HTT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description huntingtin|Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3064)
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Genes

282 genes differentially expressed following the HTT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IRF4 interferon regulatory factor 4 3.03937
ZMYND12 zinc finger, MYND-type containing 12 3.03937
RBM20 RNA binding motif protein 20 3.03937
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.03937
CPLX3 complexin 3 3.03937
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.03937
CNTD1 cyclin N-terminal domain containing 1 3.03937
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.03937
ANKRD65 ankyrin repeat domain 65 3.03937
EFCC1 EF-hand and coiled-coil domain containing 1 3.03937
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.03937
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.03937
CXCL2 chemokine (C-X-C motif) ligand 2 3.03937
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.03937
NDRG1 N-myc downstream regulated 1 3.03937
FAM228A family with sequence similarity 228, member A 3.03549
TEX36 testis expressed 36 3.03549
EXOC3L1 exocyst complex component 3-like 1 3.03549
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.03549
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.03549
PIWIL3 piwi-like RNA-mediated gene silencing 3 3.03549
MYBPC1 myosin binding protein C, slow type 3.03549
SOWAHB sosondowah ankyrin repeat domain family member B 3.03549
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.03549
RTN4RL1 reticulon 4 receptor-like 1 3.03549
SPNS2 spinster homolog 2 (Drosophila) 3.03549
ANGPTL5 angiopoietin-like 5 3.03549
ADRA1B adrenoceptor alpha 1B 3.03549
AREG amphiregulin 3.03549
DSPP dentin sialophosphoprotein 3.03549
SPDEF SAM pointed domain containing ETS transcription factor 3.03549
MS4A10 membrane-spanning 4-domains, subfamily A, member 10 3.03549
PRSS21 protease, serine, 21 (testisin) 3.03549
LTB lymphotoxin beta (TNF superfamily, member 3) 3.03549
CNTFR ciliary neurotrophic factor receptor 3.03549
LTK leukocyte receptor tyrosine kinase 3.03549
ASCL5 achaete-scute family bHLH transcription factor 5 3.03549
NMUR1 neuromedin U receptor 1 3.03549
TDO2 tryptophan 2,3-dioxygenase 3.03549
ASMT acetylserotonin O-methyltransferase 3.03549
WDR87 WD repeat domain 87 3.03549
USP26 ubiquitin specific peptidase 26 3.03549
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.03549
THPO thrombopoietin 3.03549
CHRD chordin 3.03549
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.03549
CD93 CD93 molecule 3.03549
AGTR1 angiotensin II receptor, type 1 3.03549
RAB44 RAB44, member RAS oncogene family 3.03549
TAS2R5 taste receptor, type 2, member 5 3.03549
PRB1 proline-rich protein BstNI subfamily 1 3.03549
DNAI2 dynein, axonemal, intermediate chain 2 3.03549
OR2A7 olfactory receptor, family 2, subfamily A, member 7 3.03549
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.03549
CELF3 CUGBP, Elav-like family member 3 3.03549
LIX1 Lix1 homolog (chicken) 3.03549
GPR20 G protein-coupled receptor 20 3.03549
C19ORF67 chromosome 19 open reading frame 67 3.03549
TYRP1 tyrosinase-related protein 1 3.03549
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.03549
SLAMF6 SLAM family member 6 3.03549
MYH13 myosin, heavy chain 13, skeletal muscle 3.03549
CLEC19A C-type lectin domain family 19, member A 3.03549
SCARB2 scavenger receptor class B, member 2 3.03549
DEPTOR DEP domain containing MTOR-interacting protein 3.03549
ZNF467 zinc finger protein 467 3.03549
INSM2 insulinoma-associated 2 3.03549
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.03549
DNASE1L3 deoxyribonuclease I-like 3 3.03549
ATP13A5 ATPase type 13A5 3.03549
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.03549
CFI complement factor I 3.03549
TH tyrosine hydroxylase 3.03549
TMA7B translation machinery associated 7 homolog B 3.03549
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.03549
FGB fibrinogen beta chain 3.03549
CLIC5 chloride intracellular channel 5 3.03549
LENEP lens epithelial protein 3.03549
ANKRD40CL ANKRD40 C-terminal like 3.03549
FAM135B family with sequence similarity 135, member B 3.03549
RAB40AL RAB40A, member RAS oncogene family-like 3.03549
DHH desert hedgehog 3.03549
CDK20 cyclin-dependent kinase 20 3.03549
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.03549
CCDC198 coiled-coil domain containing 198 3.03549
CD248 CD248 molecule, endosialin 3.03549
TPPP3 tubulin polymerization-promoting protein family member 3 3.03549
TMDD1 transmembrane and death domain 1 3.03549
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 3.03549
ETV3L ets variant 3-like 3.03549
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.03549
