HSPB1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description heat shock 27kDa protein 1|The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 3315)
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Genes

346 genes differentially expressed following the HSPB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
APOB apolipoprotein B 3.13969
SOSTDC1 sclerostin domain containing 1 3.13969
DUXB double homeobox B 3.13969
LRRC74B leucine rich repeat containing 74B 3.13969
PON1 paraoxonase 1 3.13969
KLHL1 kelch-like family member 1 3.13969
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.13969
GATA4 GATA binding protein 4 3.13969
LAMP5 lysosomal-associated membrane protein family, member 5 3.13969
DDN dendrin 3.13969
HSPA1L heat shock 70kDa protein 1-like 3.13969
GDF7 growth differentiation factor 7 3.13969
PCDHGA4 protocadherin gamma subfamily A, 4 3.13969
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.13969
PTCRA pre T-cell antigen receptor alpha 3.13969
SPATS1 spermatogenesis associated, serine-rich 1 3.13969
LCN12 lipocalin 12 3.13969
CLEC20A C-type lectin domain containing 20A 3.13969
GJB6 gap junction protein, beta 6, 30kDa 3.13969
C17ORF113 chromosome 17 open reading frame 113 3.13969
MYADML2 myeloid-associated differentiation marker-like 2 3.13969
JAML junction adhesion molecule like 3.13969
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.13969
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.13969
RXFP2 relaxin/insulin-like family peptide receptor 2 3.07905
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 3.07905
RHOXF2B Rhox homeobox family, member 2B 3.07905
TMEM176B transmembrane protein 176B 3.07905
PGAM4 phosphoglycerate mutase family member 4 3.07905
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.07905
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.07905
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.07905
OR10V1 olfactory receptor, family 10, subfamily V, member 1 3.07905
IL22RA1 interleukin 22 receptor, alpha 1 3.07905
SCGN secretagogin, EF-hand calcium binding protein 3.07905
SCG5 secretogranin V 3.07905
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.07905
ADGB androglobin 3.07905
MYPN myopalladin 3.07905
OCSTAMP osteoclast stimulatory transmembrane protein 3.07905
C8ORF74 chromosome 8 open reading frame 74 3.07905
TCP11 t-complex 11, testis-specific 3.07905
GNRH2 gonadotropin-releasing hormone 2 3.07905
MPO myeloperoxidase 3.07905
LGALS4 lectin, galactoside-binding, soluble, 4 3.07905
CPLX3 complexin 3 3.07905
TMEM217 transmembrane protein 217 3.07905
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.07905
OR5AR1 olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene) 3.07905
MILR1 mast cell immunoglobulin-like receptor 1 3.07905
GPR151 G protein-coupled receptor 151 3.07905
PCDHGB3 protocadherin gamma subfamily B, 3 3.07905
TMEM191B transmembrane protein 191B 3.07905
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.07905
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.07905
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.07905
GPR21 G protein-coupled receptor 21 3.07905
LUZP4 leucine zipper protein 4 3.07905
KRABD1 KRAB domain containing 1 3.07905
RD3 retinal degeneration 3 3.07905
TBC1D3L TBC1 domain family, member 3L 3.07905
PROX2 prospero homeobox 2 3.07905
ADRB3 adrenoceptor beta 3 3.07905
MIOX myo-inositol oxygenase 3.07905
ZNF705A zinc finger protein 705A 3.07905
CSAG2 CSAG family, member 2 3.07905
SYT15 synaptotagmin XV 3.07905
GIPC3 GIPC PDZ domain containing family, member 3 3.07905
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.07905
TLE7 TLE family member 7 3.07905
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.07905
CIBAR2 CBY1 interacting BAR domain containing 2 3.07905
LY6L lymphocyte antigen 6 family member L 3.07905
CFAP107 cilia and flagella associated protein 107 3.07905
GARIN6 golgi associated RAB2 interactor family member 6 3.07905
TEX55 testis expressed 55 3.07905
CCDC198 coiled-coil domain containing 198 3.07905
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.07905
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.07905
CCDC42 coiled-coil domain containing 42 3.07905
PRG4 proteoglycan 4 3.07905
