HNF4A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description hepatocyte nuclear factor 4, alpha|The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 3172)
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Genes

308 genes differentially expressed following the HNF4A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AVP arginine vasopressin 2.92538
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.92538
AMN amnion associated transmembrane protein 2.92538
SCEL sciellin 2.92538
SDSL serine dehydratase-like 2.92538
RDH8 retinol dehydrogenase 8 (all-trans) 2.92538
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.92538
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.92538
PCDHGB4 protocadherin gamma subfamily B, 4 2.92538
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.92538
FMR1NB fragile X mental retardation 1 neighbor 2.92538
DPEP2 dipeptidase 2 2.92538
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.92538
MRC1 mannose receptor, C type 1 2.92538
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.92538
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.92538
EPHB3 EPH receptor B3 2.92538
APOD apolipoprotein D 2.92538
RSPO1 R-spondin 1 2.92223
FGD2 FYVE, RhoGEF and PH domain containing 2 2.92223
SIGLEC9 sialic acid binding Ig-like lectin 9 2.92223
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.92223
FOLR2 folate receptor 2 (fetal) 2.92223
PAX2 paired box 2 2.92223
OR2J2 olfactory receptor, family 2, subfamily J, member 2 2.92223
GSTM5 glutathione S-transferase mu 5 2.92223
IGFL4 IGF-like family member 4 2.92223
PCDHB1 protocadherin beta 1 2.92223
GPR151 G protein-coupled receptor 151 2.92223
CABS1 calcium-binding protein, spermatid-specific 1 2.92223
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.92223
SSTR3 somatostatin receptor 3 2.92223
ASGR2 asialoglycoprotein receptor 2 2.92223
BMP3 bone morphogenetic protein 3 2.92223
ACY3 aminoacylase 3 2.92223
DIO3 deiodinase, iodothyronine, type III 2.92223
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.92223
MYH1 myosin, heavy chain 1, skeletal muscle, adult 2.92223
CRX cone-rod homeobox 2.92223
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.92223
OR1L4 olfactory receptor, family 1, subfamily L, member 4 2.92223
C9ORF153 chromosome 9 open reading frame 153 2.92223
C16ORF82 chromosome 16 open reading frame 82 2.92223
TRIM77 tripartite motif containing 77 2.92223
LYZL6 lysozyme-like 6 2.92223
GYPA glycophorin A (MNS blood group) 2.92223
TAS2R1 taste receptor, type 2, member 1 2.92223
OR4D9 olfactory receptor, family 4, subfamily D, member 9 2.92223
VTN vitronectin 2.92223
TMPRSS6 transmembrane protease, serine 6 2.92223
FRG2C FSHD region gene 2 family, member C 2.92223
SPEM1 spermatid maturation 1 2.92223
ALX4 ALX homeobox 4 2.92223
ZAR1 zygote arrest 1 2.92223
GBP7 guanylate binding protein 7 2.92223
MT3 metallothionein 3 2.92223
NECTIN4 nectin cell adhesion molecule 4 2.92223
LORICRIN loricrin cornified envelope precursor protein 2.92223
CCDC190 coiled-coil domain containing 190 2.92223
ODAPH odontogenesis associated phosphoprotein 2.92223
PPP1R2C PPP1R2C family member C 2.92223
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.92223
GSG1L2 GSG1 like 2 2.92223
SMIM43 small integral membrane protein 43 2.92223
LY6S-AS1 LY6S antisense RNA 1 2.92223
PNMA6F PNMA family member 6F 2.92223
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 2.92223
GRAP GRB2-related adaptor protein 2.92223
FAM228A family with sequence similarity 228, member A 2.92223
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.92223
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.92223
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.92223
ALB albumin 2.92223
GPR6 G protein-coupled receptor 6 2.92223
PTTG2 pituitary tumor-transforming 2 2.92223