TSPAN19 tetraspanin 19 3.03549
IGIP IgA-inducing protein 3.03549
FAM237A family with sequence similarity 237 member A 3.03549
SLC36A3 solute carrier family 36, member 3 3.03549
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.03549
CTRB1 chymotrypsinogen B1 3.03549
LHX2 LIM homeobox 2 3.03549
LHX3 LIM homeobox 3 3.03549
PRPH2 peripherin 2 (retinal degeneration, slow) 3.03549
SPHKAP SPHK1 interactor, AKAP domain containing 3.03549
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.03549
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.03549
TRIM29 tripartite motif containing 29 3.03549
AANAT aralkylamine N-acetyltransferase 3.03549
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.03549
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.03549
LPAR5 lysophosphatidic acid receptor 5 3.03549
MYEOV myeloma overexpressed 3.03549
TMEM132D transmembrane protein 132D 3.03549
SPATA25 spermatogenesis associated 25 3.03549
PRF1 perforin 1 (pore forming protein) 3.03549
C8ORF58 chromosome 8 open reading frame 58 3.03549
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 3.03549
CSPG4 chondroitin sulfate proteoglycan 4 3.03549
MYL10 myosin, light chain 10, regulatory 3.03549
CLDN14 claudin 14 3.03549
TMEM86A transmembrane protein 86A 3.03549
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.03549
CHAD chondroadherin 3.03549
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 3.03549
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.03549
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.03549
CXCR2 chemokine (C-X-C motif) receptor 2 3.03549
SPATS1 spermatogenesis associated, serine-rich 1 3.03549
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.03549
ALDOB aldolase B, fructose-bisphosphate 3.03549
ZC3H7B zinc finger CCCH-type containing 7B 3.03549
ZNF726 zinc finger protein 726 3.03549
NAP1L5 nucleosome assembly protein 1-like 5 3.01964
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 3.01964
SCGB3A2 secretoglobin, family 3A, member 2 2.8033
COL4A4 collagen, type IV, alpha 4 2.75479
NMD3 NMD3 ribosome export adaptor 2.72347
TCEAL4 transcription elongation factor A (SII)-like 4 2.72189
GSTK1 glutathione S-transferase kappa 1 2.65263
PCDHB2 protocadherin beta 2 2.60195
FZD4 frizzled class receptor 4 2.59886
ACSL1 acyl-CoA synthetase long-chain family member 1 2.59516
ANKRD12 ankyrin repeat domain 12 2.57662
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.50852
PRDM16 PR domain containing 16 2.50598
HORMAD2 HORMA domain containing 2 2.50598
BDKRB2 bradykinin receptor B2 2.50598
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 2.50598
DLL3 delta-like 3 (Drosophila) 2.45909
PPP1R3E protein phosphatase 1, regulatory subunit 3E 2.43602
GLYATL2 glycine-N-acyltransferase-like 2 2.42932
PPL periplakin 2.42203
FBXW10B F-box and WD repeat domain containing 10B 2.41192
HDAC4 histone deacetylase 4 2.40258
HPX hemopexin 2.39253
YPEL2 yippee-like 2 (Drosophila) 2.38894
APOOL apolipoprotein O-like 2.3647
ADAT2 adenosine deaminase, tRNA-specific 2 2.35493
TP53INP2 tumor protein p53 inducible nuclear protein 2 2.32898
CENPL centromere protein L 2.32176
PTGES prostaglandin E synthase 2.32075
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.31869
TBRG4 transforming growth factor beta regulator 4 2.31869
MEAF6 MYST/Esa1-associated factor 6 2.29352
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.25113
ZNF8 zinc finger protein 8 2.25113
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.22672
ACSL3 acyl-CoA synthetase long-chain family member 3 2.2261
LYRM1 LYR motif containing 1 2.18841
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 2.18841
MSH6 mutS homolog 6 2.16255
H2BC13 H2B clustered histone 13 2.13368
KCTD10 potassium channel tetramerization domain containing 10 2.12488
SLC33A2 solute carrier family 33 member 2 2.12154
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.11962
TOMM70 translocase of outer mitochondrial membrane 70 2.11962
ZSCAN2 zinc finger and SCAN domain containing 2 2.11148
MUC6 mucin 6, oligomeric mucus/gel-forming 2.1065
VSTM1 V-set and transmembrane domain containing 1 2.1065
ZNF750 zinc finger protein 750 2.1065
MRAP melanocortin 2 receptor accessory protein 2.1065
CAPN11 calpain 11 2.1065
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.1065
PRELID3A PRELI domain containing 3A 2.10409
DAPK3 death-associated protein kinase 3 2.10409
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 2.10409
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 2.10099
MED22 mediator complex subunit 22 2.09887
COPS5 COP9 signalosome subunit 5 2.07624
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 2.06799
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.05701