CDX2 caudal type homeobox 2 3.07905
PCDHA7 protocadherin alpha 7 3.07905
FOXD1 forkhead box D1 3.07905
RAB44 RAB44, member RAS oncogene family 3.07905
HHEX hematopoietically expressed homeobox 3.07905
FPR2 formyl peptide receptor 2 3.07905
ACR acrosin 3.07905
HLF hepatic leukemia factor 3.07905
TEX101 testis expressed 101 3.07905
DSG1 desmoglein 1 3.07905
HPR haptoglobin-related protein 3.07905
LRRC72 leucine rich repeat containing 72 3.07905
PLEK2 pleckstrin 2 3.07905
SAA4 serum amyloid A4, constitutive 3.07905
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.07905
ZAN zonadhesin (gene/pseudogene) 3.07905
TLR8 toll-like receptor 8 3.07905
TLR6 toll-like receptor 6 3.07905
OR52D1 olfactory receptor, family 52, subfamily D, member 1 3.07905
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.07905
ACY3 aminoacylase 3 3.07905
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.07905
DQX1 DEAQ box RNA-dependent ATPase 1 3.07905
EHF ets homologous factor 3.07905
CST4 cystatin S 3.07905
LCT lactase 3.07905
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.07905
LRRC46 leucine rich repeat containing 46 3.07905
RPA4 replication protein A4, 30kDa 3.07905
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.07905
PRSS57 protease, serine, 57 3.07905
DMTN dematin actin binding protein 3.07905
AGR2 anterior gradient 2 3.07905
FAM25C family with sequence similarity 25, member C 3.07905
PSORS1C1 psoriasis susceptibility 1 candidate 1 3.07905
USP17L7 ubiquitin specific peptidase 17-like family member 7 3.07905
WFDC10A WAP four-disulfide core domain 10A 3.07905
GCM2 glial cells missing homolog 2 (Drosophila) 3.07905
CD80 CD80 molecule 3.07905
ADGRA1 adhesion G protein-coupled receptor A1 3.07905
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 3.07905
C1ORF185 chromosome 1 open reading frame 185 3.07905
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.07905
GAS2L2 growth arrest-specific 2 like 2 3.07905
GPR150 G protein-coupled receptor 150 3.07905
MOBP myelin-associated oligodendrocyte basic protein 3.07905
LHX5 LIM homeobox 5 3.07905
SYNGR4 synaptogyrin 4 3.07905
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.07905
ARL13A ADP-ribosylation factor-like 13A 3.07905
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.07905
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.07905
COMP cartilage oligomeric matrix protein 3.07905
LMOD2 leiomodin 2 (cardiac) 3.07905
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.07905
KLF2 Kruppel-like factor 2 3.07905
CXCR6 chemokine (C-X-C motif) receptor 6 3.07905
DPRX divergent-paired related homeobox 3.07905
TEX35 testis expressed 35 3.07905
PADI1 peptidyl arginine deiminase, type I 3.07905
OR56A5 olfactory receptor, family 56, subfamily A, member 5 3.07905
SLC10A5 solute carrier family 10, member 5 3.07905
IL33 interleukin 33 3.07905
IL23R interleukin 23 receptor 3.07905
GRM8 glutamate receptor, metabotropic 8 3.07905
AREG amphiregulin 3.07905
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.07905
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.07905
KRTAP12-1 keratin associated protein 12-1 3.07905
TDO2 tryptophan 2,3-dioxygenase 3.07905
C5ORF46 chromosome 5 open reading frame 46 3.07905
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.07905
ANXA1 annexin A1 3.07905
NMUR2 neuromedin U receptor 2 3.07905
RTP4 receptor (chemosensory) transporter protein 4 3.07905
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.07905
NKPD1 NTPase, KAP family P-loop domain containing 1 3.07905
CD151 CD151 molecule (Raph blood group) 3.06858
MTERF2 mitochondrial transcription termination factor 2 3.01927
LOC390937 Ets2 repressor factor-like 3.00479
ADGRD1 adhesion G protein-coupled receptor D1 2.98054
GPSM3 G-protein signaling modulator 3 2.97964
CEP95 centrosomal protein 95kDa 2.956
BCL7B B-cell CLL/lymphoma 7B 2.93099
GNPAT glyceronephosphate O-acyltransferase 2.88001
ZNF23 zinc finger protein 23 2.86494
ZNF816 zinc finger protein 816 2.78005
DENND4C DENN/MADD domain containing 4C 2.69308
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2.68944
TNIP1 TNFAIP3 interacting protein 1 2.65015
FMR1 fragile X mental retardation 1 2.61752
RFX7 regulatory factor X, 7 2.57295
