HNF4A Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description hepatocyte nuclear factor 4, alpha|The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 3172)
External Link https://ncbi.nlm.nih.gov/gene/3172
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Genes

499 genes differentially expressed following the HNF4A gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
SCGB2A2 secretoglobin, family 2A, member 2 0.0145061
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0120374
ARHGAP29 Rho GTPase activating protein 29 0.0118714
CXCL5 chemokine (C-X-C motif) ligand 5 0.011587
HSPA1A heat shock 70kDa protein 1A 0.0109456
GAS1 growth arrest-specific 1 0.0108243
SCGB1D2 secretoglobin, family 1D, member 2 0.0100941
CXCL12 chemokine (C-X-C motif) ligand 12 0.00989354
TOB1 transducer of ERBB2, 1 0.00973018
CXCL8 chemokine (C-X-C motif) ligand 8 0.00947627
CCN2 cellular communication network factor 2 0.0093232
G0S2 G0/G1 switch 2 0.00931185
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.00907532
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.00905025
ADIRF adipogenesis regulatory factor 0.00896851
KRT23 keratin 23, type I 0.00889369
HOXC6 homeobox C6 0.00888808
TSPYL5 TSPY-like 5 0.00882329
MT1X metallothionein 1X 0.00877184
MFAP5 microfibrillar associated protein 5 0.00871933
PLAAT3 phospholipase A and acyltransferase 3 0.00864434
CLEC11A C-type lectin domain family 11, member A 0.00861452
SRPX sushi-repeat containing protein, X-linked 0.00853802
AKAP12 A kinase (PRKA) anchor protein 12 0.0084521
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.00828751
BLNK B-cell linker 0.0081802
WDR7 WD repeat domain 7 0.00812707
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.00798781
ASS1 argininosuccinate synthase 1 0.00797972
PCDH9 protocadherin 9 0.00794161
SCAND1 SCAN domain containing 1 0.00785209
TXLNA taxilin alpha 0.00784333
METRN meteorin, glial cell differentiation regulator 0.00782899
SYBU syntabulin (syntaxin-interacting) 0.00779386
THBS2 thrombospondin 2 0.00778996
CYBA cytochrome b-245, alpha polypeptide 0.00777769
APOD apolipoprotein D 0.00768866
RTN1 reticulon 1 0.00768417
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.00766734
INSR insulin receptor 0.00756991
CYB5R2 cytochrome b5 reductase 2 0.00756931
NID2 nidogen 2 (osteonidogen) 0.00753284
PROM1 prominin 1 0.00751496
CAV2 caveolin 2 0.00739985
TFPI2 tissue factor pathway inhibitor 2 0.00729922
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.00722164
ALCAM activated leukocyte cell adhesion molecule 0.00714825
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.00702877
MX1 MX dynamin-like GTPase 1 0.00699852
GPM6B glycoprotein M6B 0.00699286
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.00696979
SLC38A1 solute carrier family 38, member 1 0.00696893
MAT2A methionine adenosyltransferase II, alpha 0.00695218
ESR1 estrogen receptor 1 0.00688929
LY75 lymphocyte antigen 75 0.00688838
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.00684363
TPD52L1 tumor protein D52-like 1 0.00684159
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.00683978
AEBP1 AE binding protein 1 0.00680884
ADD3 adducin 3 (gamma) 0.00678724
SMAD2 SMAD family member 2 0.00677792
COL14A1 collagen, type XIV, alpha 1 0.00677148
ZBED2 zinc finger, BED-type containing 2 0.00667322
BTG1 B-cell translocation gene 1, anti-proliferative 0.00662472
BBX bobby sox homolog (Drosophila) 0.00660233
UGCG UDP-glucose ceramide glucosyltransferase 0.00658438
ELOVL2 ELOVL fatty acid elongase 2 0.00652699
ANXA1 annexin A1 0.00652358
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00643966
CA12 carbonic anhydrase XII 0.00640774
SCGB2A1 secretoglobin, family 2A, member 1 0.00637604
PIP prolactin-induced protein 0.00634161
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 0.0063346
RCAN1 regulator of calcineurin 1 0.0063326
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.00632012
MEX3C mex-3 RNA binding family member C 0.00631968
ABAT 4-aminobutyrate aminotransferase 0.0062992
ZNF423 zinc finger protein 423 0.00625485
CHRDL1 chordin-like 1 0.00623074
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.00621996
