HOXA11 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description homeobox A11|In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3207)
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Genes

316 genes differentially expressed following the HOXA11 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRDM9 PR domain containing 9 2.81098
ZPLD1 zona pellucida-like domain containing 1 2.81098
GPX2 glutathione peroxidase 2 2.81098
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.81098
GYPB glycophorin B (MNS blood group) 2.81098
CDHR4 cadherin-related family member 4 2.81098
ARR3 arrestin 3, retinal (X-arrestin) 2.81098
XCL1 chemokine (C motif) ligand 1 2.81098
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.81098
MUC19 mucin 19, oligomeric 2.81098
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.81098
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.81098
C8ORF48 chromosome 8 open reading frame 48 2.81098
APOC2 apolipoprotein C-II 2.81098
CPB1 carboxypeptidase B1 (tissue) 2.81098
ZNF98 zinc finger protein 98 2.81098
CCN5 cellular communication network factor 5 2.81098
SMIM43 small integral membrane protein 43 2.81098
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.81098
EVI2A ecotropic viral integration site 2A 2.81098
PITX2 paired-like homeodomain 2 2.81098
ETV3L ets variant 3-like 2.81098
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.81098
TDRD10 tudor domain containing 10 2.81098
ENTHD1 ENTH domain containing 1 2.74393
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.74393
TNNI2 troponin I type 2 (skeletal, fast) 2.74393
PRELP proline/arginine-rich end leucine-rich repeat protein 2.74393
TBX15 T-box 15 2.74393
ADRB2 adrenoceptor beta 2, surface 2.74393
PNMA5 paraneoplastic Ma antigen family member 5 2.74393
PDIA2 protein disulfide isomerase family A, member 2 2.74393
PCDHB6 protocadherin beta 6 2.74393
CD209 CD209 molecule 2.74393
PRODH2 proline dehydrogenase (oxidase) 2 2.74393
PLIN4 perilipin 4 2.74393
NANOS2 nanos homolog 2 (Drosophila) 2.74393
OR10A3 olfactory receptor, family 10, subfamily A, member 3 2.74393
SP7 Sp7 transcription factor 2.74393
LMBRD1 LMBR1 domain containing 1 2.74393
AIRE autoimmune regulator 2.74393
SP6 Sp6 transcription factor 2.74393
HMX3 H6 family homeobox 3 2.74393
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.74393
FAM181A family with sequence similarity 181, member A 2.74393
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.74393
STEAP4 STEAP family member 4 2.74393
UMODL1 uromodulin-like 1 2.74393
UBA7 ubiquitin-like modifier activating enzyme 7 2.74393
SLC25A45 solute carrier family 25, member 45 2.74393
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.74393
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.74393
OLIG1 oligodendrocyte transcription factor 1 2.74393
TUBB1 tubulin, beta 1 class VI 2.74393
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.74393
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.74393
TNS4 tensin 4 2.74393
ERAP2 endoplasmic reticulum aminopeptidase 2 2.74393
SPATA31H1 SPATA31 subfamily H member 1 2.74393
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.74393
CXCL13 chemokine (C-X-C motif) ligand 13 2.74393
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.74393
TMPRSS3 transmembrane protease, serine 3 2.74393
PAPOLB poly(A) polymerase beta (testis specific) 2.74393
RNF183 ring finger protein 183 2.74393
CNTN3 contactin 3 (plasmacytoma associated) 2.74393
LTK leukocyte receptor tyrosine kinase 2.74393
PCDHGC3 protocadherin gamma subfamily C, 3 2.74393
GPX5 glutathione peroxidase 5 2.74393
ROPN1B rhophilin associated tail protein 1B 2.74393
SPEGNB SPEG neighbor 2.74393
SMIM35 small integral membrane protein 35 2.74393
CIBAR2 CBY1 interacting BAR domain containing 2 2.74393
EZHIP EZH inhibitory protein 2.74393
