Harringtonine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Harringtonine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGR1 early growth response 1 0.213788
MT2A metallothionein 2A 0.163422
TMSB10 thymosin beta 10 0.125468
AKAP12 A kinase (PRKA) anchor protein 12 0.119148
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.113506
FBN1 fibrillin 1 0.0866726
LOX lysyl oxidase 0.0839229
CREB5 cAMP responsive element binding protein 5 0.0671763
COL3A1 collagen, type III, alpha 1 0.0653659
CAVIN1 caveolae associated protein 1 0.0635304
VIM vimentin 0.060615
JUN jun proto-oncogene 0.0599704
PLAT plasminogen activator, tissue 0.0561879
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0560408
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0542141
KLF10 Kruppel-like factor 10 0.0499845
THBS2 thrombospondin 2 0.0499724
GADD45B growth arrest and DNA-damage-inducible, beta 0.0469534
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0455376
AHNAK AHNAK nucleoprotein 0.0443522
SQSTM1 sequestosome 1 0.0441333
ERRFI1 ERBB receptor feedback inhibitor 1 0.0427547
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.04168
ZFP36 ZFP36 ring finger protein 0.03959
ANXA2 annexin A2 0.0391077
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0385863
NAV1 neuron navigator 1 0.0376952
STC1 stanniocalcin 1 0.0376332
CXCL8 chemokine (C-X-C motif) ligand 8 0.0371011
COL1A2 collagen, type I, alpha 2 0.036295
ATF3 activating transcription factor 3 0.0359841
CXCL3 chemokine (C-X-C motif) ligand 3 0.0353663
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0343531
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0340884
MT1X metallothionein 1X 0.0340268
COL8A1 collagen, type VIII, alpha 1 0.0315599
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0306275
IER2 immediate early response 2 0.0302383
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.0301611
APP amyloid beta (A4) precursor protein 0.0296277
HLA-B major histocompatibility complex, class I, B 0.0295961
GLIS3 GLIS family zinc finger 3 0.0291063
LOXL2 lysyl oxidase-like 2 0.0279428
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0275572
MCL1 myeloid cell leukemia 1 0.0267956
KDM6B lysine (K)-specific demethylase 6B 0.02631
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.026085
PTMA prothymosin, alpha 0.0260719
ZBTB10 zinc finger and BTB domain containing 10 0.0245351
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0240273
SKIL SKI-like proto-oncogene 0.0239903
SDC4 syndecan 4 0.0236286
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0235781
ARL4C ADP-ribosylation factor-like 4C 0.0226779
LMNA lamin A/C 0.0226454
PGK1 phosphoglycerate kinase 1 0.0225906
ALCAM activated leukocyte cell adhesion molecule 0.0223408
HMGB2 high mobility group box 2 0.022083
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0217203
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0216343
DEPP1 DEPP autophagy regulator 1 0.0212408
PSD3 pleckstrin and Sec7 domain containing 3 0.0211408
H3-3B H3.3 histone B 0.0210889
HDAC9 histone deacetylase 9 0.0210704
DENND4A DENN/MADD domain containing 4A 0.0210331
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0210087
CLSTN2 calsyntenin 2 0.0208367
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0207513
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0206408
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0204
TMSB4X thymosin beta 4, X-linked 0.0201195
ASPH aspartate beta-hydroxylase 0.0197946
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0196061
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0195211
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0190665
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0189904
ARL15 ADP-ribosylation factor-like 15 0.0188822
HLA-E major histocompatibility complex, class I, E 0.0188558
VCL vinculin 0.0186528
CTSB cathepsin B 0.0186418
WWTR1 WW domain containing transcription regulator 1 0.0185719
SPAG9 sperm associated antigen 9 0.0183475
CEP112 centrosomal protein 112kDa 0.018277
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0182625
TM4SF1 transmembrane 4 L six family member 1 0.0181579
ARF1 ADP-ribosylation factor 1 0.0180618
TPT1 tumor protein, translationally-controlled 1 0.0180194
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0180177
IFITM3 interferon induced transmembrane protein 3 0.0173445
RPS3 ribosomal protein S3 0.0173366
NEK7 NIMA-related kinase 7 0.0173131
CHRM3 cholinergic receptor, muscarinic 3 0.0172109
ADM adrenomedullin 0.0171087
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0169974
CCL20 chemokine (C-C motif) ligand 20 0.0169563
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0168469
BACE2 beta-site APP-cleaving enzyme 2 0.0165472
S100A11 S100 calcium binding protein A11 0.0164719
AHNAK2 AHNAK nucleoprotein 2 0.0161945
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.016172

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.217476
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.151628
TRIO trio Rho guanine nucleotide exchange factor -0.11025
