Harringtonine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Harringtonine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Harringtonine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.211392
KLF10 Kruppel-like factor 10 0.0848505
PLIN2 perilipin 2 0.0774925
SDC4 syndecan 4 0.0685049
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0632839
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0607096
SQSTM1 sequestosome 1 0.0579564
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0574251
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0543749
RNF213 ring finger protein 213 0.0517621
ERRFI1 ERBB receptor feedback inhibitor 1 0.0516923
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0513574
TPT1 tumor protein, translationally-controlled 1 0.0506409
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0487894
BHLHE40 basic helix-loop-helix family, member e40 0.0470109
CXCL8 chemokine (C-X-C motif) ligand 8 0.0457323
DDIT4 DNA-damage-inducible transcript 4 0.0428437
ENO1 enolase 1, (alpha) 0.0418806
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0415978
SVIL supervillin 0.0399569
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.0399364
HMGA1 high mobility group AT-hook 1 0.0399092
BIRC3 baculoviral IAP repeat containing 3 0.0396486
SKIL SKI-like proto-oncogene 0.0388264
SOD2 superoxide dismutase 2, mitochondrial 0.037354
DSPP dentin sialophosphoprotein 0.0359662
CFB complement factor B 0.0358397
MYH9 myosin, heavy chain 9, non-muscle 0.0352882
KYNU kynureninase 0.034403
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0342816
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0342539
SOX5 SRY (sex determining region Y)-box 5 0.0341657
MCL1 myeloid cell leukemia 1 0.033761
TXNRD1 thioredoxin reductase 1 0.0337183
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0336592
KDM6B lysine (K)-specific demethylase 6B 0.0330994
BRD2 bromodomain containing 2 0.0327805
H3-3B H3.3 histone B 0.0313553
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0310753
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0302224
TRIO trio Rho guanine nucleotide exchange factor 0.028893
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0283557
GRB10 growth factor receptor-bound protein 10 0.0282173
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0282136
UGDH UDP-glucose 6-dehydrogenase 0.0278561
JUN jun proto-oncogene 0.0278143
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0275663
RSRC2 arginine/serine-rich coiled-coil 2 0.0275285
BZW1 basic leucine zipper and W2 domains 1 0.0275015
ASPH aspartate beta-hydroxylase 0.0267753
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0264021
ATF4 activating transcription factor 4 0.0258886
RPS24 ribosomal protein S24 0.0257835
ATXN1 ataxin 1 0.0256715
KLF6 Kruppel-like factor 6 0.0256069
H1-0 H1.0 linker histone 0.025273
ISG15 ISG15 ubiquitin-like modifier 0.0244339
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.02416
SOX9 SRY (sex determining region Y)-box 9 0.0238927
LPP LIM domain containing preferred translocation partner in lipoma 0.0238911
MACF1 microtubule-actin crosslinking factor 1 0.0237634
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0237339
RIGI RNA sensor RIG-I 0.0235088
EIF1 eukaryotic translation initiation factor 1 0.0235084
KRT8 keratin 8, type II 0.0234215
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.0233206
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0232708
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0232345
RNASEH2A ribonuclease H2, subunit A 0.0231603
PRRC2C proline-rich coiled-coil 2C 0.0231574
IFIH1 interferon induced with helicase C domain 1 0.0231151
KIAA1217 KIAA1217 0.0225161
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.022147
EGR1 early growth response 1 0.0219522
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0218978
JAK1 Janus kinase 1 0.0216913
DTNA dystrobrevin, alpha 0.0214621
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0214528
INTS6 integrator complex subunit 6 0.0213833
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.021319
DARS1 aspartyl-tRNA synthetase 1 0.0212959
SP100 SP100 nuclear antigen 0.0212807
RBBP6 retinoblastoma binding protein 6 0.0211616
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0209177
NRIP1 nuclear receptor interacting protein 1 0.0201021
SMAD3 SMAD family member 3 0.0197779
SON SON DNA binding protein 0.019589
EEF2 eukaryotic translation elongation factor 2 0.0195313
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0192285
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.01921
CDV3 CDV3 homolog (mouse) 0.0191807
AHNAK AHNAK nucleoprotein 0.0191195
NHSL1 NHS-like 1 0.0190918
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0190647
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.018913
MX2 MX dynamin-like GTPase 2 0.0186116
RHOB ras homolog family member B 0.0185773
PTPRK protein tyrosine phosphatase, receptor type, K 0.0183389
PNRC1 proline-rich nuclear receptor coactivator 1 0.0183287
B2M beta-2-microglobulin 0.0183116

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.320334
