HMOX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description heme oxygenase 1|Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3162)
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Genes

356 genes differentially expressed following the HMOX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ALPK2 alpha-kinase 2 2.4093
MYO1G myosin IG 2.4093
CPLX4 complexin 4 2.4093
ACE2 angiotensin I converting enzyme 2 2.4093
SP1 Sp1 transcription factor 2.4093
NWD2 NACHT and WD repeat domain containing 2 2.4093
CCDC42 coiled-coil domain containing 42 2.4093
EPHB3 EPH receptor B3 2.4093
BOLA2 bolA family member 2 2.4093
EMCN endomucin 2.4093
FGFBP2 fibroblast growth factor binding protein 2 2.4093
HBM hemoglobin, mu 2.4093
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.4093
PECAM1 platelet/endothelial cell adhesion molecule 1 2.4093
HCRTR2 hypocretin (orexin) receptor 2 2.4093
TRIM74 tripartite motif containing 74 2.4093
ANKRD34A ankyrin repeat domain 34A 2.4093
BSX brain-specific homeobox 2.4093
FOXI2 forkhead box I2 2.4093
S100P S100 calcium binding protein P 2.4093
CELA1 chymotrypsin-like elastase family, member 1 2.4093
HMGN3 high mobility group nucleosomal binding domain 3 2.4093
FGF7 fibroblast growth factor 7 2.4093
CCDC83 coiled-coil domain containing 83 2.4093
MYOZ2 myozenin 2 2.4093
TMPRSS6 transmembrane protease, serine 6 2.4093
SETD1A SET domain containing 1A 2.4093
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.4093
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 2.4093
TMIGD1 transmembrane and immunoglobulin domain containing 1 2.4093
KCTD7 potassium channel tetramerization domain containing 7 2.4093
ZPLD1 zona pellucida-like domain containing 1 2.4093
DNAAF1 dynein, axonemal, assembly factor 1 2.4093
NLRP6 NLR family, pyrin domain containing 6 2.4093
PASD1 PAS domain containing 1 2.4093
BDKRB1 bradykinin receptor B1 2.4093
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 2.4093
METTL21C methyltransferase like 21C 2.4093
PODN podocan 2.4093
DSPP dentin sialophosphoprotein 2.4093
IMPG1 interphotoreceptor matrix proteoglycan 1 2.4093
FXYD3 FXYD domain containing ion transport regulator 3 2.4093
WFDC11 WAP four-disulfide core domain 11 2.4093
GC group-specific component (vitamin D binding protein) 2.4093
ANKRD30A ankyrin repeat domain 30A 2.4093
SPNS3 spinster homolog 3 (Drosophila) 2.4093
TCF23 transcription factor 23 2.4093
LOC124901449 uncharacterized LOC124901449 2.4093
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.4093
LRRD1 leucine-rich repeats and death domain containing 1 2.4093
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.4093
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.4093
ZNF492 zinc finger protein 492 2.4093
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.4093
TOR4A torsin family 4, member A 2.4093
FBXL8 F-box and leucine-rich repeat protein 8 2.4093
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.4093
WNT11 wingless-type MMTV integration site family, member 11 2.4093
AGTR1 angiotensin II receptor, type 1 2.4093
FOXL1 forkhead box L1 2.4093
PTGDR2 prostaglandin D2 receptor 2 2.4093
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.4093
TUBA3D tubulin, alpha 3d 2.4093
OASL 2'-5'-oligoadenylate synthetase-like 2.4093
SECTM1 secreted and transmembrane 1 2.4093
TBX22 T-box 22 2.4093
TAS2R5 taste receptor, type 2, member 5 2.4093
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.4093
PLVAP plasmalemma vesicle associated protein 2.4093
GNLY granulysin 2.4093
IL6 interleukin 6 2.4093
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.4093
IL17RE interleukin 17 receptor E 2.4093
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.4093
NPSR1 neuropeptide S receptor 1 2.4093
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.4093
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 2.4093
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.4093
SIGLEC9 sialic acid binding Ig-like lectin 9 2.4093
MYOT myotilin 2.4093
DDN dendrin 2.4093
TBX3 T-box 3 2.4093
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.4093
SPINK6 serine peptidase inhibitor, Kazal type 6 2.4093
NANOS2 nanos homolog 2 (Drosophila) 2.4093
TMEM176B transmembrane protein 176B 2.4093
CENPB centromere protein B, 80kDa 2.4093
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.4093
