HNRNPA1 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description heterogeneous nuclear ribonucleoprotein A1|This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3178)
External Link http://www.ncbi.nlm.nih.gov/gene/3178
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Genes

122 interacting proteins for hub protein HNRNPA1 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABHD16A abhydrolase domain containing 16A
ACTB actin, beta
AGO1 argonaute RISC catalytic component 1
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARHGAP23 Rho GTPase activating protein 23
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
BUD13 BUD13 homolog (S. cerevisiae)
C11ORF68 chromosome 11 open reading frame 68
CAPN2 calpain 2, (m/II) large subunit
CBX1 chromobox homolog 1
CCNT1 cyclin T1
CDK1 cyclin-dependent kinase 1
CDK9 cyclin-dependent kinase 9
CENPC centromere protein C
CEP55 centrosomal protein 55kDa
CSNK1E casein kinase 1, epsilon
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTCF CCCTC-binding factor (zinc finger protein)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUTA cutA divalent cation tolerance homolog (E. coli)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF4A3 eukaryotic translation initiation factor 4A3
ESR1 estrogen receptor 1
FEN1 flap structure-specific endonuclease 1
FRMD4A FERM domain containing 4A
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GRB2 growth factor receptor-bound protein 2
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
H2AFX H2A histone family, member X
HMGA1 high mobility group AT-hook 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA2 heat shock 70kDa protein 2
HSPA9 heat shock 70kDa protein 9 (mortalin)
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KHSRP KH-type splicing regulatory protein
KIAA0368 KIAA0368
LARP7 La ribonucleoprotein domain family, member 7
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MEPCE methylphosphate capping enzyme
MKNK1 MAP kinase interacting serine/threonine kinase 1
MOV10 Mov10 RISC complex RNA helicase
MRPL37 mitochondrial ribosomal protein L37
MRPS27 mitochondrial ribosomal protein S27
NCOA3 nuclear receptor coactivator 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NNT nicotinamide nucleotide transhydrogenase
NOD2 nucleotide-binding oligomerization domain containing 2
PABPC1 poly(A) binding protein, cytoplasmic 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PABPN1 poly(A) binding protein, nuclear 1
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PIAS1 protein inhibitor of activated STAT, 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PRKCZ protein kinase C, zeta
PRMT1 protein arginine methyltransferase 1
PRMT8 protein arginine methyltransferase 8
PRRC2A proline-rich coiled-coil 2A
PURA purine-rich element binding protein A
RBM39 RNA binding motif protein 39
RBM8A RNA binding motif protein 8A
RBMX RNA binding motif protein, X-linked
RECQL4 RecQ protein-like 4
RIPK3 receptor-interacting serine-threonine kinase 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPAP1 RNA polymerase II associated protein 1
RPL21 ribosomal protein L21
RRP1B ribosomal RNA processing 1B
SAFB scaffold attachment factor B
SAP25 Sin3A-associated protein, 25kDa
SF3A2 splicing factor 3a, subunit 2, 66kDa
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRP72 signal recognition particle 72kDa
SRRM2 serine/arginine repetitive matrix 2
SUFU suppressor of fused homolog (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYTL2 synaptotagmin-like 2
TARDBP TAR DNA binding protein
TNPO1 transportin 1
TOP1 topoisomerase (DNA) I
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRIM69 tripartite motif containing 69
TTF2 transcription termination factor, RNA polymerase II
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
XRN1 5'-3' exoribonuclease 1
YBX1 Y box binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFR zinc finger RNA binding protein