HMGA1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description high mobility group AT-hook 1|This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3159)
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Genes

325 genes differentially expressed following the HMGA1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LDHAL6A lactate dehydrogenase A-like 6A 3.24509
TMEM229A transmembrane protein 229A 3.24509
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.24509
SLC39A5 solute carrier family 39 (zinc transporter), member 5 3.24509
IL12RB1 interleukin 12 receptor, beta 1 3.24509
MAGEB2 melanoma antigen family B2 3.24509
TPSB2 tryptase beta 2 (gene/pseudogene) 3.24509
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.24509
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.24509
SBSN suprabasin 3.24509
LAMP3 lysosomal-associated membrane protein 3 3.24509
CLDN5 claudin 5 3.24509
PSKH2 protein serine kinase H2 3.24509
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.24509
TM4SF20 transmembrane 4 L six family member 20 3.24509
COLEC10 collectin sub-family member 10 (C-type lectin) 3.24509
EBF3 early B-cell factor 3 3.24509
CFAP206 cilia and flagella associated protein 206 3.24509
HMX1 H6 family homeobox 1 3.24509
SLC22A14 solute carrier family 22, member 14 3.24509
ZNF99 zinc finger protein 99 3.24509
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 3.24509
DUXB double homeobox B 3.22656
PI16 peptidase inhibitor 16 3.22656
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 3.22656
DDN dendrin 3.22656
CD19 CD19 molecule 3.22656
NANOS2 nanos homolog 2 (Drosophila) 3.22656
CXORF65 chromosome X open reading frame 65 3.22656
ACVRL1 activin A receptor type II-like 1 3.22656
DPEP2 dipeptidase 2 3.22656
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.22656
PCDHB4 protocadherin beta 4 3.22656
OLIG1 oligodendrocyte transcription factor 1 3.22656
LMO1 LIM domain only 1 (rhombotin 1) 3.22656
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.22656
MEIG1 meiosis/spermiogenesis associated 1 3.22656
DEFB124 defensin, beta 124 3.22656
ARPP21 cAMP-regulated phosphoprotein, 21kDa 3.22656
ERLIN2 ER lipid raft associated 2 3.22656
F2 coagulation factor II (thrombin) 3.22656
TMEM121 transmembrane protein 121 3.22656
GIMD1 GIMAP family P-loop NTPase domain containing 1 3.22656
ARHGAP36 Rho GTPase activating protein 36 3.22656
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.22656
RFPL3 ret finger protein-like 3 3.22656
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.22656
PAX4 paired box 4 3.22656
PAX5 paired box 5 3.22656
PLCH2 phospholipase C, eta 2 3.22656
FAM156B family with sequence similarity 156, member B 3.22656
TAS2R1 taste receptor, type 2, member 1 3.22656
GFI1 growth factor independent 1 transcription repressor 3.22656
RFPL2 ret finger protein-like 2 3.22656
MYO16 myosin XVI 3.22656
ZNF503 zinc finger protein 503 3.22656
KRT86 keratin 86, type II 3.22656
FMO2 flavin containing monooxygenase 2 (non-functional) 3.22656
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 3.22656
TMPRSS4 transmembrane protease, serine 4 3.22656
NHLH1 nescient helix loop helix 1 3.22656
BDKRB2 bradykinin receptor B2 3.22656
NDP Norrie disease (pseudoglioma) 3.22656
HNF1B HNF1 homeobox B 3.22656
RAG1 recombination activating gene 1 3.22656
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.22656
CIMIP7 ciliary microtubule inner protein 7 3.22656
LOC124906010 uncharacterized LOC124906010 3.22656
H3C13 H3 clustered histone 13 3.22656
ATP5MGL ATP synthase membrane subunit g like 3.22656
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.22656
RTL9 retrotransposon Gag like 9 3.22656
NSG2 neuronal vesicle trafficking associated 2 3.22656
SQOR sulfide quinone oxidoreductase 3.22656
PXDC1 PX domain containing 1 3.22656
FGFBP2 fibroblast growth factor binding protein 2 3.22656
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.22656
GRXCR1 glutaredoxin, cysteine rich 1 3.22656
ZRANB3 zinc finger, RAN-binding domain containing 3 3.22656
