HOXA9 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description homeobox A9|In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011] (NCBI Entrez Gene Database, 3205)
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Genes

328 genes differentially expressed following the HOXA9 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RAET1E retinoic acid early transcript 1E 2.83135
EPB42 erythrocyte membrane protein band 4.2 2.83135
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.83135
ELSPBP1 epididymal sperm binding protein 1 2.83135
OLIG3 oligodendrocyte transcription factor 3 2.83135
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.83135
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 2.83135
SSTR5 somatostatin receptor 5 2.83135
KCNRG potassium channel regulator 2.83135
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.83135
PCDHGB3 protocadherin gamma subfamily B, 3 2.83135
SSTR1 somatostatin receptor 1 2.83135
SYCP2 synaptonemal complex protein 2 2.83135
TPBGL trophoblast glycoprotein-like 2.83135
TMPRSS11D transmembrane protease, serine 11D 2.83135
INHBC inhibin, beta C 2.83135
ASB15 ankyrin repeat and SOCS box containing 15 2.83135
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.83135
GPR55 G protein-coupled receptor 55 2.83135
NANOS3 nanos homolog 3 (Drosophila) 2.83135
LYZL6 lysozyme-like 6 2.83135
RFPL3 ret finger protein-like 3 2.83135
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.83135
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.83135
RXRG retinoid X receptor, gamma 2.83135
BTBD16 BTB (POZ) domain containing 16 2.83135
SCIN scinderin 2.83135
PODN podocan 2.83135
OR4E2 olfactory receptor, family 4, subfamily E, member 2 2.83135
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 2.83135
TREML2 triggering receptor expressed on myeloid cells-like 2 2.83135
NPIPA3 nuclear pore complex interacting protein family, member A3 2.83135
FABP12 fatty acid binding protein 12 2.83135
ANKRD34A ankyrin repeat domain 34A 2.83135
THRSP thyroid hormone responsive 2.83135
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.83135
BSX brain-specific homeobox 2.83135
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.83135
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.83135
UMODL1 uromodulin-like 1 2.83135
CPB1 carboxypeptidase B1 (tissue) 2.83135
GALP galanin-like peptide 2.83135
PRB1 proline-rich protein BstNI subfamily 1 2.83135
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.83135
GBP3 guanylate binding protein 3 2.83135
YIPF7 Yip1 domain family, member 7 2.83135
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.83135
PNLIPRP3 pancreatic lipase-related protein 3 2.83135
HTRA4 HtrA serine peptidase 4 2.83135
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.83135
SMLR1 small leucine-rich protein 1 2.83135
SAG S-antigen; retina and pineal gland (arrestin) 2.83135
ARX aristaless related homeobox 2.83135
GOLGA6L7 golgin A6 family like 7 2.83135
MAB21L4 mab-21 like 4 2.83135
GNG5B G protein subunit gamma 5B 2.83135
EZHIP EZH inhibitory protein 2.83135
CLEC20A C-type lectin domain containing 20A 2.83135
ARMH2 armadillo like helical domain containing 2 2.83135
ODAPH odontogenesis associated phosphoprotein 2.83135
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.83135
PCARE photoreceptor cilium actin regulator 2.83135
JAML junction adhesion molecule like 2.83135
CFC1 cripto, FRL-1, cryptic family 1 2.83135
LY6H lymphocyte antigen 6 complex, locus H 2.83135
ZNF575 zinc finger protein 575 2.83135
MAL mal, T-cell differentiation protein 2.83135
CLDN5 claudin 5 2.83135
VIT vitrin 2.83135
PTPRC protein tyrosine phosphatase, receptor type, C 2.83135
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.83135
RPS12 ribosomal protein S12 2.83135
IL36G interleukin 36, gamma 2.83135
AWAT2 acyl-CoA wax alcohol acyltransferase 2 2.83135
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.83135
CLEC17A C-type lectin domain family 17, member A 2.83135