KRT7 keratin 7, type II 0.00621925
NT5E 5'-nucleotidase, ecto (CD73) 0.00620951
POU2AF1 POU class 2 associating factor 1 0.00616809
TAC1 tachykinin, precursor 1 0.00614182
CRABP2 cellular retinoic acid binding protein 2 0.00613371
ARMCX2 armadillo repeat containing, X-linked 2 0.00611024
DCLK1 doublecortin-like kinase 1 0.0060638
BHLHE41 basic helix-loop-helix family, member e41 0.00601791
TTC39A tetratricopeptide repeat domain 39A 0.00599661
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.00597619
MATN2 matrilin 2 0.00597436
MXRA5 matrix-remodelling associated 5 0.00595176
SSBP2 single-stranded DNA binding protein 2 0.00592841
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.00591741
CALB1 calbindin 1, 28kDa 0.00590659
TFF1 trefoil factor 1 0.00589276
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.00589169
COL16A1 collagen, type XVI, alpha 1 0.005891
CXCL6 chemokine (C-X-C motif) ligand 6 0.00588625
IFI27 interferon, alpha-inducible protein 27 0.0058774
GRB14 growth factor receptor-bound protein 14 0.00586567
SFRP4 secreted frizzled-related protein 4 0.00585146
ISG20 interferon stimulated exonuclease gene 20kDa 0.00584999
GPR137B G protein-coupled receptor 137B 0.0058357
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.00580003
MLF1 myeloid leukemia factor 1 0.0057698
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.00576244
TPPP3 tubulin polymerization-promoting protein family member 3 0.00575104
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.00571155
CHD1 chromodomain helicase DNA binding protein 1 0.0056888
GREM1 gremlin 1, DAN family BMP antagonist 0.00568608
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.00568201
ZNF165 zinc finger protein 165 0.00567827
COBL cordon-bleu WH2 repeat protein 0.00567746
BIRC3 baculoviral IAP repeat containing 3 0.00567649
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.00565919
BEX1 brain expressed, X-linked 1 0.00565256
COL15A1 collagen, type XV, alpha 1 0.00559744
BRD2 bromodomain containing 2 0.00559613
HSPA2 heat shock 70kDa protein 2 0.00558447
LACTB2 lactamase, beta 2 0.00557511
S100P S100 calcium binding protein P 0.00555096
WDTC1 WD and tetratricopeptide repeats 1 0.00551275
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.0055014
CPT1A carnitine palmitoyltransferase 1A (liver) 0.00549965
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.00549919
MYB v-myb avian myeloblastosis viral oncogene homolog 0.0054815
MT1H metallothionein 1H 0.00548033
CCL20 chemokine (C-C motif) ligand 20 0.00547935
MZB1 marginal zone B and B1 cell-specific protein 0.00546571
FA2H fatty acid 2-hydroxylase 0.00544506
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.00542243
CFD complement factor D (adipsin) 0.00541718
C14ORF132 chromosome 14 open reading frame 132 0.00539712
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.00539445
BEX4 brain expressed, X-linked 4 0.00539041
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.00538832
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.00538107
FOXD1 forkhead box D1 0.00537127
MUC16 mucin 16, cell surface associated 0.00537117
MMP9 matrix metallopeptidase 9 0.00535146
MBL2 mannose-binding lectin (protein C) 2, soluble 0.0053327
WWOX WW domain containing oxidoreductase 0.00532198
EGR1 early growth response 1 0.00527727
CD200 CD200 molecule 0.00527562
SAMD4A sterile alpha motif domain containing 4A 0.00527515
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.00525715
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.00524811
CP ceruloplasmin (ferroxidase) 0.00524479
CLEC3B C-type lectin domain family 3, member B 0.00523931
ASRGL1 asparaginase like 1 0.00523785
RFX5 regulatory factor X, 5 (influences HLA class II expression) 0.0052274
SFRP1 secreted frizzled-related protein 1 0.00520864
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.00520247
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.00518625
SGCE sarcoglycan, epsilon 0.00517256
HSPB1 heat shock 27kDa protein 1 0.00516333
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00514332
PBX1 pre-B-cell leukemia homeobox 1 0.0051262
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.00512507