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.22656
HLF hepatic leukemia factor 3.22656
LRRD1 leucine-rich repeats and death domain containing 1 3.22656
CARD16 caspase recruitment domain family, member 16 3.22656
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 3.22656
RAB44 RAB44, member RAS oncogene family 3.22656
CLDN9 claudin 9 3.22656
PGA4 pepsinogen 4, group I (pepsinogen A) 3.22656
TACR2 tachykinin receptor 2 3.22656
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 3.22656
SPDYC speedy/RINGO cell cycle regulator family member C 3.22656
MYOG myogenin (myogenic factor 4) 3.22656
TBX5 T-box 5 3.22656
CXCL16 chemokine (C-X-C motif) ligand 16 3.22656
CLDN2 claudin 2 3.22656
DRC11L dynein regulatory complex subunit 11 like 3.22656
MYO1G myosin IG 3.22656
SLFN12L schlafen family member 12-like 3.22656
GOLGA6A golgin A6 family, member A 3.22656
TREH trehalase (brush-border membrane glycoprotein) 3.22656
CDH19 cadherin 19, type 2 3.22656
CYS1 cystin 1 3.22656
MUCL1 mucin-like 1 3.22656
WNT7A wingless-type MMTV integration site family, member 7A 3.22656
MCCD1 mitochondrial coiled-coil domain 1 3.22656
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 3.22656
CYSLTR1 cysteinyl leukotriene receptor 1 3.22656
ADGRA1 adhesion G protein-coupled receptor A1 3.22656
PRSS57 protease, serine, 57 3.22656
HSF4 heat shock transcription factor 4 3.22656
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.22656
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.22656
SLA2 Src-like-adaptor 2 3.22656
AKR1B15 aldo-keto reductase family 1, member B15 3.22656
CNTF ciliary neurotrophic factor 3.22656
HCRT hypocretin (orexin) neuropeptide precursor 3.22656
STAB1 stabilin 1 3.22656
FGA fibrinogen alpha chain 3.22656
RBM24 RNA binding motif protein 24 3.22656
IL27 interleukin 27 3.22656
GJB6 gap junction protein, beta 6, 30kDa 3.22656
SIDT1 SID1 transmembrane family, member 1 3.22656
FAM151A family with sequence similarity 151, member A 3.22656
CNR2 cannabinoid receptor 2 (macrophage) 3.22656
C10ORF105 chromosome 10 open reading frame 105 3.22656
DRC7 dynein regulatory complex subunit 7 3.22656
BTG4 B-cell translocation gene 4 3.22656
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.22656
NYX nyctalopin 3.22656
PDCD1LG2 programmed cell death 1 ligand 2 3.22656
DMRT1 doublesex and mab-3 related transcription factor 1 3.22656
SYNGR4 synaptogyrin 4 3.22656
F13B coagulation factor XIII, B polypeptide 3.22656
OR4D2 olfactory receptor, family 4, subfamily D, member 2 3.22656
DND1 DND microRNA-mediated repression inhibitor 1 3.22656
CD28 CD28 molecule 3.22656
PRAC2 prostate cancer susceptibility candidate 2 3.22656
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.22656
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.22656
THEM6 thioesterase superfamily member 6 3.22656
LYZL1 lysozyme-like 1 3.22656
TEX35 testis expressed 35 3.22656
FRMPD1 FERM and PDZ domain containing 1 3.22656
PF4V1 platelet factor 4 variant 1 3.22656
SP6 Sp6 transcription factor 3.22656
CHIA chitinase, acidic 3.22656
IFITM10 interferon induced transmembrane protein 10 3.22656
PITX3 paired-like homeodomain 3 3.22656
TPPP tubulin polymerization promoting protein 3.22656
CD33 CD33 molecule 3.22656
CD34 CD34 molecule 3.22656
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.22656
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 3.22656
LEP leptin 3.22656
SNTN sentan, cilia apical structure protein 3.22656
OR4D10 olfactory receptor, family 4, subfamily D, member 10 3.22656
EBI3 Epstein-Barr virus induced 3 3.22656
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.22656
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.22656
TMC8 transmembrane channel-like 8 3.22656
DBX2 developing brain homeobox 2 3.22656
POTEE POTE ankyrin domain family, member E 3.22656
LRRC74B leucine rich repeat containing 74B 3.22656
RAP1GAP RAP1 GTPase activating protein 3.22478
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 3.11702
