HTR1B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled|The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009] (NCBI Entrez Gene Database, 3351)
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Genes

323 genes differentially expressed following the HTR1B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PNLIPRP2 pancreatic lipase-related protein 2 2.71697
CLEC2L C-type lectin domain family 2, member L 2.71697
CFAP299 cilia and flagella associated protein 299 2.71697
SCGN secretagogin, EF-hand calcium binding protein 2.71697
TERB1 telomere repeat binding bouquet formation protein 1 2.71697
NPPC natriuretic peptide C 2.71697
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.71697
AKR1C2 aldo-keto reductase family 1, member C2 2.71697
CNTF ciliary neurotrophic factor 2.71697
EBF2 early B-cell factor 2 2.71697
WDR64 WD repeat domain 64 2.71697
POTEJ POTE ankyrin domain family, member J 2.71697
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.71697
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.71697
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.71697
CLNK cytokine-dependent hematopoietic cell linker 2.71697
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.71697
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.71697
KCNIP3 Kv channel interacting protein 3, calsenilin 2.71697
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.71697
SCN10A sodium channel, voltage gated, type X alpha subunit 2.71697
GADL1 glutamate decarboxylase-like 1 2.71697
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.71697
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.68669
SMPX small muscle protein, X-linked 2.68669
CPB1 carboxypeptidase B1 (tissue) 2.68669
DLK2 delta-like 2 homolog (Drosophila) 2.68669
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.68669
MYEOV myeloma overexpressed 2.68669
SAG S-antigen; retina and pineal gland (arrestin) 2.68669
WNT8B wingless-type MMTV integration site family, member 8B 2.68669
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.68669
FOXC1 forkhead box C1 2.68669
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.68669
HMX3 H6 family homeobox 3 2.68669
PXT1 peroxisomal, testis specific 1 2.68669
NPAS4 neuronal PAS domain protein 4 2.68669
RNF222 ring finger protein 222 2.68669
LRRC74B leucine rich repeat containing 74B 2.68669
CIB3 calcium and integrin binding family member 3 2.68669
FRMPD1 FERM and PDZ domain containing 1 2.68669
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.68669
TAS2R46 taste receptor, type 2, member 46 2.68669
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.68669
TSSK1B testis-specific serine kinase 1B 2.68669
MEIG1 meiosis/spermiogenesis associated 1 2.68669
TWIST1 twist family bHLH transcription factor 1 2.68669
ZNF804B zinc finger protein 804B 2.68669
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.68669
NMUR2 neuromedin U receptor 2 2.68669
CRH corticotropin releasing hormone 2.68669
SOAT2 sterol O-acyltransferase 2 2.68669
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.68669
KNG1 kininogen 1 2.68669
RXFP2 relaxin/insulin-like family peptide receptor 2 2.68669
VTN vitronectin 2.68669
CEMP1 cementum protein 1 2.68669
MSX2 msh homeobox 2 2.68669
LAPTM5 lysosomal protein transmembrane 5 2.68669
SIX3 SIX homeobox 3 2.68669
COL19A1 collagen, type XIX, alpha 1 2.68669
SLC22A14 solute carrier family 22, member 14 2.68669
LOC390937 Ets2 repressor factor-like 2.68669
PTTG2 pituitary tumor-transforming 2 2.68669
OR4N2 olfactory receptor, family 4, subfamily N, member 2 2.68669
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.68669
CFAP99 cilia and flagella associated protein 99 2.68669
EDAR ectodysplasin A receptor 2.68669
FAM43B family with sequence similarity 43, member B 2.68669
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.68669
MIP major intrinsic protein of lens fiber 2.68669
GLRA3 glycine receptor, alpha 3 2.68669
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 2.68669
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.68669
