HUS1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description HUS1 checkpoint homolog (S. pombe)|The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 3364)
External Link http://www.ncbi.nlm.nih.gov/gene/3364
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Genes

55 interacting proteins for HUS1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALDOB aldolase B, fructose-bisphosphate
ATR ATR serine/threonine kinase
C17ORF70 chromosome 17 open reading frame 70
CD200 CD200 molecule
COPS5 COP9 signalosome subunit 5
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
E2F1 E2F transcription factor 1
FANCA Fanconi anemia, complementation group A
FANCB Fanconi anemia, complementation group B
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCF Fanconi anemia, complementation group F
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FEN1 flap structure-specific endonuclease 1
HDAC1 histone deacetylase 1
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
HES1 hes family bHLH transcription factor 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HUS1B HUS1 checkpoint homolog b (S. pombe)
LIG1 ligase I, DNA, ATP-dependent
MAX MYC associated factor X
MCM2 minichromosome maintenance complex component 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
NBN nibrin
PCNA proliferating cell nuclear antigen
POLB polymerase (DNA directed), beta
PSD pleckstrin and Sec7 domain containing
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
RAD1 RAD1 checkpoint DNA exonuclease
RAD17 RAD17 homolog (S. pombe)
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
SFN stratifin
STRAP serine/threonine kinase receptor associated protein
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
UBC ubiquitin C
UBE2T ubiquitin-conjugating enzyme E2T
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta