HOXB4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description homeobox B4|This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3214)
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Genes

303 genes differentially expressed following the HOXB4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.02798
SHE Src homology 2 domain containing E 3.02798
MROH2B maestro heat-like repeat family member 2B 3.02798
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.02798
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.02798
LEKR1 leucine, glutamate and lysine rich 1 3.02798
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.02798
CD48 CD48 molecule 3.02798
ZNF541 zinc finger protein 541 3.02798
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.02798
CXCL14 chemokine (C-X-C motif) ligand 14 3.02798
MEOX1 mesenchyme homeobox 1 3.02798
CDC20B cell division cycle 20B 3.02798
FPR2 formyl peptide receptor 2 3.02798
CXCR6 chemokine (C-X-C motif) receptor 6 3.02798
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.02798
CFI complement factor I 3.02798
KLHDC1 kelch domain containing 1 3.02798
SCEL sciellin 3.02798
PRR22 proline rich 22 3.02798
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.02798
WNT2 wingless-type MMTV integration site family member 2 3.02798
TRIM77 tripartite motif containing 77 2.92444
HGD homogentisate 1,2-dioxygenase 2.92444
PCDHB1 protocadherin beta 1 2.92444
GPR55 G protein-coupled receptor 55 2.92444
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.92444
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.92444
MAGEA2 melanoma antigen family A2 2.92444
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.92444
IGFL3 IGF-like family member 3 2.92444
NEUROD4 neuronal differentiation 4 2.92444
GALP galanin-like peptide 2.92444
CNTNAP4 contactin associated protein-like 4 2.92444
PNMA5 paraneoplastic Ma antigen family member 5 2.92444
CCDC87 coiled-coil domain containing 87 2.92444
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.92444
BMP5 bone morphogenetic protein 5 2.92444
KRT77 keratin 77, type II 2.92444
MRC1 mannose receptor, C type 1 2.92444
TMEM89 transmembrane protein 89 2.92444
C8ORF74 chromosome 8 open reading frame 74 2.92444
LOC105378220 macrophage receptor MARCO-like 2.92444
PTGFR prostaglandin F receptor (FP) 2.92444
CTAG2 cancer/testis antigen 2 2.92444
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.92444
MUSK muscle, skeletal, receptor tyrosine kinase 2.92444
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.92444
XCL2 chemokine (C motif) ligand 2 2.92444
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.92444
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.92444
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.92444
SMIM45 small integral membrane protein 45 2.92444
RAX2 retina and anterior neural fold homeobox 2 2.92444
MCHR1 melanin-concentrating hormone receptor 1 2.92444
ZAR1 zygote arrest 1 2.92444
MMUT methylmalonyl-CoA mutase 2.92444
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.92444
ELOA2 elongin A2 2.92444
SOFU1 sperm-oocyte fusion factor 1 2.92444
CFAP97D1 CFAP97 domain containing 1 2.92444
GNG5B G protein subunit gamma 5B 2.92444
TMA7B translation machinery associated 7 homolog B 2.92444
LOC124903372 uncharacterized LOC124903372 2.92444
DEFB109B defensin beta 109B 2.92444
WASH8P WAS protein family homolog 8, pseudogene 2.92444
PRR20G proline rich 20G 2.92444
TBC1D3L TBC1 domain family, member 3L 2.92444
ANO3 anoctamin 3 2.92444
LOC124909439 uncharacterized LOC124909439 2.92444
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.92444
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.92444
TAS1R2 taste receptor, type 1, member 2 2.92444
