HLF Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description hepatic leukemia factor|This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3131)
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Genes

228 gene knockdowns changing fitness of HLF relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 2.51647
FRMPD2 FERM and PDZ domain containing 2 2.2968
HDGFRP3 hepatoma-derived growth factor, related protein 3 2.19979
ZNF479 zinc finger protein 479 2.1336
GATAD2A GATA zinc finger domain containing 2A 1.96594
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 1.95691
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 1.94704
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 1.92664
RRM2 ribonucleotide reductase M2 1.86448
KAT8 K(lysine) acetyltransferase 8 1.80315
HABP2 hyaluronan binding protein 2 1.80122
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 1.72052
CD46 CD46 molecule, complement regulatory protein 1.62851
ARF1 ADP-ribosylation factor 1 1.60413
SF3B2 splicing factor 3b, subunit 2, 145kDa 1.54976
PHF6 PHD finger protein 6 1.54803
ZNF200 zinc finger protein 200 1.53073
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 1.51623
ANXA3 annexin A3 1.49873
OR1S2 olfactory receptor, family 1, subfamily S, member 2 1.49781
RNF213 ring finger protein 213 1.47324
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.47027
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 1.46121
PCDHB10 protocadherin beta 10 1.46007
LOC100508408 1.42429
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 1.42079
RAD23A RAD23 homolog A (S. cerevisiae) 1.38969
RPS13 ribosomal protein S13 1.38752
HIST1H3D histone cluster 1, H3d 1.38704
RFC2 replication factor C (activator 1) 2, 40kDa 1.38618
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 1.38594
HIST1H1C histone cluster 1, H1c 1.34385
UCN urocortin 1.32208
NOTCH3 notch 3 1.319
TUBB4A tubulin, beta 4A class IVa 1.30928
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 1.30432
ZNF207 zinc finger protein 207 1.27163
MAPKBP1 mitogen-activated protein kinase binding protein 1 1.26506
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 1.26425
XAB2 XPA binding protein 2 1.26014
TPCN2 two pore segment channel 2 1.26001
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.25455
SF3A1 splicing factor 3a, subunit 1, 120kDa 1.25454
ZNF273 zinc finger protein 273 1.24838
TAS1R1 taste receptor, type 1, member 1 1.2478
PCDHGA10 protocadherin gamma subfamily A, 10 1.24674
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase 1.24633
CDK11B cyclin-dependent kinase 11B 1.24331
NMRAL1 NmrA-like family domain containing 1 1.24285
RBMS1 RNA binding motif, single stranded interacting protein 1 1.24114
DMTF1 cyclin D binding myb-like transcription factor 1 1.22991
NEB nebulin 1.21865
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 1.21732
RPS27A ribosomal protein S27a 1.20292
SAG S-antigen; retina and pineal gland (arrestin) 1.2009
CDKL4 cyclin-dependent kinase-like 4 1.19345
HIST1H2AB histone cluster 1, H2ab 1.18625
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 1.18519
PRDM12 PR domain containing 12 1.17696
LOC650157 1.16817
DDR2 discoidin domain receptor tyrosine kinase 2 1.16563
LOC93432 1.16135
ZNF436 zinc finger protein 436 1.15757
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 1.15542
MAST4 microtubule associated serine/threonine kinase family member 4 1.15501
UBE2F ubiquitin-conjugating enzyme E2F (putative) 1.15449
ALPPL2 alkaline phosphatase, placental-like 2 1.14561
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.14183
NXF3 nuclear RNA export factor 3 1.14047
TUBA1A tubulin, alpha 1a 1.13799
AGA aspartylglucosaminidase 1.11872
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 1.11738
PPT2 palmitoyl-protein thioesterase 2 1.11595
CFD complement factor D (adipsin) 1.10914
BCOR BCL6 corepressor 1.09488
GLUD1 glutamate dehydrogenase 1 1.09067
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 1.08583
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 1.07269
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 1.06893
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 1.06517
ELF5 E74-like factor 5 (ets domain transcription factor) 1.06152
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 1.06019
CDCA8 cell division cycle associated 8 1.04901
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.03692
ZNF566 zinc finger protein 566 1.03668
KCTD6 potassium channel tetramerization domain containing 6 1.03276
RPS3A ribosomal protein S3A 1.03234
PFN1 profilin 1 1.02998
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 1.02982
MCM5 minichromosome maintenance complex component 5 1.02474
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 1.02259
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 1.02174
PDF peptide deformylase (mitochondrial) 1.0193
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 1.01887
GUK1 guanylate kinase 1 1.01832
CKAP5 cytoskeleton associated protein 5 1.01748
IL7R interleukin 7 receptor 1.01591
PBX2 pre-B-cell leukemia homeobox 2 1.01441
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 1.01267
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 1.00162

