HLF Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description hepatic leukemia factor|This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3131)
External Link https://depmap.org/portal/cell_line/ACH-000393
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Genes

228 gene knockdowns changing fitness of HLF relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 8.38537
DNAH1 dynein, axonemal, heavy chain 1 6.74248
DAAM2 dishevelled associated activator of morphogenesis 2 6.11425
SAMD15 sterile alpha motif domain containing 15 5.7062
CCDC7 coiled-coil domain containing 7 5.43519
DOCK10 dedicator of cytokinesis 10 5.14064
RBPMS RNA binding protein with multiple splicing 4.89135
WWP1 WW domain containing E3 ubiquitin protein ligase 1 4.6224
LSMEM2 leucine-rich single-pass membrane protein 2 4.32463
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 4.29212
RHOG ras homolog family member G 4.27351
PRSS22 protease, serine, 22 4.25597
ACKR4 atypical chemokine receptor 4 4.23552
FAIM2 Fas apoptotic inhibitory molecule 2 4.22576
PTCHD2 patched domain containing 2 4.15663
PCDHA11 protocadherin alpha 11 4.14468
CDH26 cadherin 26 4.07637
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.92172
TREML2 triggering receptor expressed on myeloid cells-like 2 3.92013
EPB41L2 erythrocyte membrane protein band 4.1-like 2 3.90658
ANXA4 annexin A4 3.86743
MARK4 MAP/microtubule affinity-regulating kinase 4 3.85931
C9ORF91 chromosome 9 open reading frame 91 3.84404
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.83474
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 3.80406
ADPRH ADP-ribosylarginine hydrolase 3.79988
TRIP12 thyroid hormone receptor interactor 12 3.7791
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 3.7574
MLIP muscular LMNA-interacting protein 3.75025
SGSM1 small G protein signaling modulator 1 3.65949
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 3.63914
GRXCR2 glutaredoxin, cysteine rich 2 3.62561
SPEF1 sperm flagellar 1 3.57615
RGS16 regulator of G-protein signaling 16 3.52537
IFI27L1 interferon, alpha-inducible protein 27-like 1 3.50739
RTN3 reticulon 3 3.50368
ZCCHC3 zinc finger, CCHC domain containing 3 3.45776
RAP1A RAP1A, member of RAS oncogene family 3.45729
ZNF223 zinc finger protein 223 3.43954
C10ORF105 chromosome 10 open reading frame 105 3.41534
ANKEF1 ankyrin repeat and EF-hand domain containing 1 3.39857
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 3.28602
TKTL2 transketolase-like 2 3.25296
RTP3 receptor (chemosensory) transporter protein 3 3.23683
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 3.21144
OR51E1 olfactory receptor, family 51, subfamily E, member 1 3.20721
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 3.20397
MPZ myelin protein zero 3.18071
LRRC8B leucine rich repeat containing 8 family, member B 3.15983
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.1242
FGFR1 fibroblast growth factor receptor 1 3.12383
RIOX2 ribosomal oxygenase 2 3.10708
WDR47 WD repeat domain 47 3.10513
OR11H4 olfactory receptor, family 11, subfamily H, member 4 3.10306
PLA2G3 phospholipase A2, group III 3.10221
TM6SF1 transmembrane 6 superfamily member 1 3.02285
KCNIP2 Kv channel interacting protein 2 3.01385
SLC35F1 solute carrier family 35, member F1 3.00217
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.99875
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.98743
NMUR1 neuromedin U receptor 1 2.97991
GJA1 gap junction protein, alpha 1, 43kDa 2.96204
FAM181B family with sequence similarity 181, member B 2.94704
GLUL glutamate-ammonia ligase 2.93748
PTPDC1 protein tyrosine phosphatase domain containing 1 2.92234
MYO3B myosin IIIB 2.92076
INHBB inhibin, beta B 2.91809
CFB complement factor B 2.91165
SELENON selenoprotein N 2.90074
PPL periplakin 2.87421
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 2.86943