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.00511169
ACKR3 atypical chemokine receptor 3 0.00511159
HOMER1 homer scaffolding protein 1 0.00511132
PHF20 PHD finger protein 20 0.00510479
GOLGA8H golgin A8 family, member H 0.0051019
ACAA1 acetyl-CoA acyltransferase 1 0.00509986
CRYBG3 beta-gamma crystallin domain containing 3 0.00509799
MEOX2 mesenchyme homeobox 2 0.0050861
CLU clusterin 0.00507239
TBCA tubulin folding cofactor A 0.00507039
PDGFRL platelet-derived growth factor receptor-like 0.00507031
KRT14 keratin 14, type I 0.00505847
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.00502815
LAMC2 laminin, gamma 2 0.00500854
DCN decorin 0.00500332
IL1B interleukin 1, beta 0.0049829
ANK2 ankyrin 2, neuronal 0.00497765
RAB29 RAB29, member RAS oncogene family 0.00496059
RPS27L ribosomal protein S27-like 0.00494175
SLC31A2 solute carrier family 31 (copper transporter), member 2 0.00493197
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.00492213
C5ORF30 chromosome 5 open reading frame 30 0.00492046
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 0.00491824
NAP1L3 nucleosome assembly protein 1-like 3 0.00491406
PDLIM4 PDZ and LIM domain 4 0.00491355
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.00491037
THBS4 thrombospondin 4 0.00489122
EHD3 EH-domain containing 3 0.00487901
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.00487375
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.00485102
CALCA calcitonin-related polypeptide alpha 0.00484867
CLDN1 claudin 1 0.00482288
C9ORF16 chromosome 9 open reading frame 16 0.00482281
SYT1 synaptotagmin I 0.00480543
CLIC5 chloride intracellular channel 5 0.00479636
OPN3 opsin 3 0.00479324
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.00478247
ZBTB35 zinc finger and BTB domain containing 35 0.00477979
HIST1H2BK histone cluster 1, H2bk 0.00477886
XIC X chromosome inactivation center 0.00477645
CCND3 cyclin D3 0.00474113
ADGRG6 adhesion G protein-coupled receptor G6 0.00474084
MT1F metallothionein 1F 0.00473947
YPEL5 yippee-like 5 (Drosophila) 0.00473908
MT1G metallothionein 1G 0.00473632
FBLN2 fibulin 2 0.00473438
GPX4 glutathione peroxidase 4 0.00472324
CFAP20 cilia and flagella associated protein 20 0.00470951
KLHL24 kelch-like family member 24 0.00470118
GRAMD2B GRAM domain containing 2B 0.0046925
FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.00467516
AKR1C2 aldo-keto reductase family 1, member C2 0.00465321
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.00463321
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.00463113
IRAK3 interleukin-1 receptor-associated kinase 3 0.004622
CTBP2 C-terminal binding protein 2 0.00460859
RFK riboflavin kinase 0.00459989
FBXO2 F-box protein 2 0.00459492
PLSCR4 phospholipid scramblase 4 0.0045921
MAGED2 melanoma antigen family D2 0.00459006
SRPK2 SRSF protein kinase 2 0.00459004
PTGES prostaglandin E synthase 0.00458816
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 0.00458656
AMIGO2 adhesion molecule with Ig-like domain 2 0.00457756
CELF2 CUGBP, Elav-like family member 2 0.00457756
NFIB nuclear factor I/B 0.00457685
SGPL1 sphingosine-1-phosphate lyase 1 0.00456451
KLC1 kinesin light chain 1 0.00455031
JMJD1C jumonji domain containing 1C 0.00455027
KRT19 keratin 19, type I 0.00454688
LMCD1 LIM and cysteine-rich domains 1 0.00454286
DEGS1 delta(4)-desaturase, sphingolipid 1 0.00454206
DDB2 damage-specific DNA binding protein 2, 48kDa 0.00454107
LHFP lipoma HMGIC fusion partner 0.0045335
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.00452978
SCAF4 SR-related CTD-associated factor 4 0.00451513
CFB complement factor B 0.0045064
GRAMD1C GRAM domain containing 1C 0.00450549
CRY1 cryptochrome circadian clock 1 0.00450547
MMP10 matrix metallopeptidase 10 0.00449696
DPYSL2 dihydropyrimidinase-like 2 0.00448738
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 0.00448279
OPTN optineurin 0.0044614
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.00446029
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.00445808
PAX5 paired box 5 0.00445293
AHCY adenosylhomocysteinase 0.00444929
VPREB1 pre-B lymphocyte 1 0.00444574
