associated protein 1 | 0.00510631 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00510532 |
| SLC30A9 | solute carrier family 30 (zinc transporter), member 9 | 0.00508337 |
| B4GALT6 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | 0.00507926 |
| IFT27 | intraflagellar transport 27 | 0.00507803 |
| XIC | X chromosome inactivation center | 0.00507338 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.00506824 |
| NUTF2 | nuclear transport factor 2 | 0.00506628 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00506606 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.00506503 |
| TRIM68 | tripartite motif containing 68 | 0.00505164 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.00504294 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.00502916 |
| FAM111A | family with sequence similarity 111, member A | 0.00501517 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | 0.00500382 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00499309 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00498785 |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.0049813 |
| S100A12 | S100 calcium binding protein A12 | 0.00497135 |
| DACH1 | dachshund family transcription factor 1 | 0.00496298 |
| GTPBP1 | GTP binding protein 1 | 0.0049591 |
| SEC14L2 | SEC14-like 2 (S. cerevisiae) | 0.00495807 |
| CLEC4A | C-type lectin domain family 4, member A | 0.00495754 |
| DCTN4 | dynactin 4 (p62) | 0.00495741 |
| HPN | hepsin | 0.00495712 |
| MRFAP1L1 | Morf4 family associated protein 1-like 1 | 0.00495615 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.00495272 |
| RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 0.00495144 |
| OARD1 | O-acyl-ADP-ribose deacylase 1 | 0.00492933 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.00492741 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00492393 |
| ACLY | ATP citrate lyase | 0.00492116 |
| PCTP | phosphatidylcholine transfer protein | 0.00491668 |
| TUBB2B | tubulin, beta 2B class IIb | 0.00491218 |
| CASC3 | cancer susceptibility candidate 3 | 0.00489777 |
| PATZ1 | POZ (BTB) and AT hook containing zinc finger 1 | 0.00488829 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.00487957 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.00487549 |
| DPYS | dihydropyrimidinase | 0.00486783 |
| FAM13A | family with sequence similarity 13, member A | 0.00485875 |
| DNTT | DNA nucleotidylexotransferase | 0.00485457 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.00485126 |
| BAAT | bile acid CoA:amino acid N-acyltransferase | 0.00484557 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00484263 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.00482825 |
| CTPS1 | CTP synthase 1 | 0.00482537 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.00482385 |
| TRIB2 | tribbles pseudokinase 2 | 0.00482002 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | 0.00481434 |
| TSG101 | tumor susceptibility 101 | 0.00478887 |
| SCARA3 | scavenger receptor class A, member 3 | 0.00478829 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00478022 |
| SRRD | SRR1 domain containing | 0.00477139 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.00475758 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.00475089 |
| ZNF395 | zinc finger protein 395 | 0.00474998 |
| FAIM | Fas apoptotic inhibitory molecule | 0.00474969 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.00474753 |
| TNS1 | tensin 1 | 0.00474153 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DLK1 | delta-like 1 homolog (Drosophila) | -0.019807 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.0159636 |
| BMP4 | bone morphogenetic protein 4 | -0.015938 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.0148642 |
| RTN2 | reticulon 2 | -0.0143696 |
| HOPX | HOP homeobox | -0.0140998 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0139446 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.0136806 |
| CFD | complement factor D (adipsin) | -0.0133691 |
| MB | myoglobin | -0.0132707 |
| S100P | S100 calcium binding protein P | -0.0128235 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0127377 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0126035 |
| MYBPC1 | myosin binding protein C, slow type | -0.0123734 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.0123434 |
| CLEC2B | C-type lectin domain family 2, member B | -0.0123233 |
| OSR2 | odd-skipped related transciption factor 2 | -0.0119708 |
| PDLIM3 | PDZ and LIM domain 3 | -0.0118922 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0118721 |
| TNNC1 | troponin C type 1 (slow) | -0.0114314 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -0.0113294 |
| TTN | titin | -0.0112693 |
| COQ8A | coenzyme Q8A | -0.0111911 |
| DCN | decorin | -0.0111111 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.0109106 |
| SRPX | sushi-repeat containing protein, X-linked | -0.0108378 |
| CKM | creatine kinase, muscle | -0.0108303 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0108297 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.010775 |
| C3 | complement component 3 | -0.0107083 |
| ZNF91 | zinc finger protein 91 | -0.010686 |
| SNAI2 | snail family zinc finger 2 | -0.0106568 |
| S100A8 | S100 calcium binding protein A8 | -0.010551 |
| KLHL41 | kelch-like family member 41 | -0.0105436 |
| ANXA10 | annexin A10 | -0.0104389 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0103465 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.0103413 |
| MFAP4 | microfibrillar-associated protein 4 | -0.0101954 |
| KRT7 | keratin 7, type II | -0.010181 |
| TOB1 | transducer of ERBB2, 1 | -0.00995259 |
| KLF2 | Kruppel-like factor 2 | -0.00988003 |
| FST | follistatin | -0.00984829 |
| DCLK1 | doublecortin-like kinase 1 | -0.00982421 |