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.090266
PALM2AKAP2 PALM2 and AKAP2 fusion -0.075491
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0625591
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0625317
DLG1 discs, large homolog 1 (Drosophila) -0.0586202
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0478858
CDH13 cadherin 13 -0.04694
NDRG1 N-myc downstream regulated 1 -0.0461464
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0453117
MSI2 musashi RNA-binding protein 2 -0.0441547
RND3 Rho family GTPase 3 -0.0412208
SLC39A11 solute carrier family 39, member 11 -0.0404099
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0395089
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0385864
PBX3 pre-B-cell leukemia homeobox 3 -0.0381134
DCLK2 doublecortin-like kinase 2 -0.0379828
CCND1 cyclin D1 -0.0375911
MAP1B microtubule-associated protein 1B -0.037499
EGFR epidermal growth factor receptor -0.036958
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0369234
CSF1 colony stimulating factor 1 (macrophage) -0.0368835
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0361967
FOSL1 FOS-like antigen 1 -0.0356842
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0347564
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0347152
CD109 CD109 molecule -0.0338169
PDIA3 protein disulfide isomerase family A, member 3 -0.033239
CD44 CD44 molecule (Indian blood group) -0.0317128
IARS1 isoleucyl-tRNA synthetase 1 -0.0315068
NAV2 neuron navigator 2 -0.03135
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0289373
GARS1 glycyl-tRNA synthetase 1 -0.0286774
COPA coatomer protein complex, subunit alpha -0.0286195
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0285982
ADAM9 ADAM metallopeptidase domain 9 -0.0279414
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0275786
ZNF292 zinc finger protein 292 -0.0274854
BIRC3 baculoviral IAP repeat containing 3 -0.0268091
ADAM17 ADAM metallopeptidase domain 17 -0.0266755
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0259295
NIBAN1 niban apoptosis regulator 1 -0.0258562
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0254227
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0252812
SOD2 superoxide dismutase 2, mitochondrial -0.0248258
GOLGA4 golgin A4 -0.0248255
DRAM1 DNA-damage regulated autophagy modulator 1 -0.0247401
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0244819
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0241071
INSIG1 insulin induced gene 1 -0.0237516
MSN moesin -0.023503
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0233191
ULK1 unc-51 like autophagy activating kinase 1 -0.0232508
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0229443
PLK2 polo-like kinase 2 -0.0226458
ABI3BP ABI family, member 3 (NESH) binding protein -0.0224211
MBNL2 muscleblind-like splicing regulator 2 -0.0223481
RUNX1 runt-related transcription factor 1 -0.0222321
IFIH1 interferon induced with helicase C domain 1 -0.0222307
PDIA6 protein disulfide isomerase family A, member 6 -0.0219917
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0218015
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0216272
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0215167
IL7R interleukin 7 receptor -0.0213189
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0210809
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0206153
AFF3 AF4/FMR2 family, member 3 -0.0205306
GTF2IRD1 GTF2I repeat domain containing 1 -0.0203011
RNMT RNA (guanine-7-) methyltransferase -0.0202316
L1CAM L1 cell adhesion molecule -0.0201304
BIRC6 baculoviral IAP repeat containing 6 -0.0200276
NCOR2 nuclear receptor corepressor 2 -0.0199643
ZNFX1 zinc finger, NFX1-type containing 1 -0.019914
GBP1 guanylate binding protein 1, interferon-inducible -0.0198117
IRF1 interferon regulatory factor 1 -0.0198111
SRGN serglycin -0.0196354
SPIRE1 spire-type actin nucleation factor 1 -0.0195078
CDK6 cyclin-dependent kinase 6 -0.01941
HILPDA hypoxia inducible lipid droplet-associated -0.0192701
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0190233
COL5A1 collagen, type V, alpha 1 -0.0189242
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0189125
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0188785
ANKRD11 ankyrin repeat domain 11 -0.0186817
SAMD9 sterile alpha motif domain containing 9 -0.0186643
POTEF POTE ankyrin domain family, member F -0.0186207
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0182551
LCOR ligand dependent nuclear receptor corepressor -0.0180826
USP34 ubiquitin specific peptidase 34 -0.017821
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0177146
GDF15 growth differentiation factor 15 -0.0176966
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0176407
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0175349
FGF13 fibroblast growth factor 13 -0.0173744
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0171004
CALR calreticulin -0.0169688
TAPBP TAP binding protein (tapasin) -0.0166913
TNIP1 TNFAIP3 interacting protein 1 -0.0165696