TMOD1 tropomodulin 1 3.0971
PCNT pericentrin 2.74451
GRIK4 glutamate receptor, ionotropic, kainate 4 2.72849
CEP192 centrosomal protein 192kDa 2.68827
RAD18 RAD18 E3 ubiquitin protein ligase 2.64254
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.61499
LYRM9 LYR motif containing 9 2.60434
SH3PXD2A SH3 and PX domains 2A 2.59849
SH3RF2 SH3 domain containing ring finger 2 2.57448
TTC33 tetratricopeptide repeat domain 33 2.56441
NFE2L3 nuclear factor, erythroid 2-like 3 2.52961
VEPH1 ventricular zone expressed PH domain-containing 1 2.48669
GPR173 G protein-coupled receptor 173 2.48669
IL6ST interleukin 6 signal transducer 2.47416
TTC5 tetratricopeptide repeat domain 5 2.42547
MEDAG mesenteric estrogen-dependent adipogenesis 2.42204
DNAAF4 dynein axonemal assembly factor 4 2.40517
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.36848
SETD2 SET domain containing 2 2.36786
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.36347
CARD18 caspase recruitment domain family, member 18 2.34691
RNF169 ring finger protein 169 2.33831
FER1L5 fer-1-like family member 5 2.31301
CHD5 chromodomain helicase DNA binding protein 5 2.30957
PRRT4 proline-rich transmembrane protein 4 2.30496
MAGIX MAGI family member, X-linked 2.30496
TMEM161B transmembrane protein 161B 2.27266
TEAD2 TEA domain family member 2 2.24384
GAL galanin/GMAP prepropeptide 2.24012
ETFRF1 electron transfer flavoprotein regulatory factor 1 2.23323
SMIM29 small integral membrane protein 29 2.23323
LAGE3 L antigen family, member 3 2.22534
EIF4H eukaryotic translation initiation factor 4H 2.20366
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 2.19072
ZNF579 zinc finger protein 579 2.19072
ZNF273 zinc finger protein 273 2.16151
AAMP angio-associated, migratory cell protein 2.14926
ZNF213 zinc finger protein 213 2.13578
STK38L serine/threonine kinase 38 like 2.13515
POLQ polymerase (DNA directed), theta 2.12353
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.11841
GOLT1B golgi transport 1B 2.11351
LINC02798 long intergenic non-protein coding RNA 2798 2.10858
GRB10 growth factor receptor-bound protein 10 2.10858
FAM78A family with sequence similarity 78, member A 2.10858
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 2.10858
GTSF1 gametocyte specific factor 1 2.10858
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 2.10525
CAB39 calcium binding protein 39 2.10525
GPR158 G protein-coupled receptor 158 2.09815
KLHDC4 kelch domain containing 4 2.07237
ERRFI1 ERBB receptor feedback inhibitor 1 2.06099
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 2.03843
HARS1 histidyl-tRNA synthetase 1 2.00168
SLC25A51 solute carrier family 25, member 51 2.00017
VEGFD vascular endothelial growth factor D 2.00017

decreased expression

Symbol Name Standardized Value
IDUA iduronidase, alpha-L- -3.24509
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -3.24509
HMGA1 high mobility group AT-hook 1 -3.24509
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -3.24509
GPR171 G protein-coupled receptor 171 -3.24509
NBPF10 neuroblastoma breakpoint family, member 10 -3.24509
MID2 midline 2 -3.22656
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -3.22656
KLF9 Kruppel-like factor 9 -3.22656
TIGD3 tigger transposable element derived 3 -3.22656
PDE1B phosphodiesterase 1B, calmodulin-dependent -3.22656
PCDHGB4 protocadherin gamma subfamily B, 4 -3.22656
MUSK muscle, skeletal, receptor tyrosine kinase -3.22656
CHD9 chromodomain helicase DNA binding protein 9 -3.22656
RUFY4 RUN and FYVE domain containing 4 -3.22656
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -3.22656
SHISA7 shisa family member 7 -3.22656
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -3.22656
TAL2 T-cell acute lymphocytic leukemia 2 -3.22656
MCFD2 multiple coagulation factor deficiency 2 -3.22656
MAMLD1 mastermind-like domain containing 1 -3.22656
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -3.22656
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -3.22656