RAX retina and anterior neural fold homeobox 2.4093
EPPIN epididymal peptidase inhibitor 2.4093
GZMM granzyme M (lymphocyte met-ase 1) 2.4093
MILR1 mast cell immunoglobulin-like receptor 1 2.4093
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.4093
SNX31 sorting nexin 31 2.4093
SST somatostatin 2.4093
SIRPD signal-regulatory protein delta 2.4093
SAMD5 sterile alpha motif domain containing 5 2.4093
C21ORF140 chromosome 21 open reading frame 140 2.4093
IL9R interleukin 9 receptor 2.4093
FGR FGR proto-oncogene, Src family tyrosine kinase 2.4093
RIPPLY1 ripply transcriptional repressor 1 2.4093
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.4093
DLX3 distal-less homeobox 3 2.4093
TTC17 tetratricopeptide repeat domain 17 2.4093
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.4093
IL19 interleukin 19 2.4093
GARIN6 golgi associated RAB2 interactor family member 6 2.4093
CGB2 chorionic gonadotropin, beta polypeptide 2 2.4093
DRD2 dopamine receptor D2 2.4093
MCCD1 mitochondrial coiled-coil domain 1 2.4093
IFITM5 interferon induced transmembrane protein 5 2.4093
CCDC179 coiled-coil domain containing 179 2.4093
MUC15 mucin 15, cell surface associated 2.4093
DNAAF6 dynein axonemal assembly factor 6 2.4093
LTA4H leukotriene A4 hydrolase 2.4093
OTOP3 otopetrin 3 2.4093
NT5C1B 5'-nucleotidase, cytosolic IB 2.4093
NOBOX NOBOX oogenesis homeobox 2.4093
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.4093
WASH8P WAS protein family homolog 8, pseudogene 2.4093
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 2.4093
ADCY4 adenylate cyclase 4 2.4093
LY6S lymphocyte antigen 6 family member S 2.4093
OR1R1 olfactory receptor family 1 subfamily R member 1 2.4093
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.4093
GOLGA8R golgin A8 family, member R 2.4093
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.4093
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.4093
KLHDC3 kelch domain containing 3 2.4093
POU4F1 POU class 4 homeobox 1 2.4093
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.4093
GLYATL1B glycine-N-acyltransferase like 1B 2.4093
SLC38A8 solute carrier family 38, member 8 2.4093
CD27 CD27 molecule 2.4093
TRIM7 tripartite motif containing 7 2.4093
LGALS12 lectin, galactoside-binding, soluble, 12 2.4093
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.4093
GREP1 glycine rich extracellular protein 1 2.4093
CPNE8-AS1 CPNE8 antisense RNA 1 2.4093
RGS13 regulator of G-protein signaling 13 2.4093
ADGRG7 adhesion G protein-coupled receptor G7 2.4093
TECRL trans-2,3-enoyl-CoA reductase-like 2.4093
CARD9 caspase recruitment domain family, member 9 2.4093
SUN5 Sad1 and UNC84 domain containing 5 2.4093
STMND1 stathmin domain containing 1 2.4093
TTLL13 tubulin tyrosine ligase like 13 2.4093
KIF4B kinesin family member 4B 2.4093
ZMYND10 zinc finger, MYND-type containing 10 2.4093
MAGEB17 melanoma antigen family B17 2.4093
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.4093
NUTM2A NUT family member 2A 2.4093
ALPG alkaline phosphatase, germ cell 2.4093
ACP3 acid phosphatase 3 2.4093
SYTL4 synaptotagmin-like 4 2.4093
PLG plasminogen 2.4093
SNTN sentan, cilia apical structure protein 2.4093
ARX aristaless related homeobox 2.4093
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.4093
TLCD2 TLC domain containing 2 2.4093
MT1A metallothionein 1A 2.4093
PXT1 peroxisomal, testis specific 1 2.4093
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.4093
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.4093
KRT15 keratin 15, type I 2.4093
SPATA3 spermatogenesis associated 3 2.4093
FHIP1A FHF complex subunit HOOK interacting protein 1A 2.4093
SOFU1 sperm-oocyte fusion factor 1 2.4093
GRK7 G protein-coupled receptor kinase 7 2.4093
VNN2 vanin 2 2.4093
HDGFL1 hepatoma derived growth factor-like 1 2.4093
H1-8 H1.8 linker histone 2.4093
CALHM1 calcium homeostasis modulator 1 2.4093
TDRD10 tudor domain containing 10 2.4093
EWSR1 EWS RNA-binding protein 1 2.4093
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.4093
SUPT20HL2 suppressor of Ty 20 homolog (S. cerevisiae)-like 2 2.4093
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.4093
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.4093
CLXN calaxin 2.4093
IL17REL interleukin 17 receptor E-like 2.4093
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.4093
