HOXB13 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description homeobox B13|This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10481)
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Genes

304 genes differentially expressed following the HOXB13 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CD1C CD1c molecule 2.94011
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.94011
NEU4 sialidase 4 2.94011
CIITA class II, major histocompatibility complex, transactivator 2.94011
GYPE glycophorin E (MNS blood group) 2.94011
OR52E8 olfactory receptor, family 52, subfamily E, member 8 2.94011
TRIM73 tripartite motif containing 73 2.94011
SPRR1B small proline-rich protein 1B 2.94011
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.94011
OCM2 oncomodulin 2 2.94011
FOLR2 folate receptor 2 (fetal) 2.94011
SLC16A6 solute carrier family 16, member 6 2.94011
PRICKLE4 prickle homolog 4 (Drosophila) 2.94011
GLUD2 glutamate dehydrogenase 2 2.94011
PRODH2 proline dehydrogenase (oxidase) 2 2.94011
GRXCR2 glutaredoxin, cysteine rich 2 2.94011
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.94011
DUSP10 dual specificity phosphatase 10 2.94011
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.94011
DSG3 desmoglein 3 2.94011
ARHGAP36 Rho GTPase activating protein 36 2.94011
CD68 CD68 molecule 2.94011
RLN3 relaxin 3 2.94011
HMX1 H6 family homeobox 1 2.94011
TPPP tubulin polymerization promoting protein 2.94011
NWD2 NACHT and WD repeat domain containing 2 2.94011
SPAG8 sperm associated antigen 8 2.94011
BOLA2 bolA family member 2 2.94011
FGF9 fibroblast growth factor 9 2.94011
PCDHGA12 protocadherin gamma subfamily A, 12 2.94011
TWIST1 twist family bHLH transcription factor 1 2.94011
SPDEF SAM pointed domain containing ETS transcription factor 2.94011
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.94011
AIRE autoimmune regulator 2.94011
TTLL2 tubulin tyrosine ligase-like family member 2 2.94011
COPG2 coatomer protein complex, subunit gamma 2 2.94011
CCDC38 coiled-coil domain containing 38 2.94011
GNRH2 gonadotropin-releasing hormone 2 2.94011
LBX2 ladybird homeobox 2 2.94011
TBATA thymus, brain and testes associated 2.94011
KRT77 keratin 77, type II 2.94011
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.94011
BMP5 bone morphogenetic protein 5 2.94011
RBP4 retinol binding protein 4, plasma 2.94011
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.94011
TEX53 testis expressed 53 2.94011
AANAT aralkylamine N-acetyltransferase 2.94011
KRT80 keratin 80, type II 2.94011
TMPRSS4 transmembrane protease, serine 4 2.94011
PROX2 prospero homeobox 2 2.94011
TTR transthyretin 2.94011
MYL10 myosin, light chain 10, regulatory 2.94011
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.94011
GATA5 GATA binding protein 5 2.94011
HNF1A HNF1 homeobox A 2.94011
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.94011
SQOR sulfide quinone oxidoreductase 2.94011
RBM33-DT RBM33 divergent transcript 2.94011
CPNE8-AS1 CPNE8 antisense RNA 1 2.94011
ZNF593OS ZNF593 opposite strand 2.94011
H3C3 H3 clustered histone 3 2.94011
CFAP97D1 CFAP97 domain containing 1 2.94011
VXN vexin 2.94011
CALHM5 calcium homeostasis modulator family member 5 2.94011
CCN6 cellular communication network factor 6 2.94011
VSIR V-set immunoregulatory receptor 2.94011
PCDHGC5 protocadherin gamma subfamily C, 5 2.94011
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.94011
VIT vitrin 2.94011
KLHL31 kelch-like family member 31 2.94011
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.94011
TSSK4 testis-specific serine kinase 4 2.94011
ELF4 E74-like factor 4 (ets domain transcription factor) 2.94011
CD6 CD6 molecule 2.94011
ZACN zinc activated ligand-gated ion channel 2.94011
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 2.94011
