HNF1B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description HNF1 homeobox B|This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 6928)
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Genes

326 genes differentially expressed following the HNF1B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.36517
KRT20 keratin 20, type I 3.36517
CABS1 calcium-binding protein, spermatid-specific 1 3.36517
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.36517
ELSPBP1 epididymal sperm binding protein 1 3.36517
AADACL4 arylacetamide deacetylase-like 4 3.36517
LRRC53 leucine rich repeat containing 53 3.36517
DSG3 desmoglein 3 3.36517
PAX9 paired box 9 3.36517
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 3.36517
SPINK4 serine peptidase inhibitor, Kazal type 4 3.36517
SCN2B sodium channel, voltage gated, type II beta subunit 3.36517
HABP2 hyaluronan binding protein 2 3.36517
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 3.36517
INHBB inhibin, beta B 3.36517
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.36517
MYO7B myosin VIIB 3.36517
IYD iodotyrosine deiodinase 3.36517
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.36517
CTRC chymotrypsin C (caldecrin) 3.36517
ADGRE1 adhesion G protein-coupled receptor E1 3.36517
OLIG1 oligodendrocyte transcription factor 1 3.36517
RSPO3 R-spondin 3 3.36517
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.36517
UMODL1 uromodulin-like 1 3.36517
MAGED4 melanoma antigen family D4 3.36517
TCP11 t-complex 11, testis-specific 3.36517
NPIPA8 nuclear pore complex interacting protein family, member A8 3.36517
WNT8B wingless-type MMTV integration site family, member 8B 3.36517
RFX6 regulatory factor X, 6 3.36517
AVP arginine vasopressin 3.36517
ASGR2 asialoglycoprotein receptor 2 3.36517
ZNF556 zinc finger protein 556 3.36517
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.36517
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 3.36517
GPR21 G protein-coupled receptor 21 3.36517
MYOM2 myomesin 2 3.36517
MYOM3 myomesin 3 3.36517
TNIP3 TNFAIP3 interacting protein 3 3.36517
TCAF2 TRPM8 channel-associated factor 2 3.36517
GFI1 growth factor independent 1 transcription repressor 3.36517
DEFB106B defensin, beta 106B 3.36517
BIRC7 baculoviral IAP repeat containing 7 3.36517
GRP gastrin-releasing peptide 3.36517
LOC107986837 uncharacterized LOC107986837 3.36517
GPX5 glutathione peroxidase 5 3.36517
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.36517
OTOR otoraplin 3.36517
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.36517
PROX2 prospero homeobox 2 3.36517
TRIM31 tripartite motif containing 31 3.36517
TSPAN1 tetraspanin 1 3.36517
LY6K lymphocyte antigen 6 complex, locus K 3.36517
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.36517
AVPR1B arginine vasopressin receptor 1B 3.36517
AVPR1A arginine vasopressin receptor 1A 3.36517
FAM90A11 family with sequence similarity 90 member A11 3.36517
ZNF593OS ZNF593 opposite strand 3.36517
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.36517
AKAIN1 A-kinase anchor inhibitor 1 3.36517
IHO1 interactor of HORMAD1 1 3.36517
SPDYE9 speedy/RINGO cell cycle regulator family member E9 3.36517
SPATA46 spermatogenesis associated 46 3.36517
GK3 glycerol kinase 3 3.36517
CCDC198 coiled-coil domain containing 198 3.36517
ZNF705D zinc finger protein 705D 3.36517
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.36517
OR2J1 olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene) 3.36517
DAO D-amino-acid oxidase 3.36517
TRIM60 tripartite motif containing 60 3.36517
MAGEB3 melanoma antigen family B3 3.36517
GGT5 gamma-glutamyltransferase 5 3.36517
PCDHA7 protocadherin alpha 7 3.36517
RAB44 RAB44, member RAS oncogene family 3.36517
RGS9BP regulator of G protein signaling 9 binding protein 3.36517
FRMD7 FERM domain containing 7 3.36517
TMEM235 transmembrane protein 235 3.36517
TMCO2 transmembrane and coiled-coil domains 2 3.36517
CSF3 colony stimulating factor 3 (granulocyte) 3.36517
