HNF1A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description HNF1 homeobox A|The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] (NCBI Entrez Gene Database, 6927)
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Genes

322 genes differentially expressed following the HNF1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FZD1 frizzled class receptor 1 3.03253
FOXG1 forkhead box G1 3.03253
WT1 Wilms tumor 1 3.03253
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.03253
SCEL sciellin 3.03253
TGM1 transglutaminase 1 3.03253
PGC progastricsin (pepsinogen C) 3.03253
NEURL3 neuralized E3 ubiquitin protein ligase 3 3.03253
EGR2 early growth response 2 3.03253
C8ORF89 chromosome 8 open reading frame 89 3.03253
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.03253
C15ORF62 chromosome 15 open reading frame 62 3.03253
IZUMO4 IZUMO family member 4 3.03253
AREG amphiregulin 3.03253
GOLGA8J golgin A8 family, member J 3.03253
C2ORF78 chromosome 2 open reading frame 78 3.03253
PMP2 peripheral myelin protein 2 3.03253
DLL4 delta-like 4 (Drosophila) 3.03253
CPB1 carboxypeptidase B1 (tissue) 3.03253
DCN decorin 3.03253
CXORF65 chromosome X open reading frame 65 2.99249
HYAL4 hyaluronoglucosaminidase 4 2.99249
TNNI2 troponin I type 2 (skeletal, fast) 2.99249
FGL2 fibrinogen-like 2 2.99249
TMEM72 transmembrane protein 72 2.99249
VTN vitronectin 2.99249
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.99249
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.99249
OR5P3 olfactory receptor, family 5, subfamily P, member 3 2.99249
HHEX hematopoietically expressed homeobox 2.99249
FOXL1 forkhead box L1 2.99249
FPR2 formyl peptide receptor 2 2.99249
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.99249
WEE2 WEE1 homolog 2 (S. pombe) 2.99249
USH1G Usher syndrome 1G (autosomal recessive) 2.99249
LCN12 lipocalin 12 2.99249
GJA10 gap junction protein, alpha 10, 62kDa 2.99249
MCTS2 MCTS family member 2 2.99249
NPIPA3 nuclear pore complex interacting protein family, member A3 2.99249
ZNF556 zinc finger protein 556 2.99249
AVPR2 arginine vasopressin receptor 2 2.99249
ALX4 ALX homeobox 4 2.99249
C11ORF87 chromosome 11 open reading frame 87 2.99249
RIMBP3C RIMS binding protein 3C 2.99249
FHL5 four and a half LIM domains 5 2.99249
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.99249
TBATA thymus, brain and testes associated 2.99249
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.99249
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 2.99249
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.99249
SPRR1B small proline-rich protein 1B 2.99249
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.99249
OR8A1 olfactory receptor, family 8, subfamily A, member 1 2.99249
HDC histidine decarboxylase 2.99249
OR1R1 olfactory receptor family 1 subfamily R member 1 2.99249
SMIM35 small integral membrane protein 35 2.99249
TEX13C TEX13 family member C 2.99249
TEX55 testis expressed 55 2.99249
BNIP5 BCL2 interacting protein 5 2.99249
LORICRIN loricrin cornified envelope precursor protein 2.99249
AFDN afadin, adherens junction formation factor 2.99249
ROPN1B rhophilin associated tail protein 1B 2.99249
PNLIPRP3 pancreatic lipase-related protein 3 2.99249
RHEX regulator of hemoglobinization and erythroid cell expansion 2.99249
H4C14 H4 clustered histone 14 2.99249
CIMIP3 ciliary microtubule inner protein 3 2.99249
TEKTL1 tektin like 1 2.99249
CIMIP2C ciliary microtubule inner protein 2C 2.99249
SSU72L2 SSU72 like 2 2.99249
EPCIP exosomal polycystin 1 interacting protein 2.99249
CIMIP7 ciliary microtubule inner protein 7 2.99249
LY6S-AS1 LY6S antisense RNA 1 2.99249
CPNE8-AS1 CPNE8 antisense RNA 1 2.99249
C1ORF232 chromosome 1 open reading frame 230 2.99249
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 2.99249
SF3B5 splicing factor 3b, subunit 5, 10kDa 2.99249
VASP vasodilator-stimulated phosphoprotein 2.99249
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.99249
C1QL4 complement component 1, q subcomponent-like 4 2.99249
