HLA-G Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description major histocompatibility complex, class I, G|HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3135)
External Link http://www.ncbi.nlm.nih.gov/gene/3135
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Genes

20 interacting proteins for HLA-G from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
B2M beta-2-microglobulin
CALR calreticulin
CANX calnexin
CD8A CD8a molecule
COPB1 coatomer protein complex, subunit beta 1
FAF2 Fas associated factor family member 2
HLA-A major histocompatibility complex, class I, A
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KLRD1 killer cell lectin-like receptor subfamily D, member 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
ONECUT1 one cut homeobox 1
PDIA3 protein disulfide isomerase family A, member 3
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
UBC ubiquitin C