HLA-E Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description major histocompatibility complex, class I, E|HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3133)
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Genes

342 genes differentially expressed following the HLA-E gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PVRIG poliovirus receptor related immunoglobulin domain containing 2.57875
PCDHB1 protocadherin beta 1 2.57875
ATXN7L2 ataxin 7-like 2 2.57875
PKP1 plakophilin 1 2.57875
CNTNAP4 contactin associated protein-like 4 2.57875
DEGS2 delta(4)-desaturase, sphingolipid 2 2.57875
MRPL53 mitochondrial ribosomal protein L53 2.57875
ADTRP androgen-dependent TFPI-regulating protein 2.57875
GSTM2 glutathione S-transferase mu 2 (muscle) 2.57875
HBA1 hemoglobin, alpha 1 2.57875
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 2.57875
PDYN prodynorphin 2.57875
CAMP cathelicidin antimicrobial peptide 2.57875
CD1D CD1d molecule 2.57875
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2.57875
KLK1 kallikrein 1 2.57875
ELF4 E74-like factor 4 (ets domain transcription factor) 2.57875
SOX1 SRY (sex determining region Y)-box 1 2.57875
MYBPHL myosin binding protein H-like 2.57875
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.57875
CHADL chondroadherin-like 2.57875
USP26 ubiquitin specific peptidase 26 2.57875
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.57875
IGFL3 IGF-like family member 3 2.57875
CSMD3 CUB and Sushi multiple domains 3 2.57875
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.57875
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.57875
PRDM1 PR domain containing 1, with ZNF domain 2.57875
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.57875
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.57875
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.57875
KRTAP5-2 keratin associated protein 5-2 2.57875
DNAH2 dynein, axonemal, heavy chain 2 2.57875
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.57875
FGF7 fibroblast growth factor 7 2.57875
PCDHGA11 protocadherin gamma subfamily A, 11 2.57875
KISS1R KISS1 receptor 2.57875
MYO16 myosin XVI 2.57875
NPIPA5 nuclear pore complex interacting protein family, member A5 2.57875
ASPA aspartoacylase 2.57875
C19ORF67 chromosome 19 open reading frame 67 2.57875
SLC23A3 solute carrier family 23, member 3 2.57875
REN renin 2.57875
SLC39A4 solute carrier family 39 (zinc transporter), member 4 2.57875
GCKR glucokinase (hexokinase 4) regulator 2.57875
TPSD1 tryptase delta 1 2.57875
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.57875
GPR183 G protein-coupled receptor 183 2.57875
IGFBP6 insulin-like growth factor binding protein 6 2.57875
GPR78 G protein-coupled receptor 78 2.57875
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.57875
ACKR5 atypical chemokine receptor 5 2.57875
PCLAF PCNA clamp associated factor 2.57875
ALDOB aldolase B, fructose-bisphosphate 2.57875
YPEL4 yippee-like 4 (Drosophila) 2.57875
STX11 syntaxin 11 2.57875
MYEOV myeloma overexpressed 2.57875
XKR4 XK, Kell blood group complex subunit-related family, member 4 2.57875
MAGIX MAGI family member, X-linked 2.57875
CD70 CD70 molecule 2.57875
GPSM2 G-protein signaling modulator 2 2.57875
CNGA4 cyclic nucleotide gated channel alpha 4 2.57875
STYXL2 serine/threonine/tyrosine interacting like 2 2.57875
TUT7 terminal uridylyl transferase 7 2.57875
H2BC12 H2B clustered histone 12 2.57875
SPMIP11 sperm microtubule inner protein 11 2.57875
SCYGR5 small cysteine and glycine repeat containing 5 2.57875
SPMIP8 sperm microtubule inner protein 8 2.57875
LOC124903372 uncharacterized LOC124903372 2.57875
CTXND1 cortexin domain containing 1 2.57875
SPAAR small regulatory polypeptide of amino acid response 2.57875
SERTM2 serine rich and transmembrane domain containing 2 2.57875
MAJIN membrane anchored junction protein 2.57875
CATSPERZ catsper channel auxiliary subunit zeta 2.57875
CFAP141 cilia and flagella associated protein 141 2.57875
ROPN1 rhophilin associated tail protein 1 2.57875
CFAP52 cilia and flagella associated protein 52 2.57875
SIM2 single-minded family bHLH transcription factor 2 2.57875
CXCL16 chemokine (C-X-C motif) ligand 16 2.57875
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.57875