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.99249
SCRT2 scratch family zinc finger 2 2.99249
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.99249
MAG myelin associated glycoprotein 2.99249
MAGEB1 melanoma antigen family B1 2.99249
PRB4 proline-rich protein BstNI subfamily 4 2.99249
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.99249
GJD4 gap junction protein, delta 4, 40.1kDa 2.99249
S100P S100 calcium binding protein P 2.99249
TTR transthyretin 2.99249
GRAP GRB2-related adaptor protein 2.99249
SELL selectin L 2.99249
DYNLRB2 dynein, light chain, roadblock-type 2 2.99249
TAS1R1 taste receptor, type 1, member 1 2.99249
IL1RN interleukin 1 receptor antagonist 2.99249
IL1R2 interleukin 1 receptor, type II 2.99249
PLD4 phospholipase D family, member 4 2.99249
SLFN14 schlafen family member 14 2.99249
PCDHGA2 protocadherin gamma subfamily A, 2 2.99249
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 2.99249
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.99249
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.99249
DMTN dematin actin binding protein 2.99249
SI sucrase-isomaltase (alpha-glucosidase) 2.99249
ADGRF5 adhesion G protein-coupled receptor F5 2.99249
LST1 leukocyte specific transcript 1 2.99249
FITM1 fat storage-inducing transmembrane protein 1 2.99249
PRSS38 protease, serine, 38 2.99249
HAND2 heart and neural crest derivatives expressed 2 2.99249
LHX3 LIM homeobox 3 2.99249
RGS8 regulator of G-protein signaling 8 2.99249
TRIM7 tripartite motif containing 7 2.99249
ESAM endothelial cell adhesion molecule 2.99249
CLEC9A C-type lectin domain family 9, member A 2.99249
ANKRD60 ankyrin repeat domain 60 2.99249
CST1 cystatin SN 2.99249
CST7 cystatin F (leukocystatin) 2.99249
CSTA cystatin A (stefin A) 2.99249
RGSL1 regulator of G-protein signaling like 1 2.99249
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.99249
MUCL1 mucin-like 1 2.99249
GPR119 G protein-coupled receptor 119 2.99249
VRTN vertebrae development associated 2.99249
OR52L1 olfactory receptor, family 52, subfamily L, member 1 2.99249
FOXS1 forkhead box S1 2.99249
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.99249
MPC1L mitochondrial pyruvate carrier 1-like 2.99249
UBD ubiquitin D 2.99249
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.99249
APOBR apolipoprotein B receptor 2.99249
PITX1 paired-like homeodomain 1 2.99249
MMP13 matrix metallopeptidase 13 2.99249
GPR150 G protein-coupled receptor 150 2.99249
IL21 interleukin 21 2.99249
FXYD2 FXYD domain containing ion transport regulator 2 2.99249
FXYD3 FXYD domain containing ion transport regulator 3 2.99249
SLC10A5 solute carrier family 10, member 5 2.99249
EOMES eomesodermin 2.99249
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 2.99249
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.99249
NPY2R neuropeptide Y receptor Y2 2.99249
RTP4 receptor (chemosensory) transporter protein 4 2.99249
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 2.99249
PHGR1 proline/histidine/glycine-rich 1 2.99249
TAS2R46 taste receptor, type 2, member 46 2.99249
LRRC31 leucine rich repeat containing 31 2.99249
CETP cholesteryl ester transfer protein, plasma 2.99249
PFN3 profilin 3 2.99249
EFCC1 EF-hand and coiled-coil domain containing 1 2.99249
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.99249
MAGEA12 melanoma antigen family A12 2.99249
CLCA2 chloride channel accessory 2 2.99249
ZPLD1 zona pellucida-like domain containing 1 2.99249
GPANK1 G patch domain and ankyrin repeats 1 2.83847
MAIP1 matrix AAA peptidase interacting protein 1 2.81955
WDR6 WD repeat domain 6 2.75778
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.69565
STAU1 staufen double-stranded RNA binding protein 1 2.60521
TBC1D7-LOC100130357 TBC1D7-LOC100130357 readthrough 2.51795
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.51307
GPSM1 G-protein signaling modulator 1 2.51307
KAT6A K(lysine) acetyltransferase 6A 2.49885
ZMYND11 zinc finger, MYND-type containing 11 2.49571