PTPRH protein tyrosine phosphatase, receptor type, H 2.92223
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.92223
CATSPER3 cation channel, sperm associated 3 2.92223
ZIC4 Zic family member 4 2.92223
SLAMF9 SLAM family member 9 2.92223
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.92223
EXOC3L4 exocyst complex component 3-like 4 2.92223
CLDN22 claudin 22 2.92223
C2CD2 C2 calcium-dependent domain containing 2 2.92223
LRRC72 leucine rich repeat containing 72 2.92223
HNF1A HNF1 homeobox A 2.92223
LOC124906892 uncharacterized LOC124906892 2.92223
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.92223
UBQLNL ubiquilin-like 2.92223
IL1A interleukin 1, alpha 2.92223
HOPX HOP homeobox 2.92223
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.92223
FAM25C family with sequence similarity 25, member C 2.92223
CFH complement factor H 2.92223
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.92223
SLITRK6 SLIT and NTRK-like family, member 6 2.92223
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.92223
FBXO47 F-box protein 47 2.92223
CDRT15L2 CMT1A duplicated region transcript 15-like 2 2.92223
SLFN12L schlafen family member 12-like 2.92223
FOXE3 forkhead box E3 2.92223
ZNF679 zinc finger protein 679 2.92223
CRYBB2 crystallin, beta B2 2.92223
MYF6 myogenic factor 6 (herculin) 2.92223
CXCR6 chemokine (C-X-C motif) receptor 6 2.92223
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 2.92223
C2CD4A C2 calcium-dependent domain containing 4A 2.92223
HGFAC HGF activator 2.92223
PMP2 peripheral myelin protein 2 2.92223
FEZF2 FEZ family zinc finger 2 2.92223
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.92223
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.92223
LRRC74A leucine rich repeat containing 74A 2.92223
TMTC2 transmembrane and tetratricopeptide repeat containing 2 2.92223
OR14J1 olfactory receptor, family 14, subfamily J, member 1 2.92223
REG1A regenerating islet-derived 1 alpha 2.92223
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 2.92223
WNT10B wingless-type MMTV integration site family, member 10B 2.92223
NEUROD2 neuronal differentiation 2 2.92223
GHRH growth hormone releasing hormone 2.92223
TPRX1 tetra-peptide repeat homeobox 1 2.92223
CD3G CD3g molecule, gamma (CD3-TCR complex) 2.92223
DSPP dentin sialophosphoprotein 2.92223
TPH1 tryptophan hydroxylase 1 2.92223
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.92223
IFNK interferon, kappa 2.92223
CLCA2 chloride channel accessory 2 2.92223
CHAT choline O-acetyltransferase 2.92223
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.92223
CD84 CD84 molecule 2.92223
SYNGR4 synaptogyrin 4 2.92223
PRAP1 proline-rich acidic protein 1 2.92223
MSLN mesothelin 2.92223
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 2.92223
PATE2 prostate and testis expressed 2 2.92223
LYZL1 lysozyme-like 1 2.92223
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.92223
TMEM238 transmembrane protein 238 2.85938
SKIDA1 SKI/DACH domain containing 1 2.7568
ADGRB1 adhesion G protein-coupled receptor B1 2.73424
PLTP phospholipid transfer protein 2.68014
BAG3 BCL2-associated athanogene 3 2.65447
RPL28 ribosomal protein L28 2.64121
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.64121
ZNF687 zinc finger protein 687 2.53653
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 2.52259
ZNF77 zinc finger protein 77 2.46599
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 2.45492
CDH18 cadherin 18, type 2 2.45447
COL18A1 collagen, type XVIII, alpha 1 2.44549
ISYNA1 inositol-3-phosphate synthase 1 2.41407
FTH1 ferritin, heavy polypeptide 1 2.39751
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.35861
TMEM250 transmembrane protein 250 2.35782
XCL1 chemokine (C motif) ligand 1 2.35545
ACE2 angiotensin I converting enzyme 2 2.34646
