HS+LS_90min_LPS vs ctrl_RAW264.7_macrophage (Mouse) [20222745] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs
Category proteomics
Type drug perturbation
Description drug perturbation identified as [drug perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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Genes

93 proteins differentially phosphorylated following the HS+LS_90min_LPS vs ctrl_RAW264.7_macrophage (Mouse) [20222745] drug perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.

increased phosphorylation

Symbol Name
AAK1 AP2 associated kinase 1
ACLY ATP citrate lyase
ANAPC1 anaphase promoting complex subunit 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ATXN2L ataxin 2-like
BCKDK branched chain ketoacid dehydrogenase kinase
BMP2K BMP2 inducible kinase
C2CD5 C2 calcium-dependent domain containing 5
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CANX calnexin
CCNE1 cyclin E1
CCNK cyclin K
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK7 cyclin-dependent kinase 7
CHEK1 checkpoint kinase 1
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CSNK2B casein kinase 2, beta polypeptide
DOCK2 dedicator of cytokinesis 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EDC4 enhancer of mRNA decapping 4
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF3C eukaryotic translation initiation factor 3, subunit C
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GIGYF2 GRB10 interacting GYF protein 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPH1 heat shock 105kDa/110kDa protein 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IVNS1ABP influenza virus NS1A binding protein
JUN jun proto-oncogene
LARP1 La ribonucleoprotein domain family, member 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MELK maternal embryonic leucine zipper kinase
MYBBP1A MYB binding protein (P160) 1a
MYO9B myosin IXB
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PKN2 protein kinase N2
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
RBM39 RNA binding motif protein 39
RIPK2 receptor-interacting serine-threonine kinase 2
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS3 ribosomal protein S3
RPS6 ribosomal protein S6
SCAMP3 secretory carrier membrane protein 3
SEC61B Sec61 beta subunit
SLK STE20-like kinase
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
STK10 serine/threonine kinase 10
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TANK TRAF family member-associated NFKB activator
TCP1 t-complex 1
TLK1 tousled-like kinase 1
UBL7 ubiquitin-like 7
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UVRAG UV radiation resistance associated
ZAK sterile alpha motif and leucine zipper containing kinase AZK

decreased phosphorylation

Symbol Name
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
CCNC cyclin C
MNAT1 MNAT CDK-activating kinase assembly factor 1
STK19 serine/threonine kinase 19