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.94011
C4ORF17 chromosome 4 open reading frame 17 2.94011
CALCA calcitonin-related polypeptide alpha 2.94011
COX8C cytochrome c oxidase subunit VIIIC 2.94011
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.94011
CLEC17A C-type lectin domain family 17, member A 2.94011
BARX2 BARX homeobox 2 2.94011
EXOC3L4 exocyst complex component 3-like 4 2.94011
GLP2R glucagon-like peptide 2 receptor 2.94011
SLAMF6 SLAM family member 6 2.94011
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.94011
MEOX1 mesenchyme homeobox 1 2.94011
DUXB double homeobox B 2.94011
CD3D CD3d molecule, delta (CD3-TCR complex) 2.94011
C22ORF31 chromosome 22 open reading frame 31 2.94011
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.94011
HAVCR1 hepatitis A virus cellular receptor 1 2.94011
NDNF neuron-derived neurotrophic factor 2.94011
POU2AF1 POU class 2 associating factor 1 2.94011
PCDHGA2 protocadherin gamma subfamily A, 2 2.94011
IFNL4 interferon, lambda 4 (gene/pseudogene) 2.94011
MUC17 mucin 17, cell surface associated 2.94011
CIDEA cell death-inducing DFFA-like effector a 2.94011
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.94011
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.94011
ANKRD62 ankyrin repeat domain 62 2.94011
BARHL2 BarH-like homeobox 2 2.94011
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.94011
A3GALT2 alpha 1,3-galactosyltransferase 2 2.94011
GAL3ST2 galactose-3-O-sulfotransferase 2 2.94011
EDN3 endothelin 3 2.94011
LCNL1 lipocalin-like 1 2.94011
GP2 glycoprotein 2 (zymogen granule membrane) 2.94011
VWA7 von Willebrand factor A domain containing 7 2.94011
ISL1 ISL LIM homeobox 1 2.94011
DAW1 dynein assembly factor with WDR repeat domains 1 2.94011
SOSTDC1 sclerostin domain containing 1 2.94011
SH2D1A SH2 domain containing 1A 2.94011
CLEC1A C-type lectin domain family 1, member A 2.94011
DEFB135 defensin, beta 135 2.94011
LMAN1L lectin, mannose-binding, 1 like 2.94011
FKBP1C FK506 binding protein 1C 2.94011
TTC22 tetratricopeptide repeat domain 22 2.94011
XIRP1 xin actin binding repeat containing 1 2.94011
SPHKAP SPHK1 interactor, AKAP domain containing 2.94011
COL17A1 collagen, type XVII, alpha 1 2.94011
PHOX2A paired-like homeobox 2a 2.94011
PLA1A phospholipase A1 member A 2.94011
KLK11 kallikrein-related peptidase 11 2.94011
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.94011
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.94011
TG thyroglobulin 2.94011
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.94011
DMTN dematin actin binding protein 2.94011
TMEM45B transmembrane protein 45B 2.94011
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.94011
IFITM10 interferon induced transmembrane protein 10 2.94011
TMEM215 transmembrane protein 215 2.94011
TAS2R46 taste receptor, type 2, member 46 2.94011
LRRC74A leucine rich repeat containing 74A 2.94011
AQP1 aquaporin 1 (Colton blood group) 2.94011
SSX3 synovial sarcoma, X breakpoint 3 2.94011
MMEL1 membrane metallo-endopeptidase-like 1 2.94011
TGM4 transglutaminase 4 2.94011
FCAR Fc fragment of IgA receptor 2.94011
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.94011
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.94011
TMPRSS15 transmembrane protease, serine 15 2.94011
PRAP1 proline-rich acidic protein 1 2.94011
ARGFX arginine-fifty homeobox 2.94011
CLCA4 chloride channel accessory 4 2.94011
CD8A CD8a molecule 2.94011
AOC1 amine oxidase, copper containing 1 2.94011
PITX2 paired-like homeodomain 2 2.94011
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.94011
SCN3A sodium channel, voltage gated, type III alpha subunit 2.94011
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.94011
ASCL3 achaete-scute family bHLH transcription factor 3 2.94011