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.92444
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 2.92444
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.92444
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.92444
EXOC3L1 exocyst complex component 3-like 1 2.92444
C7 complement component 7 2.92444
FRK fyn-related Src family tyrosine kinase 2.92444
GDF6 growth differentiation factor 6 2.92444
ZNF705D zinc finger protein 705D 2.92444
VSIG2 V-set and immunoglobulin domain containing 2 2.92444
FCMR Fc fragment of IgM receptor 2.92444
MYPN myopalladin 2.92444
LRTM3 leucine rich repeat transmembrane protein 3 2.92444
LRRC24 leucine rich repeat containing 24 2.92444
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.92444
HELT helt bHLH transcription factor 2.92444
NUP153 nucleoporin 153kDa 2.92444
AGXT2 alanine--glyoxylate aminotransferase 2 2.92444
TRIM50 tripartite motif containing 50 2.92444
MAB21L1 mab-21-like 1 (C. elegans) 2.92444
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.92444
AKNAD1 AKNA domain containing 1 2.92444
TBC1D10C TBC1 domain family, member 10C 2.92444
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.92444
GRK1 G protein-coupled receptor kinase 1 2.92444
EHF ets homologous factor 2.92444
RAD51AP2 RAD51 associated protein 2 2.92444
CGB7 chorionic gonadotropin, beta polypeptide 7 2.92444
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.92444
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.92444
PRR35 proline rich 35 2.92444
CASQ2 calsequestrin 2 (cardiac muscle) 2.92444
ADCY4 adenylate cyclase 4 2.92444
GPR149 G protein-coupled receptor 149 2.92444
GLDC glycine dehydrogenase (decarboxylating) 2.92444
ORM1 orosomucoid 1 2.92444
MYLK2 myosin light chain kinase 2 2.92444
BCL2L15 BCL2-like 15 2.92444
LHX9 LIM homeobox 9 2.92444
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 2.92444
OTOP2 otopetrin 2 2.92444
PNLIP pancreatic lipase 2.92444
LY9 lymphocyte antigen 9 2.92444
CRYBB2 crystallin, beta B2 2.92444
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.92444
TPPP2 tubulin polymerization-promoting protein family member 2 2.92444
ERICH4 glutamate-rich 4 2.92444
KCNK7 potassium channel, two pore domain subfamily K, member 7 2.92444
CETP cholesteryl ester transfer protein, plasma 2.92444
NCF1 neutrophil cytosolic factor 1 2.92444
LRRC74B leucine rich repeat containing 74B 2.92444
CHRM4 cholinergic receptor, muscarinic 4 2.92444
FITM1 fat storage-inducing transmembrane protein 1 2.92444
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.92444
AGR3 anterior gradient 3 2.92444
LPAR5 lysophosphatidic acid receptor 5 2.92444
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.92444
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.92444
ANGPTL3 angiopoietin-like 3 2.92444
SLC38A11 solute carrier family 38, member 11 2.92444
TGM7 transglutaminase 7 2.92444
TTC36 tetratricopeptide repeat domain 36 2.92444
DMBT1 deleted in malignant brain tumors 1 2.92444
ATXN7L3 ataxin 7-like 3 2.92423
SOWAHD sosondowah ankyrin repeat domain family member D 2.88205
CRYGB crystallin, gamma B 2.88205
NIM1K NIM1 serine/threonine protein kinase 2.86834
EIF3D eukaryotic translation initiation factor 3, subunit D 2.76823
U2AF1 U2 small nuclear RNA auxiliary factor 1 2.76823
HARS1 histidyl-tRNA synthetase 1 2.73585
MFSD2A major facilitator superfamily domain containing 2A 2.69775
GIN1 gypsy retrotransposon integrase 1 2.69484
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 2.69484
AP1AR adaptor-related protein complex 1 associated regulatory protein 2.67836
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 2.61806
FAM117A family with sequence similarity 117, member A 2.6016
SERTAD2 SERTA domain containing 2 2.59791