MT1X metallothionein 1X 2.49371
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 2.49061
SUSD2 sushi domain containing 2 2.48311
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 2.4477
PQBP1 polyglutamine binding protein 1 2.44469
SUN3 Sad1 and UNC84 domain containing 3 2.43544
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 2.43544
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 2.42458
FAM91A1 family with sequence similarity 91, member A1 2.4236
BAG2 BCL2-associated athanogene 2 2.41105
ALPK1 alpha-kinase 1 2.40799
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.40016
TACR2 tachykinin receptor 2 2.33014
C1ORF210 chromosome 1 open reading frame 210 2.32084
MT1E metallothionein 1E 2.28497
ITK IL2-inducible T-cell kinase 2.27708
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.27322
CPNE8 copine VIII 2.2718
SNX17 sorting nexin 17 2.2718
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.26232
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.23945
MTERF4 mitochondrial transcription termination factor 4 2.23903
COMMD6 COMM domain containing 6 2.23103
GJC2 gap junction protein, gamma 2, 47kDa 2.21349
KIAA1755 KIAA1755 2.21349
ZNF273 zinc finger protein 273 2.20623
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.1818
TBCEL tubulin folding cofactor E-like 2.17951
BUD13 BUD13 homolog (S. cerevisiae) 2.16906
SRSF3 serine/arginine-rich splicing factor 3 2.16906
RCAN3 RCAN family member 3 2.15614
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.1516
SPATA24 spermatogenesis associated 24 2.14559
SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 2.14272
GAR1 GAR1 ribonucleoprotein 2.12698
TMEM225B transmembrane protein 225B 2.11657
RILPL2 Rab interacting lysosomal protein-like 2 2.11313
FAXC failed axon connections homolog (Drosophila) 2.08709
NSUN7 NOP2/Sun domain family, member 7 2.06888
URM1 ubiquitin related modifier 1 2.06672
SCAMP5 secretory carrier membrane protein 5 2.06453
GRB7 growth factor receptor-bound protein 7 2.05527
EDNRB endothelin receptor type B 2.04418
MRPS6 mitochondrial ribosomal protein S6 2.04281
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.02481
RPL6 ribosomal protein L6 2.02481
DNAH10 dynein, axonemal, heavy chain 10 2.02481
TEX53 testis expressed 53 2.02481
SLC9C2 solute carrier family 9, member C2 (putative) 2.02481
HCRT hypocretin (orexin) neuropeptide precursor 2.02481
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.02481
PITX2 paired-like homeodomain 2 2.02481
F8A1 coagulation factor VIII-associated 1 2.003

decreased expression

Symbol Name Standardized Value
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -3.03253
NXPH4 neurexophilin 4 -3.03253
TDRD10 tudor domain containing 10 -3.03253
BTNL2 butyrophilin-like 2 -3.03253
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -3.03253
SCN2B sodium channel, voltage gated, type II beta subunit -2.99249
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) -2.99249
TWIST1 twist family bHLH transcription factor 1 -2.99249
CLDN34 claudin 34 -2.99249
NPFFR1 neuropeptide FF receptor 1 -2.99249
ZNF367 zinc finger protein 367 -2.99249
HORMAD1 HORMA domain containing 1 -2.99249
ZBTB44 zinc finger and BTB domain containing 44 -2.99249
TFPI2 tissue factor pathway inhibitor 2 -2.99249
NOTUM notum pectinacetylesterase homolog (Drosophila) -2.99249
FGF18 fibroblast growth factor 18 -2.99249
AVP arginine vasopressin -2.99249
DISP2 dispatched homolog 2 (Drosophila) -2.99249
LGALS2 lectin, galactoside-binding, soluble, 2 -2.99249
SDSL serine dehydratase-like -2.99249
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime -2.99249
KLF4 Kruppel-like factor 4 (gut) -2.99249
FAM151A family with sequence similarity 151, member A -2.99249
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.99249
ZNF593OS ZNF593 opposite strand -2.99249
BIN2 bridging integrator 2 -2.99249
GPSM2 G-protein signaling modulator 2 -2.99249
PNLIPRP1 pancreatic lipase-related protein 1 -2.99249
