HTR3A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic|The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3359)
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Genes

329 genes differentially expressed following the HTR3A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MAP3K7CL MAP3K7 C-terminal like 3.57928
PCDHGB3 protocadherin gamma subfamily B, 3 3.57928
NOD2 nucleotide-binding oligomerization domain containing 2 3.57928
OSR2 odd-skipped related transciption factor 2 3.57928
SKOR1 SKI family transcriptional corepressor 1 3.57928
ASB10 ankyrin repeat and SOCS box containing 10 3.57928
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 3.57928
ADAD2 adenosine deaminase domain containing 2 3.57928
C9ORF152 chromosome 9 open reading frame 152 3.57928
RGPD3 RANBP2-like and GRIP domain containing 3 3.57928
TM4SF20 transmembrane 4 L six family member 20 3.57928
GRXCR2 glutaredoxin, cysteine rich 2 3.57928
SCGN secretagogin, EF-hand calcium binding protein 3.57928
GPR52 G protein-coupled receptor 52 3.57928
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.57928
CD19 CD19 molecule 3.57928
CELF6 CUGBP, Elav-like family member 6 3.57928
ZEB2 zinc finger E-box binding homeobox 2 3.57928
PRSS41 protease, serine, 41 3.57928
PCDHB6 protocadherin beta 6 3.57928
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.57928
CPB1 carboxypeptidase B1 (tissue) 3.57928
S100A1 S100 calcium binding protein A1 3.57928
IL2RA interleukin 2 receptor, alpha 3.57928
MEIG1 meiosis/spermiogenesis associated 1 3.57928
PITX2 paired-like homeodomain 2 3.57928
CD226 CD226 molecule 3.57928
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.57928
ASCL5 achaete-scute family bHLH transcription factor 5 3.57928
NLRP5 NLR family, pyrin domain containing 5 3.57928
FOXG1 forkhead box G1 3.57928
OR4M2 olfactory receptor, family 4, subfamily M, member 2 3.57928
TMEM215 transmembrane protein 215 3.57928
SOST sclerostin 3.57928
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.57928
ATOH8 atonal homolog 8 (Drosophila) 3.57928
CORO6 coronin 6 3.57928
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.57928
MYO16 myosin XVI 3.57928
NMS neuromedin S 3.57928
HMX1 H6 family homeobox 1 3.57928
SPACA5 sperm acrosome associated 5 3.57928
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.57928
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 3.57928
KCNK16 potassium channel, two pore domain subfamily K, member 16 3.57928
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.57928
PDF peptide deformylase (mitochondrial) 3.57928
TFF2 trefoil factor 2 3.57928
ASB9 ankyrin repeat and SOCS box containing 9 3.57928
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.57928
LRRN4CL LRRN4 C-terminal like 3.57928
TMEM119 transmembrane protein 119 3.57928
LRRC71 leucine rich repeat containing 71 3.57928
CAPN8 calpain 8 3.57928
EXOC3L4 exocyst complex component 3-like 4 3.57928
OPRM1 opioid receptor, mu 1 3.57928
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.57928
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.57928
SPMIP11 sperm microtubule inner protein 11 3.57928
SPMIP9 sperm microtubule inner protein 9 3.57928
H2BK1 H2B.K variant histone 1 3.57928
MYMK myomaker, myoblast fusion factor 3.57928
MUCL3 mucin like 3 3.57928
H2BW1 H2B.W histone 1 3.57928
DUSP29 dual specificity phosphatase 29 3.57928
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.57928
INSRR insulin receptor-related receptor 3.57928
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.57928
PGC progastricsin (pepsinogen C) 3.57928
MAGEB2 melanoma antigen family B2 3.57928
PCDHA3 protocadherin alpha 3 3.57928
ATP13A5 ATPase type 13A5 3.57928
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.57928
ZNF99 zinc finger protein 99 3.57928
ZNF98 zinc finger protein 98 3.57928
CES1 carboxylesterase 1 3.57928
LOX lysyl oxidase 3.57928
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 3.57928
PTGDR2 prostaglandin D2 receptor 2 3.57928
NXPE4 neurexophilin and PC-esterase domain family, member 4 3.57928