| FBXO11 | F-box protein 11 | -0.00981325 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | -0.00975662 |
| APOD | apolipoprotein D | -0.0097251 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00972276 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00948135 |
| MAP7 | microtubule-associated protein 7 | -0.00943448 |
| MYOT | myotilin | -0.00943166 |
| DES | desmin | -0.00937386 |
| KRT19 | keratin 19, type I | -0.00935408 |
| PROM1 | prominin 1 | -0.00934053 |
| PEG3 | paternally expressed 3 | -0.00933706 |
| ITM2A | integral membrane protein 2A | -0.00929897 |
| FRZB | frizzled-related protein | -0.00922548 |
| TSPAN4 | tetraspanin 4 | -0.00917032 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.00914295 |
| PMP22 | peripheral myelin protein 22 | -0.00906566 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.00904046 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -0.00902244 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -0.00897745 |
| METRN | meteorin, glial cell differentiation regulator | -0.00883426 |
| GAS1 | growth arrest-specific 1 | -0.00881739 |
| LAMA2 | laminin, alpha 2 | -0.008815 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.00878576 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.0087769 |
| MFAP5 | microfibrillar associated protein 5 | -0.00876032 |
| SLN | sarcolipin | -0.00873866 |
| SMPX | small muscle protein, X-linked | -0.00873434 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | -0.00870576 |
| STK10 | serine/threonine kinase 10 | -0.0086973 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.00858071 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.00856053 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.0085556 |
| TNNI1 | troponin I type 1 (skeletal, slow) | -0.0085457 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00846497 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00845129 |
| TMEM70 | transmembrane protein 70 | -0.0084364 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00842676 |
| TAGLN | transgelin | -0.00838304 |
| TPM3 | tropomyosin 3 | -0.00835815 |
| CFH | complement factor H | -0.00820322 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00820042 |
| ASS1 | argininosuccinate synthase 1 | -0.00818149 |
| ABHD3 | abhydrolase domain containing 3 | -0.00816109 |
| THBS4 | thrombospondin 4 | -0.00815361 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | -0.00814193 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00813587 |
| PLXNC1 | plexin C1 | -0.00812868 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.00809874 |
| IL6 | interleukin 6 | -0.00808125 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.00806656 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00801979 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00786804 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.0078358 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00780424 |
| CRABP1 | cellular retinoic acid binding protein 1 | -0.00778856 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00776202 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.00774237 |
| PITX1 | paired-like homeodomain 1 | -0.00770891 |
| ENO3 | enolase 3 (beta, muscle) | -0.00769055 |
| SECTM1 | secreted and transmembrane 1 | -0.00768258 |
| PLSCR3 | phospholipid scramblase 3 | -0.00767187 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.00766545 |
| TNNC2 | troponin C type 2 (fast) | -0.00766326 |
| GOLGA8H | golgin A8 family, member H | -0.00759893 |
| MXRA5 | matrix-remodelling associated 5 | -0.00757972 |
| TFF2 | trefoil factor 2 | -0.00757575 |
| CALML5 | calmodulin-like 5 | -0.00756325 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00742249 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.00740852 |
| TNNT3 | troponin T type 3 (skeletal, fast) | -0.00739819 |
| CEL | carboxyl ester lipase | -0.00739248 |
| S100A7 | S100 calcium binding protein A7 | -0.00736706 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00732465 |
| TXNIP | thioredoxin interacting protein | -0.00732326 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00728657 |
| ADRA2A | adrenoceptor alpha 2A | -0.00727637 |
| PLTP | phospholipid transfer protein | -0.00726544 |
| FCGBP | Fc fragment of IgG binding protein | -0.00724395 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00722628 |
| RNASET2 | ribonuclease T2 | -0.00720917 |
| PIP | prolactin-induced protein | -0.00716253 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00715071 |
| TFF1 | trefoil factor 1 | -0.00712785 |
| RGS13 | regulator of G-protein signaling 13 | -0.0071184 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00711493 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.00708824 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00706853 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | -0.00703468 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00702498 |
| GATA6 | GATA binding protein 6 | -0.00701949 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00697471 |
| OLFML2A | olfactomedin-like 2A | -0.00694895 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | -0.00694553 |
| DSG3 | desmoglein 3 | -0.00691034 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00688929 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0068832 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | -0.00682223 |
| KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 | -0.00680973 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | -0.00677685 |
| PAX6 | paired box 6 | -0.00677536 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.00675033 |
| MYBPC2 | myosin binding protein C, fast type | -0.00674801 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00674156 |