ACE2 angiotensin I converting enzyme 2 3.36517
LRRC72 leucine rich repeat containing 72 3.36517
IL1R2 interleukin 1 receptor, type II 3.36517
BARX2 BARX homeobox 2 3.36517
TBX5 T-box 5 3.36517
SLAMF7 SLAM family member 7 3.36517
NHLRC4 NHL repeat containing 4 3.36517
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.36517
PDILT protein disulfide isomerase-like, testis expressed 3.36517
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 3.36517
DQX1 DEAQ box RNA-dependent ATPase 1 3.36517
SHISA8 shisa family member 8 3.36517
CCL15 chemokine (C-C motif) ligand 15 3.36517
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.36517
MAPK15 mitogen-activated protein kinase 15 3.36517
SLITRK1 SLIT and NTRK-like family, member 1 3.36517
KLK15 kallikrein-related peptidase 15 3.36517
COL22A1 collagen, type XXII, alpha 1 3.36517
CLCA2 chloride channel accessory 2 3.36517
APOL3 apolipoprotein L, 3 3.36517
EGR3 early growth response 3 3.36517
TMEM156 transmembrane protein 156 3.36517
DMRTA2 DMRT-like family A2 3.36517
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.36517
SLFN12L schlafen family member 12-like 3.36517
PRSS54 protease, serine, 54 3.36517
AQP6 aquaporin 6, kidney specific 3.36517
RGSL1 regulator of G-protein signaling like 1 3.36517
LCN9 lipocalin 9 3.36517
GML glycosylphosphatidylinositol anchored molecule like 3.36517
GOLGA6D golgin A6 family, member D 3.36517
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.36517
IL36R interleukin 36 receptor 3.36517
IL17REL interleukin 17 receptor E-like 3.36517
TTC9B tetratricopeptide repeat domain 9B 3.36517
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 3.36517
PLA2G4E phospholipase A2, group IVE 3.36517
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 3.36517
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 3.36517
SPRN shadow of prion protein homolog (zebrafish) 3.36517
SLCO1C1 solute carrier organic anion transporter family, member 1C1 3.36517
PCDHGA4 protocadherin gamma subfamily A, 4 3.36517
HOXB3 homeobox B3 3.36517
PLA2G2C phospholipase A2, group IIC 3.36517
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.36517
IL27 interleukin 27 3.36517
CTAG2 cancer/testis antigen 2 3.36517
IL25 interleukin 25 3.36517
ETV3L ets variant 3-like 3.36517
LOC102724877 uncharacterized LOC102724877 3.36517
CFI complement factor I 3.36517
KIAA1755 KIAA1755 3.36517
KCNU1 potassium channel, subfamily U, member 1 3.36517
PRR29 proline rich 29 3.36517
NKX6-1 NK6 homeobox 1 3.36517
AMIGO3 adhesion molecule with Ig-like domain 3 3.36517
CCNO cyclin O 3.36517
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 3.36517
HEPACAM hepatic and glial cell adhesion molecule 3.36517
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 3.36517
SH2D1B SH2 domain containing 1B 3.36517
CYTH4 cytohesin 4 3.36517
NEUROD1 neuronal differentiation 1 3.36517
ORM1 orosomucoid 1 3.36517
IRX1 iroquois homeobox 1 3.36517
BMX BMX non-receptor tyrosine kinase 3.31969
TMEM40 transmembrane protein 40 3.31969
TDRD1 tudor domain containing 1 3.14778
IGFLR1 IGF-like family receptor 1 3.01675
CNGB1 cyclic nucleotide gated channel beta 1 2.94257
MAEA macrophage erythroblast attacher 2.92647
FBLL1 fibrillarin-like 1 2.92647
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 2.91922
ACAT1 acetyl-CoA acetyltransferase 1 2.83295
CYRIA CYFIP related Rac1 interactor A 2.81902
PFDN5 prefoldin subunit 5 2.80935
ZNF354B zinc finger protein 354B 2.74087
LLGL1 lethal giant larvae homolog 1 (Drosophila) 2.7242
C16ORF89 chromosome 16 open reading frame 89 2.71606
COL1A1 collagen, type I, alpha 1 2.70229
NOP10 NOP10 ribonucleoprotein 2.65413
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 2.64018
CAPNS1 calpain, small subunit 1 2.57759
SARM1 sterile alpha and TIR motif containing 1 2.54707
IRF2BPL interferon regulatory factor 2 binding protein-like 2.52814
AKNA AT-hook transcription factor 2.51549
CHMP3 charged multivesicular body protein 3 2.42922
