Harringtonine_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Harringtonine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGR1 early growth response 1 0.125011
CXCL8 chemokine (C-X-C motif) ligand 8 0.11356
COL6A3 collagen, type VI, alpha 3 0.0892409
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.084749
MYH9 myosin, heavy chain 9, non-muscle 0.0765873
INHBA inhibin, beta A 0.0701547
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0649177
JUN jun proto-oncogene 0.0628718
FAT1 FAT atypical cadherin 1 0.0557053
IER2 immediate early response 2 0.0523708
ZFP36 ZFP36 ring finger protein 0.0488085
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0478925
CXCL3 chemokine (C-X-C motif) ligand 3 0.04729
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0458709
ENO1 enolase 1, (alpha) 0.0435886
UBC ubiquitin C 0.0423728
SQSTM1 sequestosome 1 0.0347395
MYO10 myosin X 0.0338691
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0329411
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0328864
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.031421
KLF10 Kruppel-like factor 10 0.0312777
ALCAM activated leukocyte cell adhesion molecule 0.0311957
ATP13A3 ATPase type 13A3 0.0310082
TRIO trio Rho guanine nucleotide exchange factor 0.0310019
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0304588
FNDC3B fibronectin type III domain containing 3B 0.0290067
SPAG9 sperm associated antigen 9 0.0283998
ZBTB10 zinc finger and BTB domain containing 10 0.027311
GADD45B growth arrest and DNA-damage-inducible, beta 0.0272027
AHNAK AHNAK nucleoprotein 0.0267959
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0267686
ERRFI1 ERBB receptor feedback inhibitor 1 0.0264273
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0258254
PLEC plectin 0.0254092
KDM6B lysine (K)-specific demethylase 6B 0.0249731
BRD2 bromodomain containing 2 0.0242618
CD83 CD83 molecule 0.0241455
STC1 stanniocalcin 1 0.0238866
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0235317
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0226703
SFPQ splicing factor proline/glutamine-rich 0.0217637
CADM1 cell adhesion molecule 1 0.0216448
JAG1 jagged 1 0.0215223
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0210709
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.020661
SMAD3 SMAD family member 3 0.0192629
CXCL2 chemokine (C-X-C motif) ligand 2 0.019253
BHLHE40 basic helix-loop-helix family, member e40 0.0187695
FOSL1 FOS-like antigen 1 0.0181127
HDAC9 histone deacetylase 9 0.0180573
SERTAD2 SERTA domain containing 2 0.0180139
IL6ST interleukin 6 signal transducer 0.0180104
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0179142
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0177425
H1-0 H1.0 linker histone 0.017514
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.0174527
PLK2 polo-like kinase 2 0.0174132
SELE selectin E 0.0172172
MCL1 myeloid cell leukemia 1 0.0167729
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0165434
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0163842
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.0159776
APP amyloid beta (A4) precursor protein 0.0159611
ELL2 elongation factor, RNA polymerase II, 2 0.0158436
DEPP1 DEPP autophagy regulator 1 0.0158431
ZFP36L1 ZFP36 ring finger protein-like 1 0.0158401
ZBTB38 zinc finger and BTB domain containing 38 0.015805
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0153866
COL7A1 collagen, type VII, alpha 1 0.0153309
QKI QKI, KH domain containing, RNA binding 0.0152735
RAD21 RAD21 homolog (S. pombe) 0.0150381
FLNA filamin A, alpha 0.0149595
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0140843
TIMP3 TIMP metallopeptidase inhibitor 3 0.0139666
PKM pyruvate kinase, muscle 0.0139066
AXL AXL receptor tyrosine kinase 0.0136078
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0134207
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0134023
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0133943
LOC102724023 ES1 protein homolog, mitochondrial 0.0133748
FBN1 fibrillin 1 0.0132889
RIPK4 receptor-interacting serine-threonine kinase 4 0.0131964
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0131504
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0131292
ZFAND3 zinc finger, AN1-type domain 3 0.0131094
VEGFA vascular endothelial growth factor A 0.013097
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0130858
TSC22D2 TSC22 domain family, member 2 0.013085
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.013028
TM4SF1 transmembrane 4 L six family member 1 0.0129158
GLS2 glutaminase 2 (liver, mitochondrial) 0.0128315
PCBP2 poly(rC) binding protein 2 0.0126293
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0125954
PICALM phosphatidylinositol binding clathrin assembly protein 0.0125619
PLAU plasminogen activator, urokinase 0.012531
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0125273