decreased fitness

Symbol Name Standardized Value
ARSF arylsulfatase F -2.38108
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 -2.3322
TULP4 tubby like protein 4 -2.26366
TNNC2 troponin C type 2 (fast) -2.17453
FGG fibrinogen gamma chain -2.16345
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 -2.13893
GUCA1A guanylate cyclase activator 1A (retina) -2.07236
SLC16A12 solute carrier family 16, member 12 -2.05218
RAB6B RAB6B, member RAS oncogene family -2.01726
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -2.00774
ARF5 ADP-ribosylation factor 5 -1.93018
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -1.90301
MTFMT mitochondrial methionyl-tRNA formyltransferase -1.90198
ZHX2 zinc fingers and homeoboxes 2 -1.89643
DAP death-associated protein -1.86036
CDH7 cadherin 7, type 2 -1.85174
SNX2 sorting nexin 2 -1.8234
STRN striatin, calmodulin binding protein -1.7308
WFDC11 WAP four-disulfide core domain 11 -1.73029
SLITRK4 SLIT and NTRK-like family, member 4 -1.72757
ZP2 zona pellucida glycoprotein 2 (sperm receptor) -1.69281
S100A7A S100 calcium binding protein A7A -1.6869
H2BFM H2B histone family, member M -1.6403
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -1.60673
PCDHGA5 protocadherin gamma subfamily A, 5 -1.602
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 -1.57973
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -1.56307
S100A13 S100 calcium binding protein A13 -1.53301
ATXN7 ataxin 7 -1.52971
ARSJ arylsulfatase family, member J -1.52763
SPTAN1 spectrin, alpha, non-erythrocytic 1 -1.52404
USP54 ubiquitin specific peptidase 54 -1.49937
RNMT RNA (guanine-7-) methyltransferase -1.49275
WHSC1 Wolf-Hirschhorn syndrome candidate 1 -1.48057
SGPP1 sphingosine-1-phosphate phosphatase 1 -1.45815
ZNF439 zinc finger protein 439 -1.44936
ZNF563 zinc finger protein 563 -1.42399
LPAR3 lysophosphatidic acid receptor 3 -1.41488
TSHZ1 teashirt zinc finger homeobox 1 -1.40933
HBG1 hemoglobin, gamma A -1.39822
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -1.38515
CDK18 cyclin-dependent kinase 18 -1.38423
HIPK4 homeodomain interacting protein kinase 4 -1.37739
POLM polymerase (DNA directed), mu -1.37564
MAN1A2 mannosidase, alpha, class 1A, member 2 -1.37455
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) -1.36818
CALB1 calbindin 1, 28kDa -1.35753
UHMK1 U2AF homology motif (UHM) kinase 1 -1.35459
TRAT1 T cell receptor associated transmembrane adaptor 1 -1.35361
FBXO24 F-box protein 24 -1.35297
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F -1.35155
MYL4 myosin, light chain 4, alkali; atrial, embryonic -1.33988
HIST4H4 histone cluster 4, H4 -1.31507
PPP2R2D protein phosphatase 2, regulatory subunit B, delta -1.31223
PCDH17 protocadherin 17 -1.30968
PCDHGA11 protocadherin gamma subfamily A, 11 -1.30542
CYLD cylindromatosis (turban tumor syndrome) -1.30306
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -1.30115
OR12D3 olfactory receptor, family 12, subfamily D, member 3 -1.29404
RWDD2A RWD domain containing 2A -1.27756
KRT13 keratin 13, type I -1.27464
MLEC malectin -1.27395
CD84 CD84 molecule -1.27363
TAS2R45 taste receptor, type 2, member 45 -1.27106
DLX6 distal-less homeobox 6 -1.26206
HAAO 3-hydroxyanthranilate 3,4-dioxygenase -1.26163
SSTR2 somatostatin receptor 2 -1.26001
C11ORF24 chromosome 11 open reading frame 24 -1.25589
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -1.25459
ADAM29 ADAM metallopeptidase domain 29 -1.24888
ARG2 arginase 2 -1.22804
MORC1 MORC family CW-type zinc finger 1 -1.22505
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -1.21996
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -1.21129
LIG3 ligase III, DNA, ATP-dependent -1.20751
FOXI1 forkhead box I1 -1.20705
ANXA1 annexin A1 -1.20667
QDPR quinoid dihydropteridine reductase -1.19702
ZNF222 zinc finger protein 222 -1.19622
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -1.19561
IL16 interleukin 16 -1.1946
AKNA AT-hook transcription factor -1.18949
KIF16B kinesin family member 16B -1.18334
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -1.17741
PPP1R9A protein phosphatase 1, regulatory subunit 9A -1.1763
RABIF RAB interacting factor -1.17478
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -1.16896
PHOX2A paired-like homeobox 2a -1.16862
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma -1.16783
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -1.14608
UBAP2 ubiquitin associated protein 2 -1.14298
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 -1.14197
CBR1 carbonyl reductase 1 -1.14093
SLC17A4 solute carrier family 17, member 4 -1.13499
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -1.12697
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 -1.11459
PEBP1 phosphatidylethanolamine binding protein 1 -1.1128
CHD2 chromodomain helicase DNA binding protein 2 -1.11176
EED embryonic ectoderm development -1.10825
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -1.10419
LALBA lactalbumin, alpha- -1.10242
POLRMT polymerase (RNA) mitochondrial (DNA directed) -1.09577
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -1.09531
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -1.09525
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -1.08388
MXI1 MAX interactor 1, dimerization protein -1.07998
DTX3L deltex 3 like, E3 ubiquitin ligase -1.07934
PCSK9 proprotein convertase subtilisin/kexin type 9 -1.07903
DRG2 developmentally regulated GTP binding protein 2 -1.07673
PSEN2 presenilin 2 -1.07348
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -1.06718
YES1 YES proto-oncogene 1, Src family tyrosine kinase -1.06633
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -1.06024
RAB35 RAB35, member RAS oncogene family -1.05455
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -1.0483
BHMT2 betaine--homocysteine S-methyltransferase 2 -1.04484
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -1.04069
OR8A1 olfactory receptor, family 8, subfamily A, member 1 -1.03946
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -1.03707
TFB2M transcription factor B2, mitochondrial -1.03179
PCCA propionyl CoA carboxylase, alpha polypeptide -1.02905
OR2T5 olfactory receptor, family 2, subfamily T, member 5 -1.02417
ANTXR2 anthrax toxin receptor 2 -1.02371
SSH3 slingshot protein phosphatase 3 -1.02097
ACBD3 acyl-CoA binding domain containing 3 -1.01241
NME1-NME2 NME1-NME2 readthrough -1.01185
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -1.00938
CBS cystathionine-beta-synthase -1.00817