IL6R interleukin 6 receptor 0.00444436
TUBB2A tubulin, beta 2A class IIa 0.0044437

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.0128028
SFTPA2 surfactant protein A2 -0.0112564
FGFR3 fibroblast growth factor receptor 3 -0.00976611
HOPX HOP homeobox -0.00962408
TGFB1 transforming growth factor, beta 1 -0.00960137
CDC20 cell division cycle 20 -0.00916519
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00887453
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -0.00880008
NUSAP1 nucleolar and spindle associated protein 1 -0.00861919
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.00859597
COPS7A COP9 signalosome subunit 7A -0.00843792
SFTPB surfactant protein B -0.00841537
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.00833075
NRGN neurogranin (protein kinase C substrate, RC3) -0.00793801
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0076933
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.00768406
GSPT1 G1 to S phase transition 1 -0.00763457
PLBD1 phospholipase B domain containing 1 -0.0073544
ACTB actin, beta -0.00735272
SFTPD surfactant protein D -0.00712033
DMBT1 deleted in malignant brain tumors 1 -0.00707492
PRC1 protein regulator of cytokinesis 1 -0.00700912
LMO3 LIM domain only 3 (rhombotin-like 2) -0.00693808
HMGB2 high mobility group box 2 -0.00693628
RNPS1 RNA binding protein S1, serine-rich domain -0.00691319
SRC SRC proto-oncogene, non-receptor tyrosine kinase -0.0069096
SFTPC surfactant protein C -0.00686182
AQP3 aquaporin 3 (Gill blood group) -0.0068532
CHKB choline kinase beta -0.00683915
TCTA T-cell leukemia translocation altered -0.00681615
P3H2 prolyl 3-hydroxylase 2 -0.0067321
XPO7 exportin 7 -0.00671283
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.00663203
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00651556
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 -0.00647744
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.00643754
NPR3 natriuretic peptide receptor 3 -0.00641414
CPA3 carboxypeptidase A3 (mast cell) -0.00641214
SLN sarcolipin -0.00639771
FOXF1 forkhead box F1 -0.00635381
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -0.00625398
POSTN periostin, osteoblast specific factor -0.00622886
PGC progastricsin (pepsinogen C) -0.00620694
CASP1 caspase 1, apoptosis-related cysteine peptidase -0.00620154
MEX3D mex-3 RNA binding family member D -0.00611745
S100A8 S100 calcium binding protein A8 -0.00607776
TCF21 transcription factor 21 -0.00605385
FABP7 fatty acid binding protein 7, brain -0.00604994
RANBP1 RAN binding protein 1 -0.00601752
FOXF2 forkhead box F2 -0.00600759
RHOBTB3 Rho-related BTB domain containing 3 -0.005987
TLR4 toll-like receptor 4 -0.0059559
GPC3 glypican 3 -0.0058841
G6PD glucose-6-phosphate dehydrogenase -0.00588366
FOLR1 folate receptor 1 (adult) -0.00586965
NDNF neuron-derived neurotrophic factor -0.00581086
SIRT3 sirtuin 3 -0.00578172
TPM4 tropomyosin 4 -0.00577582
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.00575158
RSL1D1 ribosomal L1 domain containing 1 -0.00574907
TMPRSS2 transmembrane protease, serine 2 -0.00574335
FOXM1 forkhead box M1 -0.00570996
RAD23B RAD23 homolog B (S. cerevisiae) -0.00569966
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.00569424
KRT18 keratin 18, type I -0.00568953
TUG1 taurine up-regulated 1 (non-protein coding) -0.00567685
HBD hemoglobin, delta -0.0056742
S100A9 S100 calcium binding protein A9 -0.0056527
HNMT histamine N-methyltransferase -0.00563926
NLRP2 NLR family, pyrin domain containing 2 -0.00560058
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.00557183
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -0.00556807
COL4A5 collagen, type IV, alpha 5 -0.00555584
TARP TCR gamma alternate reading frame protein -0.0055429
ODC1 ornithine decarboxylase 1 -0.00553822
GGT1 gamma-glutamyltransferase 1 -0.00551803
FZD5 frizzled class receptor 5 -0.00549711
C1QA complement component 1, q subcomponent, A chain -0.00538349
MALL mal, T-cell differentiation protein-like -0.00538185
WFDC1 WAP four-disulfide core domain 1 -0.0053651
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.00533901
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 -0.00531264
