HOXA1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description homeobox A1|In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3198)
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Genes

357 genes differentially expressed following the HOXA1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZACN zinc activated ligand-gated ion channel 3.21519
UNC13C unc-13 homolog C (C. elegans) 3.21519
CASP5 caspase 5, apoptosis-related cysteine peptidase 3.21519
TBX15 T-box 15 3.21519
CCL5 chemokine (C-C motif) ligand 5 3.21519
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.21519
SSTR5 somatostatin receptor 5 3.21519
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.21519
ADAMTSL5 ADAMTS-like 5 3.21519
C3ORF22 chromosome 3 open reading frame 22 3.21519
PGBDF plakoglobin binding and degradation factor 3.21519
ZNF467 zinc finger protein 467 3.21519
CELA3A chymotrypsin-like elastase family, member 3A 3.21519
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 3.21519
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.21519
USP26 ubiquitin specific peptidase 26 3.21519
SCGN secretagogin, EF-hand calcium binding protein 3.21519
SCG2 secretogranin II 3.21519
ADGRE1 adhesion G protein-coupled receptor E1 3.21519
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.21519
BTC betacellulin 3.21519
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.21519
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.21519
KCNIP3 Kv channel interacting protein 3, calsenilin 3.21519
OR51L1 olfactory receptor, family 51, subfamily L, member 1 3.21519
PRR29 proline rich 29 3.21519
HES2 hes family bHLH transcription factor 2 3.21519
IL18R1 interleukin 18 receptor 1 3.21519
STEAP4 STEAP family member 4 3.21519
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.21519
TECTB tectorin beta 3.21519
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.21519
TWIST1 twist family bHLH transcription factor 1 3.21519
AMIGO3 adhesion molecule with Ig-like domain 3 3.21519
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 3.21519
CRYAA crystallin, alpha A 3.21519
LDHC lactate dehydrogenase C 3.21519
C8ORF74 chromosome 8 open reading frame 74 3.21519
COL15A1 collagen, type XV, alpha 1 3.21519
GNRH2 gonadotropin-releasing hormone 2 3.21519
CRYGA crystallin, gamma A 3.21519
SCEL sciellin 3.21519
MYO1G myosin IG 3.21519
CPLX4 complexin 4 3.21519
SP6 Sp6 transcription factor 3.21519
SP5 Sp5 transcription factor 3.21519
PITX3 paired-like homeodomain 3 3.21519
FAM90A11 family with sequence similarity 90 member A11 3.21519
SQOR sulfide quinone oxidoreductase 3.21519
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 3.21519
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 3.21519
GIPC3 GIPC PDZ domain containing family, member 3 3.21519
GPX5 glutathione peroxidase 5 3.21519
LTB4R2 leukotriene B4 receptor 2 3.21519
ALX3 ALX homeobox 3 3.21519
PNLIPRP3 pancreatic lipase-related protein 3 3.21519
FRG2C FSHD region gene 2 family, member C 3.21519
H3-5 H3.5 histone 3.21519
ALPG alkaline phosphatase, germ cell 3.21519
SEPTIN4 septin 4 3.21519
CIMIP2C ciliary microtubule inner protein 2C 3.21519
TBC1D3I TBC1 domain family member 3I 3.21519
LOC124906010 uncharacterized LOC124906010 3.21519
C20ORF204 chromosome 20 open reading frame 204 3.21519
SMIM31 small integral membrane protein 31 3.21519
SEPTIN12 septin 12 3.21519
DIPK2B divergent protein kinase domain 2B 3.21519
NSG2 neuronal vesicle trafficking associated 2 3.21519
PLAAT4 phospholipase A and acyltransferase 4 3.21519
FAM220A family with sequence similarity 220, member A 3.21519
SMLR1 small leucine-rich protein 1 3.21519
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.21519
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.21519
NPNT nephronectin 3.21519
ZIC4 Zic family member 4 3.21519
PCDHB11 protocadherin beta 11 3.21519
PRB4 proline-rich protein BstNI subfamily 4 3.21519
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.21519
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.21519
SRL sarcalumenin 3.21519
SBK3 SH3 domain binding kinase family, member 3 3.21519
OVOL3 ovo-like zinc finger 3 3.21519
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.21519
SLC45A2 solute carrier family 45, member 2 3.21519
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.21519
SPATA22 spermatogenesis associated 22 3.21519
GATA2 GATA binding protein 2 3.21519
NDP Norrie disease (pseudoglioma) 3.21519
