HOXA2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description homeobox A2|In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3199)
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Genes

351 genes differentially expressed following the HOXA2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCG2 secretogranin II 2.92764
TMEM191B transmembrane protein 191B 2.92764
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.92764
GJB3 gap junction protein, beta 3, 31kDa 2.92764
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.92764
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.92764
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.92764
MYOM3 myomesin 3 2.92764
TRIM77 tripartite motif containing 77 2.92764
UNC45B unc-45 homolog B (C. elegans) 2.92764
C8ORF48 chromosome 8 open reading frame 48 2.92764
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 2.92764
AFM afamin 2.92764
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.92764
TRH thyrotropin-releasing hormone 2.92764
SIGLECL1 SIGLEC family like 1 2.92764
LIPH lipase, member H 2.92764
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.92764
GNLY granulysin 2.92764
HEATR9 HEAT repeat containing 9 2.92764
CD19 CD19 molecule 2.92764
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.92764
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.92764
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.92764
PCDH8 protocadherin 8 2.92764
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.92764
PRR22 proline rich 22 2.92764
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.92764
FAM9B family with sequence similarity 9, member B 2.92764
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.92764
CCDC83 coiled-coil domain containing 83 2.92764
PRSS21 protease, serine, 21 (testisin) 2.92764
NRSN1 neurensin 1 2.92764
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.92764
CDR2 cerebellar degeneration-related protein 2, 62kDa 2.92764
VCX variable charge, X-linked 2.92764
JCHAIN joining chain of multimeric IgA and IgM 2.92764
TDRD6 tudor domain containing 6 2.92764
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.92764
PSCA prostate stem cell antigen 2.92764
TRIM47 tripartite motif containing 47 2.92764
ZBTB37 zinc finger and BTB domain containing 37 2.92764
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.92764
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.92764
GNRHR gonadotropin-releasing hormone receptor 2.92764
IL2RA interleukin 2 receptor, alpha 2.92764
NPR3 natriuretic peptide receptor 3 2.92764
SPMIP10 sperm microtubule inner protein 10 2.92764
ANGPTL8 angiopoietin like 8 2.92764
H3-5 H3.5 histone 2.92764
H1-6 H1.6 linker histone, cluster member 2.92764
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.92764
PTH1R parathyroid hormone 1 receptor 2.92764
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 2.92764
FMO3 flavin containing monooxygenase 3 2.92764
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.92764
ADRB1 adrenoceptor beta 1 2.92764
CRACDL CRACD like 2.92764
VXN vexin 2.92764
DUSP29 dual specificity phosphatase 29 2.92764
SPATA31H1 SPATA31 subfamily H member 1 2.92764
FAM240C family with sequence similarity 240 member C 2.92764
KIF1C-AS1 KIF1C antisense RNA 1 2.92764
SMIM45 small integral membrane protein 45 2.92764
ACP4 acid phosphatase 4 2.92764
CLEC20A C-type lectin domain containing 20A 2.92764
AKR1C8 aldo-keto reductase family 1 member C8 2.92764
ODAPH odontogenesis associated phosphoprotein 2.92764
DEFB131B defensin beta 131B 2.92764
TTR transthyretin 2.92764
XKRX XK, Kell blood group complex subunit-related, X-linked 2.92764
SOAT2 sterol O-acyltransferase 2 2.92764
ITK IL2-inducible T-cell kinase 2.92764
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.92764
NRN1 neuritin 1 2.92764
HNF4A hepatocyte nuclear factor 4, alpha 2.92764
SRPX2 sushi-repeat containing protein, X-linked 2 2.92764
GJA3 gap junction protein, alpha 3, 46kDa 2.92764
NAPSA napsin A aspartic peptidase 2.92764
LRRD1 leucine-rich repeats and death domain containing 1 2.92764
ASB15 ankyrin repeat and SOCS box containing 15 2.92764
CHRD chordin 2.92764
IL31RA interleukin 31 receptor A 2.92764
ANXA10 annexin A10 2.92764
IL16 interleukin 16 2.92764
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.92764