DNAAF4 dynein axonemal assembly factor 4 2.4043
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.39649
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.39649
C1QL2 complement component 1, q subcomponent-like 2 2.39649
PLLP plasmolipin 2.39462
RAG2 recombination activating gene 2 2.33211
KIF1C-AS1 KIF1C antisense RNA 1 2.32394
SNTN sentan, cilia apical structure protein 2.32394
ZNF337 zinc finger protein 337 2.31565
MRO maestro 2.31015
COQ4 coenzyme Q4 2.29292
TRIT1 tRNA isopentenyltransferase 1 2.29292
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.27433
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.27433
ZNF99 zinc finger protein 99 2.27433
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.25559
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.25559
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.25559
ZFAT zinc finger and AT hook domain containing 2.25559
G6PD glucose-6-phosphate dehydrogenase 2.24291
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 2.24223
ZBTB7A zinc finger and BTB domain containing 7A 2.23334
SLC18B1 solute carrier family 18, subfamily B, member 1 2.23242
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.23224
NSRP1 nuclear speckle splicing regulatory protein 1 2.23119
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.218
STIM1 stromal interaction molecule 1 2.21035
SETD6 SET domain containing 6 2.18366
TGM3 transglutaminase 3 2.17057
AOAH acyloxyacyl hydrolase (neutrophil) 2.16299
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 2.13783
FLOT1 flotillin 1 2.11842
CXXC1 CXXC finger protein 1 2.11842
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.08615
CDR2L cerebellar degeneration-related protein 2-like 2.08199
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.08199
H3C7 H3 clustered histone 7 2.0731
NCAPG2 non-SMC condensin II complex, subunit G2 2.07028
RPS15 ribosomal protein S15 2.06855
LRP2 low density lipoprotein receptor-related protein 2 2.06855
HDAC8 histone deacetylase 8 2.06855
CHST10 carbohydrate sulfotransferase 10 2.05754
HMGN5 high mobility group nucleosome binding domain 5 2.04047
C12ORF56 chromosome 12 open reading frame 56 2.03801
TMEM170B transmembrane protein 170B 2.02088
VAMP3 vesicle-associated membrane protein 3 2.01643
LITAF lipopolysaccharide-induced TNF factor 2.00315

decreased expression

Symbol Name Standardized Value
CD300A CD300a molecule -3.36517
FAM177A1 family with sequence similarity 177, member A1 -3.36517
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -3.36517
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -3.36517
CIDEA cell death-inducing DFFA-like effector a -3.36517
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -3.36517
FOLR1 folate receptor 1 (adult) -3.36517
IZUMO4 IZUMO family member 4 -3.36517
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -3.36517
PON1 paraoxonase 1 -3.36517
XCR1 chemokine (C motif) receptor 1 -3.36517
PTH2 parathyroid hormone 2 -3.36517
OC90 otoconin 90 -3.36517
MPL MPL proto-oncogene, thrombopoietin receptor -3.36517
GJB5 gap junction protein, beta 5, 31.1kDa -3.36517
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -3.36517
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 -3.36517
ZNF814 zinc finger protein 814 -3.36517
RP1 retinitis pigmentosa 1 (autosomal dominant) -3.36517
TEX101 testis expressed 101 -3.36517
MEOX2 mesenchyme homeobox 2 -3.36517
VAV1 vav 1 guanine nucleotide exchange factor -3.36517
MLANA melan-A -3.36517
LHX2 LIM homeobox 2 -3.36517
PRRT1B proline rich transmembrane protein 1B -3.36517
STPG3 sperm-tail PG-rich repeat containing 3 -3.36517
CD28 CD28 molecule -3.36517
GSC2 goosecoid homeobox 2 -3.36517
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 -3.36517
DRC1 dynein regulatory complex subunit 1 -3.36517
GDF6 growth differentiation factor 6 -3.36517
H3-5 H3.5 histone -3.36517
GOLGA6L4 golgin A6 family-like 4 -3.36517
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -3.36517