CATSPER3 cation channel, sperm associated 3 2.57875
CD48 CD48 molecule 2.57875
AMBP alpha-1-microglobulin/bikunin precursor 2.57875
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.57875
PCDHB11 protocadherin beta 11 2.57875
RHOXF2 Rhox homeobox family, member 2 2.57875
KLHL31 kelch-like family member 31 2.57875
TLR6 toll-like receptor 6 2.57875
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.57875
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.57875
PXDC1 PX domain containing 1 2.57875
LRRC72 leucine rich repeat containing 72 2.57875
FRK fyn-related Src family tyrosine kinase 2.57875
IL1R1 interleukin 1 receptor, type I 2.57875
FAM186B family with sequence similarity 186, member B 2.57875
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.57875
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.57875
TBX5 T-box 5 2.57875
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.57875
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.57875
TMEM229A transmembrane protein 229A 2.57875
HSPB9 heat shock protein, alpha-crystallin-related, B9 2.57875
ZMIZ2 zinc finger, MIZ-type containing 2 2.57875
FAM163A family with sequence similarity 163, member A 2.57875
RNASE13 ribonuclease, RNase A family, 13 (non-active) 2.57875
RNASE11 ribonuclease, RNase A family, 11 (non-active) 2.57875
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.57875
WFDC8 WAP four-disulfide core domain 8 2.57875
CALHM3 calcium homeostasis modulator 3 2.57875
HPX hemopexin 2.57875
SERINC4 serine incorporator 4 2.57875
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.57875
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.57875
CST7 cystatin F (leukocystatin) 2.57875
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.57875
DES desmin 2.57875
DYTN dystrotelin 2.57875
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 2.57875
FNDC1 fibronectin type III domain containing 1 2.57875
TSNAXIP1 translin-associated factor X interacting protein 1 2.57875
ZSCAN4 zinc finger and SCAN domain containing 4 2.57875
BRDT bromodomain, testis-specific 2.57875
TCEA3 transcription elongation factor A (SII), 3 2.57875
ZNF703 zinc finger protein 703 2.57875
CLEC4D C-type lectin domain family 4, member D 2.57875
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.57875
LYPD5 LY6/PLAUR domain containing 5 2.57875
CFP complement factor properdin 2.57875
TMPPE transmembrane protein with metallophosphoesterase domain 2.57875
CYTH4 cytohesin 4 2.57875
TRIM3 tripartite motif containing 3 2.57875
RAB27B RAB27B, member RAS oncogene family 2.57875
TSPAN19 tetraspanin 19 2.57875
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.57875
ADRA2A adrenoceptor alpha 2A 2.57875
GOLGA8K golgin A8 family, member K 2.57875
CA5A carbonic anhydrase VA, mitochondrial 2.57875
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.57875
SNX31 sorting nexin 31 2.57875
C2CD4B C2 calcium-dependent domain containing 4B 2.57875
WNT7A wingless-type MMTV integration site family, member 7A 2.57875
LMOD2 leiomodin 2 (cardiac) 2.57875
CLEC18C C-type lectin domain family 18, member C 2.57875
FBXO40 F-box protein 40 2.57875
KLK6 kallikrein-related peptidase 6 2.57875
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.57875
CHIT1 chitinase 1 (chitotriosidase) 2.57875
CALR3 calreticulin 3 2.57875
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.57875
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.57875
TAS2R46 taste receptor, type 2, member 46 2.57875
IRX1 iroquois homeobox 1 2.57875
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.57875
TRAF3IP3 TRAF3 interacting protein 3 2.57875
HHIPL2 HHIP-like 2 2.57875
RNF224 ring finger protein 224 2.57875
CLCA4 chloride channel accessory 4 2.57875
LAMP3 lysosomal-associated membrane protein 3 2.57875
PRAP1 proline-rich acidic protein 1 2.57875
PARP15 poly (ADP-ribose) polymerase family, member 15 2.57875
IL10RA interleukin 10 receptor, alpha 2.57875
NRGN neurogranin (protein kinase C substrate, RC3) 2.57875
CCNO cyclin O 2.57875
ASCL2 achaete-scute family bHLH transcription factor 2 2.57875
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.57875
HYOU1 hypoxia up-regulated 1 2.57875
ADRA1B adrenoceptor alpha 1B 2.57875
ANXA1 annexin A1 2.57875
CHRM1 cholinergic receptor, muscarinic 1 2.57875