FAM184B family with sequence similarity 184, member B 2.86673
TMEM54 transmembrane protein 54 2.86433
OR4N5 olfactory receptor, family 4, subfamily N, member 5 2.85687
TMEM74 transmembrane protein 74 2.84127
ARMC9 armadillo repeat containing 9 2.81452
TEPP testis, prostate and placenta expressed 2.80968
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 2.7955
LRRC1 leucine rich repeat containing 1 2.79039
PRODH proline dehydrogenase (oxidase) 1 2.78936
TULP3 tubby like protein 3 2.78468
AICDA activation-induced cytidine deaminase 2.77998
RBMS2 RNA binding motif, single stranded interacting protein 2 2.76552
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.75856
CYTH4 cytohesin 4 2.75367
PABPN1L poly(A) binding protein, nuclear 1-like (cytoplasmic) 2.75324
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 2.74128
ZMYND10 zinc finger, MYND-type containing 10 2.73962
ZNF720 zinc finger protein 720 2.73661
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.72794
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.72509
SBK2 SH3 domain binding kinase family, member 2 2.71556
LIN7B lin-7 homolog B (C. elegans) 2.71412
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.67673
USHBP1 Usher syndrome 1C binding protein 1 2.67134
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 2.67105
CLDN16 claudin 16 2.66682
DCHS1 dachsous cadherin-related 1 2.66353
F2R coagulation factor II (thrombin) receptor 2.66233
RELL2 RELT-like 2 2.65481
ARMC8 armadillo repeat containing 8 2.64716
PROK1 prokineticin 1 2.63317
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.62844
PLA2G2F phospholipase A2, group IIF 2.61922
ZNF322 zinc finger protein 322 2.61439
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.60923
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.60349
HTN1 histatin 1 2.60296
FRS3 fibroblast growth factor receptor substrate 3 2.60203
NLRP8 NLR family, pyrin domain containing 8 2.60185
NECTIN4 nectin cell adhesion molecule 4 2.59833
SYNGR1 synaptogyrin 1 2.59701
STAG3 stromal antigen 3 2.58675
FBXO9 F-box protein 9 2.58013
SECISBP2 SECIS binding protein 2 2.57414
ABHD14A abhydrolase domain containing 14A 2.55494
POU5F2 POU domain class 5, transcription factor 2 2.53062
ACP5 acid phosphatase 5, tartrate resistant 2.52939
MOB3A MOB kinase activator 3A 2.52496
STMN1 stathmin 1 2.50832
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.50107
KCTD18 potassium channel tetramerization domain containing 18 2.49903
ANKHD1 ankyrin repeat and KH domain containing 1 2.49537
OR13C5 olfactory receptor, family 13, subfamily C, member 5 2.48496
TSSK6 testis-specific serine kinase 6 2.48278
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.48158
H3-5 H3.5 histone 2.47728
GSTM5 glutathione S-transferase mu 5 2.47225
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.46267
C2ORF69 chromosome 2 open reading frame 69 2.45577
PARP4 poly (ADP-ribose) polymerase family, member 4 2.4402
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2.43897
EYA2 EYA transcriptional coactivator and phosphatase 2 2.43216
MMP19 matrix metallopeptidase 19 2.4275
POGZ pogo transposable element with ZNF domain 2.42442
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.42434
TRIP10 thyroid hormone receptor interactor 10 2.42186
C11ORF1 chromosome 11 open reading frame 1 2.41893
VCAM1 vascular cell adhesion molecule 1 2.4042
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 2.40375
C2ORF50 chromosome 2 open reading frame 50 2.38857
PCSK7 proprotein convertase subtilisin/kexin type 7 2.38373
SLITRK2 SLIT and NTRK-like family, member 2 2.37316
KCNIP3 Kv channel interacting protein 3, calsenilin 2.37245
HNF1B HNF1 homeobox B 2.37126
B3GAT3 beta-1,3-glucuronyltransferase 3 2.36088
TMEM106A transmembrane protein 106A 2.36081
ADGRF3 adhesion G protein-coupled receptor F3 2.35608
