HNF1B Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description HNF1 homeobox B|This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 6928)
External Link https://ncbi.nlm.nih.gov/gene/6928
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Genes

500 genes differentially expressed following the HNF1B gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
BMP4 bone morphogenetic protein 4 0.0206456
S100A7 S100 calcium binding protein A7 0.0176527
XPO7 exportin 7 0.0163161
KLK10 kallikrein-related peptidase 10 0.0153345
HIST1H2AC histone cluster 1, H2ac 0.0143307
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0142999
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0138303
IFI27 interferon, alpha-inducible protein 27 0.0137376
KRT14 keratin 14, type I 0.0136062
WDR7 WD repeat domain 7 0.013414
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.0133717
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0130278
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0128754
CAPG capping protein (actin filament), gelsolin-like 0.012636
PI3 peptidase inhibitor 3, skin-derived 0.0126037
C10ORF10 chromosome 10 open reading frame 10 0.0125598
IFI6 interferon, alpha-inducible protein 6 0.0120833
S100A8 S100 calcium binding protein A8 0.0120766
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0119767
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.0119235
MT1E metallothionein 1E 0.0117815
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0116578
LTF lactotransferrin 0.0114276
BAMBI BMP and activin membrane-bound inhibitor 0.0114198
S100A9 S100 calcium binding protein A9 0.0114046
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.0110865
VAMP8 vesicle-associated membrane protein 8 0.0110426
IL1RN interleukin 1 receptor antagonist 0.0109549
CCN2 cellular communication network factor 2 0.0109536
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0109347
KLK11 kallikrein-related peptidase 11 0.0108927
TM4SF1 transmembrane 4 L six family member 1 0.0108184
HIST1H2BD histone cluster 1, H2bd 0.0107436
CRYAB crystallin, alpha B 0.0107302
ISG20 interferon stimulated exonuclease gene 20kDa 0.0106787
MZB1 marginal zone B and B1 cell-specific protein 0.0105864
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0103631
RSAD2 radical S-adenosyl methionine domain containing 2 0.0103372
ADIRF adipogenesis regulatory factor 0.0102739
KRT5 keratin 5, type II 0.0101004
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.0100786
MT1X metallothionein 1X 0.00993774
TMEM140 transmembrane protein 140 0.00975181
EIF5A eukaryotic translation initiation factor 5A 0.00973585
IFI44L interferon-induced protein 44-like 0.00972586
CARMIL1 capping protein regulator and myosin 1 linker 1 0.00962645
FXYD3 FXYD domain containing ion transport regulator 3 0.00957448
XIC X chromosome inactivation center 0.00951917
JCHAIN joining chain of multimeric IgA and IgM 0.00950478
RCAN1 regulator of calcineurin 1 0.00930986
KRT15 keratin 15, type I 0.00930206
KRT6A keratin 6A, type II 0.00913667
SPRR1B small proline-rich protein 1B 0.00909988
IFITM1 interferon induced transmembrane protein 1 0.00893562
TUBB2A tubulin, beta 2A class IIa 0.00886411
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.00885588
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00882523
BHLHE41 basic helix-loop-helix family, member e41 0.00882347
HSPB1 heat shock 27kDa protein 1 0.00881798
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00875747
H1-2 H1.2 linker histone, cluster member 0.00868681
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.00865168
TPD52 tumor protein D52 0.00862274
IGFBP6 insulin-like growth factor binding protein 6 0.00858914
CD9 CD9 molecule 0.00857609
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.00856522
HTRA1 HtrA serine peptidase 1 0.00854179
TRIM29 tripartite motif containing 29 0.00846065
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00843076
MYBPC1 myosin binding protein C, slow type 0.00842661
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00838841
LY96 lymphocyte antigen 96 0.00838581
MT1G metallothionein 1G 0.00834323
ICAM2 intercellular adhesion molecule 2 0.00833935
ISG15 ISG15 ubiquitin-like modifier 0.00831177
ANXA1 annexin A1 0.00826046