CLDN20 claudin 20 2.59791
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 2.58149
MBP myelin basic protein 2.57673
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 2.57088
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.53799
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 2.52473
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 2.52336
C11ORF98 chromosome 11 open reading frame 98 2.48842
ALKBH5 AlkB family member 5, RNA demethylase 2.45236
RSPRY1 ring finger and SPRY domain containing 1 2.44643
BBS4 Bardet-Biedl syndrome 4 2.44035
LARS2 leucyl-tRNA synthetase 2, mitochondrial 2.43033
INPP5J inositol polyphosphate-5-phosphatase J 2.41813
DRICH1 aspartate-rich 1 2.40471
AGBL4 ATP/GTP binding protein-like 4 2.40471
UBXN10 UBX domain protein 10 2.40471
GJD3 gap junction protein, delta 3, 31.9kDa 2.30382
INSIG2 insulin induced gene 2 2.29343
CALCOCO2 calcium binding and coiled-coil domain 2 2.29149
TMEM52 transmembrane protein 52 2.29149
SHCBP1 SHC SH2-domain binding protein 1 2.29149
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.27273
SCAF8 SR-related CTD-associated factor 8 2.27121
TTLL7 tubulin tyrosine ligase-like family member 7 2.25801
ANKRD36B ankyrin repeat domain 36B 2.25427
CCDC88C coiled-coil domain containing 88C 2.23418
ZNF69 zinc finger protein 69 2.22515
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.21618
SCMH1 sex comb on midleg homolog 1 (Drosophila) 2.21198
RTCA RNA 3'-terminal phosphate cyclase 2.21089
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 2.19646
COL18A1 collagen, type XVIII, alpha 1 2.19609
APOOL apolipoprotein O-like 2.18203
KIFC1 kinesin family member C1 2.17079
RALBP1 ralA binding protein 1 2.15006
SPDYA speedy/RINGO cell cycle regulator family member A 2.13894
ZNF165 zinc finger protein 165 2.1194
SPATA2 spermatogenesis associated 2 2.11443
CLSTN2 calsyntenin 2 2.10286
CLUL1 clusterin-like 1 (retinal) 2.0817
ZNF830 zinc finger protein 830 2.07435
PAWR PRKC, apoptosis, WT1, regulator 2.06924
COMMD6 COMM domain containing 6 2.03205
TAS2R4 taste receptor, type 2, member 4 2.03132
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 2.0279
SESN2 sestrin 2 2.0154
HAUS3 HAUS augmin-like complex, subunit 3 2.01318

decreased expression

Symbol Name Standardized Value
ASIC1 acid sensing (proton gated) ion channel 1 -3.02798
SPATA45 spermatogenesis associated 45 -3.02798
TMT1B thiol methyltransferase 1B -2.92444
OPRK1 opioid receptor, kappa 1 -2.92444
MST1R macrophage stimulating 1 receptor -2.92444
IL32 interleukin 32 -2.92444
F10 coagulation factor X -2.92444
C17ORF114 chromosome 17 open reading frame 114 -2.92444
PROX1 prospero homeobox 1 -2.92444
KIAA1614 KIAA1614 -2.92444
GLA galactosidase, alpha -2.92444
RIMKLB ribosomal modification protein rimK-like family member B -2.92433
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -2.92423
ERAS ES cell expressed Ras -2.76823
HIGD1C HIG1 hypoxia inducible domain family, member 1C -2.76823
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.76823
SDSL serine dehydratase-like -2.76823
NUTM2G NUT family member 2G -2.76823
ASB14 ankyrin repeat and SOCS box containing 14 -2.76823
TPTE transmembrane phosphatase with tensin homology -2.76823
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -2.76823
SYCP1 synaptonemal complex protein 1 -2.76823
KLHL35 kelch-like family member 35 -2.76823
SRL sarcalumenin -2.76823
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.76823
TMEM176A transmembrane protein 176A -2.76823
CA1 carbonic anhydrase I -2.76823
KYNU kynureninase -2.76823
RNF39 ring finger protein 39 -2.76823
NXPH3 neurexophilin 3 -2.76823
RGS11 regulator of G-protein signaling 11 -2.76823
C2CD4B C2 calcium-dependent domain containing 4B -2.76823