ZNF705D zinc finger protein 705D 2.83135
GATA5 GATA binding protein 5 2.83135
C4ORF50 chromosome 4 open reading frame 50 2.83135
SYT15 synaptotagmin XV 2.83135
LTB lymphotoxin beta (TNF superfamily, member 3) 2.83135
ACE2 angiotensin I converting enzyme 2 2.83135
IL1R2 interleukin 1 receptor, type II 2.83135
SAA2 serum amyloid A2 2.83135
FRMD7 FERM domain containing 7 2.83135
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.83135
NXNL1 nucleoredoxin-like 1 2.83135
KLF1 Kruppel-like factor 1 (erythroid) 2.83135
EBF3 early B-cell factor 3 2.83135
C11ORF42 chromosome 11 open reading frame 42 2.83135
VAV1 vav 1 guanine nucleotide exchange factor 2.83135
RPA4 replication protein A4, 30kDa 2.83135
PYHIN1 pyrin and HIN domain family, member 1 2.83135
PMP2 peripheral myelin protein 2 2.83135
NT5C1B 5'-nucleotidase, cytosolic IB 2.83135
CALML6 calmodulin-like 6 2.83135
OR4D2 olfactory receptor, family 4, subfamily D, member 2 2.83135
CTRB1 chymotrypsinogen B1 2.83135
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.83135
ZC3H12D zinc finger CCCH-type containing 12D 2.83135
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.83135
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.83135
CPA2 carboxypeptidase A2 (pancreatic) 2.83135
ILDR2 immunoglobulin-like domain containing receptor 2 2.83135
CHI3L2 chitinase 3-like 2 2.83135
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.83135
C11ORF16 chromosome 11 open reading frame 16 2.83135
WFDC8 WAP four-disulfide core domain 8 2.83135
TBX1 T-box 1 2.83135
SCML4 sex comb on midleg-like 4 (Drosophila) 2.83135
PRR35 proline rich 35 2.83135
ARR3 arrestin 3, retinal (X-arrestin) 2.83135
OTC ornithine carbamoyltransferase 2.83135
RAD51AP2 RAD51 associated protein 2 2.83135
RGS4 regulator of G-protein signaling 4 2.83135
ZC2HC1B zinc finger, C2HC-type containing 1B 2.83135
MEPE matrix extracellular phosphoglycoprotein 2.83135
NNMT nicotinamide N-methyltransferase 2.83135
WNT2 wingless-type MMTV integration site family member 2 2.83135
SYT5 synaptotagmin V 2.83135
IFNK interferon, kappa 2.83135
PLA2G5 phospholipase A2, group V 2.83135
TEX26 testis expressed 26 2.83135
KCNK18 potassium channel, two pore domain subfamily K, member 18 2.83135
GOLGA8N golgin A8 family, member N 2.83135
VWC2L von Willebrand factor C domain containing protein 2-like 2.83135
ICAM5 intercellular adhesion molecule 5, telencephalin 2.83135
ART1 ADP-ribosyltransferase 1 2.83135
AREG amphiregulin 2.83135
LRRC31 leucine rich repeat containing 31 2.83135
LMAN1L lectin, mannose-binding, 1 like 2.83135
SPTA1 spectrin, alpha, erythrocytic 1 2.83135
AHCY adenosylhomocysteinase 2.83135
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.83135
CD34 CD34 molecule 2.83135
PLGLB2 plasminogen-like B2 2.83135
CAPSL calcyphosine-like 2.83135
CASQ2 calsequestrin 2 (cardiac muscle) 2.83135
LPAR5 lysophosphatidic acid receptor 5 2.83135
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.77561
PTMS parathymosin 2.77561
EXOSC7 exosome component 7 2.76063
CCDC93 coiled-coil domain containing 93 2.74979
SKA2 spindle and kinetochore associated complex subunit 2 2.65075
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 2.61432
WDR37 WD repeat domain 37 2.5913
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.57028
STARD3 StAR-related lipid transfer (START) domain containing 3 2.56272
RPL29 ribosomal protein L29 2.49871
SYS1 Sys1 golgi trafficking protein 2.47871
G6PD glucose-6-phosphate dehydrogenase 2.46837
AQP11 aquaporin 11 2.43316
EMILIN1 elastin microfibril interfacer 1 2.41197
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.37459
PLPP1 phospholipid phosphatase 1 2.37131
ZNF180 zinc finger protein 180 2.3576
RP1L1 retinitis pigmentosa 1-like 1 2.35017
TXNRD2 thioredoxin reductase 2 2.33027
PAQR7 progestin and adipoQ receptor family member VII 2.31082
PLD3 phospholipase D family, member 3 2.29867
PEBP1 phosphatidylethanolamine binding protein 1 2.29833
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 2.28646