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.00825094
KRT6B keratin 6B, type II 0.00823424
IRF1 interferon regulatory factor 1 0.00823244
CFB complement factor B 0.00820465
TXNL1 thioredoxin-like 1 0.00820037
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.00816713
CCNG2 cyclin G2 0.0081037
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.00808109
MT1H metallothionein 1H 0.00807744
KRT13 keratin 13, type I 0.0080739
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.00805933
MT2A metallothionein 2A 0.00803462
GPX1 glutathione peroxidase 1 0.00801586
FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.0080062
MX1 MX dynamin-like GTPase 1 0.00800515
ITGB4 integrin, beta 4 0.00800167
SPRR3 small proline-rich protein 3 0.00793722
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00793038
BTG2 BTG family, member 2 0.00786103
SELE selectin E 0.00784462
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.0078359
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.00783482
HSPA1A heat shock 70kDa protein 1A 0.00783128
MTUS1 microtubule associated tumor suppressor 1 0.00782457
PITX3 paired-like homeodomain 3 0.00776778
RPS27L ribosomal protein S27-like 0.00776062
DAXX death-domain associated protein 0.00774739
C1ORF54 chromosome 1 open reading frame 54 0.00770912
WASHC4 WASH complex subunit 4 0.00766169
MALL mal, T-cell differentiation protein-like 0.00759254
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00757966
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.00757831
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00756888
EFHD1 EF-hand domain family, member D1 0.0075578
MCTP1 multiple C2 domains, transmembrane 1 0.00755207
CYRIA CYFIP related Rac1 interactor A 0.00754187
ATF3 activating transcription factor 3 0.00751748
POU2AF1 POU class 2 associating factor 1 0.00751193
SLAMF7 SLAM family member 7 0.00747299
SAT1 spermidine/spermine N1-acetyltransferase 1 0.00744656
KLK6 kallikrein-related peptidase 6 0.0074232
GLUD1 glutamate dehydrogenase 1 0.00741183
PADI2 peptidyl arginine deiminase, type II 0.00740045
AOC1 amine oxidase, copper containing 1 0.00737097
RBM47 RNA binding motif protein 47 0.00735584
NCF2 neutrophil cytosolic factor 2 0.00735375
SIRT3 sirtuin 3 0.00732117
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.00730056
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.00727262
ACTB actin, beta 0.00726633
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.00726454
IFIH1 interferon induced with helicase C domain 1 0.00724351
REEP5 receptor accessory protein 5 0.00723759
TRIM16 tripartite motif containing 16 0.00722819
SOX9 SRY (sex determining region Y)-box 9 0.00722116
SH3BGR SH3 domain binding glutamate-rich protein 0.0071858
RHCG Rh family, C glycoprotein 0.00718201
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.00717532
STOM stomatin 0.00715383
SP110 SP110 nuclear body protein 0.00712395
S100P S100 calcium binding protein P 0.00710052
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 0.00709385
KRT16 keratin 16, type I 0.00706949
PLAAT3 phospholipase A and acyltransferase 3 0.00705185
MT1HL1 metallothionein 1H-like 1 0.00701
KRT17 keratin 17, type I 0.00700053
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.00694828
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 0.00693728
MYO1C myosin IC 0.00693651
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00690413
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.00690149
GHITM growth hormone inducible transmembrane protein 0.00689771
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.00686538
S100A14 S100 calcium binding protein A14 0.00686529
CLU clusterin 0.00685636
PARP12 poly (ADP-ribose) polymerase family, member 12 0.00681741
OPTN optineurin 0.00681595
BIK BCL2-interacting killer (apoptosis-inducing) 0.00679275
ARMCX3 armadillo repeat containing, X-linked 3 0.00675839
OASL 2'-5'-oligoadenylate synthetase-like 0.00674067
KRT23 keratin 23, type I 0.00670441
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.00669989
KIFAP3 kinesin-associated protein 3 0.00669085
ARMCX1 armadillo repeat containing, X-linked 1 0.0066671
PDZK1IP1 PDZK1 interacting protein 1 0.00666358
CYBB cytochrome b-245, beta polypeptide 0.00664903