MSMO1 methylsterol monooxygenase 1 2.04602
HDAC3 histone deacetylase 3 2.04171
CAPN5 calpain 5 2.03374
METTL2A methyltransferase like 2A 2.0116
SLC44A2 solute carrier family 44 (choline transporter), member 2 2.00832

decreased expression

Symbol Name Standardized Value
TSPAN10 tetraspanin 10 -3.03937
GRM2 glutamate receptor, metabotropic 2 -3.03937
SOX7 SRY (sex determining region Y)-box 7 -3.03937
PGAP1 post-GPI attachment to proteins 1 -3.03549
KLF5 Kruppel-like factor 5 (intestinal) -3.03549
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 -3.03549
FAM209B family with sequence similarity 209, member B -3.03549
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -3.02262
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -3.02262
FADS6 fatty acid desaturase 6 -3.02262
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -3.02262
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -3.02262
ASCL3 achaete-scute family bHLH transcription factor 3 -3.02262
APOA1 apolipoprotein A-I -3.02262
HIGD1B HIG1 hypoxia inducible domain family, member 1B -3.02262
GRM6 glutamate receptor, metabotropic 6 -3.02262
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -3.02262
OIT3 oncoprotein induced transcript 3 -3.02262
IL2RB interleukin 2 receptor, beta -3.02262
THSD1 thrombospondin, type I, domain containing 1 -3.02262
KRT17 keratin 17, type I -3.02262
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -3.02262
PWWP3B PWWP domain containing 3B -3.02262
KY kyphoscoliosis peptidase -3.02262
CLDN16 claudin 16 -3.02262
PROC protein C (inactivator of coagulation factors Va and VIIIa) -3.02262
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 -3.02262
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -3.02262
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -3.02262
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 -3.02262
TTLL9 tubulin tyrosine ligase-like family member 9 -3.02262
COL20A1 collagen, type XX, alpha 1 -3.02262
TNR tenascin R -3.02262
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -3.02262
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -3.02262
CCN5 cellular communication network factor 5 -3.02262
C19ORF25 chromosome 19 open reading frame 25 -3.01964
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -2.89486
SAMD14 sterile alpha motif domain containing 14 -2.86752
AKAP6 A kinase (PRKA) anchor protein 6 -2.86752
PCGF3 polycomb group ring finger 3 -2.85912
SCARA3 scavenger receptor class A, member 3 -2.85444
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.85444
CALCOCO1 calcium binding and coiled-coil domain 1 -2.84628
DIO2 deiodinase, iodothyronine, type II -2.6963
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.65914
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -2.65151
BAZ1B bromodomain adjacent to zinc finger domain, 1B -2.64007
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.60134
C9ORF153 chromosome 9 open reading frame 153 -2.498
BCL3 B-cell CLL/lymphoma 3 -2.48164
TMEM98 transmembrane protein 98 -2.39381
SLC22A25 solute carrier family 22, member 25 -2.38556
ZNF365 zinc finger protein 365 -2.38556
FBXO36 F-box protein 36 -2.36162
MED8 mediator complex subunit 8 -2.34855
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.33212
RAB34 RAB34, member RAS oncogene family -2.32161
ANKRD40 ankyrin repeat domain 40 -2.28844
TMEM214 transmembrane protein 214 -2.28074
PHF12 PHD finger protein 12 -2.27305
CEP63 centrosomal protein 63kDa -2.25113
RAB1B RAB1B, member RAS oncogene family -2.25113
CAPN3 calpain 3, (p94) -2.24154
ZNF784 zinc finger protein 784 -2.24154
C1ORF210 chromosome 1 open reading frame 210 -2.22884
DNAAF2 dynein, axonemal, assembly factor 2 -2.21433
CYTIP cytohesin 1 interacting protein -2.16452
RAB24 RAB24, member RAS oncogene family -2.13502
CLIC4 chloride intracellular channel 4 -2.12476
COX6C cytochrome c oxidase subunit VIc -2.12212
MLH3 mutL homolog 3 -2.11925
RNF123 ring finger protein 123 -2.1125
MRPL17 mitochondrial ribosomal protein L17 -2.11148
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.1065
ADSS1 adenylosuccinate synthase 1 -2.10409
TRIM3 tripartite motif containing 3 -2.10409
ATP7B ATPase, Cu++ transporting, beta polypeptide -2.09787
THSD7A thrombospondin, type I, domain containing 7A -2.07832
FECH ferrochelatase -2.06799
SPARCL1 SPARC-like 1 (hevin) -2.06799
SACK1G scaffolding CK1 anchoring protein G -2.04602
TMEM59 transmembrane protein 59 -2.03783
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -2.03719
PLPPR4 phospholipid phosphatase related 4 -2.01892
MRPL49 mitochondrial ribosomal protein L49 -2.01892
HTT huntingtin -2.01857
C1QBP complement component 1, q subcomponent binding protein -2.00327
IMMT inner membrane protein, mitochondrial -2.00214