CBR3 carbonyl reductase 3 2.57875
PLGLB1 plasminogen-like B1 2.57875
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.57875
ANXA2R annexin A2 receptor 2.57875
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 2.57875
STMND1 stathmin domain containing 1 2.57875
ZC2HC1B zinc finger, C2HC-type containing 1B 2.57875
TSPAN32 tetraspanin 32 2.57875
PRAM1 PML-RARA regulated adaptor molecule 1 2.57875
MED13L mediator complex subunit 13-like 2.56059
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 2.50257
CSNK1A1 casein kinase 1, alpha 1 2.50257
FPGT fucose-1-phosphate guanylyltransferase 2.50257
LRRC26 leucine rich repeat containing 26 2.50257
AUTS2 autism susceptibility candidate 2 2.50257
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 2.50257
ANGPTL4 angiopoietin-like 4 2.50257
KLHDC3 kelch domain containing 3 2.46768
CHMP7 charged multivesicular body protein 7 2.44635
NT5DC2 5'-nucleotidase domain containing 2 2.37929
ARL11 ADP-ribosylation factor-like 11 2.37273
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.33164
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.27545
MSH2 mutS homolog 2 2.2693
RNF157 ring finger protein 157 2.2693
EVA1C eva-1 homolog C (C. elegans) 2.24381
RBM3 RNA binding motif (RNP1, RRM) protein 3 2.23459
AKAP17A A kinase (PRKA) anchor protein 17A 2.22776
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 2.22127
BMP2K BMP2 inducible kinase 2.20162
BCL7C B-cell CLL/lymphoma 7C 2.19948
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 2.18902
KIAA1328 KIAA1328 2.18491
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 2.16678
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 2.166
USP8 ubiquitin specific peptidase 8 2.16369
PLBD2 phospholipase B domain containing 2 2.16369
NOD1 nucleotide-binding oligomerization domain containing 1 2.16369
DOCK4 dedicator of cytokinesis 4 2.16047
TET2 tet methylcytosine dioxygenase 2 2.15827
PLSCR3 phospholipid scramblase 3 2.15591
ZGRF1 zinc finger, GRF-type containing 1 2.13713
ZNF250 zinc finger protein 250 2.11203
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 2.11203
GLI4 GLI family zinc finger 4 2.10669
UBA1 ubiquitin-like modifier activating enzyme 1 2.09858
ARMCX5 armadillo repeat containing, X-linked 5 2.08763
CCDC80 coiled-coil domain containing 80 2.07874
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.06846
THOC1 THO complex 1 2.06354
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 2.06354
SIPA1L2 signal-induced proliferation-associated 1 like 2 2.06223
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.06223
ARL14EP ADP-ribosylation factor-like 14 effector protein 2.06223
SPATA2L spermatogenesis associated 2-like 2.05968
RASL11B RAS-like, family 11, member B 2.05968
ANKRD18B ankyrin repeat domain 18B 2.05762
MYO1H myosin IH 2.02389
PNISR PNN-interacting serine/arginine-rich protein 2.02389
TMEM70 transmembrane protein 70 2.01355

decreased expression

Symbol Name Standardized Value
MRPL15 mitochondrial ribosomal protein L15 -2.57875
PTPRO protein tyrosine phosphatase, receptor type, O -2.57875
SDC3 syndecan 3 -2.57875
TCP11L2 t-complex 11, testis-specific-like 2 -2.57875
ZNF517 zinc finger protein 517 -2.57875
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 -2.57875
C19ORF73 chromosome 19 open reading frame 73 -2.57875
COIL coilin -2.57875
PMFBP1 polyamine modulated factor 1 binding protein 1 -2.57875
CCL28 chemokine (C-C motif) ligand 28 -2.57875
OR52A1 olfactory receptor, family 52, subfamily A, member 1 -2.57875
DNAH7 dynein, axonemal, heavy chain 7 -2.57875
IL18BP interleukin 18 binding protein -2.57875
H1-1 H1.1 linker histone, cluster member -2.57875
COMMD3 COMM domain containing 3 -2.57875
MEIS2 Meis homeobox 2 -2.57875
CD101 CD101 molecule -2.57875
CD247 CD247 molecule -2.57875
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -2.51165
EPHX4 epoxide hydrolase 4 -2.50257
OLIG1 oligodendrocyte transcription factor 1 -2.50257
ACAN aggrecan -2.50257
ARSI arylsulfatase family, member I -2.50257
CHD5 chromodomain helicase DNA binding protein 5 -2.50257
ATAD3C ATPase family, AAA domain containing 3C -2.50257
POPDC2 popeye domain containing 2 -2.50257
ECEL1 endothelin converting enzyme-like 1 -2.50257
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -2.50257