SAA2 serum amyloid A2 2.92764
SASH3 SAM and SH3 domain containing 3 2.92764
EXOC3L4 exocyst complex component 3-like 4 2.92764
TMEM179 transmembrane protein 179 2.92764
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.92764
IL4 interleukin 4 2.92764
CBLN3 cerebellin 3 precursor 2.92764
CDH5 cadherin 5, type 2 (vascular endothelium) 2.92764
NIM1K NIM1 serine/threonine protein kinase 2.92764
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.92764
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.92764
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.92764
CDH19 cadherin 19, type 2 2.92764
C2CD4B C2 calcium-dependent domain containing 4B 2.92764
PCDHGA3 protocadherin gamma subfamily A, 3 2.92764
PCDHGA2 protocadherin gamma subfamily A, 2 2.92764
TMEM130 transmembrane protein 130 2.92764
BCO1 beta-carotene oxygenase 1 2.92764
KRT222 keratin 222, type II 2.92764
HHATL hedgehog acyltransferase-like 2.92764
RNF112 ring finger protein 112 2.92764
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.92764
AMIGO1 adhesion molecule with Ig-like domain 1 2.92764
EHF ets homologous factor 2.92764
HCRT hypocretin (orexin) neuropeptide precursor 2.92764
KLHL1 kelch-like family member 1 2.92764
THTPA thiamine triphosphatase 2.92764
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.92764
AQP6 aquaporin 6, kidney specific 2.92764
TEKT5 tektin 5 2.92764
HOPX HOP homeobox 2.92764
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.92764
RBBP8NL RBBP8 N-terminal like 2.92764
POU4F1 POU class 4 homeobox 1 2.92764
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.92764
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.92764
ADCY4 adenylate cyclase 4 2.92764
FKBP1C FK506 binding protein 1C 2.92764
SYT5 synaptotagmin V 2.92764
CCDC177 coiled-coil domain containing 177 2.92764
MOBP myelin-associated oligodendrocyte basic protein 2.92764
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.92764
KLK2 kallikrein-related peptidase 2 2.92764
EPHA10 EPH receptor A10 2.92764
CTXN2 cortexin 2 2.92764
FGB fibrinogen beta chain 2.92764
ITGB7 integrin, beta 7 2.92764
DMRT2 doublesex and mab-3 related transcription factor 2 2.92764
DMRT1 doublesex and mab-3 related transcription factor 1 2.92764
SPHKAP SPHK1 interactor, AKAP domain containing 2.92764
INSM1 insulinoma-associated 1 2.92764
PHACTR3 phosphatase and actin regulator 3 2.92764
SRRM5 serine/arginine repetitive matrix 5 2.92764
LRRC46 leucine rich repeat containing 46 2.92764
COL12A1 collagen, type XII, alpha 1 2.92764
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.92764
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.92764
NUTM2A NUT family member 2A 2.92764
TCF21 transcription factor 21 2.92764
NELL1 NEL-like 1 (chicken) 2.92764
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.92764
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.92764
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.92764
TMEM45B transmembrane protein 45B 2.92764
ANGPTL3 angiopoietin-like 3 2.92764
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.92764
SMIM22 small integral membrane protein 22 2.92764
PALMD palmdelphin 2.92764
MT1M metallothionein 1M 2.92764
WFDC11 WAP four-disulfide core domain 11 2.92764
HHIPL2 HHIP-like 2 2.92764
NGB neuroglobin 2.92764
ITGA8 integrin, alpha 8 2.92764
STAB1 stabilin 1 2.92764
KCTD11 potassium channel tetramerization domain containing 11 2.92764
IRX1 iroquois homeobox 1 2.92764
ZBED6 zinc finger, BED-type containing 6 2.92764
FRMD5 FERM domain containing 5 2.92281
F3 coagulation factor III (thromboplastin, tissue factor) 2.90968
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.90968
GRHL1 grainyhead-like 1 (Drosophila) 2.90968
OIP5 Opa interacting protein 5 2.89904
NCAPH2 non-SMC condensin II complex, subunit H2 2.8832
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 2.8504
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 2.8398
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.83492
UXS1 UDP-glucuronate decarboxylase 1 2.663
ZNF322 zinc finger protein 322 2.65698
PIANP PILR alpha associated neural protein 2.53748
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.52632
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 2.51868
FOS FBJ murine osteosarcoma viral oncogene homolog 2.50547