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.55716
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 2.55702
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 2.55255
CEND1 cell cycle exit and neuronal differentiation 1 2.55255
TMX2 thioredoxin-related transmembrane protein 2 2.55018
MEIOB meiosis specific with OB domains 2.55018
UBXN1 UBX domain protein 1 2.47675
PSPC1 paraspeckle component 1 2.44557
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.41884
USP54 ubiquitin specific peptidase 54 2.41884
NCAPH2 non-SMC condensin II complex, subunit H2 2.377
NADK2 NAD kinase 2, mitochondrial 2.37376
DUSP8 dual specificity phosphatase 8 2.36642
BCAP31 B-cell receptor-associated protein 31 2.35586
RGPD3 RANBP2-like and GRIP domain containing 3 2.3514
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.32977
ENTREP2 endosomal transmembrane epsin interactor 2 2.32977
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.28814
ZC3H8 zinc finger CCCH-type containing 8 2.25084
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.23318
IQANK1 IQ motif and ankyrin repeat containing 1 2.22772
PLPP1 phospholipid phosphatase 1 2.22217
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) 2.20011
NOL8 nucleolar protein 8 2.20011
PRSS8 protease, serine, 8 2.19936
AQP11 aquaporin 11 2.17363
JAK2 Janus kinase 2 2.15472
CFAP69 cilia and flagella associated protein 69 2.14012
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 2.13229
NCK1 NCK adaptor protein 1 2.12948
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 2.12556
ARPIN actin-related protein 2/3 complex inhibitor 2.12414
FBXO10 F-box protein 10 2.10739
TNRC6C trinucleotide repeat containing 6C 2.10739
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C 2.10381
CTCFL CCCTC-binding factor (zinc finger protein)-like 2.10214
NUP54 nucleoporin 54kDa 2.06915
RBM15 RNA binding motif protein 15 2.06915
FBXW4 F-box and WD repeat domain containing 4 2.0641
RBL2 retinoblastoma-like 2 2.03249
SALL4 spalt-like transcription factor 4 2.03214
BMS1 BMS1 ribosome biogenesis factor 2.02774
DEXI Dexi homolog (mouse) 2.02774
MAP4 microtubule-associated protein 4 2.02488
UROS uroporphyrinogen III synthase 2.01892
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.00829
FYTTD1 forty-two-three domain containing 1 2.00829
PYY peptide YY 2.00631
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.00063
TMEM238L transmembrane protein 238 like 2.00063
KCNK2 potassium channel, two pore domain subfamily K, member 2 2.00063
VSTM2A V-set and transmembrane domain containing 2A 2.00063
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.00063
CXCL14 chemokine (C-X-C motif) ligand 14 2.00063

decreased expression

Symbol Name Standardized Value
LIPH lipase, member H -3.13969
HSPB1 heat shock 27kDa protein 1 -3.13969
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -3.07905
BSND barttin CLCNK-type chloride channel accessory beta subunit -3.07905
TBC1D28 TBC1 domain family, member 28 -3.07905
SMIM22 small integral membrane protein 22 -3.07905
PHOSPHO1 phosphatase, orphan 1 -3.07905
IGFBP7 insulin-like growth factor binding protein 7 -3.07905
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -3.07905
KLF1 Kruppel-like factor 1 (erythroid) -3.07905
TAS2R46 taste receptor, type 2, member 46 -3.07905
TRAF3IP3 TRAF3 interacting protein 3 -3.07905
CLNK cytokine-dependent hematopoietic cell linker -3.07905
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -3.07905
ASMT acetylserotonin O-methyltransferase -3.07905
GRM3 glutamate receptor, metabotropic 3 -3.07905
MYOM2 myomesin 2 -3.07905
RHOJ ras homolog family member J -3.07905
TM4SF20 transmembrane 4 L six family member 20 -3.07905
PSD2 pleckstrin and Sec7 domain containing 2 -3.07905
COL8A2 collagen, type VIII, alpha 2 -3.07905
GGN gametogenetin -3.07905
JSRP1 junctional sarcoplasmic reticulum protein 1 -3.07905
SRP54 signal recognition particle 54kDa -3.07905
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -3.07905
CATIP ciliogenesis associated TTC17 interacting protein -3.07905
TMPRSS4 transmembrane protease, serine 4 -3.07905
LMNTD1 lamin tail domain containing 1 -3.07905
OR2T8 olfactory receptor, family 2, subfamily T, member 8 -3.07905