SMIM38 small integral membrane protein 38 -2.50257
CGAS cyclic GMP-AMP synthase -2.50257
CES4A carboxylesterase 4A -2.50257
LEKR1 leucine, glutamate and lysine rich 1 -2.50257
OSTN osteocrin -2.50257
SCART1 scavenger receptor protein family member -2.50257
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.50257
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -2.50257
MLANA melan-A -2.50257
KIRREL2 kin of IRRE like 2 (Drosophila) -2.50257
EQTN equatorin, sperm acrosome associated -2.50257
NPPC natriuretic peptide C -2.50257
PLIN4 perilipin 4 -2.50257
MUC1 mucin 1, cell surface associated -2.50257
OSGIN1 oxidative stress induced growth inhibitor 1 -2.50257
GARIN1B golgi associated RAB2 interactor 1B -2.50257
BHLHA15 basic helix-loop-helix family, member a15 -2.50257
VSTM1 V-set and transmembrane domain containing 1 -2.50257
ITGA10 integrin, alpha 10 -2.50257
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -2.50257
SHISA8 shisa family member 8 -2.50257
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 -2.50257
CASS4 Cas scaffolding protein family member 4 -2.50257
ANKRD65 ankyrin repeat domain 65 -2.50257
TSLP thymic stromal lymphopoietin -2.50257
RGS11 regulator of G-protein signaling 11 -2.50257
SHOX short stature homeobox -2.50257
PTGDR prostaglandin D2 receptor (DP) -2.50257
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.50257
LYG2 lysozyme G-like 2 -2.50257
LAMP5 lysosomal-associated membrane protein family, member 5 -2.50257
MPHOSPH6 M-phase phosphoprotein 6 -2.50257
RIBC2 RIB43A domain with coiled-coils 2 -2.50257
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -2.50257
NUF2 NUF2, NDC80 kinetochore complex component -2.47872
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.43684
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.42823
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.42753
SAMD3 sterile alpha motif domain containing 3 -2.41744
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -2.41744
H2AC14 H2A clustered histone 14 -2.40079
SPMIP6 sperm microtubule inner protein 6 -2.37929
UCMA upper zone of growth plate and cartilage matrix associated -2.37929
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -2.37929
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.35225
CANT1 calcium activated nucleotidase 1 -2.31791
MSMO1 methylsterol monooxygenase 1 -2.30746
NDNF neuron-derived neurotrophic factor -2.29752
PPCDC phosphopantothenoylcysteine decarboxylase -2.29752
METTL27 methyltransferase like 27 -2.29752
EHBP1L1 EH domain binding protein 1-like 1 -2.29749
PLAGL1 pleiomorphic adenoma gene-like 1 -2.29749
BUD31 BUD31 homolog (S. cerevisiae) -2.28549
KCTD6 potassium channel tetramerization domain containing 6 -2.27255
AP1B1 adaptor-related protein complex 1, beta 1 subunit -2.2693
GOLPH3 golgi phosphoprotein 3 (coat-protein) -2.26688
KHK ketohexokinase (fructokinase) -2.25646
ASNSD1 asparagine synthetase domain containing 1 -2.253
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -2.25177
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.23699
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) -2.21181
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.1918
HUS1 HUS1 checkpoint homolog (S. pombe) -2.1918
PRX periaxin -2.18491
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.18148
CYB561A3 cytochrome b561 family, member A3 -2.17773
FAM219A family with sequence similarity 219, member A -2.16369
HOMER1 homer scaffolding protein 1 -2.15827
CPNE3 copine III -2.15827
TM9SF4 transmembrane 9 superfamily protein member 4 -2.15827
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -2.15827
STC1 stanniocalcin 1 -2.15591
TRAIP TRAF interacting protein -2.15544
RFC4 replication factor C (activator 1) 4, 37kDa -2.11203
ARHGAP21 Rho GTPase activating protein 21 -2.10876
WDR7 WD repeat domain 7 -2.10543
AEBP2 AE binding protein 2 -2.09587
RET ret proto-oncogene -2.07874
DNASE1 deoxyribonuclease I -2.06223
RADIL Ras association and DIL domains -2.06223
C5 complement component 5 -2.06223
NOXO1 NADPH oxidase organizer 1 -2.06223
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -2.02485
NDOR1 NADPH dependent diflavin oxidoreductase 1 -2.02389
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -2.00911