TPTE transmembrane phosphatase with tensin homology 3.57928
TLR1 toll-like receptor 1 3.57928
IL5 interleukin 5 3.57928
ZIC4 Zic family member 4 3.57928
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.57928
TMCO2 transmembrane and coiled-coil domains 2 3.57928
MSX2 msh homeobox 2 3.57928
CATSPER1 cation channel, sperm associated 1 3.57928
MEOX1 mesenchyme homeobox 1 3.57928
NKAPL NFKB activating protein-like 3.57928
QRFP pyroglutamylated RFamide peptide 3.57928
PAGE4 P antigen family, member 4 (prostate associated) 3.57928
SPATA3 spermatogenesis associated 3 3.57928
HKDC1 hexokinase domain containing 1 3.57928
NMBR neuromedin B receptor 3.57928
TRADD TNFRSF1A-associated via death domain 3.57928
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.57928
WFDC9 WAP four-disulfide core domain 9 3.57928
ERICH6B glutamate-rich 6B 3.57928
KLF2 Kruppel-like factor 2 3.57928
CTAGE9 CTAGE family, member 9 3.57928
C11ORF91 chromosome 11 open reading frame 91 3.57928
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.57928
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.57928
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.57928
C10ORF105 chromosome 10 open reading frame 105 3.57928
IGFBP1 insulin-like growth factor binding protein 1 3.57928
FKBP1C FK506 binding protein 1C 3.57928
APOC4 apolipoprotein C-IV 3.57928
IL36R interleukin 36 receptor 3.57928
MAB21L1 mab-21-like 1 (C. elegans) 3.57928
PSG1 pregnancy specific beta-1-glycoprotein 1 3.57928
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.57928
SLC38A3 solute carrier family 38, member 3 3.57928
TAGAP T-cell activation RhoGTPase activating protein 3.57928
OTOP2 otopetrin 2 3.57928
PRH2 proline-rich protein HaeIII subfamily 2 3.57928
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.57928
LOC124901872 uncharacterized LOC124901872 3.57928
HK3 hexokinase 3 (white cell) 3.57928
CYTH4 cytohesin 4 3.57928
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.57928
PDZRN4 PDZ domain containing ring finger 4 3.57928
HELT helt bHLH transcription factor 3.57928
LOC102723971 beta-lactoglobulin-like 3.57928
LRRC25 leucine rich repeat containing 25 3.57928
CAPSL calcyphosine-like 3.57928
HPGDS hematopoietic prostaglandin D synthase 3.57928
APOF apolipoprotein F 3.57928
BMX BMX non-receptor tyrosine kinase 3.57928
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.57928
ERMN ermin, ERM-like protein 3.57928
NLRP14 NLR family, pyrin domain containing 14 3.57928
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.57928
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.57928
CLPS colipase, pancreatic 3.57928
PHACTR3 phosphatase and actin regulator 3 3.57928
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.57928
CD84 CD84 molecule 3.57928
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.57928
DMRTC1 DMRT-like family C1 3.57928
HSF4 heat shock transcription factor 4 3.57928
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.57928
FITM1 fat storage-inducing transmembrane protein 1 3.57928
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.57928
CD80 CD80 molecule 3.57928
ANGPTL5 angiopoietin-like 5 3.57928
ACSM4 acyl-CoA synthetase medium-chain family member 4 3.57928
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.57928
GREM1 gremlin 1, DAN family BMP antagonist 3.57928
TSPAN32 tetraspanin 32 3.57928
ERP27 endoplasmic reticulum protein 27 3.57928
GCM1 glial cells missing homolog 1 (Drosophila) 3.57928
DRC1 dynein regulatory complex subunit 1 3.57928
TEX26 testis expressed 26 3.57928
FAM25G family with sequence similarity 25, member G 3.57928
ANGPTL4 angiopoietin-like 4 3.53817
ITM2C integral membrane protein 2C 3.52747
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 3.03952
DTYMK deoxythymidylate kinase (thymidylate kinase) 3.00899
S100A2 S100 calcium binding protein A2 2.98518
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 2.98026
TMEM165 transmembrane protein 165 2.95858
FBXL5 F-box and leucine-rich repeat protein 5 2.85437
TAC3 tachykinin 3 2.83926