COX5B cytochrome c oxidase subunit Vb 0.00662671
AFF1 AF4/FMR2 family, member 1 0.00662419
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.00662303
STXBP2 syntaxin binding protein 2 0.00662063
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.00660941
IL15 interleukin 15 0.00659656
MYOF myoferlin 0.00656913
ADM adrenomedullin 0.00655951
NT5C2 5'-nucleotidase, cytosolic II 0.00655778
TARP TCR gamma alternate reading frame protein 0.00652883
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 0.00652471
CAV1 caveolin 1, caveolae protein, 22kDa 0.00652188
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.00651735
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.00651585
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00650521
FN1 fibronectin 1 0.00649811
ZBTB18 zinc finger and BTB domain containing 18 0.00649677
RIOK3 RIO kinase 3 0.00648986
CRYBG1 crystallin beta-gamma domain containing 1 0.00646845
LST1 leukocyte specific transcript 1 0.00646312
IFI44 interferon-induced protein 44 0.00645767
GTF3A general transcription factor IIIA 0.00644936
TSPAN7 tetraspanin 7 0.00643075
ELF5 E74-like factor 5 (ets domain transcription factor) 0.00642307
SLPI secretory leukocyte peptidase inhibitor 0.006411
AQP1 aquaporin 1 (Colton blood group) 0.00639583
ALOX5 arachidonate 5-lipoxygenase 0.00637606
AHNAK2 AHNAK nucleoprotein 2 0.00636903
SAMD9 sterile alpha motif domain containing 9 0.00636328
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00636014
GIMAP4 GTPase, IMAP family member 4 0.00634706
CSRP2 cysteine and glycine-rich protein 2 0.00633776
H1-0 H1.0 linker histone 0.00632098
KYNU kynureninase 0.0062832
TACSTD2 tumor-associated calcium signal transducer 2 0.0062574
CLTB clathrin, light chain B 0.00625204
PYCARD PYD and CARD domain containing 0.00625126
COL11A1 collagen, type XI, alpha 1 0.00624232
SLN sarcolipin 0.00624097
KLK12 kallikrein-related peptidase 12 0.00624076
RRAS related RAS viral (r-ras) oncogene homolog 0.00623741
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.00623275
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.00623139
BBX bobby sox homolog (Drosophila) 0.00620093
GM2A GM2 ganglioside activator 0.00619705
XBP1 X-box binding protein 1 0.00615219
CLDN8 claudin 8 0.00614673
S100A2 S100 calcium binding protein A2 0.0061067
CEPT1 choline/ethanolamine phosphotransferase 1 0.00610258
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.00609722
DSG3 desmoglein 3 0.00609345
SPRR1A small proline-rich protein 1A 0.00609253
KLK13 kallikrein-related peptidase 13 0.00608799
VAMP5 vesicle-associated membrane protein 5 0.00607874
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.00607506
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.00606763
ATG4A autophagy related 4A, cysteine peptidase 0.00606535
CD38 CD38 molecule 0.00605611
DUSP5 dual specificity phosphatase 5 0.00605335
LMBRD1 LMBR1 domain containing 1 0.00605222
TSG101 tumor susceptibility 101 0.00605173
CHPT1 choline phosphotransferase 1 0.00605139
RAB29 RAB29, member RAS oncogene family 0.00604777
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.00604272
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.00598841
TPM2 tropomyosin 2 (beta) 0.00598482
PPL periplakin 0.00597632
ZBED2 zinc finger, BED-type containing 2 0.00597595
CSTB cystatin B (stefin B) 0.00596725
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.00595857
BPGM 2,3-bisphosphoglycerate mutase 0.00593593
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.00590922
CXCL10 chemokine (C-X-C motif) ligand 10 0.00590916
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.00589985
CTBS chitobiase, di-N-acetyl- 0.00589961
WBP1L WW domain binding protein 1-like 0.00589924
COPG1 coatomer protein complex, subunit gamma 1 0.00589864
APOL2 apolipoprotein L, 2 0.00589024
RABAC1 Rab acceptor 1 (prenylated) 0.00586251
IRF7 interferon regulatory factor 7 0.00584906
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.00584775
LYPD3 LY6/PLAUR domain containing 3 0.00584457
TRIM22 tripartite motif containing 22 0.00583293
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 0.00581714
CSTA cystatin A (stefin A) 0.00581112
DSC2 desmocollin 2 0.00581079
IFI35 interferon-induced protein 35 0.00578853