CFAP276 cilia and flagella associated protein 276 2.74393
SEPTIN12 septin 12 2.74393
FLACC1 flagellum associated containing coiled-coil domains 1 2.74393
KASH5 KASH domain containing 5 2.74393
DEFB108B defensin, beta 108B 2.74393
GPR132 G protein-coupled receptor 132 2.74393
FGFBP1 fibroblast growth factor binding protein 1 2.74393
ACOT4 acyl-CoA thioesterase 4 2.74393
IZUMO4 IZUMO family member 4 2.74393
SPMAP1 sperm microtubule associated protein 1 2.74393
FAM153A family with sequence similarity 153, member A 2.74393
SLC22A10 solute carrier family 22, member 10 2.74393
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.74393
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.74393
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.74393
GPR52 G protein-coupled receptor 52 2.74393
TLE6 transducin-like enhancer of split 6 2.74393
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.74393
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.74393
GJD2 gap junction protein, delta 2, 36kDa 2.74393
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.74393
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.74393
CFAP45 cilia and flagella associated protein 45 2.74393
RNF113B ring finger protein 113B 2.74393
MIP major intrinsic protein of lens fiber 2.74393
TLR7 toll-like receptor 7 2.74393
DAO D-amino-acid oxidase 2.74393
PI16 peptidase inhibitor 16 2.74393
ART1 ADP-ribosyltransferase 1 2.74393
CCL27 chemokine (C-C motif) ligand 27 2.74393
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.74393
GFI1B growth factor independent 1B transcription repressor 2.74393
PCDHGB4 protocadherin gamma subfamily B, 4 2.74393
HSF4 heat shock transcription factor 4 2.74393
RORC RAR-related orphan receptor C 2.74393
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.74393
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.74393
TBC1D10C TBC1 domain family, member 10C 2.74393
DMTN dematin actin binding protein 2.74393
CYTH3 cytohesin 3 2.74393
CSF1R colony stimulating factor 1 receptor 2.74393
PCDHGA2 protocadherin gamma subfamily A, 2 2.74393
TRADD TNFRSF1A-associated via death domain 2.74393
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.74393
APLNR apelin receptor 2.74393
RGS4 regulator of G-protein signaling 4 2.74393
DGCR6 DiGeorge syndrome critical region gene 6 2.74393
SMIM23 small integral membrane protein 23 2.74393
CATIP ciliogenesis associated TTC17 interacting protein 2.74393
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.74393
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.74393
CHIT1 chitinase 1 (chitotriosidase) 2.74393
S100A14 S100 calcium binding protein A14 2.74393
ITGA11 integrin, alpha 11 2.74393
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.74393
IL9R interleukin 9 receptor 2.74393
KLHL41 kelch-like family member 41 2.74393
DLX3 distal-less homeobox 3 2.74393
CLDN34 claudin 34 2.74393
SLC22A24 solute carrier family 22, member 24 2.74393
TBC1D26 TBC1 domain family, member 26 2.74393
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.74393
RANBP3L RAN binding protein 3-like 2.74393
WFDC6 WAP four-disulfide core domain 6 2.74393
GBX2 gastrulation brain homeobox 2 2.74393
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.74393
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.74393
MYOZ2 myozenin 2 2.74393
PRND prion protein 2 (dublet) 2.74393
GSDMC gasdermin C 2.74393
MAGEC3 melanoma antigen family C3 2.74393
NR1D1 nuclear receptor subfamily 1, group D, member 1 2.74393
CD22 CD22 molecule 2.74393
GRM6 glutamate receptor, metabotropic 6 2.74393
CFI complement factor I 2.74393
OTULIN OTU deubiquitinase with linear linkage specificity 2.74393
ANXA8 annexin A8 2.74393
DRD1 dopamine receptor D1 2.74393
NUTM2B NUT family member 2B 2.74393
POTEI POTE ankyrin domain family, member I 2.74393
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.74393