S100G S100 calcium binding protein G 3.21519
EXOC3L4 exocyst complex component 3-like 4 3.21519
OR2L8 olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene) 3.21519
CREB3L3 cAMP responsive element binding protein 3-like 3 3.21519
GLP2R glucagon-like peptide 2 receptor 3.21519
INHBB inhibin, beta B 3.21519
TTC16 tetratricopeptide repeat domain 16 3.21519
ANKRD63 ankyrin repeat domain 63 3.21519
HCRT hypocretin (orexin) neuropeptide precursor 3.21519
CERKL ceramide kinase-like 3.21519
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 3.21519
NT5C1B 5'-nucleotidase, cytosolic IB 3.21519
LRRC25 leucine rich repeat containing 25 3.21519
PCDHA11 protocadherin alpha 11 3.21519
SHOX2 short stature homeobox 2 3.21519
GAGE10 G antigen 10 3.21519
MYLK2 myosin light chain kinase 2 3.21519
NGB neuroglobin 3.21519
OR52L1 olfactory receptor, family 52, subfamily L, member 1 3.21519
SMIM22 small integral membrane protein 22 3.21519
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.21519
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.21519
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 3.21519
ACKR2 atypical chemokine receptor 2 3.21519
NANOGNB NANOG neighbor homeobox 3.21519
RTBDN retbindin 3.21519
UTS2R urotensin 2 receptor 3.21519
HRCT1 histidine rich carboxyl terminus 1 3.21519
CHIT1 chitinase 1 (chitotriosidase) 3.21519
C17ORF99 chromosome 17 open reading frame 99 3.21519
MUCL1 mucin-like 1 3.21519
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.21519
AMN amnion associated transmembrane protein 3.21519
C16ORF78 chromosome 16 open reading frame 78 3.21519
CALHM1 calcium homeostasis modulator 1 3.21519
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.21519
ADAM7 ADAM metallopeptidase domain 7 3.21519
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.21519
LYZ lysozyme 3.21519
KLHDC1 kelch domain containing 1 3.21519
TBC1D10C TBC1 domain family, member 10C 3.21519
SDS serine dehydratase 3.21519
FAM163A family with sequence similarity 163, member A 3.21519
CARD9 caspase recruitment domain family, member 9 3.21519
CLCNKA chloride channel, voltage-sensitive Ka 3.21519
SLC51B solute carrier family 51, beta subunit 3.21519
GRAPL GRB2-related adaptor protein-like 3.21519
CSHL1 chorionic somatomammotropin hormone-like 1 3.21519
LRRC38 leucine rich repeat containing 38 3.21519
TMEM156 transmembrane protein 156 3.21519
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.21519
TTC22 tetratricopeptide repeat domain 22 3.21519
GOLGA8K golgin A8 family, member K 3.21519
TAS2R40 taste receptor, type 2, member 40 3.21519
DENR density-regulated protein 3.21519
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 3.21519
SPINK4 serine peptidase inhibitor, Kazal type 4 3.21519
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.21519
GOLGA8H golgin A8 family, member H 3.21519
KIF19 kinesin family member 19 3.21519
PASD1 PAS domain containing 1 3.21519
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 3.21519
TTC36 tetratricopeptide repeat domain 36 3.21519
AMER3 APC membrane recruitment protein 3 3.21519
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 3.21519
FITM1 fat storage-inducing transmembrane protein 1 3.21519
NUTM2D NUT family member 2D 3.21519
FAM151A family with sequence similarity 151, member A 3.21519
HHIPL1 HHIP-like 1 3.21519
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.21519
ROM1 retinal outer segment membrane protein 1 3.21519
WNT10B wingless-type MMTV integration site family, member 10B 3.21519
ADCY4 adenylate cyclase 4 3.21519
TMEM41A transmembrane protein 41A 3.21266
NGEF neuronal guanine nucleotide exchange factor 3.17389
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 3.17389
SYK spleen tyrosine kinase 3.14284
TNN tenascin N 3.03307
LOC124904942 uncharacterized LOC124904942 3.00886
TMEM231 transmembrane protein 231 2.96672
CARS1 cysteinyl-tRNA synthetase 1 2.91133
ITLN2 intelectin 2 2.80265
ZNF281 zinc finger protein 281 2.79386
ZNF182 zinc finger protein 182 2.6668
SKAP2 src kinase associated phosphoprotein 2 2.6664
CDK1 cyclin-dependent kinase 1 2.59753
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 2.5869
ADAM32 ADAM metallopeptidase domain 32 2.55299
TM2D3 TM2 domain containing 3 2.54297
ZNF169 zinc finger protein 169 2.52931
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae) 2.51504
PRPF38B pre-mRNA processing factor 38B 2.51402
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.51402
