HMX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description H6 family homeobox 2|The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. [provided by RefSeq, Aug 2012] (NCBI Entrez Gene Database, 3167)
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Genes

318 genes differentially expressed following the HMX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.57361
OLIG1 oligodendrocyte transcription factor 1 3.57361
OLIG2 oligodendrocyte lineage transcription factor 2 3.57361
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 3.57361
TAL2 T-cell acute lymphocytic leukemia 2 3.57361
MYOM3 myomesin 3 3.57361
ALPK2 alpha-kinase 2 3.57361
CA1 carbonic anhydrase I 3.57361
FAM221B family with sequence similarity 221, member B 3.57361
NCKAP1L NCK-associated protein 1-like 3.57361
IL5RA interleukin 5 receptor, alpha 3.57361
PCDHGB3 protocadherin gamma subfamily B, 3 3.57361
SCGN secretagogin, EF-hand calcium binding protein 3.57361
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.57361
SPINK4 serine peptidase inhibitor, Kazal type 4 3.57361
CAMP cathelicidin antimicrobial peptide 3.57361
FGL1 fibrinogen-like 1 3.57361
PRSS41 protease, serine, 41 3.57361
TMEM151A transmembrane protein 151A 3.57361
HES4 hes family bHLH transcription factor 4 3.57361
GRXCR2 glutaredoxin, cysteine rich 2 3.57361
PCDH8 protocadherin 8 3.57361
PPIAL4G peptidylprolyl isomerase A (cyclophilin A)-like 4G 3.57361
F2 coagulation factor II (thrombin) 3.57361
STEAP4 STEAP family member 4 3.57361
NWD1 NACHT and WD repeat domain containing 1 3.57361
ARSH arylsulfatase family, member H 3.57361
WAS Wiskott-Aldrich syndrome 3.57361
RHOJ ras homolog family member J 3.57361
FXYD2 FXYD domain containing ion transport regulator 2 3.57361
CD22 CD22 molecule 3.57361
ASTE1 asteroid homolog 1 (Drosophila) 3.57361
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.57361
HES2 hes family bHLH transcription factor 2 3.57361
KCNU1 potassium channel, subfamily U, member 1 3.57361
MEIKIN meiotic kinetochore factor 3.57361
DLL4 delta-like 4 (Drosophila) 3.57361
PNOC prepronociceptin 3.57361
FAM216B family with sequence similarity 216, member B 3.57361
BFSP2 beaded filament structural protein 2, phakinin 3.57361
PRDM13 PR domain containing 13 3.57361
BMP5 bone morphogenetic protein 5 3.57361
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.57361
OR5M11 olfactory receptor, family 5, subfamily M, member 11 3.57361
CDCP2 CUB domain containing protein 2 3.57361
POU2AF2 POU class 2 homeobox associating factor 2 3.57361
DNAAF1 dynein, axonemal, assembly factor 1 3.57361
SRGN serglycin 3.57361
FMOD fibromodulin 3.57361
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 3.57361
TMPRSS4 transmembrane protease, serine 4 3.57361
TEDDM1 transmembrane epididymal protein 1 3.57361
MAGIX MAGI family member, X-linked 3.57361
PRDM7 PR domain containing 7 3.57361
CNTN6 contactin 6 3.57361
TCERG1L transcription elongation regulator 1-like 3.57361
ACER1 alkaline ceramidase 1 3.57361
H2BW1 H2B.W histone 1 3.57361
CBY2 chibby family member 2 3.57361
AJM1 apical junction component 1 homolog 3.57361
ANKRD40CL ANKRD40 C-terminal like 3.57361
GPAT3 glycerol-3-phosphate acyltransferase 3 3.57361
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.57361
MT4 metallothionein 4 3.57361
PTH1R parathyroid hormone 1 receptor 3.57361
ROPN1L rhophilin associated tail protein 1-like 3.57361
HNF1A HNF1 homeobox A 3.57361
NPIPB8 nuclear pore complex interacting protein family, member B8 3.57361
FGFBP1 fibroblast growth factor binding protein 1 3.57361
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.57361
DNAI2 dynein, axonemal, intermediate chain 2 3.57361
OSTN osteocrin 3.57361
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.57361
KLF17 Kruppel-like factor 17 3.57361
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 3.57361
GPR6 G protein-coupled receptor 6 3.57361
SLFN11 schlafen family member 11 3.57361
LURAP1L leucine rich adaptor protein 1-like 3.57361