PCDHAC1 protocadherin alpha subfamily C, 1 2.74393
CHRM4 cholinergic receptor, muscarinic 4 2.74393
FGF17 fibroblast growth factor 17 2.74393
GJB6 gap junction protein, beta 6, 30kDa 2.74393
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.74393
CETP cholesteryl ester transfer protein, plasma 2.74393
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.74393
LAMB3 laminin, beta 3 2.74393
TGM6 transglutaminase 6 2.74393
AOC1 amine oxidase, copper containing 1 2.74393
STYXL1 serine/threonine/tyrosine interacting-like 1 2.74295
TENM4 teneurin transmembrane protein 4 2.72155
CD81 CD81 molecule 2.7072
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2.66617
DCLK3 doublecortin-like kinase 3 2.64015
ZGLP1 zinc finger, GATA-like protein 1 2.64015
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.64015
PCDH20 protocadherin 20 2.64015
CPNE7 copine VII 2.61142
PSPC1 paraspeckle component 1 2.55015
DHDH dihydrodiol dehydrogenase (dimeric) 2.50264
YY1 YY1 transcription factor 2.49214
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 2.46228
DENND4A DENN/MADD domain containing 4A 2.38912
ORM2 orosomucoid 2 2.36501
TPH1 tryptophan hydroxylase 1 2.36501
C17ORF67 chromosome 17 open reading frame 67 2.3638
AMPD2 adenosine monophosphate deaminase 2 2.3638
YDJC YdjC homolog (bacterial) 2.35754
CPNE5 copine V 2.35754
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 2.3552
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 2.3552
ATP10A ATPase, class V, type 10A 2.34641
COL5A1 collagen, type V, alpha 1 2.32582
PNMA8C PNMA family member 8C 2.32408
EIF3A eukaryotic translation initiation factor 3, subunit A 2.30753
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.28535
CCDC97 coiled-coil domain containing 97 2.27826
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 2.27158
CD99L2 CD99 molecule-like 2 2.268
CLN5 ceroid-lipofuscinosis, neuronal 5 2.26238
S100B S100 calcium binding protein B 2.25104
OXT oxytocin/neurophysin I prepropeptide 2.25104
RAD54L RAD54-like (S. cerevisiae) 2.24363
TARBP2 TAR (HIV-1) RNA binding protein 2 2.21636
KLRG1 killer cell lectin-like receptor subfamily G, member 1 2.20939
AFF1 AF4/FMR2 family, member 1 2.19254
SOCS5 suppressor of cytokine signaling 5 2.19023
CCNL2 cyclin L2 2.17818
F13A1 coagulation factor XIII, A1 polypeptide 2.16515
SCFD1 sec1 family domain containing 1 2.15193
KLHL3 kelch-like family member 3 2.13717
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.13717
SEPTIN9 septin 9 2.11951
DRAXIN dorsal inhibitory axon guidance protein 2.11441
SMO smoothened, frizzled class receptor 2.11027
NUP214 nucleoporin 214kDa 2.10355
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 2.0964
PTCHD1 patched domain containing 1 2.08088
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 2.08088
HPS3 Hermansky-Pudlak syndrome 3 2.06612
TENT5B terminal nucleotidyltransferase 5B 2.06057
CRTC3 CREB regulated transcription coactivator 3 2.06005
SOX5 SRY (sex determining region Y)-box 5 2.05017
CCNH cyclin H 2.01287

decreased expression

Symbol Name Standardized Value
IL4I1 interleukin 4 induced 1 -2.81098
NME5 NME/NM23 family member 5 -2.81098
IAPP islet amyloid polypeptide -2.81098
VTCN1 V-set domain containing T cell activation inhibitor 1 -2.74393
BMP8B bone morphogenetic protein 8b -2.74393
ASPA aspartoacylase -2.74393
POSTN periostin, osteoblast specific factor -2.74393
FOXJ3 forkhead box J3 -2.74393
HBEGF heparin-binding EGF-like growth factor -2.74393
GRM7 glutamate receptor, metabotropic 7 -2.74393
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.74393
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -2.74393
NOS2 nitric oxide synthase 2, inducible -2.74393
C1ORF202 chromosome 1 open reading frame 202 -2.74393
FAM3D family with sequence similarity 3, member D -2.74393
ACTL8 actin-like 8 -2.74393
GLYATL1B glycine-N-acyltransferase like 1B -2.74393