POU3F3 POU class 3 homeobox 3 2.94011
C9ORF57 chromosome 9 open reading frame 57 2.94011
C11ORF65 chromosome 11 open reading frame 65 2.91163
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.89949
SPATA32 spermatogenesis associated 32 2.83247
CNBD1 cyclic nucleotide binding domain containing 1 2.7228
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.64724
GPANK1 G patch domain and ankyrin repeats 1 2.57387
ADAM9 ADAM metallopeptidase domain 9 2.46245
PXT1 peroxisomal, testis specific 1 2.40052
GDNF glial cell derived neurotrophic factor 2.40052
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.40052
YPEL1 yippee-like 1 (Drosophila) 2.38223
BRICD5 BRICHOS domain containing 5 2.3681
RAG1 recombination activating gene 1 2.35623
GPSM3 G-protein signaling modulator 3 2.31265
CLEC2A C-type lectin domain family 2, member A 2.29954
FAM171B family with sequence similarity 171, member B 2.29273
SRRM4 serine/arginine repetitive matrix 4 2.26161
E2F3 E2F transcription factor 3 2.25417
PLN phospholamban 2.25116
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.23481
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2.22835
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 2.2209
RAD18 RAD18 E3 ubiquitin protein ligase 2.22077
MFAP2 microfibrillar-associated protein 2 2.20954
HRAS Harvey rat sarcoma viral oncogene homolog 2.20177
PRPF8 pre-mRNA processing factor 8 2.19801
GINS1 GINS complex subunit 1 (Psf1 homolog) 2.19258
GPN2 GPN-loop GTPase 2 2.1637
RPGRIP1L RPGRIP1-like 2.15276
MRI1 methylthioribose-1-phosphate isomerase 1 2.15122
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.15122
FAM120A family with sequence similarity 120A 2.14984
JAG2 jagged 2 2.14286
P3H3 prolyl 3-hydroxylase 3 2.1391
CEP128 centrosomal protein 128kDa 2.12478
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.1225
PDIA4 protein disulfide isomerase family A, member 4 2.10321
TMX2 thioredoxin-related transmembrane protein 2 2.10131
JUN jun proto-oncogene 2.10103
KDM8 lysine (K)-specific demethylase 8 2.06731
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.05184
MTMR1 myotubularin related protein 1 2.04672
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 2.03746
NOVA1 neuro-oncological ventral antigen 1 2.01972
RAD51AP1 RAD51 associated protein 1 2.01972
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 2.00558
FAM171A1 family with sequence similarity 171, member A1 2.00123

decreased expression

Symbol Name Standardized Value
DLX4 distal-less homeobox 4 -2.94011
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 -2.94011
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.94011
TAS2R31 taste receptor, type 2, member 31 -2.94011
PLGLB1 plasminogen-like B1 -2.94011
TMIGD2 transmembrane and immunoglobulin domain containing 2 -2.94011
TCF21 transcription factor 21 -2.94011
ZNHIT2 zinc finger, HIT-type containing 2 -2.94011
DNAI2 dynein, axonemal, intermediate chain 2 -2.94011
MYH13 myosin, heavy chain 13, skeletal muscle -2.94011
ZAN zonadhesin (gene/pseudogene) -2.94011
GAK cyclin G associated kinase -2.94011
IL17B interleukin 17B -2.94011
KCNIP1 Kv channel interacting protein 1 -2.94011
PELP1 proline, glutamate and leucine rich protein 1 -2.94011
TRIM74 tripartite motif containing 74 -2.94011
LIMD1 LIM domains containing 1 -2.94011
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.94011
FABP6 fatty acid binding protein 6, ileal -2.94011
VSTM2A V-set and transmembrane domain containing 2A -2.94011
SH2D7 SH2 domain containing 7 -2.94011
PLXNA3 plexin A3 -2.94011
AGTR1 angiotensin II receptor, type 1 -2.94011
RGS22 regulator of G-protein signaling 22 -2.94011
PPOX protoporphyrinogen oxidase -2.94011
FBXO47 F-box protein 47 -2.94011
SVOP SV2 related protein homolog (rat) -2.94011