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.4093
APLNR apelin receptor 2.4093
PLPP4 phospholipid phosphatase 4 2.4093
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.4093
MPZL3 myelin protein zero-like 3 2.39406
RECQL5 RecQ protein-like 5 2.36036
ZFR zinc finger RNA binding protein 2.36036
TMPRSS7 transmembrane protease, serine 7 2.36036
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 2.36036
CHD9 chromodomain helicase DNA binding protein 9 2.35931
LYPD6 LY6/PLAUR domain containing 6 2.33639
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 2.33389
DIAPH1 diaphanous-related formin 1 2.32974
MYEF2 myelin expression factor 2 2.29807
KLHL9 kelch-like family member 9 2.29508
MEIS3 Meis homeobox 3 2.2818
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.27163
OAT ornithine aminotransferase 2.27163
TBX10 T-box 10 2.26684
KCTD6 potassium channel tetramerization domain containing 6 2.26684
RAD21 RAD21 homolog (S. pombe) 2.26684
MGAM maltase-glucoamylase 2.26684
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.2539
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.24877
ZNF613 zinc finger protein 613 2.2394
RAB12 RAB12, member RAS oncogene family 2.23161
CDK9 cyclin-dependent kinase 9 2.23014
KRT8 keratin 8, type II 2.23014
PLEC plectin 2.23014
THY1 Thy-1 cell surface antigen 2.22867
TMEM106C transmembrane protein 106C 2.20866
FKBP1A FK506 binding protein 1A, 12kDa 2.20276
SNX2 sorting nexin 2 2.19039
ZNF43 zinc finger protein 43 2.18831
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.17794
KLF9 Kruppel-like factor 9 2.16804
MXD1 MAX dimerization protein 1 2.16804
LXN latexin 2.16804
SH3GL1 SH3-domain GRB2-like 1 2.16804
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 2.15917
RUFY1 RUN and FYVE domain containing 1 2.12951
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.12347
STXBP5 syntaxin binding protein 5 (tomosyn) 2.12262
ASB7 ankyrin repeat and SOCS box containing 7 2.1191
PHETA1 PH domain containing endocytic trafficking adaptor 1 2.11906
TPBG trophoblast glycoprotein 2.09548
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 2.09536
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 2.08061
CLPTM1L CLPTM1-like 2.08061
WNT5A wingless-type MMTV integration site family, member 5A 2.06647
PPT1 palmitoyl-protein thioesterase 1 2.06437
SERTAD1 SERTA domain containing 1 2.06379
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 2.06379
TRAF3 TNF receptor-associated factor 3 2.06114
EML4 echinoderm microtubule associated protein like 4 2.06033
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 2.05103
ZBTB11 zinc finger and BTB domain containing 11 2.0456
ZDHHC2 zinc finger, DHHC-type containing 2 2.04304
SRCAP Snf2-related CREBBP activator protein 2.03245
CA14 carbonic anhydrase XIV 2.03245
CHSY1 chondroitin sulfate synthase 1 2.03051
RDM1 RAD52 motif containing 1 2.02282
SGSH N-sulfoglucosamine sulfohydrolase 2.01095
LIF leukemia inhibitory factor 2.01095
HNRNPR heterogeneous nuclear ribonucleoprotein R 2.00496
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.00282

decreased expression

Symbol Name Standardized Value
RAD51AP2 RAD51 associated protein 2 -2.4093
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -2.4093
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -2.4093
MORC3 MORC family CW-type zinc finger 3 -2.4093
ECE2 endothelin converting enzyme 2 -2.4093
CHD7 chromodomain helicase DNA binding protein 7 -2.4093
EXOG endo/exonuclease (5'-3'), endonuclease G-like -2.4093
MROH5 maestro heat-like repeat family member 5 -2.4093
RLN1 relaxin 1 -2.4093
AGBL1 ATP/GTP binding protein-like 1 -2.4093
C22ORF23 chromosome 22 open reading frame 23 -2.4093
CNOT6L CCR4-NOT transcription complex, subunit 6-like -2.4093
BKGD beta-keto-L-gulonate decarboxylase -2.4093
PCDHGA9 protocadherin gamma subfamily A, 9 -2.4093
TSSK6 testis-specific serine kinase 6 -2.4093
EFNA3 ephrin-A3 -2.4093
SPMIP8 sperm microtubule inner protein 8 -2.4093
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.4093
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.4093
YARS1 tyrosyl-tRNA synthetase 1 -2.4093
FAM217A family with sequence similarity 217, member A -2.3873
HSPA4 heat shock 70kDa protein 4 -2.37
GNRHR gonadotropin-releasing hormone receptor -2.36036
CRYGB crystallin, gamma B -2.36036
AKR1C2 aldo-keto reductase family 1, member C2 -2.36036