GIMAP6 GTPase, IMAP family member 6 0.00578738

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0180695
MAP7 microtubule-associated protein 7 -0.0131942
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0125224
BTBD3 BTB (POZ) domain containing 3 -0.0119786
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -0.0115336
GOLGA8A golgin A8 family, member A -0.0110749
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.00992028
FASN fatty acid synthase -0.00991431
PHACTR2 phosphatase and actin regulator 2 -0.00944878
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.00914463
AKAP8 A kinase (PRKA) anchor protein 8 -0.00909306
TARDBP TAR DNA binding protein -0.00862527
FABP6 fatty acid binding protein 6, ileal -0.00862464
NBPF10 neuroblastoma breakpoint family, member 10 -0.00854257
POSTN periostin, osteoblast specific factor -0.00849214
SLIT2 slit homolog 2 (Drosophila) -0.00845837
SLC38A1 solute carrier family 38, member 1 -0.00835293
NELL2 NEL-like 2 (chicken) -0.00816861
DUSP2 dual specificity phosphatase 2 -0.00809381
ACTG2 actin, gamma 2, smooth muscle, enteric -0.00804387
SPRY2 sprouty homolog 2 (Drosophila) -0.00796544
COL4A5 collagen, type IV, alpha 5 -0.00795191
INPP5A inositol polyphosphate-5-phosphatase, 40kDa -0.0078878
SDC2 syndecan 2 -0.00781565
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -0.00772994
ASRGL1 asparaginase like 1 -0.00761625
BEX1 brain expressed, X-linked 1 -0.0076086
KDM5D lysine (K)-specific demethylase 5D -0.00760283
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -0.00759883
CCND2 cyclin D2 -0.00756506
KANK2 KN motif and ankyrin repeat domains 2 -0.00753008
SPON1 spondin 1, extracellular matrix protein -0.00739879
SRSF6 serine/arginine-rich splicing factor 6 -0.00738245
CYTH1 cytohesin 1 -0.00734772
PNN pinin, desmosome associated protein -0.00733583
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0073044
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.00716706
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.00702292
PRKD3 protein kinase D3 -0.00694339
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.00693793
BCLAF1 BCL2-associated transcription factor 1 -0.00690619
HP haptoglobin -0.00686337
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 -0.00684308
TGFBI transforming growth factor, beta-induced, 68kDa -0.00683287
GSTM3 glutathione S-transferase mu 3 (brain) -0.00680436
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.00679555
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -0.00675618
YEATS4 YEATS domain containing 4 -0.00673231
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.00672847
NPTX1 neuronal pentraxin I -0.00672569
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -0.00666945
CPE carboxypeptidase E -0.00666587
PLXNA1 plexin A1 -0.00663617
CADM1 cell adhesion molecule 1 -0.00660263
NOTCH2NL notch 2 N-terminal like -0.00659281
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -0.0065903
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.0065038
CD320 CD320 molecule -0.00646698
NCALD neurocalcin delta -0.00646589
C4BPA complement component 4 binding protein, alpha -0.00644761
GSTM2 glutathione S-transferase mu 2 (muscle) -0.00644461
SNX7 sorting nexin 7 -0.00644065
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -0.00642749
HMGB3 high mobility group box 3 -0.00641053
LAPTM4B lysosomal protein transmembrane 4 beta -0.00640972
MEIS2 Meis homeobox 2 -0.00636272
AKAP7 A kinase (PRKA) anchor protein 7 -0.00634207
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.00633817
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.00630689
APOA1 apolipoprotein A-I -0.00628622
SPRED2 sprouty-related, EVH1 domain containing 2 -0.00625508
XYLT1 xylosyltransferase I -0.00625158
CLEC2B C-type lectin domain family 2, member B -0.00623023
AUTS2 autism susceptibility candidate 2 -0.0062174
CHKB choline kinase beta -0.00621401
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.00620727
ZNF266 zinc finger protein 266 -0.00620541
WNT5A wingless-type MMTV integration site family, member 5A -0.00620064
GSTM1 glutathione S-transferase mu 1 -0.00617396
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.00615749
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -0.00613332
