| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11752486 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in HMB-Val-Ser-Leu-VE relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 2.77 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 2.68 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 2.21 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 1.4 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 1.06 |
| PEX2 | peroxisomal biogenesis factor 2 | 1.04 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.83 |
| FAM193B | family with sequence similarity 193, member B | 0.83 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.8 |
| AMPD1 | adenosine monophosphate deaminase 1 | 0.77 |
| ZNF335 | zinc finger protein 335 | 0.74 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.69 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.69 |
| DENND4B | DENN/MADD domain containing 4B | 0.6 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | 0.58 |
| SORT1 | sortilin 1 | 0.58 |
| ZNF354A | zinc finger protein 354A | 0.55 |
| AGRN | agrin | 0.54 |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.54 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.53 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | 0.5 |
| IFT22 | intraflagellar transport 22 | 0.48 |
| GALNT4 | polypeptide N-acetylgalactosaminyltransferase 4 | 0.47 |
| TTC27 | tetratricopeptide repeat domain 27 | 0.47 |
| MRC2 | mannose receptor, C type 2 | 0.46 |
| EPHX4 | epoxide hydrolase 4 | 0.46 |
| PRXL2A | peroxiredoxin like 2A | 0.46 |
| CEP112 | centrosomal protein 112kDa | 0.46 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | 0.45 |
| EBAG9 | estrogen receptor binding site associated, antigen, 9 | 0.45 |
| IMPACT | impact RWD domain protein | 0.45 |
| ZNF581 | zinc finger protein 581 | 0.45 |
| E4F1 | E4F transcription factor 1 | 0.45 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.45 |
| IL17RB | interleukin 17 receptor B | 0.44 |
| TMEM101 | transmembrane protein 101 | 0.44 |
| GSTO2 | glutathione S-transferase omega 2 | 0.43 |
| ARL13B | ADP-ribosylation factor-like 13B | 0.42 |
| LAMA3 | laminin, alpha 3 | 0.42 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 0.41 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.41 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.41 |
| POTEI | POTE ankyrin domain family, member I | 0.4 |
| NAGS | N-acetylglutamate synthase | 0.4 |
| ENO1 | enolase 1, (alpha) | 0.4 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | 0.39 |
| NDST1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.39 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 0.39 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.38 |
| LRP1 | low density lipoprotein receptor-related protein 1 | 0.38 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | 0.38 |
| ZNF57 | zinc finger protein 57 | 0.37 |
| KANK3 | KN motif and ankyrin repeat domains 3 | 0.37 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.37 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | 0.37 |
| CTSA | cathepsin A | 0.36 |
| AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | 0.36 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.36 |
| HOMEZ | homeobox and leucine zipper encoding | 0.35 |
| TRIM37 | tripartite motif containing 37 | 0.35 |
| DNAJC14 | DnaJ (Hsp40) homolog, subfamily C, member 14 | 0.34 |
| SNAPC2 | small nuclear RNA activating complex, polypeptide 2, 45kDa | 0.34 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.34 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | 0.34 |
| RNF149 | ring finger protein 149 | 0.34 |
| CFAP410 | cilia and flagella associated protein 410 | 0.34 |
| JAG2 | jagged 2 | 0.34 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.33 |
| ZHX1 | zinc fingers and homeoboxes 1 | 0.33 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.33 |
| HLA-E | major histocompatibility complex, class I, E | 0.33 |
| TBC1D14 | TBC1 domain family, member 14 | 0.33 |
| MAPK12 | mitogen-activated protein kinase 12 | 0.33 |
| PVR | poliovirus receptor | 0.32 |
| CST6 | cystatin E/M | 0.32 |
| ATP5MG | ATP synthase membrane subunit g | 0.32 |
| RGS19 | regulator of G-protein signaling 19 | 0.32 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | 0.32 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.32 |
| CTSL | cathepsin L | 0.32 |
| MPZL2 | myelin protein zero-like 2 | 0.32 |
| GRAMD2A | GRAM domain containing 2A | 0.32 |
| BAHD1 | bromo adjacent homology domain containing 1 | 0.32 |
| MYOM3 | myomesin 3 | 0.32 |
| SNX13 | sorting nexin 13 | 0.32 |
| BCLAF3 | BCLAF1 and THRAP3 family member 3 | 0.31 |
| C1ORF198 | chromosome 1 open reading frame 198 | 0.31 |
| ESRRA | estrogen-related receptor alpha | 0.31 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.31 |
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.31 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.31 |
| POLK | polymerase (DNA directed) kappa | 0.31 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | 0.31 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.31 |
| NKAP | NFKB activating protein | 0.3 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.3 |
| ZBED5 | zinc finger, BED-type containing 5 | 0.3 |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.3 |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.3 |