CFAP126 cilia and flagella associated protein 126 -3.22656
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -3.22656
ADCY10 adenylate cyclase 10 (soluble) -3.22656
MYL7 myosin, light chain 7, regulatory -3.22656
DENND2D DENN/MADD domain containing 2D -3.22656
LIF leukemia inhibitory factor -3.22656
WDR31 WD repeat domain 31 -3.22656
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -3.22656
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -3.22656
ALKAL1 ALK and LTK ligand 1 -3.22656
SETDB1 SET domain, bifurcated 1 -3.22656
FSHR follicle stimulating hormone receptor -3.22656
FGF20 fibroblast growth factor 20 -3.22656
MAP6 microtubule-associated protein 6 -3.22656
PTX3 pentraxin 3, long -3.22656
CYTIP cytohesin 1 interacting protein -3.22656
DDIT3 DNA-damage-inducible transcript 3 -3.0971
TMEM183A transmembrane protein 183A -2.99295
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.98726
HIGD2A HIG1 hypoxia inducible domain family, member 2A -2.97136
TDRP testis development related protein -2.92099
ACOT13 acyl-CoA thioesterase 13 -2.72849
PIMREG PICALM interacting mitotic regulator -2.72828
FZD8 frizzled class receptor 8 -2.71484
GYPC glycophorin C (Gerbich blood group) -2.68763
ZNF480 zinc finger protein 480 -2.59849
RBM34 RNA binding motif protein 34 -2.59506
CFAP119 cilia and flagella associated protein 119 -2.59506
TFCP2L1 transcription factor CP2-like 1 -2.594
CCDC110 coiled-coil domain containing 110 -2.57791
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -2.55466
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.55264
CCDC125 coiled-coil domain containing 125 -2.54656
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I -2.53021
SLC49A3 solute carrier family 49 member 3 -2.51105
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 -2.47464
FHOD3 formin homology 2 domain containing 3 -2.47416
CCNG1 cyclin G1 -2.45859
DUSP14 dual specificity phosphatase 14 -2.45768
FBXO33 F-box protein 33 -2.45768
SEPTIN8 septin 8 -2.42587
FAM227B family with sequence similarity 227, member B -2.42575
KPNB1 karyopherin (importin) beta 1 -2.37432
ANK1 ankyrin 1, erythrocytic -2.35416
SSBP4 single stranded DNA binding protein 4 -2.33831
ZBTB26 zinc finger and BTB domain containing 26 -2.32299
CNOT6 CCR4-NOT transcription complex, subunit 6 -2.30496
LIPT2 lipoyl(octanoyl) transferase 2 (putative) -2.28297
PCCA propionyl CoA carboxylase, alpha polypeptide -2.26129
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.2571
IL23A interleukin 23, alpha subunit p19 -2.2571
RUFY1 RUN and FYVE domain containing 1 -2.22746
H2BC8 H2B clustered histone 8 -2.20532
MRPS2 mitochondrial ribosomal protein S2 -2.20366
AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 -2.20053
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.20053
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.19138
ELOA elongin A -2.15969
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 -2.15582
INSYN2B inhibitory synaptic factor family member 2B -2.15511
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.15511
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -2.15511
IFNAR2 interferon (alpha, beta and omega) receptor 2 -2.14999
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) -2.14678
FZD7 frizzled class receptor 7 -2.13482
UBE2B ubiquitin-conjugating enzyme E2B -2.12712
BCL2L11 BCL2-like 11 (apoptosis facilitator) -2.12488
NADK NAD kinase -2.11299
SERINC2 serine incorporator 2 -2.10877
ISCU iron-sulfur cluster assembly enzyme -2.08691
RPL13A ribosomal protein L13a -2.07739
YIPF2 Yip1 domain family, member 2 -2.07237
ZNF746 zinc finger protein 746 -2.07047
PPP1R13B protein phosphatase 1, regulatory subunit 13B -2.06574
GPN3 GPN-loop GTPase 3 -2.05955
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.05423
RHOBTB1 Rho-related BTB domain containing 1 -2.04739
BSG basigin (Ok blood group) -2.03801
R3HDM2 R3H domain containing 2 -2.01959
DLL3 delta-like 3 (Drosophila) -2.00955
PTGES3L prostaglandin E synthase 3 (cytosolic)-like -2.00955
RTKN2 rhotekin 2 -2.00017