HMGB2 high mobility group box 2 2.83926
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.76323
TRPT1 tRNA phosphotransferase 1 2.74719
MRPL10 mitochondrial ribosomal protein L10 2.73512
ZNF611 zinc finger protein 611 2.73512
KRTCAP2 keratinocyte associated protein 2 2.73221
PRRC2B proline-rich coiled-coil 2B 2.64665
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 2.64653
UTP11 UTP11 small subunit processome component 2.64653
RPL9 ribosomal protein L9 2.60083
FKBP9 FK506 binding protein 9, 63 kDa 2.5856
FAM181B family with sequence similarity 181, member B 2.50165
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.50165
KIAA2012 KIAA2012 2.50165
SHC4 SHC (Src homology 2 domain containing) family, member 4 2.50165
ABHD15 abhydrolase domain containing 15 2.50165
IHO1 interactor of HORMAD1 1 2.50165
ETNPPL ethanolamine-phosphate phospho-lyase 2.50165
INHA inhibin, alpha 2.50165
HEATR9 HEAT repeat containing 9 2.50165
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.50165
MYZAP myocardial zonula adherens protein 2.50165
GPANK1 G patch domain and ankyrin repeats 1 2.49463
NHSL3 NHS like 3 2.49463
PSENEN presenilin enhancer gamma secretase subunit 2.49463
GABARAP GABA(A) receptor-associated protein 2.49322
FAR1 fatty acyl CoA reductase 1 2.3962
CORO1B coronin, actin binding protein, 1B 2.3881
ASMTL acetylserotonin O-methyltransferase-like 2.37968
ADAMTSL5 ADAMTS-like 5 2.37263
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 2.34909
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 2.33891
COLEC10 collectin sub-family member 10 (C-type lectin) 2.31566
LRRC8C leucine rich repeat containing 8 family, member C 2.29966
SOCS5 suppressor of cytokine signaling 5 2.29913
IFI30 interferon, gamma-inducible protein 30 2.29913
MRPS33 mitochondrial ribosomal protein S33 2.29492
TMEM216 transmembrane protein 216 2.28584
TPM4 tropomyosin 4 2.26876
GMIP GEM interacting protein 2.26876
HTD2 hydroxyacyl-thioester dehydratase type 2 2.25757
COG7 component of oligomeric golgi complex 7 2.25242
RPS18 ribosomal protein S18 2.24294
CLDN15 claudin 15 2.23443
TIMCC TIM double twin CX3C motif chaperone 2.22669
GPR75-ASB3 GPR75-ASB3 readthrough 2.20506
CSRP2 cysteine and glycine-rich protein 2 2.19959
CRYZ crystallin, zeta (quinone reductase) 2.18153
EEA1 early endosome antigen 1 2.17885
POR P450 (cytochrome) oxidoreductase 2.17879
TCOF1 Treacher Collins-Franceschetti syndrome 1 2.15325
RIPK2 receptor-interacting serine-threonine kinase 2 2.15323
RPS13 ribosomal protein S13 2.14284
CHMP2B charged multivesicular body protein 2B 2.14059
SGK2 serum/glucocorticoid regulated kinase 2 2.12617
DENND4C DENN/MADD domain containing 4C 2.12113
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 2.12113
COPG2 coatomer protein complex, subunit gamma 2 2.11078
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 2.11078
SCCPDH saccharopine dehydrogenase (putative) 2.10627
SNX19 sorting nexin 19 2.09948
PKDCC protein kinase domain containing, cytoplasmic 2.07701
CLTRN collectrin, amino acid transport regulator 2.06981
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 2.05448
MGME1 mitochondrial genome maintenance exonuclease 1 2.05431
KCTD12 potassium channel tetramerization domain containing 12 2.05177
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.0507
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.0507
SEC24A SEC24 family member A 2.0152
CTCFL CCCTC-binding factor (zinc finger protein)-like 2.01205

decreased expression

Symbol Name Standardized Value
TTC22 tetratricopeptide repeat domain 22 -3.57928
CD5 CD5 molecule -3.57928
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -3.57928
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -3.57928
RNF112 ring finger protein 112 -3.57928
CHADL chondroadherin-like -3.57928
DNASE1L2 deoxyribonuclease I-like 2 -3.57928
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -3.57928
RORC RAR-related orphan receptor C -3.57928
SLC35G5 solute carrier family 35, member G5 -3.57928
PDZD7 PDZ domain containing 7 -3.57928