WNT4 wingless-type MMTV integration site family, member 4 -2.76823
ERVV-2 endogenous retrovirus group V, member 2 -2.76823
PLA1A phospholipase A1 member A -2.76823
CFAP126 cilia and flagella associated protein 126 -2.76823
FSHR follicle stimulating hormone receptor -2.76823
ITGA10 integrin, alpha 10 -2.76823
IBSP integrin-binding sialoprotein -2.76823
MUC16 mucin 16, cell surface associated -2.76823
CA5A carbonic anhydrase VA, mitochondrial -2.76823
PRTN3 proteinase 3 -2.76823
GPR12 G protein-coupled receptor 12 -2.76823
CSAG3 CSAG family, member 3 -2.76823
IRF2BP2 interferon regulatory factor 2 binding protein 2 -2.74517
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.69883
SPDYE12 speedy/RINGO cell cycle regulator family member E12 -2.69484
THBS1 thrombospondin 1 -2.67836
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.65384
CCDC62 coiled-coil domain containing 62 -2.64836
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.6016
LIMS1 LIM and senescent cell antigen-like domains 1 -2.58149
RHCE Rh blood group, CcEe antigens -2.56417
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -2.53909
GLCE glucuronic acid epimerase -2.51781
ZNF711 zinc finger protein 711 -2.50427
SLC25A27 solute carrier family 25, member 27 -2.50427
RUSC1 RUN and SH3 domain containing 1 -2.49851
ANKRD49 ankyrin repeat domain 49 -2.49484
H2AC13 H2A clustered histone 13 -2.41006
TMEM255B transmembrane protein 255B -2.40575
CCDC159 coiled-coil domain containing 159 -2.3914
LINGO2 leucine rich repeat and Ig domain containing 2 -2.38784
PRPF3 pre-mRNA processing factor 3 -2.37018
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -2.36812
IFT70A intraflagellar transport 70A -2.35426
SFRP4 secreted frizzled-related protein 4 -2.35426
ABAT 4-aminobutyrate aminotransferase -2.35426
AP4M1 adaptor-related protein complex 4, mu 1 subunit -2.30718
SOBP sine oculis binding protein homolog (Drosophila) -2.26727
TTLL5 tubulin tyrosine ligase-like family member 5 -2.2544
FTO fat mass and obesity associated -2.25427
NCSTN nicastrin -2.24033
RECK reversion-inducing-cysteine-rich protein with kazal motifs -2.23957
LRRC40 leucine rich repeat containing 40 -2.23114
WDR11 WD repeat domain 11 -2.22229
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -2.20852
LRMDA leucine rich melanocyte differentiation associated -2.20699
CNOT9 CCR4-NOT transcription complex subunit 9 -2.19853
LRRC49 leucine rich repeat containing 49 -2.16843
TSC22D4 TSC22 domain family, member 4 -2.16711
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.15672
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.13894
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -2.1194
FAM50B family with sequence similarity 50, member B -2.11443
ATG13 autophagy related 13 -2.11443
SRRM3 serine/arginine repetitive matrix 3 -2.10179
WDR83 WD repeat domain 83 -2.09098
SDC4 syndecan 4 -2.08404
FOXL2 forkhead box L2 -2.07789
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.07471
DAPK1 death-associated protein kinase 1 -2.07471
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -2.07471
SPAG4 sperm associated antigen 4 -2.07435
CRYGS crystallin, gamma S -2.07435
TRIQK triple QxxK/R motif containing -2.06924
PAQR6 progestin and adipoQ receptor family member VI -2.06924
CCDC107 coiled-coil domain containing 107 -2.06295
ZFTA zinc finger translocation associated -2.04607
ARHGAP35 Rho GTPase activating protein 35 -2.04607
MEDAG mesenteric estrogen-dependent adipogenesis -2.03205
ACKR4 atypical chemokine receptor 4 -2.03205
MROH8 maestro heat-like repeat family member 8 -2.03205
LIN52 lin-52 DREAM MuvB core complex component -2.03205
COL27A1 collagen, type XXVII, alpha 1 -2.0195
POMT2 protein-O-mannosyltransferase 2 -2.0154