ZFHX3 zinc finger homeobox 3 -3.07905
FAIM2 Fas apoptotic inhibitory molecule 2 -3.07905
CATSPERZ catsper channel auxiliary subunit zeta -3.07905
INSYN1 inhibitory synaptic factor 1 -3.07905
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 -3.07905
CFP complement factor properdin -3.07905
ARG1 arginase 1 -3.07905
MRPS12 mitochondrial ribosomal protein S12 -3.07905
LRRC28 leucine rich repeat containing 28 -2.97964
RNASET2 ribonuclease T2 -2.97964
NELFCD negative elongation factor complex member C/D -2.96707
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.87877
ZC3H11A zinc finger CCCH-type containing 11A -2.78005
ADGRE5 adhesion G protein-coupled receptor E5 -2.78005
RUNX1 runt-related transcription factor 1 -2.70705
CLU clusterin -2.68944
BMPR1B bone morphogenetic protein receptor, type IB -2.64457
JAGN1 jagunal homolog 1 (Drosophila) -2.61674
RNF212 ring finger protein 212 -2.56646
NARF nuclear prelamin A recognition factor -2.55361
FBXL4 F-box and leucine-rich repeat protein 4 -2.55255
IFT70B intraflagellar transport 70B -2.5276
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa -2.50309
SCML1 sex comb on midleg-like 1 (Drosophila) -2.49017
B9D1 B9 protein domain 1 -2.49017
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.4629
ESR1 estrogen receptor 1 -2.4629
PMM2 phosphomannomutase 2 -2.4267
KEL Kell blood group, metallo-endopeptidase -2.4267
TMC3 transmembrane channel-like 3 -2.41049
SYPL1 synaptophysin-like 1 -2.39183
CLDN11 claudin 11 -2.37292
AKT1S1 AKT1 substrate 1 (proline-rich) -2.31398
MRPL36 mitochondrial ribosomal protein L36 -2.3122
C10ORF143 chromosome 10 open reading frame 143 -2.31143
BCL9L B-cell CLL/lymphoma 9-like -2.31143
RELT RELT tumor necrosis factor receptor -2.30985
SP6 Sp6 transcription factor -2.29861
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.29861
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -2.29861
TP53BP1 tumor protein p53 binding protein 1 -2.29178
RPS24 ribosomal protein S24 -2.29178
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -2.27375
AHRR aryl-hydrocarbon receptor repressor -2.26159
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 -2.25405
PER2 period circadian clock 2 -2.22928
CDC34 cell division cycle 34 -2.22906
TMEM14C transmembrane protein 14C -2.22563
GRK7 G protein-coupled receptor kinase 7 -2.22217
ASB1 ankyrin repeat and SOCS box containing 1 -2.21858
FREM1 FRAS1 related extracellular matrix 1 -2.20011
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.19937
DENND1C DENN/MADD domain containing 1C -2.19937
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.19411
PPIF peptidylprolyl isomerase F -2.16571
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.16036
F8 coagulation factor VIII, procoagulant component -2.16036
ZBTB33 zinc finger and BTB domain containing 33 -2.16036
ZNF425 zinc finger protein 425 -2.15992
RER1 retention in endoplasmic reticulum sorting receptor 1 -2.15543
MTMR9 myotubularin related protein 9 -2.15543
MELTF melanotransferrin -2.12556
DUSP10 dual specificity phosphatase 10 -2.12556
CYGB cytoglobin -2.12556
CDK10 cyclin-dependent kinase 10 -2.12414
SH2D3A SH2 domain containing 3A -2.12414
ZNF234 zinc finger protein 234 -2.12414
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -2.11216
TSPAN5 tetraspanin 5 -2.10381
ZNF609 zinc finger protein 609 -2.09347
NPB neuropeptide B -2.08972
PPP4R3B protein phosphatase 4 regulatory subunit 3B -2.08903
NEMF nuclear export mediator factor -2.07917
NDC80 NDC80 kinetochore complex component -2.07784
CLCN6 chloride channel, voltage-sensitive 6 -2.06915
ZNF711 zinc finger protein 711 -2.05265
MYCBP MYC binding protein -2.05038
SESN2 sestrin 2 -2.05038
CNFN cornifelin -2.03441
SURF1 surfeit 1 -2.02612
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.02612
NUDC nudC nuclear distribution protein -2.01093
COMMD10 COMM domain containing 10 -2.00829
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -2.00809
HRK harakiri, BCL2 interacting protein -2.00631
ANKRD10 ankyrin repeat domain 10 -2.00063
ANKRD9 ankyrin repeat domain 9 -2.00063
MINK1 misshapen-like kinase 1 -2.00063
VAMP8 vesicle-associated membrane protein 8 -2.00063
C1ORF50 chromosome 1 open reading frame 50 -2.00063