KL klotho -2.36036
PSCA prostate stem cell antigen -2.36036
COPZ2 coatomer protein complex, subunit zeta 2 -2.36036
TRIM15 tripartite motif containing 15 -2.36036
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) -2.36036
IRF8 interferon regulatory factor 8 -2.36036
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.36036
AMBP alpha-1-microglobulin/bikunin precursor -2.36036
FAM90A1 family with sequence similarity 90, member A1 -2.36036
GDNF glial cell derived neurotrophic factor -2.36036
RGPD4 RANBP2-like and GRIP domain containing 4 -2.36036
SLC23A3 solute carrier family 23, member 3 -2.36036
ZNF804A zinc finger protein 804A -2.36036
NR4A3 nuclear receptor subfamily 4, group A, member 3 -2.36036
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) -2.36036
MAP3K19 mitogen-activated protein kinase kinase kinase 19 -2.36036
TRIM52 tripartite motif containing 52 -2.36036
CER1 cerberus 1, DAN family BMP antagonist -2.36036
TBXT T-box transcription factor T -2.36036
H2BW2 H2B.W histone 2 -2.36036
ITGA10 integrin, alpha 10 -2.36036
CPHXL cytoplasmic polyadenylated homeobox like -2.36036
CDH24 cadherin 24, type 2 -2.36036
CDH22 cadherin 22, type 2 -2.36036
DNAAF19 dynein axonemal assembly factor 19 -2.36036
PDF peptide deformylase (mitochondrial) -2.36036
RSAD2 radical S-adenosyl methionine domain containing 2 -2.36036
NHLRC4 NHL repeat containing 4 -2.36036
SPDEF SAM pointed domain containing ETS transcription factor -2.36036
PSD2 pleckstrin and Sec7 domain containing 2 -2.36036
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.36036
LRRC73 leucine rich repeat containing 73 -2.36036
DLK2 delta-like 2 homolog (Drosophila) -2.36036
WFDC10A WAP four-disulfide core domain 10A -2.36036
LIMS2 LIM and senescent cell antigen-like domains 2 -2.36036
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.36036
GBX1 gastrulation brain homeobox 1 -2.36036
SRP68 signal recognition particle 68kDa -2.35597
RGS7BP regulator of G-protein signaling 7 binding protein -2.32284
ITFG2 integrin alpha FG-GAP repeat containing 2 -2.3224
BMP8A bone morphogenetic protein 8a -2.29807
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -2.29807
FAM209A family with sequence similarity 209, member A -2.29807
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.29807
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa -2.29776
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -2.29641
RETREG2 reticulophagy regulator family member 2 -2.29508
KIF5B kinesin family member 5B -2.28877
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.28501
NOL4L nucleolar protein 4-like -2.27163
CREG1 cellular repressor of E1A-stimulated genes 1 -2.27163
SIRT6 sirtuin 6 -2.27163
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) -2.26684
CDC25C cell division cycle 25C -2.26684
KATNB1 katanin p80 (WD repeat containing) subunit B 1 -2.25654
S100A6 S100 calcium binding protein A6 -2.24281
TMEM59L transmembrane protein 59-like -2.23161
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.227
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) -2.18786
FGD6 FYVE, RhoGEF and PH domain containing 6 -2.16979
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator -2.16804
HDAC2 histone deacetylase 2 -2.16804
SPDYE18 speedy/RINGO cell cycle regulator family member E18 -2.16547
DEPDC4 DEP domain containing 4 -2.13367
S100PBP S100P binding protein -2.12951
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.12175
CCDC170 coiled-coil domain containing 170 -2.12148
C11ORF42 chromosome 11 open reading frame 42 -2.12148
CPT1B carnitine palmitoyltransferase 1B (muscle) -2.11906
RIPK4 receptor-interacting serine-threonine kinase 4 -2.10078
GPR87 G protein-coupled receptor 87 -2.10078
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -2.08398
ZSCAN30 zinc finger and SCAN domain containing 30 -2.08061
STX18 syntaxin 18 -2.07871
AGO2 argonaute RISC catalytic component 2 -2.06647
ATP10A ATPase, class V, type 10A -2.06523
ZCCHC7 zinc finger, CCHC domain containing 7 -2.06379
HAGHL hydroxyacylglutathione hydrolase-like -2.06379
DHFR dihydrofolate reductase -2.06075
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.03245
CFAP54 cilia and flagella associated 54 -2.0324
MRPL12 mitochondrial ribosomal protein L12 -2.02282
PCDHA5 protocadherin alpha 5 -2.02282
PXN paxillin -2.02282