AHR aryl hydrocarbon receptor 0.0123105
MACF1 microtubule-actin crosslinking factor 1 0.0122589
FRMD6 FERM domain containing 6 0.0122362

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.142147
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0993763
NDRG1 N-myc downstream regulated 1 -0.0795252
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0587006
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0550382
CDH13 cadherin 13 -0.0525305
RPL35A ribosomal protein L35a -0.0507802
CD44 CD44 molecule (Indian blood group) -0.0495008
MT2A metallothionein 2A -0.0478829
VIM vimentin -0.0456921
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0456863
CSF1 colony stimulating factor 1 (macrophage) -0.043693
RPS6 ribosomal protein S6 -0.0430264
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0402576
FN1 fibronectin 1 -0.0394669
GBP1 guanylate binding protein 1, interferon-inducible -0.0378535
HLA-B major histocompatibility complex, class I, B -0.0368681
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0365436
RPS8 ribosomal protein S8 -0.0361209
FTL ferritin, light polypeptide -0.0358519
TMSB10 thymosin beta 10 -0.0354409
ZBTB20 zinc finger and BTB domain containing 20 -0.0334438
S100A9 S100 calcium binding protein A9 -0.0328237
RSAD2 radical S-adenosyl methionine domain containing 2 -0.030655
ACTG1 actin gamma 1 -0.030225
TGFBI transforming growth factor, beta-induced, 68kDa -0.0301976
EIF1 eukaryotic translation initiation factor 1 -0.0294667
SAMD9 sterile alpha motif domain containing 9 -0.028949
FBXL7 F-box and leucine-rich repeat protein 7 -0.0287178
DPYD dihydropyrimidine dehydrogenase -0.0286896
RND3 Rho family GTPase 3 -0.0281898
ZNFX1 zinc finger, NFX1-type containing 1 -0.0257666
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0255464
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0250899
TPT1 tumor protein, translationally-controlled 1 -0.0249804
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0248087
EXT1 exostosin glycosyltransferase 1 -0.0238645
COL1A2 collagen, type I, alpha 2 -0.0238365
RPLP1 ribosomal protein, large, P1 -0.023758
MAP4 microtubule-associated protein 4 -0.0233545
LMAN1 lectin, mannose-binding, 1 -0.0220478
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0219602
RPS19 ribosomal protein S19 -0.0215421
MT1X metallothionein 1X -0.0215189
RRBP1 ribosome binding protein 1 -0.0214507
RPL28 ribosomal protein L28 -0.02125
APOL6 apolipoprotein L, 6 -0.0212115
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0206745
CCL2 chemokine (C-C motif) ligand 2 -0.0205886
RPL8 ribosomal protein L8 -0.0204919
RPLP2 ribosomal protein, large, P2 -0.0204801
RPS21 ribosomal protein S21 -0.0197245
RPL34 ribosomal protein L34 -0.0190633
IFIH1 interferon induced with helicase C domain 1 -0.0189636
RPL11 ribosomal protein L11 -0.0189536
RPLP0 ribosomal protein, large, P0 -0.0180129
PSD3 pleckstrin and Sec7 domain containing 3 -0.0179459
NALF1 NALCN channel auxiliary factor 1 -0.0179207
GARS1 glycyl-tRNA synthetase 1 -0.0178163
MTDH metadherin -0.0177208
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0175697
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0174702
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0173904
FTH1 ferritin, heavy polypeptide 1 -0.0173711
RPS13 ribosomal protein S13 -0.0170956
RPS11 ribosomal protein S11 -0.0167988
RPS23 ribosomal protein S23 -0.0166889
TTC3 tetratricopeptide repeat domain 3 -0.0165433
RPS16 ribosomal protein S16 -0.0164199
RPS20 ribosomal protein S20 -0.0163595
SP100 SP100 nuclear antigen -0.0160587
TMEM165 transmembrane protein 165 -0.0158653
RAB2A RAB2A, member RAS oncogene family -0.0158335
LOXL2 lysyl oxidase-like 2 -0.0157811
RPL12 ribosomal protein L12 -0.0154967
TRPS1 trichorhinophalangeal syndrome I -0.0154458
RPS24 ribosomal protein S24 -0.01541
RIGI RNA sensor RIG-I -0.0149292
CCND1 cyclin D1 -0.0147632
TRIM56 tripartite motif containing 56 -0.0145391
GOLGA4 golgin A4 -0.0144784
RPL32 ribosomal protein L32 -0.0144767
MAML2 mastermind-like 2 (Drosophila) -0.0143812
B2M beta-2-microglobulin -0.0143024
COG5 component of oligomeric golgi complex 5 -0.0142146
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0141922
ATXN1 ataxin 1 -0.0140326
TAPBP TAP binding protein (tapasin) -0.01399
VDAC1 voltage-dependent anion channel 1 -0.0139715
RPL37 ribosomal protein L37 -0.0138474
TRAM1 translocation associated membrane protein 1 -0.0136172
DLG1 discs, large homolog 1 (Drosophila) -0.0135608
INSIG1 insulin induced gene 1 -0.0135599
HM13 histocompatibility (minor) 13 -0.0134979
RPL7 ribosomal protein L7 -0.0134934
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.013325
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0132698
RPL30 ribosomal protein L30 -0.0131253
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0129471
RPS14 ribosomal protein S14 -0.0128701