MRPL35 mitochondrial ribosomal protein L35 2.50292
FSTL4 follistatin-like 4 2.4999
C11ORF68 chromosome 11 open reading frame 68 2.47433
ZNF791 zinc finger protein 791 2.45855
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 2.45461
SLC31A1 solute carrier family 31 (copper transporter), member 1 2.4276
FGD6 FYVE, RhoGEF and PH domain containing 6 2.42604
CCR6 chemokine (C-C motif) receptor 6 2.42604
CHMP4B charged multivesicular body protein 4B 2.41016
TBPL2 TATA box binding protein like 2 2.41016
MACIR macrophage immunometabolism regulator 2.37859
ZNF101 zinc finger protein 101 2.36582
ADGRB2 adhesion G protein-coupled receptor B2 2.3426
TMEM121 transmembrane protein 121 2.30899
GLB1L galactosidase, beta 1-like 2.30899
TBC1D30 TBC1 domain family, member 30 2.29719
EPO erythropoietin 2.29719
DAPK2 death-associated protein kinase 2 2.29719
CREBZF CREB/ATF bZIP transcription factor 2.29719
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.29719
KLHL34 kelch-like family member 34 2.29719
DNAAF2 dynein, axonemal, assembly factor 2 2.2708
DNASE1 deoxyribonuclease I 2.24427
DTX4 deltex 4, E3 ubiquitin ligase 2.23184
NUB1 negative regulator of ubiquitin-like proteins 1 2.20918
MSI1 musashi RNA-binding protein 1 2.19079
RMP24 ribonuclease MRP subunit p24 2.16958
FABP3 fatty acid binding protein 3, muscle and heart 2.15608
NUP210L nucleoporin 210kDa-like 2.14986
RLIM ring finger protein, LIM domain interacting 2.13956
YME1L1 YME1-like 1 ATPase 2.139
FANCE Fanconi anemia, complementation group E 2.12576
SNX5 sorting nexin 5 2.10627
TRNP1 TMF1-regulated nuclear protein 1 2.10555
RBP5 retinol binding protein 5, cellular 2.10344
ANTKMT adenine nucleotide translocase lysine methyltransferase 2.10015
LYRM7 LYR motif containing 7 2.09943
SELENON selenoprotein N 2.09936
CD44 CD44 molecule (Indian blood group) 2.0802
SETD9 SET domain containing 9 2.07887
USP6NL USP6 N-terminal like 2.05555
SPART spartin 2.05555
PTCH1 patched 1 2.04811
PRELID3A PRELI domain containing 3A 2.04811
STC1 stanniocalcin 1 2.03887
RBM43 RNA binding motif protein 43 2.03317
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 2.03317
STK17B serine/threonine kinase 17b 2.03317
CBR4 carbonyl reductase 4 2.01746
SRRD SRR1 domain containing 2.00761
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.00242

decreased expression

Symbol Name Standardized Value
MGARP mitochondria-localized glutamic acid-rich protein -2.92764
ZNF395 zinc finger protein 395 -2.92764
HPCAL4 hippocalcin like 4 -2.92764
ALK anaplastic lymphoma receptor tyrosine kinase -2.92764
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.92764
ADAM21 ADAM metallopeptidase domain 21 -2.92764
DAND5 DAN domain family member 5, BMP antagonist -2.92764
POMC proopiomelanocortin -2.92764
ZBTB16 zinc finger and BTB domain containing 16 -2.92764
C1QTNF1 C1q and tumor necrosis factor related protein 1 -2.92764
TMEM151A transmembrane protein 151A -2.92764
PSD4 pleckstrin and Sec7 domain containing 4 -2.92764
PGBDF plakoglobin binding and degradation factor -2.92764
STOML1 stomatin (EPB72)-like 1 -2.92764
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.92764
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.92764
MROH6 maestro heat-like repeat family member 6 -2.92764
TMC8 transmembrane channel-like 8 -2.92764
SLC39A5 solute carrier family 39 (zinc transporter), member 5 -2.92764
ENC1 ectodermal-neural cortex 1 (with BTB domain) -2.92764
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -2.92764
ASB12 ankyrin repeat and SOCS box containing 12 -2.92764
LECT2 leukocyte cell-derived chemotaxin 2 -2.92764
GOLGA6L10 golgin A6 family-like 10 -2.92764
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.92764
RASL11A RAS-like, family 11, member A -2.92764
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.92764
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.92764
TAFA5 TAFA chemokine like family member 5 -2.92764
KCP kielin/chordin-like protein -2.92764
TTC22 tetratricopeptide repeat domain 22 -2.92764
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -2.92764
AMER2 APC membrane recruitment protein 2 -2.92764
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.92764
PMP22 peripheral myelin protein 22 -2.92764
CDK20 cyclin-dependent kinase 20 -2.92764
ZNF688 zinc finger protein 688 -2.92764