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.34646
CBS cystathionine-beta-synthase 2.34332
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 2.33658
PHF10 PHD finger protein 10 2.31805
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.31083
EXOSC1 exosome component 1 2.28929
CIB2 calcium and integrin binding family member 2 2.27284
CRHBP corticotropin releasing hormone binding protein 2.26814
UBE3B ubiquitin protein ligase E3B 2.26657
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.25678
SESN1 sestrin 1 2.25275
CFAP100 cilia and flagella associated protein 100 2.2329
GLOD5 glyoxalase domain containing 5 2.22967
IL18BP interleukin 18 binding protein 2.22899
FUBP1 far upstream element (FUSE) binding protein 1 2.22658
TEX10 testis expressed 10 2.21488
SHF Src homology 2 domain containing F 2.21368
CCM2 cerebral cavernous malformation 2 2.20974
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 2.20633
TMEM35A transmembrane protein 35A 2.20568
YPEL5 yippee-like 5 (Drosophila) 2.17506
TBCC tubulin folding cofactor C 2.14196
TESMIN testis expressed metallothionein like protein 2.14196
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 2.13802
KAT14 lysine acetyltransferase 14 2.13684
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 2.13649
FIGNL2 fidgetin-like 2 2.13465
POLR3GL polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like 2.12398
ZNF136 zinc finger protein 136 2.1052
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.10282
ACTL10 actin-like 10 2.10228
FGF22 fibroblast growth factor 22 2.08666
LAMA3 laminin, alpha 3 2.08052
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.07076
RPL18A ribosomal protein L18a 2.06013
ZER1 zyg-11 related, cell cycle regulator 2.04481
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.04481
BMP7 bone morphogenetic protein 7 2.04272
PCED1B PC-esterase domain containing 1B 2.01688
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 2.01298

decreased expression

Symbol Name Standardized Value
GRID2 glutamate receptor, ionotropic, delta 2 -2.92538
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.92223
RAB5C RAB5C, member RAS oncogene family -2.92223
CCDC27 coiled-coil domain containing 27 -2.92223
TMIGD3 transmembrane and immunoglobulin domain containing 3 -2.92223
KIF19 kinesin family member 19 -2.92223
IFT38 intraflagellar transport 38 -2.92223
PIWIL3 piwi-like RNA-mediated gene silencing 3 -2.92223
FAN1 FANCD2/FANCI-associated nuclease 1 -2.92223
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -2.92223
POTEF POTE ankyrin domain family, member F -2.92223
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.92223
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.92223
MEIS1 Meis homeobox 1 -2.92223
SLC38A5 solute carrier family 38, member 5 -2.92223
BMERB1 bMERB domain containing 1 -2.86341
KHDC3L KH domain containing 3-like, subcortical maternal complex member -2.85938
NPAP1 nuclear pore associated protein 1 -2.85938
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -2.85938
APOL6 apolipoprotein L, 6 -2.85938
RERGL RERG/RAS-like -2.85938
CABP4 calcium binding protein 4 -2.85938
PRELP proline/arginine-rich end leucine-rich repeat protein -2.85938
OR10A2 olfactory receptor, family 10, subfamily A, member 2 -2.85938
ZNF556 zinc finger protein 556 -2.85938
SOWAHB sosondowah ankyrin repeat domain family member B -2.85938
ADTRP androgen-dependent TFPI-regulating protein -2.85938
PNOC prepronociceptin -2.85938
LOXL4 lysyl oxidase-like 4 -2.85938
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.85938
GIMAP4 GTPase, IMAP family member 4 -2.85938
ZNF189 zinc finger protein 189 -2.85938
IHO1 interactor of HORMAD1 1 -2.85938
SMPX small muscle protein, X-linked -2.85938
CXCL13 chemokine (C-X-C motif) ligand 13 -2.85938