SAMD11 sterile alpha motif domain containing 11 2.68669
BAAT bile acid CoA:amino acid N-acyltransferase 2.68669
ACTBL2 actin, beta-like 2 2.68669
GPR26 G protein-coupled receptor 26 2.68669
SSTR3 somatostatin receptor 3 2.68669
TCL1B T-cell leukemia/lymphoma 1B 2.68669
FFAR4 free fatty acid receptor 4 2.68669
C8ORF48 chromosome 8 open reading frame 48 2.68669
PKP1 plakophilin 1 2.68669
TSPO2 translocator protein 2 2.68669
DEFB104B defensin, beta 104B 2.68669
ZNF662 zinc finger protein 662 2.68669
CELA3A chymotrypsin-like elastase family, member 3A 2.68669
GFRA3 GDNF family receptor alpha 3 2.68669
ZSWIM2 zinc finger, SWIM-type containing 2 2.68669
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 2.68669
SPHKAP SPHK1 interactor, AKAP domain containing 2.68669
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.68669
FCRL1 Fc receptor-like 1 2.68669
TMEM191B transmembrane protein 191B 2.68669
ODAPH odontogenesis associated phosphoprotein 2.68669
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.68669
LY96 lymphocyte antigen 96 2.68669
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.68669
CALR3 calreticulin 3 2.68669
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.68669
ZC3H11D zinc finger CCCH-type containing 11D 2.68669
PRPH peripherin 2.68669
EGR3 early growth response 3 2.68669
PLA1A phospholipase A1 member A 2.68669
TEKT5 tektin 5 2.68669
SEC14L3 SEC14-like 3 (S. cerevisiae) 2.68669
ISL1 ISL LIM homeobox 1 2.68669
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.68669
NTN3 netrin 3 2.68669
MAJIN membrane anchored junction protein 2.68669
SLC36A3 solute carrier family 36, member 3 2.68669
SPEGNB SPEG neighbor 2.68669
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.68669
FAM240C family with sequence similarity 240 member C 2.68669
TEX29 testis expressed 29 2.68669
FKBP1C FK506 binding protein 1C 2.68669
LRRN4 leucine rich repeat neuronal 4 2.68669
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.68669
C1ORF232 chromosome 1 open reading frame 230 2.68669
TSPAN19 tetraspanin 19 2.68669
ZNF593OS ZNF593 opposite strand 2.68669
MINDY4B MINDY family member 4B 2.68669
EFCAB11 EF-hand calcium binding domain 11 2.68669
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.68669
CTRB1 chymotrypsinogen B1 2.68669
NCR3 natural cytotoxicity triggering receptor 3 2.68669
CTSW cathepsin W 2.68669
C17ORF99 chromosome 17 open reading frame 99 2.68669
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.68669
SLITRK1 SLIT and NTRK-like family, member 1 2.68669
MAGEA2B melanoma antigen family A2B 2.68669
GAL3ST2 galactose-3-O-sulfotransferase 2 2.68669
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.68669
PCDHGB2 protocadherin gamma subfamily B, 2 2.68669
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.68669
HGFAC HGF activator 2.68669
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.68669
RORC RAR-related orphan receptor C 2.68669
ZMYND10 zinc finger, MYND-type containing 10 2.68669
ECM1 extracellular matrix protein 1 2.68669
MAPK11 mitogen-activated protein kinase 11 2.68669
DBX2 developing brain homeobox 2 2.68669
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.68669
STMND1 stathmin domain containing 1 2.68669
NUTM2F NUT family member 2F 2.68669
EPX eosinophil peroxidase 2.68669
ADGRF1 adhesion G protein-coupled receptor F1 2.68669
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.68669
AGXT2 alanine--glyoxylate aminotransferase 2 2.68669
GCH1 GTP cyclohydrolase 1 2.68669
CDHR4 cadherin-related family member 4 2.68669
CCN6 cellular communication network factor 6 2.68669
HTD2 hydroxyacyl-thioester dehydratase type 2 2.68669
WFDC8 WAP four-disulfide core domain 8 2.68669
WFDC9 WAP four-disulfide core domain 9 2.68669
NPFFR1 neuropeptide FF receptor 1 2.68669
PCDHGA3 protocadherin gamma subfamily A, 3 2.68669
TSLP thymic stromal lymphopoietin 2.68669
ERVW-1 endogenous retrovirus group W, member 1 2.68669
SHOX2 short stature homeobox 2 2.68669
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 2.68669