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.00612437
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.00609921
GCH1 GTP cyclohydrolase 1 -0.00608173
RPL10 ribosomal protein L10 -0.00608023
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.00602157
HOPX HOP homeobox -0.00600203
SCGB2A1 secretoglobin, family 2A, member 1 -0.00599415
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00597319
CTPS1 CTP synthase 1 -0.00597217
SFTPC surfactant protein C -0.00596682
RBL2 retinoblastoma-like 2 -0.00596601
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 -0.0059621
SIDT2 SID1 transmembrane family, member 2 -0.00596063
PRKCZ protein kinase C, zeta -0.00595123
ZNF83 zinc finger protein 83 -0.00594239
IL13RA2 interleukin 13 receptor, alpha 2 -0.0059176
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0059142
RACGAP1 Rac GTPase activating protein 1 -0.00589192
BCHE butyrylcholinesterase -0.00587107
HCRT hypocretin (orexin) neuropeptide precursor -0.0058586
TSPAN12 tetraspanin 12 -0.00584576
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.00584573
ISYNA1 inositol-3-phosphate synthase 1 -0.00583857
NPTX2 neuronal pentraxin II -0.00583716
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.00583462
PAEP progestagen-associated endometrial protein -0.00582797
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.00581808
QPCT glutaminyl-peptide cyclotransferase -0.00578948
FBXO21 F-box protein 21 -0.00577608
DMBT1 deleted in malignant brain tumors 1 -0.00575034
IGF1 insulin-like growth factor 1 (somatomedin C) -0.00574007
EMID1 EMI domain containing 1 -0.00573673
PRAME preferentially expressed antigen in melanoma -0.00572874
FBXO11 F-box protein 11 -0.00572542
FZD2 frizzled class receptor 2 -0.00572236
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00569519
MPZL2 myelin protein zero-like 2 -0.00569474
RAD51AP1 RAD51 associated protein 1 -0.00569424
PTK2 protein tyrosine kinase 2 -0.00568381
SPC25 SPC25, NDC80 kinetochore complex component -0.00567006
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.00566905
GPC3 glypican 3 -0.00566453
CCNL2 cyclin L2 -0.00565945
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.00565436
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -0.00561925
SI sucrase-isomaltase (alpha-glucosidase) -0.00561304
CAMP cathelicidin antimicrobial peptide -0.00560655
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0056049
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -0.00559829
MDM1 Mdm1 nuclear protein homolog (mouse) -0.00559652
OLFM1 olfactomedin 1 -0.00559485
CLCA1 chloride channel accessory 1 -0.0055919
NTS neurotensin -0.00559095
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -0.00558935
IFT81 intraflagellar transport 81 -0.00558535
TBC1D16 TBC1 domain family, member 16 -0.00558025
ACTL6A actin-like 6A -0.00557004
WT1 Wilms tumor 1 -0.0055614
TLE2 transducin-like enhancer of split 2 -0.00554337
TRAF5 TNF receptor-associated factor 5 -0.00553995
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.00553454
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 -0.00552681
WFDC2 WAP four-disulfide core domain 2 -0.0055155
LAMA4 laminin, alpha 4 -0.00551332
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -0.00549109
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.00548911
TNC tenascin C -0.00548843
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -0.00548093
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 -0.00546918
LPCAT1 lysophosphatidylcholine acyltransferase 1 -0.00546001
SPAG5 sperm associated antigen 5 -0.00545938
IRF8 interferon regulatory factor 8 -0.00545084
GRIA2 glutamate receptor, ionotropic, AMPA 2 -0.00543838
POGLUT2 protein O-glucosyltransferase 2 -0.00543828
USP36 ubiquitin specific peptidase 36 -0.00543757
KCNK3 potassium channel, two pore domain subfamily K, member 3 -0.00543561
CHD1L chromodomain helicase DNA binding protein 1-like -0.0054171
MECOM MDS1 and EVI1 complex locus -0.00541451
SUB1 SUB1 homolog (S. cerevisiae) -0.00541356
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0054084
CERK ceramide kinase -0.00538907
DGAT1 diacylglycerol O-acyltransferase 1 -0.0053864
DLK1 delta-like 1 homolog (Drosophila) -0.0053805
RUSC1 RUN and SH3 domain containing 1 -0.00537679