PROP1 PROP paired-like homeobox 1 -2.85938
H2BC1 H2B clustered histone 1 -2.85938
TH tyrosine hydroxylase -2.85938
MRNIP MRN complex interacting protein -2.85938
PGR progesterone receptor -2.85938
SLC38A3 solute carrier family 38, member 3 -2.85938
AOPEP aminopeptidase O (putative) -2.85938
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -2.85938
LY6K lymphocyte antigen 6 complex, locus K -2.85938
LST1 leukocyte specific transcript 1 -2.85938
TBC1D28 TBC1 domain family, member 28 -2.85938
ZNF99 zinc finger protein 99 -2.85938
FOXD1 forkhead box D1 -2.85938
STMN4 stathmin-like 4 -2.85938
APOH apolipoprotein H (beta-2-glycoprotein I) -2.85938
CCR9 chemokine (C-C motif) receptor 9 -2.85938
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) -2.85938
C11ORF96 chromosome 11 open reading frame 96 -2.85938
ELF2 E74-like factor 2 (ets domain transcription factor) -2.83182
LTBP2 latent transforming growth factor beta binding protein 2 -2.80277
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -2.80277
DES desmin -2.80277
HAUS5 HAUS augmin-like complex, subunit 5 -2.72867
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -2.65006
ATRX alpha thalassemia/mental retardation syndrome X-linked -2.63733
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -2.60671
BATF3 basic leucine zipper transcription factor, ATF-like 3 -2.60079
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.55071
USP34 ubiquitin specific peptidase 34 -2.54796
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -2.54609
SLC6A16 solute carrier family 6, member 16 -2.51617
KIAA0825 KIAA0825 -2.51395
ATF7IP2 activating transcription factor 7 interacting protein 2 -2.49409
ZNF75A zinc finger protein 75a -2.45447
FNIP1 folliculin interacting protein 1 -2.37726
C1ORF74 chromosome 1 open reading frame 74 -2.36913
CNTRL centriolin -2.35003
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -2.33638
SPEF1 sperm flagellar 1 -2.33638
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -2.31805
FCRLB Fc receptor-like B -2.30162
TOX2 TOX high mobility group box family member 2 -2.28828
SLC10A3 solute carrier family 10, member 3 -2.27656
ZNF169 zinc finger protein 169 -2.26657
SULF2 sulfatase 2 -2.26176
ATP9B ATPase, class II, type 9B -2.24261
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.2329
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 -2.22833
ATG9A autophagy related 9A -2.2109
SELENOI selenoprotein I -2.21085
FAM217A family with sequence similarity 217, member A -2.18108
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -2.17865
SYT1 synaptotagmin I -2.17506
AK5 adenylate kinase 5 -2.11656
LRRC32 leucine rich repeat containing 32 -2.11656
MAP3K4-AS1 MAP3K4 antisense RNA 1 -2.11656
H2AC13 H2A clustered histone 13 -2.10557
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -2.10557
SLC38A8 solute carrier family 38, member 8 -2.10228
PNMA8B PNMA family member 8B -2.10228
MMP19 matrix metallopeptidase 19 -2.10228
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled -2.10228
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.10228
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 -2.09338
MAST1 microtubule associated serine/threonine kinase 1 -2.09028
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.08523
DCAF10 DDB1 and CUL4 associated factor 10 -2.08512
TIAM1 T-cell lymphoma invasion and metastasis 1 -2.0765
PDZD2 PDZ domain containing 2 -2.05628
DEGS2 delta(4)-desaturase, sphingolipid 2 -2.05038
QRICH2 glutamine rich 2 -2.04842
ARHGAP32 Rho GTPase activating protein 32 -2.04799
AHNAK2 AHNAK nucleoprotein 2 -2.0432
ZNF100 zinc finger protein 100 -2.0432
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.02129
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -2.01688
NLRP1 NLR family, pyrin domain containing 1 -2.00036