HTT Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description huntingtin|Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3064)
External Link http://www.ncbi.nlm.nih.gov/gene/3064
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95 interacting proteins for hub protein HTT from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ADIRF adipogenesis regulatory factor
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMPH amphiphysin
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ATG12 autophagy related 12
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG5 autophagy related 5
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CDK5 cyclin-dependent kinase 5
CEP126 centrosomal protein 126kDa
CHD3 chromodomain helicase DNA binding protein 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREBBP CREB binding protein
CRMP1 collapsin response mediator protein 1
CTBP1 C-terminal binding protein 1
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DLG4 discs, large homolog 4 (Drosophila)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNALI1 dynein, axonemal, light intermediate chain 1
ECH1 enoyl CoA hydratase 1, peroxisomal
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
F8A1 coagulation factor VIII-associated 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FICD FIC domain containing
FPR2 formyl peptide receptor 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPRASP2 G protein-coupled receptor associated sorting protein 2
GRB2 growth factor receptor-bound protein 2
GSX2 GS homeobox 2
HAGH hydroxyacylglutathione hydrolase
HAP1 huntingtin-associated protein 1
HIP1 huntingtin interacting protein 1
HIP1R huntingtin interacting protein 1 related
HYPK huntingtin interacting protein K
HYPM huntingtin interacting protein M
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KAT2B K(lysine) acetyltransferase 2B
MAGEA3 melanoma antigen family A3
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MED31 mediator complex subunit 31
MTSS1 metastasis suppressor 1
NBR1 neighbor of BRCA1 gene 1
NCOR1 nuclear receptor corepressor 1
NEUROD1 neuronal differentiation 1
OPTN optineurin
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PFN2 profilin 2
PIAS4 protein inhibitor of activated STAT, 4
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
PSPC1 paraspeckle component 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
REST RE1-silencing transcription factor
RIMS4 regulating synaptic membrane exocytosis 4
SAP30 Sin3A-associated protein, 30kDa
SETD2 SET domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SGK2 serum/glucocorticoid regulated kinase 2
SGK3 serum/glucocorticoid regulated kinase family, member 3
SH3GL3 SH3-domain GRB2-like 3
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIN3A SIN3 transcription regulator family member A
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
SP1 Sp1 transcription factor
SQSTM1 sequestosome 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SUMO1 small ubiquitin-like modifier 1
SYMPK symplekin
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TBP TATA box binding protein
TCERG1 transcription elongation regulator 1
TGM2 transglutaminase 2
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TPR translocated promoter region, nuclear basket protein
TRIP10 thyroid hormone receptor interactor 10
TUBB tubulin, beta class I
UBC ubiquitin C
UBE2K ubiquitin-conjugating enzyme E2K
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WDFY3 WD repeat and FYVE domain containing 3
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZDHHC17 zinc finger, DHHC-type containing 17