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic -2.99249
CCR6 chemokine (C-C motif) receptor 6 -2.99249
PIWIL1 piwi-like RNA-mediated gene silencing 1 -2.99249
KLK15 kallikrein-related peptidase 15 -2.99249
LRTM3 leucine rich repeat transmembrane protein 3 -2.99249
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -2.99249
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.99073
OAF OAF homolog (Drosophila) -2.99073
PHC3 polyhomeotic homolog 3 (Drosophila) -2.89973
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -2.89973
MRTFB myocardin related transcription factor B -2.85804
CDC73 cell division cycle 73 -2.82299
NUP188 nucleoporin 188kDa -2.81476
SCRN3 secernin 3 -2.79376
CC2D1B coiled-coil and C2 domain containing 1B -2.76841
ZBTB43 zinc finger and BTB domain containing 43 -2.75961
SLC10A4 solute carrier family 10, member 4 -2.75004
AGMO alkylglycerol monooxygenase -2.74728
MTBP MDM2 binding protein -2.72805
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa -2.69399
TTC12 tetratricopeptide repeat domain 12 -2.66655
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -2.62003
ISM1 isthmin 1, angiogenesis inhibitor -2.59073
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -2.59073
FAF1 Fas (TNFRSF6) associated factor 1 -2.57373
PPP6R3 protein phosphatase 6, regulatory subunit 3 -2.56181
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -2.55241
IL12RB2 interleukin 12 receptor, beta 2 -2.53982
ACSF3 acyl-CoA synthetase family member 3 -2.53508
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.49571
TOR1AIP2 torsin A interacting protein 2 -2.47903
ZDHHC20 zinc finger, DHHC-type containing 20 -2.43544
FAM117B family with sequence similarity 117, member B -2.43497
RNF141 ring finger protein 141 -2.40961
MSN moesin -2.38595
ZNF568 zinc finger protein 568 -2.38014
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -2.34984
ZMYM4 zinc finger, MYM-type 4 -2.33014
EXD2 exonuclease 3'-5' domain containing 2 -2.31584
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -2.30135
CFAP52 cilia and flagella associated protein 52 -2.29544
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -2.2931
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.28776
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.27835
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.27322
OCLN occludin -2.26505
NKX3-1 NK3 homeobox 1 -2.2612
ANKRD55 ankyrin repeat domain 55 -2.2612
CXCR2 chemokine (C-X-C motif) receptor 2 -2.2612
FITM2 fat storage-inducing transmembrane protein 2 -2.24168
MANEA mannosidase, endo-alpha -2.19308
SPA17 sperm autoantigenic protein 17 -2.1818
ARHGAP19 Rho GTPase activating protein 19 -2.1818
MEIKIN meiotic kinetochore factor -2.17939
CLCNKA chloride channel, voltage-sensitive Ka -2.17939
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.17939
LYST lysosomal trafficking regulator -2.16332
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F -2.1516
HK2 hexokinase 2 -2.14625
LRRC69 leucine rich repeat containing 69 -2.14559
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -2.14272
RND2 Rho family GTPase 2 -2.14272
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator -2.13461
ZNF776 zinc finger protein 776 -2.12714
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.12248
GCHFR GTP cyclohydrolase I feedback regulator -2.11278
ACSL3 acyl-CoA synthetase long-chain family member 3 -2.08856
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -2.08802
ZNF71 zinc finger protein 71 -2.07109
HADH hydroxyacyl-CoA dehydrogenase -2.07087
S100A2 S100 calcium binding protein A2 -2.06888
NUPR1 nuclear protein, transcriptional regulator, 1 -2.06888
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.06672
C1RL complement component 1, r subcomponent-like -2.06672
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.04708
FAM47E family with sequence similarity 47, member E -2.04418
PUM2 pumilio RNA-binding family member 2 -2.01013
BCO2 beta-carotene oxygenase 2 -2.0053
SMTN smoothelin -2.003