SLC35E2B solute carrier family 35, member E2B -0.00534106
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 -0.00529532
DLG1 discs, large homolog 1 (Drosophila) -0.00528626
STXBP6 syntaxin binding protein 6 (amisyn) -0.00528511
ADARB1 adenosine deaminase, RNA-specific, B1 -0.00528494
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00527976
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.00527388
VLDLR very low density lipoprotein receptor -0.00527261
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2 -0.00526822
B3GNT1 -0.00526506
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.00526329
PRELID3B PRELI domain containing 3B -0.00525217
TRAF4 TNF receptor-associated factor 4 -0.00524025
CRMP1 collapsin response mediator protein 1 -0.00523296
DNM1 dynamin 1 -0.00523063
APOB apolipoprotein B -0.00521062
EML4 echinoderm microtubule associated protein like 4 -0.00520824
H2AX H2A.X variant histone -0.0052067
ADGRA3 adhesion G protein-coupled receptor A3 -0.00520349
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -0.00519944
LYZ lysozyme -0.00519857
C7 complement component 7 -0.00519359
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 -0.00517898
APMAP adipocyte plasma membrane associated protein -0.00517276
CEMIP2 cell migration inducing hyaluronidase 2 -0.00515324
PTPRM protein tyrosine phosphatase, receptor type, M -0.00514932
ACO1 aconitase 1, soluble -0.00514916
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.00513935
KANSL2 KAT8 regulatory NSL complex subunit 2 -0.00513632
CHKA choline kinase alpha -0.00511997
PASK PAS domain containing serine/threonine kinase -0.00511788
IL1R1 interleukin 1 receptor, type I -0.00511331
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.00510961
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -0.00510716
SLC19A1 solute carrier family 19 (folate transporter), member 1 -0.0050887
PSRC1 proline/serine-rich coiled-coil 1 -0.00508016
SKI SKI proto-oncogene -0.00507749
HOXB6 homeobox B6 -0.00507651
EPCAM epithelial cell adhesion molecule -0.0050669
THAP12 THAP domain containing 12 -0.00505801
MEIS1 Meis homeobox 1 -0.00505707
HOXB7 homeobox B7 -0.00504158
RAPSN receptor-associated protein of the synapse -0.00503815
LIMA1 LIM domain and actin binding 1 -0.00502265
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.00500987
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -0.00498753
APOC3 apolipoprotein C-III -0.00498221
MAOA monoamine oxidase A -0.00497796
CCL2 chemokine (C-C motif) ligand 2 -0.00497219
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.00497177
EFNB3 ephrin-B3 -0.00496094
TMEM204 transmembrane protein 204 -0.0049555
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00493328
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 -0.00491447
AURKB aurora kinase B -0.0049124
IPO5 importin 5 -0.00490237
PCOLCE procollagen C-endopeptidase enhancer -0.00490223
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.00490208
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -0.00489935
TCF4 transcription factor 4 -0.00487781
KLHL23 kelch-like family member 23 -0.00487444
COL4A1 collagen, type IV, alpha 1 -0.00487325
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.00487184
RHOBTB3 Rho-related BTB domain containing 3 -0.00487182
DGKZ diacylglycerol kinase, zeta -0.00486077
TOP2A topoisomerase (DNA) II alpha 170kDa -0.00485261
MMP2 matrix metallopeptidase 2 -0.00484563
DENND4B DENN/MADD domain containing 4B -0.00484373
CBX6 chromobox homolog 6 -0.00484217
ZDHHC17 zinc finger, DHHC-type containing 17 -0.00483513
NUP107 nucleoporin 107kDa -0.00482919
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -0.00481496
DPP3 dipeptidyl-peptidase 3 -0.00481345
PRKCB protein kinase C, beta -0.00480781
GPM6A glycoprotein M6A -0.00480501
PGC progastricsin (pepsinogen C) -0.0047839
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.00477582
ELAC2 elaC ribonuclease Z 2 -0.00477168
NOTCH2 notch 2 -0.00476791
SCAF4 SR-related CTD-associated factor 4 -0.00475601
OPLAH 5-oxoprolinase (ATP-hydrolysing) -0.00475339
GPR161 G protein-coupled receptor 161 -0.00475147
SMTN smoothelin -0.00474956
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -0.00474666
MAPK9 mitogen-activated protein kinase 9 -0.00473226