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.270857
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.128359
FN1 fibronectin 1 -0.123864
MT2A metallothionein 2A -0.0983272
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0955701
C3 complement component 3 -0.072139
ELL2 elongation factor, RNA polymerase II, 2 -0.069551
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0661475
GPC3 glypican 3 -0.0625795
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0624583
FNDC3B fibronectin type III domain containing 3B -0.057951
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.046857
NKD1 naked cuticle homolog 1 (Drosophila) -0.0460524
CPE carboxypeptidase E -0.0457882
MAML2 mastermind-like 2 (Drosophila) -0.0425178
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0398911
FBF1 Fas (TNFRSF6) binding factor 1 -0.0397401
TF transferrin -0.0385628
AHSG alpha-2-HS-glycoprotein -0.0371379
SLC38A2 solute carrier family 38, member 2 -0.0363983
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0361476
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.035622
EML4 echinoderm microtubule associated protein like 4 -0.034992
DOCK4 dedicator of cytokinesis 4 -0.0340018
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0339732
TRIM26 tripartite motif containing 26 -0.0323491
APOE apolipoprotein E -0.0322846
MALT1 MALT1 paracaspase -0.0318855
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0304012
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0299378
TMEM123 transmembrane protein 123 -0.0295918
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0285555
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.028125
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0279911
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0268176
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0265035
A2M alpha-2-macroglobulin -0.0264531
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0262796
SESTD1 SEC14 and spectrin domains 1 -0.025198
MBNL2 muscleblind-like splicing regulator 2 -0.0250267
INSIG2 insulin induced gene 2 -0.0246398
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0244137
LYZ lysozyme -0.02438
APLP2 amyloid beta (A4) precursor-like protein 2 -0.023802
APOB apolipoprotein B -0.0232774
APOH apolipoprotein H (beta-2-glycoprotein I) -0.022405
VEGFA vascular endothelial growth factor A -0.0223266
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0220947
VMP1 vacuole membrane protein 1 -0.0218985
PCBP2 poly(rC) binding protein 2 -0.0214986
MBNL3 muscleblind-like splicing regulator 3 -0.0214949
NPAS2 neuronal PAS domain protein 2 -0.0207648
WDFY2 WD repeat and FYVE domain containing 2 -0.0204557
AMBP alpha-1-microglobulin/bikunin precursor -0.0204291
PTPRM protein tyrosine phosphatase, receptor type, M -0.0204278
PDIA3 protein disulfide isomerase family A, member 3 -0.0197934
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0190659
PEG10 paternally expressed 10 -0.0189819
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0189052
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0188903
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0188062
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0184595
SOS1 son of sevenless homolog 1 (Drosophila) -0.0181669
CST3 cystatin C -0.0177145
MTUS1 microtubule associated tumor suppressor 1 -0.0176661
APOA1 apolipoprotein A-I -0.0175557
ADAM9 ADAM metallopeptidase domain 9 -0.0174558
RTN4 reticulon 4 -0.0169965
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0169119
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0168843
KIZ kizuna centrosomal protein -0.0168067
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0163234
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0160539
DLC1 DLC1 Rho GTPase activating protein -0.0160404
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0153162
GDF15 growth differentiation factor 15 -0.0152642
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -0.0152442
CD46 CD46 molecule, complement regulatory protein -0.0148593
ADAM10 ADAM metallopeptidase domain 10 -0.014737
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.014683
ESYT2 extended synaptotagmin-like protein 2 -0.014639
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0146052
RPS3 ribosomal protein S3 -0.0144179
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -0.0142976
AGXT alanine-glyoxylate aminotransferase -0.014284
ADGRG6 adhesion G protein-coupled receptor G6 -0.0141906
CRLS1 cardiolipin synthase 1 -0.0140828
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0140286
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0139817
PHF21A PHD finger protein 21A -0.0139425
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.0134887
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0134447
PNISR PNN-interacting serine/arginine-rich protein -0.0133165
LMAN1 lectin, mannose-binding, 1 -0.0132981
PTBP3 polypyrimidine tract binding protein 3 -0.0131663
GRK3 G protein-coupled receptor kinase 3 -0.0130864
BPIFB2 BPI fold containing family B, member 2 -0.0130185
LMCD1 LIM and cysteine-rich domains 1 -0.0129437
PERP PERP, TP53 apoptosis effector -0.012743