GOLGA6B golgin A6 family, member B -3.36517
MYO3A myosin IIIA -3.33946
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -3.24231
TMEM74B transmembrane protein 74B -3.18034
SP3 Sp3 transcription factor -3.17249
GRIK1 glutamate receptor, ionotropic, kainate 1 -2.98052
AADACL3 arylacetamide deacetylase-like 3 -2.87907
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor -2.82887
ZNF746 zinc finger protein 746 -2.82404
EME2 essential meiotic structure-specific endonuclease subunit 2 -2.81382
SPNS1 spinster homolog 1 (Drosophila) -2.79179
IER5 immediate early response 5 -2.79179
ASPNAT aspartate N-acetyltransferase -2.71386
DENND4C DENN/MADD domain containing 4C -2.62695
ZNF428 zinc finger protein 428 -2.58765
KLHL20 kelch-like family member 20 -2.58765
ZNF711 zinc finger protein 711 -2.54114
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 -2.53046
PDE5A phosphodiesterase 5A, cGMP-specific -2.52579
IQUB IQ motif and ubiquitin domain containing -2.52414
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.4989
LDHAL6A lactate dehydrogenase A-like 6A -2.48758
XKR9 XK, Kell blood group complex subunit-related family, member 9 -2.47322
SUSD1 sushi domain containing 1 -2.42793
CRBN cereblon -2.41625
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.39222
MTA1 metastasis associated 1 -2.37131
SEMG1 semenogelin I -2.3683
QPRT quinolinate phosphoribosyltransferase -2.3683
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -2.3683
KRTAP13-4 keratin associated protein 13-4 -2.3683
RARG retinoic acid receptor, gamma -2.36273
C1ORF87 chromosome 1 open reading frame 87 -2.35123
F5 coagulation factor V (proaccelerin, labile factor) -2.35123
ADRA2A adrenoceptor alpha 2A -2.35123
TTC36 tetratricopeptide repeat domain 36 -2.35123
CFAP141 cilia and flagella associated protein 141 -2.35123
ZNF723 zinc finger protein 723 -2.31572
GAGE10 G antigen 10 -2.29292
FAM167B family with sequence similarity 167, member B -2.29292
FAM43B family with sequence similarity 43, member B -2.29292
RIMBP2 RIMS binding protein 2 -2.29292
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.29292
OAF OAF homolog (Drosophila) -2.28541
UBAP2 ubiquitin associated protein 2 -2.27433
COX4I1 cytochrome c oxidase subunit IV isoform 1 -2.27433
BHLHA15 basic helix-loop-helix family, member a15 -2.26385
MGAM maltase-glucoamylase -2.26385
CABLES2 Cdk5 and Abl enzyme substrate 2 -2.26385
MEMO1 mediator of cell motility 1 -2.25559
PHC3 polyhomeotic homolog 3 (Drosophila) -2.25559
SERF1A small EDRK-rich factor 1A (telomeric) -2.23396
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -2.22161
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.21176
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.20524
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.20524
DIAPH3 diaphanous-related formin 3 -2.19535
CA5B carbonic anhydrase VB, mitochondrial -2.19111
ATG4B autophagy related 4B, cysteine peptidase -2.19111
SLC7A6OS solute carrier family 7, member 6 opposite strand -2.17932
PRKCD protein kinase C, delta -2.17287
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.17287
HAX1 HCLS1 associated protein X-1 -2.1451
MZT1 mitotic spindle organizing protein 1 -2.13126
DAP death-associated protein -2.13107
ZNF385C zinc finger protein 385C -2.12955
SUFU suppressor of fused homolog (Drosophila) -2.11842
MYO5C myosin VC -2.115
BCDIN3D BCDIN3 domain containing -2.09001
GALM galactose mutarotase (aldose 1-epimerase) -2.08519
CADPS2 Ca++-dependent secretion activator 2 -2.06855
ARHGAP5 Rho GTPase activating protein 5 -2.06855
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -2.06642
MTNAP1 mitochondrial nucleoid associated protein 1 -2.02692
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 -2.02635
EFHD2 EF-hand domain family, member D2 -2.01289
RNFT1 ring finger protein, transmembrane 1 -2.01101
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 -2.0104
RADIL Ras association and DIL domains -2.00442