BCR breakpoint cluster region 2.51402
DLG3 discs, large homolog 3 (Drosophila) 2.50356
AHNAK2 AHNAK nucleoprotein 2 2.44035
CRH corticotropin releasing hormone 2.41974
RNF112 ring finger protein 112 2.41974
CHMP4A charged multivesicular body protein 4A 2.40831
EOLA1 endothelium and lymphocyte associated ASCH domain 1 2.40292
HAX1 HCLS1 associated protein X-1 2.395
BYSL bystin-like 2.35649
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 2.3559
CHD3 chromodomain helicase DNA binding protein 3 2.34301
VMA22 vacuolar ATPase assembly factor VMA22 2.30762
LINS1 lines homolog 1 2.3001
CMTR2 cap methyltransferase 2 2.29964
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 2.28995
TRIM33 tripartite motif containing 33 2.28995
FANCA Fanconi anemia, complementation group A 2.28756
CLN5 ceroid-lipofuscinosis, neuronal 5 2.28756
ZNF48 zinc finger protein 48 2.28756
SAFB2 scaffold attachment factor B2 2.28432
IRX3 iroquois homeobox 3 2.26322
FAM13A family with sequence similarity 13, member A 2.24696
CNIH2 cornichon family AMPA receptor auxiliary protein 2 2.24209
CFAP299 cilia and flagella associated protein 299 2.22545
GRAMD2A GRAM domain containing 2A 2.22545
CLEC4A C-type lectin domain family 4, member A 2.22545
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.22545
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 2.22545
CYS1 cystin 1 2.22545
RTCA RNA 3'-terminal phosphate cyclase 2.22545
SUCLG1 succinate-CoA ligase, alpha subunit 2.20875
STX16 syntaxin 16 2.20576
FOXK1 forkhead box K1 2.1688
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 2.16442
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 2.12567
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 2.12567
PNN pinin, desmosome associated protein 2.11829
GRIK3 glutamate receptor, ionotropic, kainate 3 2.11611
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.11158
WFDC8 WAP four-disulfide core domain 8 2.11158
ARHGAP18 Rho GTPase activating protein 18 2.10723
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2.10604
CCNY cyclin Y 2.09969
CRIP1 cysteine-rich protein 1 (intestinal) 2.0926
SCARF1 scavenger receptor class F, member 1 2.0926
MEX3A mex-3 RNA binding family member A 2.09059
ZYX zyxin 2.08727
GTF3A general transcription factor IIIA 2.08194
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 2.07012
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 2.06869
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 2.05883
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.05395
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 2.04493
ATP10B ATPase, class V, type 10B 2.04025
STXBP5 syntaxin binding protein 5 (tomosyn) 2.0293
ZNF620 zinc finger protein 620 2.0293
BFAR bifunctional apoptosis regulator 2.02544
NR2E3 nuclear receptor subfamily 2, group E, member 3 2.02512

decreased expression

Symbol Name Standardized Value
FCGBP Fc fragment of IgG binding protein -3.21519
NEURL2 neuralized E3 ubiquitin protein ligase 2 -3.21519
LOC107985101 uncharacterized LOC107985101 -3.21519
ZNF600 zinc finger protein 600 -3.21519
IRF9 interferon regulatory factor 9 -3.21519
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -3.21519
ACVR1C activin A receptor, type IC -3.21519
FAM43B family with sequence similarity 43, member B -3.1898
TCEA3 transcription elongation factor A (SII), 3 -3.1898
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -3.1898
CMKLR1 chemerin chemokine-like receptor 1 -3.1898
ZMYND12 zinc finger, MYND-type containing 12 -3.1898
ABHD15 abhydrolase domain containing 15 -3.1898
CLDN23 claudin 23 -3.1898
ZNF99 zinc finger protein 99 -3.1898
CKM creatine kinase, muscle -3.1898
CALCA calcitonin-related polypeptide alpha -3.1898
TRIM17 tripartite motif containing 17 -3.1898
RDH16 retinol dehydrogenase 16 (all-trans) -3.1898
TRAM1L1 translocation associated membrane protein 1-like 1 -3.1898
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -3.1898
SOX21 SRY (sex determining region Y)-box 21 -3.1898
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -3.1898
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -3.1898
ATG4A autophagy related 4A, cysteine peptidase -3.1898
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -3.1898
LRRN4 leucine rich repeat neuronal 4 -3.1898
PVALEF parvalbumin like EF-hand containing -3.1898
TSPAN16 tetraspanin 16 -3.1898
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -3.1898