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.92764
PCDHA10 protocadherin alpha 10 -2.92764
LIPI lipase, member I -2.8832
SYNDIG1L synapse differentiation inducing 1-like -2.8832
MYO3B myosin IIIB -2.8832
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -2.87072
HMX2 H6 family homeobox 2 -2.82223
NAGS N-acetylglutamate synthase -2.82223
SYTL2 synaptotagmin-like 2 -2.79002
SAXO2 stabilizer of axonemal microtubules 2 -2.76815
ROR1 receptor tyrosine kinase-like orphan receptor 1 -2.75545
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.72979
JMJD7 jumonji domain containing 7 -2.65698
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.56916
SH2D4B SH2 domain containing 4B -2.56916
EXD1 exonuclease 3'-5' domain containing 1 -2.56916
ADRA1A adrenoceptor alpha 1A -2.56916
MBTPS2 membrane-bound transcription factor peptidase, site 2 -2.56065
ARK2C arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C -2.52458
PDE11A phosphodiesterase 11A -2.45855
PTGES prostaglandin E synthase -2.45855
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.45855
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.4542
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.44763
DPPA5 developmental pluripotency associated 5 -2.44158
BICD1 bicaudal D homolog 1 (Drosophila) -2.40893
CENPN centromere protein N -2.40893
TAFA1 TAFA chemokine like family member 1 -2.36101
ARSA arylsulfatase A -2.36101
MPZL3 myelin protein zero-like 3 -2.34089
ZNF286A zinc finger protein 286A -2.30899
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -2.29928
FBXL4 F-box and leucine-rich repeat protein 4 -2.29719
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.29719
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.27885
METTL23 methyltransferase like 23 -2.27208
CKS1B CDC28 protein kinase regulatory subunit 1B -2.25934
BBS2 Bardet-Biedl syndrome 2 -2.2503
PIKFYVE phosphoinositide kinase, FYVE finger containing -2.2435
PANK3 pantothenate kinase 3 -2.22792
TMEM177 transmembrane protein 177 -2.22089
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.21206
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.21117
FAM131B family with sequence similarity 131, member B -2.20403
CMTR1 cap methyltransferase 1 -2.19862
PARVA parvin, alpha -2.19415
MSL3 male-specific lethal 3 homolog (Drosophila) -2.19079
SCAMP3 secretory carrier membrane protein 3 -2.19079
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -2.19079
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.18188
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) -2.18188
TPM4 tropomyosin 4 -2.17583
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.17173
ARRDC4 arrestin domain containing 4 -2.15608
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.15608
LIN37 lin-37 DREAM MuvB core complex component -2.15608
SKIC8 SKI8 subunit of superkiller complex -2.15215
PRPF4 pre-mRNA processing factor 4 -2.14986
CC2D1A coiled-coil and C2 domain containing 1A -2.13885
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.13757
FBXL17 F-box and leucine-rich repeat protein 17 -2.13442
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -2.13421
SEC24A SEC24 family member A -2.12006
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 -2.12006
TRAF2 TNF receptor-associated factor 2 -2.09936
ETFRF1 electron transfer flavoprotein regulatory factor 1 -2.09376
FAM184B family with sequence similarity 184, member B -2.08866
HAVCR2 hepatitis A virus cellular receptor 2 -2.07887
ZNF486 zinc finger protein 486 -2.07688
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 -2.06083
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 -2.05926
CCDC126 coiled-coil domain containing 126 -2.05555
ZNF385A zinc finger protein 385A -2.05555
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -2.05406
ZFHX3 zinc finger homeobox 3 -2.05002
LRRC59 leucine rich repeat containing 59 -2.03887
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -2.03207
OAF OAF homolog (Drosophila) -2.03207
SYPL2 synaptophysin-like 2 -2.03207
ZNF354B zinc finger protein 354B -2.03207
TMEM272 transmembrane protein 272 -2.03207
PLK3 polo-like kinase 3 -2.03207
PLAC8 placenta-specific 8 -2.03207
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.028
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -2.00761