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -3.57928
XCL1 chemokine (C motif) ligand 1 -3.57928
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -3.57928
GADL1 glutamate decarboxylase-like 1 -3.57928
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -3.57928
WEE2 WEE1 homolog 2 (S. pombe) -3.57928
CXCR4 chemokine (C-X-C motif) receptor 4 -3.57928
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -3.57928
NYX nyctalopin -3.57928
H3C13 H3 clustered histone 13 -3.57928
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) -3.57928
TMEM272 transmembrane protein 272 -3.57928
RNF227 ring finger protein 227 -3.57928
ETV2 ets variant 2 -3.57928
LRRC15 leucine rich repeat containing 15 -3.57928
C20ORF144 chromosome 20 open reading frame 144 -3.57928
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 -3.57928
EDAR ectodysplasin A receptor -3.57928
TREH trehalase (brush-border membrane glycoprotein) -3.57928
UROC1 urocanate hydratase 1 -3.57928
TBXA2R thromboxane A2 receptor -3.57928
MYH13 myosin, heavy chain 13, skeletal muscle -3.57928
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -3.52155
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase -3.39867
C3ORF49 chromosome 3 open reading frame 49 -3.08444
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -2.94826
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.73512
KIF21B kinesin family member 21B -2.63127
NOCT nocturnin -2.495
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.495
LINC02798 long intergenic non-protein coding RNA 2798 -2.49463
IZUMO1 izumo sperm-egg fusion 1 -2.49463
TCAP titin-cap -2.49463
HES2 hes family bHLH transcription factor 2 -2.49463
FAR2 fatty acyl CoA reductase 2 -2.49322
STYX serine/threonine/tyrosine interacting protein -2.49322
LIPT1 lipoyltransferase 1 -2.48725
EPAS1 endothelial PAS domain protein 1 -2.46763
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -2.43276
TTLL10 tubulin tyrosine ligase-like family member 10 -2.43038
SUSD2 sushi domain containing 2 -2.43038
NPPC natriuretic peptide C -2.43038
FAM194C family with sequence similarity 149 member C -2.37968
IL17RD interleukin 17 receptor D -2.37152
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.3545
MID1 midline 1 -2.30589
CMC4 C-x(9)-C motif containing 4 -2.30017
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -2.29966
TMEM31 transmembrane protein 31 -2.29913
ZNF324 zinc finger protein 324 -2.29573
DDAH2 dimethylarginine dimethylaminohydrolase 2 -2.29573
KLF4 Kruppel-like factor 4 (gut) -2.29573
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.29573
ERO1B endoplasmic reticulum oxidoreductase 1 beta -2.27767
PRTN3 proteinase 3 -2.26876
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.26876
CFAP126 cilia and flagella associated protein 126 -2.26876
DGCR2 DiGeorge syndrome critical region gene 2 -2.23443
OSTM1 osteopetrosis associated transmembrane protein 1 -2.19633
SFXN1 sideroflexin 1 -2.1824
CFAP36 cilia and flagella associated protein 36 -2.1824
CTCF CCCTC-binding factor (zinc finger protein) -2.1812
LRRTM2 leucine rich repeat transmembrane neuronal 2 -2.17553
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -2.16234
ATOSB atos homolog B -2.14932
EMP2 epithelial membrane protein 2 -2.14596
ZCCHC2 zinc finger, CCHC domain containing 2 -2.12399
HYAL2 hyaluronoglucosaminidase 2 -2.12113
DCTN3 dynactin 3 (p22) -2.11078
PDE8A phosphodiesterase 8A -2.08315
LAMA5 laminin, alpha 5 -2.07735
CLDN7 claudin 7 -2.07701
TOLLIP toll interacting protein -2.06574
ZNF680 zinc finger protein 680 -2.06566
ULK1 unc-51 like autophagy activating kinase 1 -2.05197
YIPF2 Yip1 domain family, member 2 -2.05197
WRNIP1 Werner helicase interacting protein 1 -2.04697
BAG2 BCL2-associated athanogene 2 -2.04482
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.04364
AVPI1 arginine vasopressin-induced 1 -2.03834
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -2.0277
CANT1 calcium activated nucleotidase 1 -2.02559
SHF Src homology 2 domain containing F -2.01463