AVPR1A arginine vasopressin receptor 1A 2.68669
DERPC DERPC proline and glycine rich nuclear protein 2.68669
BRD4 bromodomain containing 4 2.68669
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.68669
EXD2 exonuclease 3'-5' domain containing 2 2.64856
NOTCH4 notch 4 2.62561
GLYCTK glycerate kinase 2.62561
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K 2.60827
TTPAL tocopherol (alpha) transfer protein-like 2.59928
CA1 carbonic anhydrase I 2.56268
CDC37 cell division cycle 37 2.55967
SURF4 surfeit 4 2.44733
CHN1 chimerin 1 2.43858
ASRGL1 asparaginase like 1 2.42532
RAB23 RAB23, member RAS oncogene family 2.42532
ABR active BCR-related 2.4213
ZSCAN9 zinc finger and SCAN domain containing 9 2.42057
CPEB3 cytoplasmic polyadenylation element binding protein 3 2.41394
ANKRD33 ankyrin repeat domain 33 2.41325
METAP1D methionyl aminopeptidase type 1D (mitochondrial) 2.41325
CLSPN claspin 2.40275
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.39702
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.39702
LGALS1 lectin, galactoside-binding, soluble, 1 2.3591
C5ORF24 chromosome 5 open reading frame 24 2.35165
AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2.32017
ARL1 ADP-ribosylation factor-like 1 2.31017
RNF10 ring finger protein 10 2.28984
KLC3 kinesin light chain 3 2.26372
NOTCH3 notch 3 2.25621
PLXDC1 plexin domain containing 1 2.25621
RAG2 recombination activating gene 2 2.2469
HPDL 4-hydroxyphenylpyruvate dioxygenase-like 2.2456
ICA1 islet cell autoantigen 1, 69kDa 2.2456
TTC1 tetratricopeptide repeat domain 1 2.23388
BCO1 beta-carotene oxygenase 1 2.2332
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.22515
RWDD2A RWD domain containing 2A 2.20156
RFX1 regulatory factor X, 1 (influences HLA class II expression) 2.20156
CD4 CD4 molecule 2.19432
PRPS1 phosphoribosyl pyrophosphate synthetase 1 2.18507
DNAAF9 dynein axonemal assembly factor 9 2.17885
TTLL3 tubulin tyrosine ligase-like family member 3 2.16351
SERF2 small EDRK-rich factor 2 2.15042
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 2.14209
RPL23A ribosomal protein L23a 2.14209
MOB4 MOB family member 4, phocein 2.13349
ZNF775 zinc finger protein 775 2.13349
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.12508
THSD7A thrombospondin, type I, domain containing 7A 2.11288
ZNF770 zinc finger protein 770 2.1022
HIKESHI heat shock protein nuclear import factor hikeshi 2.09708
CHMP4A charged multivesicular body protein 4A 2.09293
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 2.08422
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.0817
RAD51AP1 RAD51 associated protein 1 2.04479
TPD52L1 tumor protein D52-like 1 2.03938
SLC35G1 solute carrier family 35, member G1 2.03381
COPZ1 coatomer protein complex, subunit zeta 1 2.02102
CDR2 cerebellar degeneration-related protein 2, 62kDa 2.0194
NAV2 neuron navigator 2 2.0194
BRPF3 bromodomain and PHD finger containing, 3 2.0142
PLAU plasminogen activator, urokinase 2.00382
WSCD1 WSC domain containing 1 2.00382

decreased expression

Symbol Name Standardized Value
ESR1 estrogen receptor 1 -2.71697
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha -2.71185
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 -2.7117
NUP54 nucleoporin 54kDa -2.68669
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -2.68669
ACOX2 acyl-CoA oxidase 2, branched chain -2.68669
STKLD1 serine/threonine kinase-like domain containing 1 -2.68669
FLT3 fms-related tyrosine kinase 3 -2.68669
SYT15 synaptotagmin XV -2.68669
RBM5 RNA binding motif protein 5 -2.68669
OR14A2 olfactory receptor, family 14, subfamily A, member 2 -2.68669
GCKR glucokinase (hexokinase 4) regulator -2.68669
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.68669
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.68669
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.68669
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.68669
FOXP3 forkhead box P3 -2.68669
ZNF343 zinc finger protein 343 -2.68669
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -2.68669