| FILIP1L | filamin A interacting protein 1-like | -0.00673144 |
| RCAN2 | regulator of calcineurin 2 | -0.00671683 |
| PTK2 | protein tyrosine kinase 2 | -0.00671284 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -0.00666515 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.00665127 |
| GUCY2C | guanylate cyclase 2C | -0.00660107 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.00659541 |
| KRT17 | keratin 17, type I | -0.00659351 |
| IRAG2 | inositol 1,4,5-triphosphate receptor associated 2 | -0.00657901 |
| SLC16A6 | solute carrier family 16, member 6 | -0.00656635 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | -0.00656052 |
| C1R | complement component 1, r subcomponent | -0.00655021 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00651251 |
| CA3 | carbonic anhydrase III | -0.00650485 |
| COL10A1 | collagen, type X, alpha 1 | -0.00650071 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -0.00649323 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00646247 |
| SYNM | synemin, intermediate filament protein | -0.00646145 |
| FBLN2 | fibulin 2 | -0.00645835 |
| ACKR3 | atypical chemokine receptor 3 | -0.00644133 |
| CD163 | CD163 molecule | -0.00642551 |
| HMOX1 | heme oxygenase 1 | -0.00642359 |
| LYZ | lysozyme | -0.00642159 |
| SPHK1 | sphingosine kinase 1 | -0.00642115 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00641125 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00640715 |
| SVEP1 | sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 | -0.00639681 |
| FADD | Fas (TNFRSF6)-associated via death domain | -0.00636848 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.00634296 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.00632284 |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 | -0.00631354 |
| ABHD17A | abhydrolase domain containing 17A | -0.00630401 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.00630128 |
| LDB3 | LIM domain binding 3 | -0.00625234 |
| BTG2 | BTG family, member 2 | -0.0062508 |
| C1ORF56 | chromosome 1 open reading frame 56 | -0.00621738 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00619706 |
| CSTA | cystatin A (stefin A) | -0.00617711 |
| KRT13 | keratin 13, type I | -0.006175 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.00617363 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00616983 |
| MYOZ2 | myozenin 2 | -0.0061643 |
| ADCY9 | adenylate cyclase 9 | -0.0061632 |
| USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | -0.00615728 |
| MARCH3 | membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase | -0.00614357 |
| SDF4 | stromal cell derived factor 4 | -0.00613387 |
| PTK6 | protein tyrosine kinase 6 | -0.00612176 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00610355 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00609211 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00605422 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | -0.00604175 |
| SYNC | syncoilin, intermediate filament protein | -0.00601754 |
| MYOZ1 | myozenin 1 | -0.00599919 |
| TMEM45A | transmembrane protein 45A | -0.00598398 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00597664 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | -0.00596398 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00595435 |
| ASPN | asporin | -0.00594288 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0059374 |
| HSPB3 | heat shock 27kDa protein 3 | -0.0059321 |
| ARL14 | ADP-ribosylation factor-like 14 | -0.0059278 |
| PRSS3 | protease, serine, 3 | -0.00590452 |
| RGS16 | regulator of G-protein signaling 16 | -0.00588991 |
| CHGB | chromogranin B | -0.00585077 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00580024 |
| EMID1 | EMI domain containing 1 | -0.00579684 |
| OLFML1 | olfactomedin-like 1 | -0.00578932 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00577279 |
| HSPA2 | heat shock 70kDa protein 2 | -0.00577263 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.00577185 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00577102 |
| ACTN2 | actinin, alpha 2 | -0.00576914 |
| NELL2 | NEL-like 2 (chicken) | -0.00576706 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00574551 |
| SDC1 | syndecan 1 | -0.00574161 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00574064 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | -0.00573512 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00573135 |
| VPS4B | vacuolar protein sorting 4 homolog B (S. cerevisiae) | -0.00572949 |
| ANXA6 | annexin A6 | -0.00572664 |
| PLK2 | polo-like kinase 2 | -0.00571678 |
| MARCKSL1 | MARCKS-like 1 | -0.00571145 |
| SIM2 | single-minded family bHLH transcription factor 2 | -0.00570305 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | -0.00569127 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.00568606 |
| PLN | phospholamban | -0.0056425 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.00564224 |
| MAGEA12 | melanoma antigen family A12 | -0.00563517 |
| LAMB1 | laminin, beta 1 | -0.0056303 |
| TMED5 | transmembrane emp24 protein transport domain containing 5 | -0.00562613 |
| SYT1 | synaptotagmin I | -0.00562027 |
| PKP2 | plakophilin 2 | -0.00560945 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00560918 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | -0.00560454 |
| CASQ2 | calsequestrin 2 (cardiac muscle) | -0.0055876 |
| NMU | neuromedin U | -0.00557333 |
| MX2 | MX dynamin-like GTPase 2 | -0.00554958 |
| IRS1 | insulin receptor substrate 1 | -0.00554695 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00553216 |
| PYGM | phosphorylase, glycogen, muscle | -0.00549797 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.00549235 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0054847 |
| SUSD4 | sushi domain containing 4 | -0.00548006 |