CLCN3 chloride channel, voltage-sensitive 3 -0.00528354
GSTT1 glutathione S-transferase theta 1 -0.00527898
SPRR1B small proline-rich protein 1B -0.00522926
ACSL5 acyl-CoA synthetase long-chain family member 5 -0.00522621
TMEM14B transmembrane protein 14B -0.00520312
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -0.00518563
NPTX1 neuronal pentraxin I -0.00517896
IL2RB interleukin 2 receptor, beta -0.00516524
LMNB1 lamin B1 -0.00515609
MPP1 membrane protein, palmitoylated 1, 55kDa -0.00513602
GDE1 glycerophosphodiester phosphodiesterase 1 -0.00513106
EPAS1 endothelial PAS domain protein 1 -0.00511054
LGALS2 lectin, galactoside-binding, soluble, 2 -0.00509983
PGD phosphogluconate dehydrogenase -0.00508525
MAPK1 mitogen-activated protein kinase 1 -0.00507673
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.00504324
NELFCD negative elongation factor complex member C/D -0.00499635
CA9 carbonic anhydrase IX -0.00499583
XCL1 chemokine (C motif) ligand 1 -0.00499356
CLIC3 chloride intracellular channel 3 -0.00496158
CHRM3 cholinergic receptor, muscarinic 3 -0.00493918
NKX2-1 NK2 homeobox 1 -0.00493709
S100A2 S100 calcium binding protein A2 -0.00491074
ANOS1 anosmin 1 -0.00490535
DENND2B DENN domain containing 2B -0.00486955
LAPTM4B lysosomal protein transmembrane 4 beta -0.00485621
ZDHHC6 zinc finger, DHHC-type containing 6 -0.00485557
MTCL1 microtubule crosslinking factor 1 -0.00484744
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.00484067
ZDHHC4 zinc finger, DHHC-type containing 4 -0.0048343
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.00482127
TTLL12 tubulin tyrosine ligase-like family member 12 -0.00481202
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -0.00479218
UNC13B unc-13 homolog B (C. elegans) -0.00479016
CD34 CD34 molecule -0.00478399
AHSP alpha hemoglobin stabilizing protein -0.00475219
PDGFC platelet derived growth factor C -0.00474972
CLTC clathrin, heavy chain (Hc) -0.0047404
COL1A2 collagen, type I, alpha 2 -0.00471165
TSPAN4 tetraspanin 4 -0.00470656
ENO2 enolase 2 (gamma, neuronal) -0.00470602
KIF20A kinesin family member 20A -0.00468512
RUSF1 RUS family member 1 -0.00467286
JCHAIN joining chain of multimeric IgA and IgM -0.00466278
ACP3 acid phosphatase 3 -0.00465989
CPVL carboxypeptidase, vitellogenic-like -0.00464275
EMID1 EMI domain containing 1 -0.00463461
TSPAN6 tetraspanin 6 -0.00460474
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.00458482
CLEC7A C-type lectin domain family 7, member A -0.00457826
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.00457248
SPRR3 small proline-rich protein 3 -0.00454391
PRF1 perforin 1 (pore forming protein) -0.0045291
EXPH5 exophilin 5 -0.00452812
CNTN1 contactin 1 -0.00451079
ADAT1 adenosine deaminase, tRNA-specific 1 -0.00450454
CD177 CD177 molecule -0.00447648
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.00447349
FAM13A family with sequence similarity 13, member A -0.00446244
ALG8 ALG8, alpha-1,3-glucosyltransferase -0.00445906
LOXL2 lysyl oxidase-like 2 -0.00445652
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -0.00444669
GANAB glucosidase, alpha; neutral AB -0.00444498
SPRR2B small proline-rich protein 2B -0.0044407
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.00443982
IFITM3 interferon induced transmembrane protein 3 -0.00443677
GNLY granulysin -0.00443242
ARSL arylsulfatase L -0.0044314
NES nestin -0.00441969
MOXD1 monooxygenase, DBH-like 1 -0.00441834
PDIA3 protein disulfide isomerase family A, member 3 -0.00441526
FOXA2 forkhead box A2 -0.00440769
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.00434266
PARVB parvin, beta -0.00434083
NBL1 neuroblastoma 1, DAN family BMP antagonist -0.00432463
KLHDC3 kelch domain containing 3 -0.00432094
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.00432014
CXCL14 chemokine (C-X-C motif) ligand 14 -0.00431872
BMP4 bone morphogenetic protein 4 -0.00431852
HACD1 3-hydroxyacyl-CoA dehydratase 1 -0.00431634
NUCB1 nucleobindin 1 -0.00431216
RPS5 ribosomal protein S5 -0.00430918
SUMO1 small ubiquitin-like modifier 1 -0.00430466
MAP7 microtubule-associated protein 7 -0.00428079