RLBP1 retinaldehyde binding protein 1 3.57361
ACTL8 actin-like 8 3.57361
STARD6 StAR-related lipid transfer (START) domain containing 6 3.57361
SBSN suprabasin 3.57361
RASAL3 RAS protein activator like 3 3.57361
C1QL2 complement component 1, q subcomponent-like 2 3.57361
SLAMF1 signaling lymphocytic activation molecule family member 1 3.57361
BHLHA9 basic helix-loop-helix family, member a9 3.57361
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.57361
GOLGA6L2 golgin A6 family-like 2 3.57361
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 3.57361
KLRC3 killer cell lectin-like receptor subfamily C, member 3 3.57361
BANF2 barrier to autointegration factor 2 3.57361
HP haptoglobin 3.57361
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.57361
AKNAD1 AKNA domain containing 1 3.57361
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.57361
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.57361
LMOD2 leiomodin 2 (cardiac) 3.57361
PLEKHN1 pleckstrin homology domain containing, family N member 1 3.57361
DSC1 desmocollin 1 3.57361
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.57361
FBXO47 F-box protein 47 3.57361
CALHM1 calcium homeostasis modulator 1 3.57361
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.57361
CABP7 calcium binding protein 7 3.57361
ZNF366 zinc finger protein 366 3.57361
CCL23 chemokine (C-C motif) ligand 23 3.57361
NIM1K NIM1 serine/threonine protein kinase 3.57361
EDN3 endothelin 3 3.57361
RESP18 regulated endocrine-specific protein 18 3.57361
SPATA31A1 SPATA31 subfamily A, member 1 3.57361
CXCR2 chemokine (C-X-C motif) receptor 2 3.57361
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.57361
SLC31A2 solute carrier family 31 (copper transporter), member 2 3.57361
LRRC19 leucine rich repeat containing 19 3.57361
CYTH4 cytohesin 4 3.57361
CLEC1B C-type lectin domain family 1, member B 3.57361
MYLK2 myosin light chain kinase 2 3.57361
LGALS12 lectin, galactoside-binding, soluble, 12 3.57361
GPR149 G protein-coupled receptor 149 3.57361
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 3.57361
LAMB3 laminin, beta 3 3.57361
ADAM18 ADAM metallopeptidase domain 18 3.57361
STH saitohin 3.57361
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.57361
CD27 CD27 molecule 3.57361
SPEF1 sperm flagellar 1 3.57361
AICDA activation-induced cytidine deaminase 3.57361
ANKRD53 ankyrin repeat domain 53 3.57361
SIGLEC15 sialic acid binding Ig-like lectin 15 3.57361
PRPH2 peripherin 2 (retinal degeneration, slow) 3.57361
GPR62 G protein-coupled receptor 62 3.57361
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.57361
CA5A carbonic anhydrase VA, mitochondrial 3.57361
LHX5 LIM homeobox 5 3.57361
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.57361
ANXA1 annexin A1 3.57361
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 3.57361
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.57361
TBC1D26 TBC1 domain family, member 26 3.57361
TMEM86B transmembrane protein 86B 3.57361
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.57361
CHAD chondroadherin 3.57361
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 3.57361
ST18 suppression of tumorigenicity 18, zinc finger 3.57361
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.57361
CD8A CD8a molecule 3.57361
LAMP5 lysosomal-associated membrane protein family, member 5 3.57361
ROM1 retinal outer segment membrane protein 1 3.57361
MAGEA11 melanoma antigen family A11 3.57361
ANGPTL5 angiopoietin-like 5 3.57361
NNMT nicotinamide N-methyltransferase 3.57361
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.57361
FITM1 fat storage-inducing transmembrane protein 1 3.57361
SLFN12L schlafen family member 12-like 3.57361
ZNF534 zinc finger protein 534 3.57361
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 3.56502
C12ORF42 chromosome 12 open reading frame 42 3.56502
LINC02983 long intergenic non-protein coding RNA 2983 3.35921
SLFNL1 schlafen-like 1 3.34669
MDC1 mediator of DNA-damage checkpoint 1 3.30032