CFAP61 cilia and flagella associated protein 61 -2.94011
SLX9 SLX9 ribosome biogenesis factor -2.94011
DMRT1 doublesex and mab-3 related transcription factor 1 -2.94011
LOC114841035 uncharacterized LOC114841035 -2.94011
GPR68 G protein-coupled receptor 68 -2.94011
UBXN10 UBX domain protein 10 -2.94011
MOG myelin oligodendrocyte glycoprotein -2.94011
GPR146 G protein-coupled receptor 146 -2.94011
MINAR2 membrane integral NOTCH2 associated receptor 2 -2.94011
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.94011
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.94011
VSIG1 V-set and immunoglobulin domain containing 1 -2.94011
FAM131C family with sequence similarity 131, member C -2.94011
REP15 RAB15 effector protein -2.94011
ZNF540 zinc finger protein 540 -2.94011
CFAP65 cilia and flagella associated protein 65 -2.94011
YAE1 YAE1 maturation factor of ABCE1 -2.94011
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 -2.94011
TMEM231 transmembrane protein 231 -2.92886
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.89554
GASK1A golgi associated kinase 1A -2.84507
TPH2 tryptophan hydroxylase 2 -2.83692
ZNF674 zinc finger protein 674 -2.82557
SH2D4B SH2 domain containing 4B -2.68437
HARS2 histidyl-tRNA synthetase 2, mitochondrial -2.6642
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -2.62627
DNAAF11 dynein axonemal assembly factor 11 -2.55208
GTPBP2 GTP binding protein 2 -2.54808
TMT1B thiol methyltransferase 1B -2.52158
RAB11FIP1 RAB11 family interacting protein 1 (class I) -2.50435
ZC3H18 zinc finger CCCH-type containing 18 -2.4901
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.48515
GTF2B general transcription factor IIB -2.47545
UBE2D1 ubiquitin-conjugating enzyme E2D 1 -2.45427
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.44992
LASP1NB LASP1 neighbor -2.44398
RSPH3 radial spoke 3 homolog (Chlamydomonas) -2.42633
NBPF11 neuroblastoma breakpoint family, member 11 -2.40052
POU6F2 POU class 6 homeobox 2 -2.3737
IGSF23 immunoglobulin superfamily, member 23 -2.36502
TUBA8 tubulin, alpha 8 -2.36502
DRD3 dopamine receptor D3 -2.36502
TDRD7 tudor domain containing 7 -2.36502
BICRA BRD4 interacting chromatin remodeling complex associated protein -2.35931
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.31265
SLC46A1 solute carrier family 46 (folate transporter), member 1 -2.31265
TARS3 threonyl-tRNA synthetase 3 -2.28819
PCDHGA8 protocadherin gamma subfamily A, 8 -2.25417
DSE dermatan sulfate epimerase -2.23481
RFXAP regulatory factor X-associated protein -2.23016
ZNF107 zinc finger protein 107 -2.22523
CNN2 calponin 2 -2.20578
COPS4 COP9 signalosome subunit 4 -2.20177
CFAP52 cilia and flagella associated protein 52 -2.19801
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -2.19801
ACADVL acyl-CoA dehydrogenase, very long chain -2.17942
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -2.16992
ZC3H14 zinc finger CCCH-type containing 14 -2.15231
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.1391
USP34 ubiquitin specific peptidase 34 -2.1391
HSPG2 heparan sulfate proteoglycan 2 -2.13884
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -2.13238
LAP3 leucine aminopeptidase 3 -2.13144
TMEM161B transmembrane protein 161B -2.10321
PTCD3 pentatricopeptide repeat domain 3 -2.10125
COX18 COX18 cytochrome c oxidase assembly factor -2.09655
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -2.07989
FBXL2 F-box and leucine-rich repeat protein 2 -2.07989
PABIR3 PABIR family member 3 -2.07738
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 -2.07155
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.04672
ETV1 ets variant 1 -2.03844
ARFIP1 ADP-ribosylation factor interacting protein 1 -2.03764
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B -2.01972