HSBP1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description heat shock factor binding protein 1|The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3281)
External Link http://www.ncbi.nlm.nih.gov/gene/3281
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Genes

77 interacting proteins for HSBP1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATG13 autophagy related 13
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B2M beta-2-microglobulin
C9ORF72 chromosome 9 open reading frame 72
CCDC53 coiled-coil domain containing 53
COG5 component of oligomeric golgi complex 5
COG7 component of oligomeric golgi complex 7
CORO1C coronin, actin binding protein, 1C
CSTB cystatin B (stefin B)
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4H eukaryotic translation initiation factor 4H
EXOC3 exocyst complex component 3
EXOC4 exocyst complex component 4
FOLR1 folate receptor 1 (adult)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GOLGA4 golgin A4
HDAC3 histone deacetylase 3
HIST1H4F histone cluster 1, H4f
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HSF1 heat shock transcription factor 1
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
LIN37 lin-37 DREAM MuvB core complex component
LIN52 lin-52 DREAM MuvB core complex component
LIN54 lin-54 DREAM MuvB core complex component
LIN9 lin-9 DREAM MuvB core complex component
LONP2 lon peptidase 2, peroxisomal
MAP4 microtubule-associated protein 4
MISP mitotic spindle positioning
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCOR1 nuclear receptor corepressor 1
NFS1 NFS1 cysteine desulfurase
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSFL1C NSFL1 (p97) cofactor (p47)
PARK7 parkinson protein 7
PDAP1 PDGFA associated protein 1
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
POC1A POC1 centriolar protein A
POC1B POC1 centriolar protein B
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRDX5 peroxiredoxin 5
RAI14 retinoic acid induced 14
RB1CC1 RB1-inducible coiled-coil 1
RBBP4 retinoblastoma binding protein 4
RBL2 retinoblastoma-like 2
RBMX RNA binding motif protein, X-linked
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPLP2 ribosomal protein, large, P2
RRBP1 ribosome binding protein 1
SAFB scaffold attachment factor B
SAFB2 scaffold attachment factor B2
SH3GL1 SH3-domain GRB2-like 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SQSTM1 sequestosome 1
SRP9 signal recognition particle 9kDa
STOM stomatin
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBK1 TANK-binding kinase 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMOD3 tropomodulin 3 (ubiquitous)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM33 tripartite motif containing 33
UBC ubiquitin C
ULK1 unc-51 like autophagy activating kinase 1
VCP valosin containing protein
WDR41 WD repeat domain 41