CIMIP3 ciliary microtubule inner protein 3 -3.1898
IRF2-DT IRF2 divergent transcript -3.1898
ACSL5 acyl-CoA synthetase long-chain family member 5 -3.1898
TSNAXIP1 translin-associated factor X interacting protein 1 -3.05507
TTC28 tetratricopeptide repeat domain 28 -3.03307
INSIG1 insulin induced gene 1 -2.96404
LRRN3 leucine rich repeat neuronal 3 -2.88732
MINDY2 MINDY lysine 48 deubiquitinase 2 -2.85433
DYDC2 DPY30 domain containing 2 -2.77068
RETREG2 reticulophagy regulator family member 2 -2.77068
PELI3 pellino E3 ubiquitin protein ligase family member 3 -2.65106
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 -2.53342
ZNF723 zinc finger protein 723 -2.53342
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -2.50356
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -2.50356
RAPSN receptor-associated protein of the synapse -2.50356
SHISA2 shisa family member 2 -2.49434
SOCS7 suppressor of cytokine signaling 7 -2.48808
TFEB transcription factor EB -2.47637
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -2.47366
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.44949
TRIP12 thyroid hormone receptor interactor 12 -2.41974
JMJD4 jumonji domain containing 4 -2.41974
GINM1 glycoprotein integral membrane 1 -2.41974
ZNF383 zinc finger protein 383 -2.38345
ASXL1 additional sex combs like transcriptional regulator 1 -2.35739
SPATA6 spermatogenesis associated 6 -2.35179
IRAK2 interleukin-1 receptor-associated kinase 2 -2.35179
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.34073
MLF2 myeloid leukemia factor 2 -2.30762
NBPF14 neuroblastoma breakpoint family, member 14 -2.30418
PRDX3 peroxiredoxin 3 -2.29676
PHIP pleckstrin homology domain interacting protein -2.2868
HTRA1 HtrA serine peptidase 1 -2.27608
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog -2.27401
TBC1D5 TBC1 domain family, member 5 -2.24998
RIMS3 regulating synaptic membrane exocytosis 3 -2.23945
FTO fat mass and obesity associated -2.23353
ZNF331 zinc finger protein 331 -2.22545
ARL13B ADP-ribosylation factor-like 13B -2.22545
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.21921
ARL11 ADP-ribosylation factor-like 11 -2.21921
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.21757
PPP1R3D protein phosphatase 1, regulatory subunit 3D -2.21757
ZNF773 zinc finger protein 773 -2.20875
TMEM221 transmembrane protein 221 -2.20875
MMP21 matrix metallopeptidase 21 -2.20875
FRMPD4 FERM and PDZ domain containing 4 -2.20581
BTG1 B-cell translocation gene 1, anti-proliferative -2.20576
STK10 serine/threonine kinase 10 -2.20576
PRMT2 protein arginine methyltransferase 2 -2.18616
KIAA1549L KIAA1549-like -2.16526
MYCBPAP MYCBP associated protein -2.16057
JMY junction mediating and regulatory protein, p53 cofactor -2.16054
SACK1H scaffolding CK1 anchoring protein H -2.15999
MT1G metallothionein 1G -2.15812
VDAC3 voltage-dependent anion channel 3 -2.14662
CAB39L calcium binding protein 39-like -2.142
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -2.14133
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -2.13426
MAP1B microtubule-associated protein 1B -2.13214
GORAB golgin, RAB6-interacting -2.12567
RIPOR1 RHO family interacting cell polarization regulator 1 -2.12567
ACP3 acid phosphatase 3 -2.12567
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -2.12567
PWWP3B PWWP domain containing 3B -2.12567
AFF2 AF4/FMR2 family, member 2 -2.12567
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.12567
NPC1 Niemann-Pick disease, type C1 -2.12567
CATSPER4 cation channel, sperm associated 4 -2.12567
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.12567
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.12567
HHAT hedgehog acyltransferase -2.12567
ACKR4 atypical chemokine receptor 4 -2.12567
LDHAL6A lactate dehydrogenase A-like 6A -2.12567
PLEKHO1 pleckstrin homology domain containing, family O member 1 -2.11158
MEF2B myocyte enhancer factor 2B -2.10746
TSPYL5 TSPY-like 5 -2.10746
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -2.10604
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -2.09558
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.05421
OXA1L oxidase (cytochrome c) assembly 1-like -2.03511
ZNF677 zinc finger protein 677 -2.03324
OXTR oxytocin receptor -2.02906
ZNF823 zinc finger protein 823 -2.02885
GSTZ1 glutathione S-transferase zeta 1 -2.0278
ANKRD36 ankyrin repeat domain 36 -2.0163
RFT1 RFT1 homolog (S. cerevisiae) -2.00631