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 3.1322
ALOX15B arachidonate 15-lipoxygenase, type B 3.11027
AQP3 aquaporin 3 (Gill blood group) 3.09835
TCF3 transcription factor 3 3.00579
TRMT9B tRNA methyltransferase 9B (putative) 2.98917
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 2.79783
MAST3 microtubule associated serine/threonine kinase 3 2.73859
ZNF514 zinc finger protein 514 2.72409
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.57741
RASGEF1C RasGEF domain family, member 1C 2.57741
PNPLA1 patatin-like phospholipase domain containing 1 2.57741
UPK1B uroplakin 1B 2.57741
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.57459
TM4SF18 transmembrane 4 L six family member 18 2.57459
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.56328
EBF2 early B-cell factor 2 2.44617
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 2.44617
MIMS2 mitochondrial inner membrane scaffold 2 2.42641
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 2.41834
GNB5 guanine nucleotide binding protein (G protein), beta 5 2.40693
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 2.40355
ARL8A ADP-ribosylation factor-like 8A 2.37833
WDR19 WD repeat domain 19 2.37465
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.36709
XYLT2 xylosyltransferase II 2.32364
NT5M 5',3'-nucleotidase, mitochondrial 2.31232
CPVL carboxypeptidase, vitellogenic-like 2.31028
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.28046
GARIN1B golgi associated RAB2 interactor 1B 2.27824
TTF1 transcription termination factor, RNA polymerase I 2.27529
MRPS23 mitochondrial ribosomal protein S23 2.26866
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 2.26866
MOXD1 monooxygenase, DBH-like 1 2.26866
BLACAT1 bladder cancer associated transcript 1 (non-protein coding) 2.26385
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 2.25613
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.25613
NNT nicotinamide nucleotide transhydrogenase 2.25613
STAB1 stabilin 1 2.25613
HIRIP3 HIRA interacting protein 3 2.21428
ACACA acetyl-CoA carboxylase alpha 2.19893
RAB17 RAB17, member RAS oncogene family 2.19741
ZBTB45 zinc finger and BTB domain containing 45 2.14862
C5ORF24 chromosome 5 open reading frame 24 2.14862
TTC23 tetratricopeptide repeat domain 23 2.13651
ASIC1 acid sensing (proton gated) ion channel 1 2.13458
TLCD2 TLC domain containing 2 2.13458
MESD mesoderm development LRP chaperone 2.11943
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) 2.10771
EXPH5 exophilin 5 2.08418
MAPK13 mitogen-activated protein kinase 13 2.05521
GDF3 growth differentiation factor 3 2.03156
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.03156
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.0295
LIMS1 LIM and senescent cell antigen-like domains 1 2.00917
ZFX zinc finger protein, X-linked 2.00917

decreased expression

Symbol Name Standardized Value
TLE6 transducin-like enhancer of split 6 -3.57361
STAB2 stabilin 2 -3.57361
NHLH1 nescient helix loop helix 1 -3.57361
C19ORF38 chromosome 19 open reading frame 38 -3.56502
RPA4 replication protein A4, 30kDa -3.56502
GRM6 glutamate receptor, metabotropic 6 -3.56502
MEI1 meiosis inhibitor 1 -3.56502
GFAP glial fibrillary acidic protein -3.56502
CCNB3 cyclin B3 -3.56502
RUNDC3B RUN domain containing 3B -3.56502
MAPK11 mitogen-activated protein kinase 11 -3.56502
ADIRF adipogenesis regulatory factor -3.56502
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -3.56502
PADI1 peptidyl arginine deiminase, type I -3.56502
TMEM45B transmembrane protein 45B -3.56502
THSD1 thrombospondin, type I, domain containing 1 -3.56502
CRYGN crystallin, gamma N -3.56502
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -3.56502
KYNU kynureninase -3.56502
PSORS1C1 psoriasis susceptibility 1 candidate 1 -3.56502
TMEM176A transmembrane protein 176A -3.56502
GPRC5D G protein-coupled receptor, class C, group 5, member D -3.56502
CLEC4A C-type lectin domain family 4, member A -3.56502