PLAC8L1 PLAC8-like 1 2.35487
MYO1E myosin IE 2.33986
PSAT1 phosphoserine aminotransferase 1 2.33002
CCDC78 coiled-coil domain containing 78 2.32355
CKM creatine kinase, muscle 2.3024
SLC22A14 solute carrier family 22, member 14 2.30119
ADGRD1 adhesion G protein-coupled receptor D1 2.29879
KDM3B lysine (K)-specific demethylase 3B 2.29528
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.29032
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.27529
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.27252
TWSG1 twisted gastrulation BMP signaling modulator 1 2.27189
GPANK1 G patch domain and ankyrin repeats 1 2.26098
RGS8 regulator of G-protein signaling 8 2.25899
C2ORF57 chromosome 2 open reading frame 57 2.2518
VWC2 von Willebrand factor C domain containing 2 2.2335
GLS2 glutaminase 2 (liver, mitochondrial) 2.21602
FXR2 fragile X mental retardation, autosomal homolog 2 2.20708
TMEM200A transmembrane protein 200A 2.20637
EME2 essential meiotic structure-specific endonuclease subunit 2 2.2045
TLX2 T-cell leukemia homeobox 2 2.19762
ZNF606 zinc finger protein 606 2.19208
TAS1R3 taste receptor, type 1, member 3 2.19138
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2.18855
OCLN occludin 2.18469
TENM3 teneurin transmembrane protein 3 2.18234
ARHGAP10 Rho GTPase activating protein 10 2.18049
SGPP1 sphingosine-1-phosphate phosphatase 1 2.1803
HID1 HID1 domain containing 2.17639
LMF1 lipase maturation factor 1 2.17537
AIRE autoimmune regulator 2.17279
KRTAP11-1 keratin associated protein 11-1 2.17176
NPPC natriuretic peptide C 2.1674
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.15747
OLFML2A olfactomedin-like 2A 2.14733
CNIH3 cornichon family AMPA receptor auxiliary protein 3 2.14545
OR11H6 olfactory receptor, family 11, subfamily H, member 6 2.14113
PWWP3B PWWP domain containing 3B 2.129
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.12158
SH3D19 SH3 domain containing 19 2.11917
ZFYVE28 zinc finger, FYVE domain containing 28 2.11767
TRIM41 tripartite motif containing 41 2.11725
TPD52L1 tumor protein D52-like 1 2.11694
LOXHD1 lipoxygenase homology domains 1 2.11498
OR10G2 olfactory receptor, family 10, subfamily G, member 2 2.11085
ELMO2 engulfment and cell motility 2 2.11015
RAP1GAP RAP1 GTPase activating protein 2.11009
DMRTA2 DMRT-like family A2 2.10702
CACNG7 calcium channel, voltage-dependent, gamma subunit 7 2.10585
ART5 ADP-ribosyltransferase 5 2.10408
SLX4IP SLX4 interacting protein 2.09042
TMC8 transmembrane channel-like 8 2.08873
OR5K4 olfactory receptor, family 5, subfamily K, member 4 2.08324
TMEM132A transmembrane protein 132A 2.08273
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.07549
LINGO2 leucine rich repeat and Ig domain containing 2 2.0731
DNAH2 dynein, axonemal, heavy chain 2 2.07126
IL17F interleukin 17F 2.06872
TLR3 toll-like receptor 3 2.06732
FYB1 FYN binding protein 1 2.05917
TSHR thyroid stimulating hormone receptor 2.05435
TREM1 triggering receptor expressed on myeloid cells 1 2.05133
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 2.05089
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 2.04729
FKBP8 FK506 binding protein 8, 38kDa 2.04468
EDNRA endothelin receptor type A 2.04291
OR10V1 olfactory receptor, family 10, subfamily V, member 1 2.04131
RBP1 retinol binding protein 1, cellular 2.04045
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.03893
S100Z S100 calcium binding protein Z 2.03387
WDTC1 WD and tetratricopeptide repeats 1 2.0322
SNPH syntaphilin 2.02741
CDA cytidine deaminase 2.02004
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 2.01177
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 2.01002
INMT indolethylamine N-methyltransferase 2.00896
TRIM61 tripartite motif containing 61 2.00628
TUBB6 tubulin, beta 6 class V 2.00288
C11ORF71 chromosome 11 open reading frame 71 2.00218
UMODL1 uromodulin-like 1 2.0017