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2.28646
RFX7 regulatory factor X, 7 2.26544
DUSP15 dual specificity phosphatase 15 2.26106
SYTL4 synaptotagmin-like 4 2.26106
MAGIX MAGI family member, X-linked 2.26106
EFCAB9 EF-hand calcium binding domain 9 2.26106
DAAM1 dishevelled associated activator of morphogenesis 1 2.26106
HAUS8 HAUS augmin-like complex, subunit 8 2.25631
CLMB calcimembrin 2.22592
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 2.21471
PUM1 pumilio RNA-binding family member 1 2.21471
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.21326
RPL18A ribosomal protein L18a 2.19002
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 2.19002
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 2.16909
SIRT7 sirtuin 7 2.15738
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.15691
ZNF782 zinc finger protein 782 2.15456
RPL32 ribosomal protein L32 2.15137
RPL34 ribosomal protein L34 2.13649
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 2.13479
ZNF814 zinc finger protein 814 2.1275
RNF4 ring finger protein 4 2.12243
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.11928
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.11423
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.10833
C6ORF132 chromosome 6 open reading frame 132 2.08945
SLIT1 slit homolog 1 (Drosophila) 2.07383
PLXNB2 plexin B2 2.06762
TSPYL5 TSPY-like 5 2.06126
ATP5MG ATP synthase membrane subunit g 2.05597
MAN1A1 mannosidase, alpha, class 1A, member 1 2.05488
ZRANB3 zinc finger, RAN-binding domain containing 3 2.05488
LIME1 Lck interacting transmembrane adaptor 1 2.03973
CPOX coproporphyrinogen oxidase 2.03291
SPARCL1 SPARC-like 1 (hevin) 2.02853
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.02853
TBC1D31 TBC1 domain family, member 31 2.02015
FOXH1 forkhead box H1 2.01323
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 2.01103
ZNF140 zinc finger protein 140 2.00822
LIAS lipoic acid synthetase 2.00344
PON3 paraoxonase 3 2.00134
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 2.00012

decreased expression

Symbol Name Standardized Value
SOST sclerostin -2.83135
ZBED6 zinc finger, BED-type containing 6 -2.83135
NOS3 nitric oxide synthase 3 (endothelial cell) -2.83135
CCDC33 coiled-coil domain containing 33 -2.83135
RGPD6 RANBP2-like and GRIP domain containing 6 -2.83135
SHOX short stature homeobox -2.83135
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.83135
DES desmin -2.83135
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -2.83135
LCN15 lipocalin 15 -2.83135
RFPL2 ret finger protein-like 2 -2.83135
HBZ hemoglobin, zeta -2.83135
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.83135
ATOH8 atonal homolog 8 (Drosophila) -2.83135
ZBBX zinc finger, B-box domain containing -2.83135
GLE1 GLE1 RNA export mediator -2.83135
IL33 interleukin 33 -2.83135
GREM1 gremlin 1, DAN family BMP antagonist -2.83135
EBI3 Epstein-Barr virus induced 3 -2.83135
TGM6 transglutaminase 6 -2.83135
FRMPD2 FERM and PDZ domain containing 2 -2.83135
TMPRSS12 transmembrane (C-terminal) protease, serine 12 -2.83135
ETV2 ets variant 2 -2.83135
LGALS4 lectin, galactoside-binding, soluble, 4 -2.83135
C19ORF67 chromosome 19 open reading frame 67 -2.83135
DUSP10 dual specificity phosphatase 10 -2.83135
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -2.83135
SOCS5 suppressor of cytokine signaling 5 -2.83135
HAS1 hyaluronan synthase 1 -2.83135
STARD6 StAR-related lipid transfer (START) domain containing 6 -2.83135
RASA4 RAS p21 protein activator 4 -2.83135
TMPPE transmembrane protein with metallophosphoesterase domain -2.83135
CLEC4A C-type lectin domain family 4, member A -2.83135
IMPG1 interphotoreceptor matrix proteoglycan 1 -2.83135
DUSP29 dual specificity phosphatase 29 -2.83135
DEFB131B defensin beta 131B -2.83135
TMEM255A transmembrane protein 255A -2.83135
CXCR4 chemokine (C-X-C motif) receptor 4 -2.83135
HPX hemopexin -2.83135
NFILZ NFIL3 like basic leucine zipper -2.83135