CFP complement factor properdin -2.68669
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -2.68669
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -2.68669
ZBED6 zinc finger, BED-type containing 6 -2.68669
IRF2-DT IRF2 divergent transcript -2.68669
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.68669
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.68669
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.68669
KISS1 KiSS-1 metastasis-suppressor -2.68669
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.66878
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D -2.64063
NLGN3 neuroligin 3 -2.56268
HOMER3 homer scaffolding protein 3 -2.51802
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -2.51746
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.51227
MSRB2 methionine sulfoxide reductase B2 -2.50821
APRT adenine phosphoribosyltransferase -2.50463
PRR16 proline rich 16 -2.41394
EMILIN3 elastin microfibril interfacer 3 -2.41325
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.41325
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.39573
TBC1D7-LOC100130357 TBC1D7-LOC100130357 readthrough -2.39517
FUZ fuzzy planar cell polarity protein -2.38729
PDIA5 protein disulfide isomerase family A, member 5 -2.38444
AFF2 AF4/FMR2 family, member 2 -2.37417
DCAF5 DDB1 and CUL4 associated factor 5 -2.35527
YDJC YdjC homolog (bacterial) -2.35176
TMEM109 transmembrane protein 109 -2.3515
CCNY cyclin Y -2.33844
ZDHHC16 zinc finger, DHHC-type containing 16 -2.33591
ECI2 enoyl-CoA delta isomerase 2 -2.32353
ANK2 ankyrin 2, neuronal -2.29174
C9ORF72 chromosome 9 open reading frame 72 -2.29093
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.28702
MTHFSD methenyltetrahydrofolate synthetase domain containing -2.27596
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like -2.2456
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) -2.24044
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -2.2332
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein -2.21122
TMEM9B TMEM9 domain family, member B -2.18766
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.18507
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.18507
NRTN neurturin -2.18037
MED6 mediator complex subunit 6 -2.17916
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.17885
PML promyelocytic leukemia -2.17208
LOC124904942 uncharacterized LOC124904942 -2.147
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J -2.147
PGM1 phosphoglucomutase 1 -2.1221
DUSP22 dual specificity phosphatase 22 -2.11528
IFRD2 interferon-related developmental regulator 2 -2.09786
MYCT1 myc target 1 -2.09708
TMEM35A transmembrane protein 35A -2.09293
SDHAF1 succinate dehydrogenase complex assembly factor 1 -2.09293
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.09147
ADGRV1 adhesion G protein-coupled receptor V1 -2.09147
PARP11 poly (ADP-ribose) polymerase family, member 11 -2.08723
UNK unkempt family zinc finger -2.08723
C2ORF72 chromosome 2 open reading frame 72 -2.07308
NUTM2E NUT family member 2E -2.07308
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.0665
RAB42 RAB42, member RAS oncogene family -2.05738
CCDC51 coiled-coil domain containing 51 -2.05294
AKT3 v-akt murine thymoma viral oncogene homolog 3 -2.04549
CRPPA CDP-L-ribitol pyrophosphorylase A -2.04544
IGSF1 immunoglobulin superfamily, member 1 -2.04479
PLXNC1 plexin C1 -2.04479
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 -2.03847
SPEN spen family transcriptional repressor -2.03381
DYNLT5 dynein light chain Tctex-type family member 5 -2.03381
FAM20B family with sequence similarity 20, member B -2.02389
CCNJL cyclin J-like -2.02304
TSLIG3A tRNA splicing ligase complex subunit 3A -2.01566
THAP6 THAP domain containing 6 -2.01439
RCAN2 regulator of calcineurin 2 -2.01401
AGFG1 ArfGAP with FG repeats 1 -2.01401
SMYD4 SET and MYND domain containing 4 -2.00869
NAAA N-acylethanolamine acid amidase -2.00719
LRRC8A leucine rich repeat containing 8 family, member A -2.00251