PNLIPRP2 pancreatic lipase-related protein 2 -3.56502
ILDR2 immunoglobulin-like domain containing receptor 2 -3.56502
ZFP92 ZFP92 zinc finger protein -3.56502
FAM131C family with sequence similarity 131, member C -3.56502
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -3.56502
ZACN zinc activated ligand-gated ion channel -3.56502
DND1 DND microRNA-mediated repression inhibitor 1 -3.56502
TTC22 tetratricopeptide repeat domain 22 -3.56502
KIAA0586 KIAA0586 -3.30614
SLAIN1 SLAIN motif family, member 1 -3.27669
ISOC2 isochorismatase domain containing 2 -3.00409
CST6 cystatin E/M -2.9466
LMCD1 LIM and cysteine-rich domains 1 -2.93975
STX19 syntaxin 19 -2.938
SAMD10 sterile alpha motif domain containing 10 -2.90151
EYA3 EYA transcriptional coactivator and phosphatase 3 -2.89447
SERP1 stress-associated endoplasmic reticulum protein 1 -2.85866
TLE3 transducin-like enhancer of split 3 -2.74887
C6ORF47 chromosome 6 open reading frame 47 -2.68413
CHD4 chromodomain helicase DNA binding protein 4 -2.64977
RNASEH2C ribonuclease H2, subunit C -2.63266
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 -2.61207
SIRT6 sirtuin 6 -2.59055
SPIRE1 spire-type actin nucleation factor 1 -2.57741
CHMP5 charged multivesicular body protein 5 -2.56164
GAPVD1 GTPase activating protein and VPS9 domains 1 -2.54401
PPP1R42 protein phosphatase 1, regulatory subunit 42 -2.45808
MYLK3 myosin light chain kinase 3 -2.44954
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -2.44954
OPRD1 opioid receptor, delta 1 -2.44102
TAPT1 transmembrane anterior posterior transformation 1 -2.40719
ZNF554 zinc finger protein 554 -2.40693
GJA4 gap junction protein, alpha 4, 37kDa -2.40693
CORIN corin, serine peptidase -2.40693
ZNF292 zinc finger protein 292 -2.40355
RPAP2 RNA polymerase II associated protein 2 -2.40013
SLITRK4 SLIT and NTRK-like family, member 4 -2.34881
ZSCAN12 zinc finger and SCAN domain containing 12 -2.32364
AHRR aryl-hydrocarbon receptor repressor -2.32364
MOGS mannosyl-oligosaccharide glucosidase -2.32271
FER fer (fps/fes related) tyrosine kinase -2.31245
NSL1 NSL1, MIS12 kinetochore complex component -2.31232
MACC1 metastasis associated in colon cancer 1 -2.30429
UBA6 ubiquitin-like modifier activating enzyme 6 -2.30427
CATSPERG catsper channel auxiliary subunit gamma -2.30324
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.30324
SPDYE18 speedy/RINGO cell cycle regulator family member E18 -2.26866
CLPSL1 colipase-like 1 -2.26866
ARHGAP9 Rho GTPase activating protein 9 -2.26866
VWF von Willebrand factor -2.26866
LAMA4 laminin, alpha 4 -2.24813
ATOX1 antioxidant 1 copper chaperone -2.22499
PRSS3 protease, serine, 3 -2.20508
CD37 CD37 molecule -2.19741
RPH3A rabphilin 3A -2.19741
U2SURP U2 snRNP-associated SURP domain containing -2.1956
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.19079
MAN2B2 mannosidase, alpha, class 2B, member 2 -2.18876
SYP synaptophysin -2.1796
IRF6 interferon regulatory factor 6 -2.17637
RPS25 ribosomal protein S25 -2.15204
FMC1 formation of mitochondrial complex V assembly factor 1 homolog -2.13458
CENPS centromere protein S -2.11524
DRC9 dynein regulatory complex subunit 9 -2.0864
MRPL55 mitochondrial ribosomal protein L55 -2.07813
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) -2.07792
LSG1 large 60S subunit nuclear export GTPase 1 -2.06213
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit -2.05749
FAM124A family with sequence similarity 124A -2.05521
KLHL9 kelch-like family member 9 -2.04336
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -2.03586
PRPF6 pre-mRNA processing factor 6 -2.03377
CTPS1 CTP synthase 1 -2.03156
PNKP polynucleotide kinase 3'-phosphatase -2.03156
MAT2A methionine adenosyltransferase II, alpha -2.03156
LRP4 low density lipoprotein receptor-related protein 4 -2.01637
DENND10 DENN domain containing 10 -2.01637
STN1 STN1 subunit of CST complex -2.01637
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.00917
MDK midkine (neurite growth-promoting factor 2) -2.00136