ACOX2 acyl-CoA oxidase 2, branched chain -2.83135
ITPRID1 ITPR interacting domain containing 1 -2.83135
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -2.83135
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 -2.83135
GZMM granzyme M (lymphocyte met-ase 1) -2.83135
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.83135
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -2.78212
RBM45 RNA binding motif protein 45 -2.77495
EMP3 epithelial membrane protein 3 -2.76063
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -2.66238
NEK7 NIMA-related kinase 7 -2.63888
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.60891
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -2.54967
SLC10A3 solute carrier family 10, member 3 -2.54881
WRNIP1 Werner helicase interacting protein 1 -2.54272
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.53966
COL4A5 collagen, type IV, alpha 5 -2.53966
RDH16 retinol dehydrogenase 16 (all-trans) -2.53966
CTXN1 cortexin 1 -2.49853
ENO1 enolase 1, (alpha) -2.42829
SLC16A6 solute carrier family 16, member 6 -2.40924
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -2.38182
RNF166 ring finger protein 166 -2.37459
CDK8 cyclin-dependent kinase 8 -2.37131
SPEG SPEG complex locus -2.36961
RAD51AP1 RAD51 associated protein 1 -2.35861
SCRN2 secernin 2 -2.34427
SF1 splicing factor 1 -2.32843
WDR5 WD repeat domain 5 -2.31292
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.29833
RCC1 regulator of chromosome condensation 1 -2.29484
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.29484
ZFAND3 zinc finger, AN1-type domain 3 -2.29359
ITGA1 integrin, alpha 1 -2.28646
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.28434
AP3B2 adaptor-related protein complex 3, beta 2 subunit -2.28434
SOWAHD sosondowah ankyrin repeat domain family member D -2.28434
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.25631
NHLH1 nescient helix loop helix 1 -2.25631
CAMTA1 calmodulin binding transcription activator 1 -2.2367
ZNF616 zinc finger protein 616 -2.2219
MAST1 microtubule associated serine/threonine kinase 1 -2.21471
PARD3 par-3 family cell polarity regulator -2.21471
QRICH1 glutamine-rich 1 -2.19846
DENND4B DENN/MADD domain containing 4B -2.18291
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -2.15923
WNT3A wingless-type MMTV integration site family, member 3A -2.15456
MYT1 myelin transcription factor 1 -2.15456
EIF3M eukaryotic translation initiation factor 3, subunit M -2.15244
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -2.138
EMC7 ER membrane protein complex subunit 7 -2.12826
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.12766
SP1 Sp1 transcription factor -2.12243
CAVIN1 caveolae associated protein 1 -2.12236
TNIP2 TNFAIP3 interacting protein 2 -2.12236
AKAP3 A kinase (PRKA) anchor protein 3 -2.08643
OSTN osteocrin -2.08643
ILK integrin-linked kinase -2.08259
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 -2.07603
NSUN7 NOP2/Sun domain family, member 7 -2.06762
TKT transketolase -2.06762
NECTIN2 nectin cell adhesion molecule 2 -2.06113
KIAA0825 KIAA0825 -2.06113
CLU clusterin -2.05895
CD2AP CD2-associated protein -2.05597
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.05597
BTBD2 BTB (POZ) domain containing 2 -2.05594
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) -2.05488
SULF1 sulfatase 1 -2.05488
CCDC175 coiled-coil domain containing 175 -2.05488
NFE2L3 nuclear factor, erythroid 2-like 3 -2.05488
CISD1 CDGSH iron sulfur domain 1 -2.05488
SNRPC small nuclear ribonucleoprotein polypeptide C -2.05488
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -2.04442
GEMIN5 gem (nuclear organelle) associated protein 5 -2.03301
SYT11 synaptotagmin XI -2.03125
RPL38 ribosomal protein L38 -2.02885
SMAD3 SMAD family member 3 -2.01371
CCN1 cellular communication network factor 1 -2.01371
PFKL phosphofructokinase, liver -2.01323
ATP5MC2 ATP synthase membrane subunit c locus 2 -2.00679
SAMD8 sterile alpha motif domain containing 8 -2.0023