HLA-F Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description major histocompatibility complex, class I, F|This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3134)
External Link http://www.ncbi.nlm.nih.gov/gene/3134
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Genes

15 interacting proteins for HLA-F from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
B2M beta-2-microglobulin
CALR calreticulin
CANX calnexin
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HNF4A hepatocyte nuclear factor 4, alpha
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
MAX MYC associated factor X
MYC v-myc avian myelocytomatosis viral oncogene homolog
PDIA3 protein disulfide isomerase family A, member 3
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
UBC ubiquitin C