LTA4H leukotriene A4 hydrolase -0.0042807
KDM5D lysine (K)-specific demethylase 5D -0.00427873
EPHA4 EPH receptor A4 -0.0042771
TNNC1 troponin C type 1 (slow) -0.00427182
PPP1R3C protein phosphatase 1, regulatory subunit 3C -0.0042406
DHRS11 dehydrogenase/reductase (SDR family) member 11 -0.00422156
METTL9 methyltransferase like 9 -0.00421828
COL4A6 collagen, type IV, alpha 6 -0.00421748
FAM198B family with sequence similarity 198, member B -0.0042029
RERE arginine-glutamic acid dipeptide (RE) repeats -0.00420034
JOSD1 Josephin domain containing 1 -0.00419817
PHC1 polyhomeotic homolog 1 (Drosophila) -0.00418729
ADM adrenomedullin -0.00418722
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -0.00418561
CLCA4 chloride channel accessory 4 -0.00418437
DAPK1 death-associated protein kinase 1 -0.00417426
LAMP3 lysosomal-associated membrane protein 3 -0.00417379
NOP10 NOP10 ribonucleoprotein -0.00417143
ASCC2 activating signal cointegrator 1 complex subunit 2 -0.00416833
GLS glutaminase -0.00416816
ROGDI rogdi homolog (Drosophila) -0.00416623
PHB2 prohibitin 2 -0.00415221
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 -0.00413821
MYL1 myosin, light chain 1, alkali; skeletal, fast -0.00413172
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.00413129
PTK7 protein tyrosine kinase 7 (inactive) -0.00411706
UXT ubiquitously-expressed, prefoldin-like chaperone -0.00410612
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.00409695
ZWINT ZW10 interacting kinetochore protein -0.00409193
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -0.00408606
PKM pyruvate kinase, muscle -0.00408339
CASP8 caspase 8, apoptosis-related cysteine peptidase -0.00408217
CSK c-src tyrosine kinase -0.00406888
CCKBR cholecystokinin B receptor -0.00406095
PLXNA2 plexin A2 -0.00405405
DSC2 desmocollin 2 -0.00404638
KLF1 Kruppel-like factor 1 (erythroid) -0.00404453
DYNLL1 dynein, light chain, LC8-type 1 -0.00403846
TPI1 triosephosphate isomerase 1 -0.00402735
C4BPA complement component 4 binding protein, alpha -0.00402531
UBB ubiquitin B -0.00402525
CD59 CD59 molecule, complement regulatory protein -0.00402381
NDFIP1 Nedd4 family interacting protein 1 -0.00401737
TPSAB1 tryptase alpha/beta 1 -0.00401474
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -0.00401354
COL3A1 collagen, type III, alpha 1 -0.00398944
APLP2 amyloid beta (A4) precursor-like protein 2 -0.00398903
PSRC1 proline/serine-rich coiled-coil 1 -0.0039877
PRDX6 peroxiredoxin 6 -0.00397655
GPM6A glycoprotein M6A -0.00397645
LST1 leukocyte specific transcript 1 -0.00397105
CGA glycoprotein hormones, alpha polypeptide -0.00396798
ENG endoglin -0.00396257
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0039609
RACGAP1 Rac GTPase activating protein 1 -0.00395585
TTN titin -0.00395129
GJA1 gap junction protein, alpha 1, 43kDa -0.0039496
HMBS hydroxymethylbilane synthase -0.00394044
CHN1 chimerin 1 -0.00393911
TEAD4 TEA domain family member 4 -0.00393649
DIO2 deiodinase, iodothyronine, type II -0.0039361
LPAR6 lysophosphatidic acid receptor 6 -0.00391334
SPARCL1 SPARC-like 1 (hevin) -0.00391291
RNF187 ring finger protein 187 -0.00391097
CD36 CD36 molecule (thrombospondin receptor) -0.00391094
SLC10A3 solute carrier family 10, member 3 -0.00390612
TEX261 testis expressed 261 -0.00390584
ALOX5AP arachidonate 5-lipoxygenase-activating protein -0.00390529
OCA2 oculocutaneous albinism II -0.0039034
TAL1 T-cell acute lymphocytic leukemia 1 -0.00390009
H2AX H2A.X variant histone -0.00389994
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.00389181
SELENBP1 selenium binding protein 1 -0.00388895
LOX lysyl oxidase -0.00388581
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 -0.00388309
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.00387167
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.00387088
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -0.00386873
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -0.0038663
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -0.00386283
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.0038607
NMU neuromedin U -0.00385288
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.00384923