MUCL3 mucin like 3 -2.74393
DEUP1 deuterosome assembly protein 1 -2.74393
DNAI7 dynein axonemal intermediate chain 7 -2.74393
NIBAN3 niban apoptosis regulator 3 -2.74393
MLANA melan-A -2.74393
PRG4 proteoglycan 4 -2.74393
MMD2 monocyte to macrophage differentiation-associated 2 -2.74393
ARHGAP15 Rho GTPase activating protein 15 -2.74393
ABHD15 abhydrolase domain containing 15 -2.74393
RPS15 ribosomal protein S15 -2.74393
ZNF471 zinc finger protein 471 -2.74393
KLF2 Kruppel-like factor 2 -2.74393
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.74393
FIBP fibroblast growth factor (acidic) intracellular binding protein -2.74393
MOB1B MOB kinase activator 1B -2.74393
CLEC4C C-type lectin domain family 4, member C -2.74393
ITGA10 integrin, alpha 10 -2.74393
CD248 CD248 molecule, endosialin -2.74393
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.74393
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -2.74393
IGF1 insulin-like growth factor 1 (somatomedin C) -2.74393
CTSS cathepsin S -2.74393
CLIC5 chloride intracellular channel 5 -2.74393
EFCAB12 EF-hand calcium binding domain 12 -2.74393
PLCD4 phospholipase C, delta 4 -2.74393
TTC29 tetratricopeptide repeat domain 29 -2.72155
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.64016
TNNI1 troponin I type 1 (skeletal, slow) -2.6394
XK X-linked Kx blood group -2.6394
CETN3 centrin, EF-hand protein, 3 -2.59553
JMJD4 jumonji domain containing 4 -2.59045
DOC2A double C2-like domains, alpha -2.57493
ZFAND2A zinc finger, AN1-type domain 2A -2.57147
OGDHL oxoglutarate dehydrogenase-like -2.55136
ANAPC5 anaphase promoting complex subunit 5 -2.47698
COL6A6 collagen, type VI, alpha 6 -2.45173
ECHDC3 enoyl CoA hydratase domain containing 3 -2.3862
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -2.37926
CEP128 centrosomal protein 128kDa -2.3647
LRRC42 leucine rich repeat containing 42 -2.3638
PDCD7 programmed cell death 7 -2.35861
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -2.3552
UBE2S ubiquitin-conjugating enzyme E2S -2.34676
ZEB1 zinc finger E-box binding homeobox 1 -2.33427
LIPG lipase, endothelial -2.32408
BSPRY B-box and SPRY domain containing -2.31769
RAB39A RAB39A, member RAS oncogene family -2.30017
DPH1 diphthamide biosynthesis 1 -2.28535
ING5 inhibitor of growth family, member 5 -2.28295
PTPRM protein tyrosine phosphatase, receptor type, M -2.27158
TRAM1L1 translocation associated membrane protein 1-like 1 -2.268
MYG1 MYG1 exonuclease -2.24363
HDGFL2 HDGF like 2 -2.21628
CIAO3 cytosolic iron-sulfur assembly component 3 -2.20939
CFAP57 cilia and flagella associated protein 57 -2.20939
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -2.20116
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.17644
FBN1 fibrillin 1 -2.17644
PPIB peptidylprolyl isomerase B (cyclophilin B) -2.17644
COQ8B coenzyme Q8B -2.16929
GPR87 G protein-coupled receptor 87 -2.16515
DIO1 deiodinase, iodothyronine, type I -2.16515
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -2.15607
UNC80 unc-80 homolog (C. elegans) -2.11951
BOD1 biorientation of chromosomes in cell division 1 -2.11897
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.10514
CYTL1 cytokine-like 1 -2.10042
THAP5 THAP domain containing 5 -2.08088
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 -2.08041
NRM nurim (nuclear envelope membrane protein) -2.06974
MAP1S microtubule-associated protein 1S -2.06005
MTRFR mitochondrial translation release factor in rescue -2.06005
SPAG16 sperm associated antigen 16 -2.06005
SCNN1A sodium channel, non voltage gated 1 alpha subunit -2.05545
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.05017
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.03821
APOO apolipoprotein O -2.03075
PARP12 poly (ADP-ribose) polymerase family, member 12 -2.02508
ADCK2 aarF domain containing kinase 2 -2.01287