| CTSB | cathepsin B | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTOV1 | prostate tumor overexpressed 1 | -0.81 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.63 |
| TLCD4 | TLC domain containing 4 | -0.61 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.6 |
| ZNF711 | zinc finger protein 711 | -0.57 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 | -0.57 |
| TMEM14C | transmembrane protein 14C | -0.53 |
| NRBF2 | nuclear receptor binding factor 2 | -0.52 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.51 |
| ZNF431 | zinc finger protein 431 | -0.5 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.5 |
| MRPL52 | mitochondrial ribosomal protein L52 | -0.48 |
| SAP30L | SAP30-like | -0.44 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.43 |
| ONECUT2 | one cut homeobox 2 | -0.42 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.42 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | -0.42 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -0.41 |
| ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 | -0.4 |
| GRAMD4 | GRAM domain containing 4 | -0.4 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.39 |
| ITPKB | inositol-trisphosphate 3-kinase B | -0.39 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.39 |
| S100A16 | S100 calcium binding protein A16 | -0.38 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.37 |
| TPM1 | tropomyosin 1 (alpha) | -0.37 |
| UBN2 | ubinuclein 2 | -0.37 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.36 |
| IL10RB | interleukin 10 receptor, beta | -0.36 |
| PSMG4 | proteasome (prosome, macropain) assembly chaperone 4 | -0.36 |
| LETMD1 | LETM1 domain containing 1 | -0.34 |
| ZNF185 | zinc finger protein 185 (LIM domain) | -0.34 |
| S100A5 | S100 calcium binding protein A5 | -0.34 |
| CDK18 | cyclin-dependent kinase 18 | -0.34 |
| ZNF611 | zinc finger protein 611 | -0.33 |
| LYRM1 | LYR motif containing 1 | -0.33 |
| EMP3 | epithelial membrane protein 3 | -0.33 |
| ANKRD36 | ankyrin repeat domain 36 | -0.33 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.33 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.32 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.31 |
| CIC | capicua transcriptional repressor | -0.31 |
| TMC4 | transmembrane channel-like 4 | -0.31 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.3 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.3 |
| CCNE2 | cyclin E2 | -0.3 |
| ADIRF | adipogenesis regulatory factor | -0.3 |
| TP73 | tumor protein p73 | -0.29 |
| GABPB2 | GA binding protein transcription factor, beta subunit 2 | -0.29 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | -0.29 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | -0.29 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | -0.29 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.29 |
| KMT5B | lysine methyltransferase 5B | -0.29 |
| OSMR | oncostatin M receptor | -0.29 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | -0.28 |
| BAX | BCL2-associated X protein | -0.28 |
| ZBTB5 | zinc finger and BTB domain containing 5 | -0.28 |
| ZNF557 | zinc finger protein 557 | -0.28 |
| C16ORF70 | chromosome 16 open reading frame 70 | -0.28 |
| DENND11 | DENN domain containing 11 | -0.28 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.28 |
| USP31 | ubiquitin specific peptidase 31 | -0.28 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | -0.28 |
| ASTE1 | asteroid homolog 1 (Drosophila) | -0.28 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.28 |
| PXN | paxillin | -0.27 |
| FAM234A | family with sequence similarity 234 member A | -0.27 |
| MZT2B | mitotic spindle organizing protein 2B | -0.27 |
| NFYA | nuclear transcription factor Y, alpha | -0.27 |
| ACTBL2 | actin, beta-like 2 | -0.27 |
| YIF1B | Yip1 interacting factor homolog B (S. cerevisiae) | -0.26 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -0.26 |
| CLCN5 | chloride channel, voltage-sensitive 5 | -0.26 |
| FGF19 | fibroblast growth factor 19 | -0.26 |
| C2CD3 | C2 calcium-dependent domain containing 3 | -0.26 |
| UBXN8 | UBX domain protein 8 | -0.26 |
| TBC1D13 | TBC1 domain family, member 13 | -0.25 |
| TBC1D10B | TBC1 domain family, member 10B | -0.25 |
| HRH1 | histamine receptor H1 | -0.25 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -0.25 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.25 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | -0.25 |
| ANGPTL4 | angiopoietin-like 4 | -0.25 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.25 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.25 |
| PLAUR | plasminogen activator, urokinase receptor | -0.24 |
| SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28 | -0.24 |
| AKTIP | AKT interacting protein | -0.24 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | -0.24 |
| KIAA1191 | KIAA1191 | -0.24 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.24 |
| CCNYL1 | cyclin Y-like 1 | -0.24 |
| ZNF700 | zinc finger protein 700 | -0.24 |
| SCAND1 | SCAN domain containing 1 | -0.24 |
| FKBP14 | FK506 binding protein 14, 22 kDa | -0.23 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.23 |
| DENND2D | DENN/MADD domain containing 2D | -0.23 |
| BTN2A1 | butyrophilin, subfamily 2, member A1 | -0.23 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | -0.23 |
